Man

Carmen Aurora Romero Osses

Jefe Laboratorio Endocrinología y Biología Reproductiva

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


- Neuroendocrinología del ovario de mamíferos.- Importancia de las neurotrofinas en especial del factor de crecimiento nervioso (NGF) en la función ovárica normal y en cancer ovárico. Evaluación de oncoproteínas y microRNAs en Cáncer de Ovario.

Educación

  •  Bioquimica, UNIVERSIDAD DE CHILE. Chile, 1973
  •  Biología de la Reproducción, UNIVERSIDAD DE CHILE. Chile, 1983
  •  Neuro-Endocrinología del Ovario, OREGON HEALTH SCIENCES UNIVERSITY. Estados Unidos, 1999
  •  Gestión en Salud, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    2010 - A la fecha

  •   Docente en diferentes cursos de pre y post grado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1973 - A la fecha

Experiencia Profesional

  •   Jefe Laboratorio de Endocrinología y Biología Reproductiva Hospital Clínico Universidad de Chile Full Time

    Universidad de Chile

    Santiago, Chile

    1973 - A la fecha

  •   Académico de Facultad de Ciencias Químicas y Farmacéuticas Part Time

    Universidad de Chile

    Santiago, Chile

    2009 - A la fecha

  •   WHO Fellow Full Time

    London University

    Londres, Reino Unido

    1977 - 1978

  •   WHO Fellow Full Time

    Hospital Libre de Bruselas

    Bruselas, Bélgica

    1978 - 1978

Formación de Capital Humano


Durante mi carrera profesional y académica he dirigido variadas Tesis tanto de pregrado como de postgrado:

ALUMNOS DE LA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS, UNIVERSIDAD DE CHIE:

- Tesis Optar el Título de Bioquímico
- Tesis de Magister en Bioquímica
- Tesis de Doctorado en Bioquímica
- Tesis de Doctorado en Ciencias Farmacológicas,
- Tesis de Doctorado en Farmacología

ALUMNOS DE LA FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

- Tesis para optar al Título de Tecnólogo Médico,
- Tesis de Magister en Ciencias Biomédicas


Difusión y Transferencia


HE REALIZADO DIFUSIÓN DE MI TRABAJO DE INVESTIGACIÓN A ALUMNOS DE LA COMUNA DE INDEPENDENCIA

SE HA REALIZADO DIFUSIÓN DE MI TRABAJO DE INVESTIGACIÓN EN VARIOS SIMPOSIOS NACIONALES E INTERNACIONALES ASI COMO TAMBIEN EN CONGRESOS NACIONALES E INTERNACIONALES



 

Article (78)

