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Maria Margarita Vega Blanco

Academico Profesora Titular

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Regulation of female reproduction function: Cellular and molecular regulatory mechanisms of normal and pathological ovarian and endometrial function; Regulation of endometrial homeostasis and function in tissues obtained from patients with polycystic ovary syndrome

Biochemist, UNIVERSIDAD DE CHILE. Chile, 1972

Academico - Profesora Titular Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1972 - A la fecha

Academico - Profesora Titular Full Time

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1972 - A la fecha


Metformin improves ovarian insulin signaling alterations caused by fetal programming Heber, MF; Ferreira, SR; Abruzzese, GA; Trinidad, R; Pignataro, OP; Motta, AB Article ISI SCOPUS JOURNAL OF ENDOCRINOLOGY (2019)
Effect of TNF-alpha on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome Garcia V. Article ISI SCOPUS REPRODUCTIVE SCIENCES (2018)
Metformin prevents Nerve Growth Factor-dependent proliferative and pro-angiogenic effects in epithelial ovarian cancer cells and endothelial cellsc Garrido M, Vera C, Vega M, Quest A, Romero C Article Therapeutical Advances in Medical Oncology (2018)
Effect of estradiol on the expression of angiogenic factors in epithelial ovarian cancer Article ISI SCOPUS HISTOLOGY AND HISTOPATHOLOGY (2017)
Molecular Mechanisms of Androstenediol in the Regulation of the Proliferative Process of Human Endometrial Cells Article ISI SCOPUS REPRODUCTIVE SCIENCES (2017)
The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells Article ISI SCOPUS INTERNATIONAL JOURNAL OF ONCOLOGY (2017)
Altered steroid metabolism and insulin signaling in PCOS endometria: Impact in tissue function Orostica L, Rosas C, Plaza-Parrochia F, Astorga I, Gabler F, Garcia V, Romero C, Vega M Article CURRENT PHARMACEUTICAL DESIGN (2016)
Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia Bacallao, K; Plaza-Parrochia F.; Cerda A.; Gabler F.; Romero C.; Vantman D.; Vega M. Article ISI SCOPUS REPRODUCTIVE SCIENCES (2016)
Pro-inflammatory environment and role of TNF-a in endometrial function of obese women having Polycystic Ovarian Syndrome Orostica L, Astorga I, Plaza-Parrochia F, Vera C, Garcia V, Carvajal R, Gabler F, Romero C, Vega M Article INTERNATIONAL JOURNAL OF OBESITY (2016)
Role of dihydrotestosterone (DHT) on TGF-beta 1 signaling pathway in epithelial ovarian cancer cells Kohan-Ivani, K; Gabler F.; Selman A.; Vega M.; Romero C. Article ISI SCOPUS JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2016)
Endometria from Obese PCOS Women with Hyperinsulinemia Exhibit Altered Adiponectin Signaling Garcia V.; Oróstica, L; Poblete C.; Rosas C.; Astorga I.; Romero C.; Vega M. Article ISI SCOPUS Hormone and Metabolic Research (2015)
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells Diaz-Valdivia, N.; Bravo D.; Huerta H.; Henriquez, S; Gabler F.; Vega M.; Romero C.; Calderon C.; Owen G.I.; Leyton L.; et al. Article ISI SCOPUS BMC Cancer (2015)
Expression of steroid sulfated transporters and 3 beta-HSD activity in endometrium of women having polycystic ovary syndrome Plaza-Parrochia F.; Poblete C.; Gabler F.; Carvajal R.; Romero C.; Valladares L.; Vega M. Article ISI SCOPUS Steroids (2015)
Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells Rosas C.; Oróstica, L; Poblete C.; Carvajal R.; Gabler F.; Romero C.; Lavandero S.; Vega M. Article SCOPUS Reproductive Sciences (2015)
The role of androst-5-ene-3 beta,17 beta-diol (androstenediol) in cell proliferation in endometrium of women with polycystic ovary syndrome Plaza-Parrochia F.; Bacallao, K; Poblete C.; Gabler F.; Carvajal R.; Romero C.; Valladares L.; Vega M. Article ISI SCOPUS STEROIDS (2014)
Decreased Phosphorylation of Y(14)Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue Ormazabal P.; Romero C.; Gabler F.; Quest A.F.G.; Vega M. Article ISI SCOPUS Hormone and Metabolic Research (2013)
Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients Carvajal R.; Rosas C.; Kohan, K; Gabler F.; Vantman D.; Romero C.; Vega M. Article ISI SCOPUS Human Reproduction (2013)
Testosterone Modulates the Expression of Molecules Linked to Insulin Action and Glucose Uptake in Endometrial Cells Ormazabal P.; Romero C.; Quest A.F.G.; Vega M. Article ISI SCOPUS Hormone and Metabolic Research (2013)
Nerve Growth Factor Induces the Expression of Chaperone Protein Calreticulin in Human Epithelial Ovarian Cells Vera C.; Tapia V.; Kohan, K; Gabler F.; Ferreira A.; Selman A.; Vega M.; Romero C. Article ISI SCOPUS Hormone and Metabolic Research (2012)
Nerve Growth Factor Stimulates Cellular Proliferation of Human Epithelial Ovarian Cancer Urzua, U; Tapia V.; Geraldo M.P.; Selman A.; Vega M.; Romero C. Article ISI SCOPUS Hormone and Metabolic Research (2012)
Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS) Rivero R.; Ormazabal P.; Silva A.; Carvajal R.; Gabler F.; Romero C.; Vega M. Article ISI SCOPUS Reproductive Biology and Endocrinology (2012)
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer Tapia V.; Gabler F.; Munoz, M.; Yazigi R.; Paredes Ã.; Selman A.; Vega M.; Romero C. Article ISI SCOPUS Gynecologic Oncology (2011)
Changes in the Expression of Insulin Signaling Pathway Molecules in Endometria from Polycystic Ovary Syndrome Women with or without Hyperinsulinemia Fornes R.; Ormazabal P.; Rosas C.; Gabler F.; Vantman D.; Romero C.; Vega M. Article ISI SCOPUS Molecular Medicine (2010)
Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women Rosas C.; Gabler F.; Vantman D.; Romero C.; Vega M. Article ISI SCOPUS Human Reproduction (2010)
Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome Kohan, K; Carvajal R.; Gabler F.; Vantman D.; Romero C.; Vega M. Article ISI SCOPUS Reproduction (2010)
The conversion of dehydroepiandrosterone into androst-5-ene-3 beta,17 beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome Plaza F.; Gabler F.; Romero C.; Vantman D.; Valladares L.; Vega M. Article ISI SCOPUS Steroids (2010)
Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome Villavicencio A.; Goyeneche, A; Telleria, C; Bacallao, K; Gabler F.; Fuentes, A.; Vega M. Article ISI SCOPUS GYNECOLOGIC ONCOLOGY (2009)
Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway Julio-Pieper M.; Lozada, P; Tapia V.; Vega M.; Miranda C.; Vantman D.; Ojeda, SR; Romero C. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome León, L; Bacallao, K; Gabler F.; Romero C.; Valladares L.; Vega M. Article ISI SCOPUS STEROIDS (2008)
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia Bacallao, K; León, L; Gabler F.; Soto E.; Romero C.; Valladares L.; Vega M. Article ISI SCOPUS JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
Deregulation of tissue homeostasis in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia Villavicencio A.; Bacallao, K; Gabler F.; Fuentes, A.; Albornoz J.; Casals, A; Vega M. Article ISI SCOPUS GYNECOLOGIC ONCOLOGY (2007)
Sex hormone-binding globulin expression in the endometria of women with polycystic ovary syndrome Maliqueo M.; Bacallao, K; Quezada S.; Clementi M.; Gabler F.; Johnson M.C.; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2007)
Androgen and estrogen receptors and co-regulators levels in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia Villavicencio A.; Bacallao, K; Avellaira, C; Gabler F.; Fuentes, A.; Vega M. Article ISI SCOPUS GYNECOLOGIC ONCOLOGY (2006)
Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome Quezada S.; Avellaira, C; Johnson M.C.; Gabler F.; Fuentes, A.; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2006)
Expression of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome Avellaira, C; Villavicencio A.; Bacallao, K; Gabler F.; Wells, P; Romero C.; Vega M. Article ISI SCOPUS HUMAN REPRODUCTION (2006)
Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion Salas C.; Julio-Pieper M.; Valladares M.; Pommer R.; Vega M.; Mastronardi C.; Kerr B.; Ojeda, SR; Romero C. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-betaI and bax genes Johnson M.C.; Torres M.; Alves A.; Bacallao, K; Fuentes, A.; Vega M. Article ISI SCOPUS REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2005)
Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clorniphene citrate Fuentes, A.; Gabler F.; Vega M.; Devoto L. Article ISI SCOPUS FERTILITY AND STERILITY (2005)
Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients Cortinez, A; De Carvalho, I; Vantman D.; Gabler F.; Iñiguez, G; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2005)
Differential in vitro actions of nitric oxide on human endometrial cell survival Johnson M.C.; Maliqueo M.; Villavicencio A.; Vantman D.; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2004)
Interleukin-1 beta up-regulates nitrite production: effects on ovarian function Estevez A.; Farina M.; Franchi Ã?.; Johnson C.; Vega M.; Motta, AB Article ISI SCOPUS Nitric Oxide (2004)
P(450)Arom and estrogenic microenvironment of eutopic endometria in endometriosis Johnson M.C.; Pinto C.; Alves A.; Palomino A.; Fuentes, A.; Boric, A; Vega M. Article ISI REVISTA MEDICA DE CHILE (2004)
Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells Maliqueo M.A.; Quezada S.; Clementi M.; Bacallao, K; Anido, M; Johnson C.; Vega M. Article SCOPUS REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2004)
Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome Maliqueo M.; Clementi M.; Gabler F.; Johnson M.C.; Palomino A.; Sir Petermann T; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2003)
Control of human luteal steroidogenesis Devoto L.; Kohen P.; Vega M.; Castro O.; Retamales, I.; Carvallo P.; Christenson, LK; Strauss J.F. Article ISI MOLECULAR AND CELLULAR ENDOCRINOLOGY (2002)
Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycle Devoto L.; Vega M.; Kohen P.; Castro O.; Carvallo P.; Palomino A. Article ISI JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2002)
Regulation of steroid synthesis and apoptosis by insulin-like growth factor I and insulin-like growth factor binding protein 3 in human corpus luteum during the midluteal phase Villavicencio A.; Iñiguez, G; Johnson M.C.; Gabler F.; Palomino A.; Vega M. Article ISI REPRODUCTION (2002)
Role of nitric oxide and bcl-2 family genes in the regulation of human endometrial apoptosis Castro A.; Johnson M.C.; Anido, M; Cortinez, A; Gabler F.; Vega M. Article ISI SCOPUS FERTILITY AND STERILITY (2002)
Effect of nitric oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum Iñiguez, G; Villavicencio A.; Gabler F.; Palomino A.; Vega M. Article ISI REPRODUCTION (2001)
Effect of nitrix oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum Iñiguez, G; Villavicencio A.; Gabler F.; Palomino A.; Vega M. Article SCOPUS REPRODUCTION (2001)
Expression of steroidogenic acute regulatory protein in the human corpus luteum throughout the luteal phase Devoto L.; Kohen P.; Castro O.; Retamales, I.; Vega M.; Carvallo P.; Chrisenson, LK; Strauss J.F. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)
Endocrine and paracrine-autocrine regulation of the human corpus luteum during the mid-luteal phase Devoto L.; Vega M.; Kohen P.; Castro A.; Castro O.; Christenson, LK; Carvallo P.; Strauss J.F. Article ISI JOURNAL OF REPRODUCTION AND FERTILITY (2000)
Nitric oxide induces apoptosis in the human corpus luteum in vitro Vega M.; Urrutia L.; Iñiguez, G; Gabler F.; Devoto L.; Johnson M.C. Article ISI SCOPUS MOLECULAR HUMAN REPRODUCTION (2000)


Activation of TRKA receptor by nerve growth factor induces shedding of P75 receptor related with progression of epithelial ovarian cancer Romero C.; Vallejos C.; Gabler F.; Selman A.; Vega M. Abstract ISI EUROPEAN JOURNAL OF CANCER (2014)
Is DHT involved in the action of TGF-beta 1 in epithelial ovarian cancer? Kohan, K; Poblete C.; Vega M.; Romero C. Abstract ISI CANCER RESEARCH (2013)
ADAM17 and TRKA receptor are involved in epithelial ovarian cancer progression Girardi S.; Tapia V.; Kohan, K; Contreras H.; Gabler F.; Selman A.; Vega M.; Romero C. Abstract ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Role of dihydrotestosterone (DHT) on the TGF-beta 1 receptors expression in epithelial ovarian cancer Kohan, K; Tapia V.; Vega M.; Romero C. Abstract ISI TUMOR BIOLOGY (2012)
ADAM17 Expression Is Increased in Epithelial Ovarian Carcinoma. Tapia, VM; Amtmann, N; Gabler F.; Selman A.; Vega M.; Romero C. Abstract ISI BIOLOGY OF REPRODUCTION (2011)
The Chaperone Protein Calreticulin Is Expressed in Human Ovarian Tissues Romero C.; Vera C.; Gabler F.; Ferreira A.; Selman A.; Vega M. Abstract ISI BIOLOGY OF REPRODUCTION (2011)
Differential molecule expression in eutopic secretory endometria from women with endometriosis Torres M.; Galleguillos C.; Ponce C.; Vega M.; Johnson M.C. Abstract ISI PLACENTA (2006)
Effect of embryonic culture media (ECM) on the expression of marker molecules of endometrial function Quezada S.; Quezada M.; Anido, M; Soto E.; Gabler F.; Pommer, A; Arguello, A; Vega M. Abstract ISI PLACENTA (2006)
Cell survival in endometria from polycystic ovary syndrome patients. Clementi M.; Maliqueo M.; Gabler F.; Sir Petermann T; Johnson C.; Palomino A.; Vega M. Abstract ISI BIOLOGY OF REPRODUCTION (2002)