Follicle-stimulating hormone promotes nerve growth factor and vascular endothelial growth factor expression in epithelial ovarian cells.
NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells.
Angiogenesis in Gynecological Cancers: Role of Neurotrophins
NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis.
Effect of TNF-alpha on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome
Effect of TNF-α on molecules related to the insulin action in endometrial cells exposed to hyperandrogenic and hyoerinsulinic conditions characteristics of Polycystic Ovary Syndrome (PCOS).
Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells
Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells.
Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells.
Combined dexamethasone and desmopressin test in the differential diagnosis of ACTH-dependent Cushing's syndrome and pseudo-cushing's states.
Effect of estradiol on the expression of angiogenic factors in epithelial ovarian cancer
Effect of estradiol on the expression of angiogenic factors in epithelial ovarian cancer
Endometrium and steroids, a pathologic overview
Maternal Plasma Nerve Growth Factor at the 11(+0)-13(+6) Weeks' Scan as a Potential Angiogenic Marker of Preeclampsia: A Pilot Study
Molecular Mechanisms of Androstenediol in the Regulation of the Proliferative Process of Human Endometrial Cells
Molecular mechanisms of androstenediol in the regulation of the proliferative process of human endometrial cells.
Role of Nerve Growth Factor (NGF) and miRNAs in epithelial ovarian cancer.
The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells
The Nerve Growth Factor calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer.
Altered steroid metabolism and insulin signaling in PCOS endometria: Impact in tissue function
https://pubmed.ncbi.nlm.nih.gov/26614265/
Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia
Role of dihydrotestosterone (DHT) on TGF-beta 1 signaling pathway in epithelial ovarian cancer cells
Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells.
Causes and management of severe acute liver damage during pregnancy [Actualización en el diagnóstico y manejo del daño hepático agudo grave en el embarazo]
Endometria from Obese PCOS Women with Hyperinsulinemia Exhibit Altered Adiponectin Signaling
Endometria from Obese PCOS women with hyperinsulinemia exhibit altered adiponectin signaling
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells
Expression of steroid sulfated transporters and 3 beta-HSD activity in endometrium of women having polycystic ovary syndrome
Expression of steroid sulfated transporters and 3β-HSD activity in endometrium of women having polycystic ovary syndrome
Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells
Plasma ghrelin levels in the late postoperative period of vertical sleeve gastrectomy
Plasma ghrelin levels in the late postoperative period of vertical sleeve gastrectomy [Efecto de la gastrectomía tubular vertical en los niveles de ghrelina plasmática en pacientes obesos]
Association between obesity and ovarian cancer
Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population
Role of Nerve Growth Factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ovary syndrome
Decreased Phosphorylation of Y(14)Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue
Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population
Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients
Testosterone Modulates the Expression of Molecules Linked to Insulin Action and Glucose Uptake in Endometrial Cells
ADAM17 and TRKA receptor are involved in epithelial ovarian cancer progression,
Advances in Neuroendocrine Mechanisms,
Advances in Neuroendocrine Mechanisms,
Nerve Growth Factor Induces the Expression of Chaperone Protein Calreticulin in Human Epithelial Ovarian Cells
Nerve growth factor induces the expression of chaperone protein calreticulin in human epithelial ovarian cells.
Nerve Growth Factor Stimulates Cellular Proliferation of Human Epithelial Ovarian Cancer
Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)
Role of dihydrotestosterone (DHT) on the TGF-beta 1 receptors expression in epithelial ovarian cancer,
The Chaperone Protein Calreticulin Is Expressed in Human Ovarian Tissues
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer
Changes in the Expression of Insulin Signaling Pathway Molecules in Endometria from Polycystic Ovary Syndrome Women with or without Hyperinsulinemia
Changes in the Expression of Insulin Signaling Pathway Molecules in Endometria from Polycystic Ovary Syndrome Women with or without Hyperinsulinemia. Molecular medicine,
Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
Isolation of Viable Porcine Islets by Selective Osmotic Shock Without Enzymatic Digestion
Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women
Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome
Salivary cortisol among subjects with and without Cushing syndrome
Salivary cortisol among subjects with and without Cushing Syndrome [Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile]
The conversion of dehydroepiandrosterone into androst-5-ene-3 beta,17 beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome
Increased free fetal DNA levels in early pregnancy plasma of women who subsequently develop preeclampsia and intrauterine growth restriction
Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia
Nerve growth factor and its high-affinity receptor trkA participate in the control of vascular endothelial growth factor expression in epithelial ovarian cancer
Effects of nerve growth factor (NGF) on blood vessels area and expression of the angiogenic factors VEGF and TGFbetaI in the rat ovary
Expression of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome
Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion
TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary
Evaluation of tumor necrosis factor alpha production in ex vivo short term cultured whole blood from women with polycystic ovary syndrome
Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary
Neurotrophic control of ovarian development
Nerve growth factor is required for early follicular development in the mammalian ovary
Release of norepinephrine from human ovary - Coupling to steroidogenic response
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
Pro-Inflammatory Markers Negatively Regulate IRS1 in Endometrial Cells and Endometrium from Women with Obesity and PCOS
The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment
The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer

Abstract (7)

Activation of TRKA receptor by nerve growth factor induces shedding of P75 receptor related with progression of epithelial ovarian cancer
Is DHT involved in the action of TGF-beta 1 in epithelial ovarian cancer?
ADAM17 and TRKA receptor are involved in epithelial ovarian cancer progression
Role of dihydrotestosterone (DHT) on the TGF-beta 1 receptors expression in epithelial ovarian cancer
ADAM17 Expression Is Increased in Epithelial Ovarian Carcinoma.
The Chaperone Protein Calreticulin Is Expressed in Human Ovarian Tissues
NGF increases the expression of VEGF in epithelial ovarian carcinoma.

EditorialMaterial (1)

Advances in Neuroendocrine Mechanisms

Proyecto (12)

ROLE OF NERVE GROWTH FACTOR ON THE REGULATION OF MIRNAS 23B AND MIRNA145 AND INFLAMMATORY MOLECULES INVOLVED IN CELL PROLIFERATION AND TUMOR ANGIOGENESIS OF EPITHELIAL OVARIAN CANCER
Centro de estudios avanzados de enfermedades crónicas (ACCDiS)
Involvement of adiponectin in the regulation of endometrial metabolic function of obese women bearing polycystic ovarian syndrome and hiperinsulinism
Ovarian cancer initiation and spread in a syngeneic mouse model at estropausal state
Desarrollo de una plataforma tecnológica para análisis cuantitativos, cualitativo y de distribución subcelular de proteínas
"CONTRIBUTION OF TRKA RECEPTOR ISOFORMS TO THE CELLULAR PROLIFERATION AND ANGIOGENESIS OF EPITHELIAL OVARIAN CANCER=> POTENTIAL TARGETS FOR THERAPEUTIC INTERVENTION"
Contribution of trkA receptor isoforms to the cellular proliferation and angiogenesis of epithelial ovarian cancer=> Potential targets for therapeutic intervention.
EFECTO DE LA CONDICION HIPERANDROGENICA E HIPERINSULINICA SOBRE MOLECULAS REGULADORAS DE LA EXPRESION Y TRAFICO INTRACELULAR DEL TRANSPORTADOR DE GLUCOSA GLUT4 EN ENDOMETRIOS DE PACIENTES CON SINDROME DE OVARI POLIQUISTICO
PARTICIPACION DEL RECEPTOR trkA Y SU LIGANDO, EL FACTOR DE CRECIMIENTO NERVIOSO (NGF), EN LA GENESIS Y PROGRESION DEL CANCER OVARICO EPITELIAL.
"PARTICIPACION DEL MICROAMBIENTE ESTEROIDAL SOBRE LA PROLIFERACION Y SUPERVIVENCIA CELULAR EN ENDOMETRIOS OBTENIDOS DE PACIENTES CON SINDROME DE OVARIO POLIQUISTICO (SOP)"
PARTICIPACION DEL FACTOR DE CRECIMIENTO NERVIOSO(NGF) Y SU RELACION CON EL FACTOR DE CRECIMIENTO DEL EPITELIO VASCULAR(VEGF) EN LA ANGIOGENESIS DEL OVARIO. ESTUDIO EN OVARIO NORMAL Y CANCER EPITELIAL
ESTUDIO DEL EFECTO ANTIPROLIFERATIVO Y APOPTOTICO DE ANALOGOS DE GnRH SOBRE CELULAS DE CANCER PROSTATICO HUMANO EN CULTIVOS BICAMERALES. INTERACCION CON NGF Y SUS RECEPTORES

Review (2)

Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer
Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
72
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

33
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

4
Alfonso Paredes

Investigador principal

Bioquímica y Biología Molecular

University of Chile / Faculty of Chemical Sciences and Pharmacy

Santiago, Chile

4
Alfonso Paredes

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Paulina Ormazábal

Assistant Professor

Institute of Health Sciences

Universidad de O'Higgins

Rancagua, Chile

3
Marcela Julio

Profesor Adjunto

Instituto de Química

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

Valparaiso, Chile

2
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

2
Hernan Lara

Profesor Titular

Bioquimica y Biologia Molecular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

2
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Luis Leon

Director of Bioinformatics

R&D

Genoma Mayor SpA

Santiago, Chile

2
Macarena Valladares

Profesor asociado

UNIVERSIDAD BERNARDO O'HIGGINS

Santiago, Chile

1
Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

1
Daniela Parrau

Profesor asistente

Morfofunción

Universidad Diego Portales

Santiago, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Lilian Jara

Titular Professor

Human Molecular Genetic

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

Santiago, Chile

1
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
JAVIER BRAVO

PROFESOR ADJUNTO

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

1
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Yenny Muñoz

sin cargo

Particular

santiago, Chile

1
Rocío Retamales

Docente

Facultad de Ciencias Agropecuarias

Universidad Pedro de Valdivia

Santiago, Chile