Differential steroidogenic effect of pituitary hormones in primate corpus luteum Devoto L.; Kohen P.; Castro O.; Palomino A.; Vega M. ConferencePaper ISI ADVANCES IN GYNECOLOGICAL ENDOCRINOLOGY (2002)


Role of nerve growth on the regulation of miRNAs 23b and miRNA145 and inflammatory molecules involved in cell proliferation and tumor angiogenesis of epithelial ovarian cancer Main Researcher: Romero, Carmen; Vega, Maria Proyecto (2016)
Involvement Of Adiponectin In The Regulation Of Endometrial Metabolic Function Of Obese Women Bearing Polycystic Ovarian Syndrome And Hyperinsulinism Main researcher Proyecto (2013)
Contribution of trkA receptor isoforms to the cellular proliferation and angiogenesis of epithelial ovarian cancer: Potential targets for therapeutic intervention Vega, Maria Proyecto (2011)


Endometrium and steroids, a pathologic overview Review ISI SCOPUS STEROIDS (2017)
Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer Review ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis Vera C.; Tapia V.; Vega M.; Romero C. Review ISI SCOPUS JOURNAL OF OVARIAN RESEARCH (2014)
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature Devoto L.; Durand M.; Ezcurra E.; Larrea, F; Nagle, C; Vantman D.; Vega M.; von Hertzen, H Review ISI CONTRACEPTION (2001)

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Germán Iñiguez

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Denisse Bravo

Profesora Titular

Odontología

Universidad Andrés Bello

Santiago, Chile

Lisette Leyton

Full Professor

Núcleo Interdisciplinario Biología y Genética

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Alfonso Paredes

UNIVERSIDAD DE CHILE

Santiago, Chile

Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Marcela Julio

Profesor Adjunto

Instituto de Química

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

Valparaiso, Chile

ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Luis Leon

Head of Bioinformatics and Computational Biology

Technology

PhageLab

Santiago, Chile

Macarena Valladares

Profesor asociado

Universidad de Las Américas

Santiago, Chile

Paulina Ormazábal

Docente investigador

Facultad de Ciencias para el cuidado de la Salud

Universidad San Sebastián

Santiago, Chile

Alfonso Paredes

Investigador principal

Bioquímica y Biología Molecular

University of Chile / Faculty of Chemical Sciences and Pharmacy

Santiago, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Susana Quezada

Consultora

Banco Mundial

McLean, Estados Unidos

Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

Rocío Retamales

Consultora de análisis genómicos

Freelance

Dresden, Alemania

Karla Kohan

Profesional de laboratorio

Instituto de Salud Pública

Santiago, Chile

Maria Margarita Vega Blanco

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CHILE. Chile, 1972

Experiencia Académica

Academico - Profesora Titular Full Time

Experiencia Profesional

Academico - Profesora Titular Full Time

Article (53)

Abstract (9)

ConferencePaper (1)

Proyecto (3)

Review (4)