Captura_de_pantalla_2020-05-18_a_la(s)_22.54.52.png_thumb90

Gareth Ivor Owen Jardine

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Oncologia; Biologia Molecular; Cancer; Canceres Ginecologicos; Biologia del cancer; Terapias Biologicas del cancer; angiogenesis; vascularogenic mimicry; Immunoterapia en cancer

Educación

  •  Biotecnologia, KINGS COLLEGE LONDON. Reino Unido, 1992
  •  Bioquimica, UNIVERSITY OF LONDON. Chile, 1996

Experiencia Académica

  •   Profesor Asistente / Asociado Full Time

    Pontificia Universidad Católica de Chile

    Ciencias Biológicas

    Santiago, Chile

    2000 - 2018

  •   Profesor Titular Full Time

    Pontificia Universidad Católica de Chile

    Ciencias Biológicas

    Santiago, Chile

    2018 - A la fecha

  •   Profesor Titular Full Time

    Pontificia Universidad Católica de Chile

    Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Post doctorado Full Time

    University of Colorado Health Science Center

    Denver, Estados Unidos

    1996 - 1998

  •   Postdoctorado Full Time

    Institute of Cancer Reseach

    Londres, Reino Unido

    1998 - 2000

  •   Medical Directior Part Time

    Mygoldex Chile (Biotech cGMP Company)

    Santiago, Chile

    2004 - 2007

  •   Board Member Part Time

    Fundación Foro Nacional de Cancer

    Santiago, Chile

    2012 - A la fecha

  •   Board Member Part Time

    Grupo Oncológico Cooperativo Chileno de Investigación

    Santiago, Chile

    2016 - A la fecha

Formación de Capital Humano


Post-Graduate Students Graduated. (20 PhD / 2 MSc)

Student Dept/University Level Year Participation

20. Miguel Cordova Q&F, U. Chile Doctorate Graduated 2020 Tutor
19. Cristobal Fuentes Physiology PUC Doctorate Graduated 2020 co-tutor /Vecchiola
18. Maximiliano Arce Physiology PUC Doctorate Graduated 2019 Tutor
17. Andres Valdivia Physiology PUC Doctorate Graduated 2019 Tutor
16. Monica Marquez Physiology PUC Doctorate Graduated 2019 Tutor
15. Dusan Racordon Physiology PUC Doctorate Graduated 2018 Tutor
14. Renan Orellana Physiology PUC Doctorate Graduated 2014 Tutor
13. Rafaela Erices U.N.Andres Bello Doctorate Graduated 2013 Tutor
12. Cristian Carvajal Medicine PUC Doctorate Graduated 2013 co-tutor /Fardella
11. Soledad Lange Physiology PUC Doctorate Graduated 2013 Tutor
10. Macarena Vargas Physiology PUC Doctorate Graduated 2011 Tutor
9. Ma. Loreto Bravo Physiology PUC Doctorate Graduated 2010 Tutor
8. Marisol Quezada Physiology PUC Doctorate Graduated 2009 Tutor
7. Soledad Henriquez Physiology PUC Doctorate Graduated 2009 Tutor
6. Evelyn Aranda Physiology PUC Doctorate Graduated 2008 Tutor
5. Ethel Velasquez Physiology PUC Doctorate Graduated 2008 Tutor
4. Anil Sadarangani Physiology PUC Doctorate Graduated 2007 Tutor
3. Ana Maria Meneses U.N. Andres Bello Doctorate Graduated 2006 Tutor
2. Mauricio Pinto Physiology PUC Doctorate Graduated 2005 Tutor
1. Andres Carvajal Physiology PUC Doctorate Graduated 2004 Tutor

1. Sumie Kato Physiology PUC Masters Graduated 2004 Tutor
2. Antonela Rosetti Biol Cel. Mol. PUC Masters Graduated 2017 co-tutor / Nervi


Difusión y Transferencia


Patent Applications

Andrea Vecchiola, Cristian Carvajal, María del Carmen Campino, Sandra Solari, Fidel Allende, Gareth Owen, Carlos Fardella.
Methods to identify inhibitors of 11?-HSD1. Application (DPI): 5237 20150115 P- 11BHSD1. Enero 2015

Owen, GI. Bravo, María Loreto, Kato Sumie, Cuello, Mauricio, Orellana, Renán, Gonzalez, Pamela.
Process for obtaining cell culture to perform personalized medicine. Application a (DPI): Pat 3449-2014 Dec 2014

Ma. Soledad Lange Smith, Evelyn Aranda Jaque y Gareth Owen.
Use of coagulation Factor X and Xa in the treatment of angiogenic disorders”. Application (DPI): Jan 2013, No. 300912

Owen GI., Sadarangani A., Velasquez E., Croxatto H:
Use of a FSH fraction in the control of cell proliferation.
Reception at Patent Office (DPI): 10/12/08 December 2008. No. 03692 PCT, Diciembre 11, 2009



 

Article (118)

Impact of the Potential Antitumor Agent 2-(4-Hydroxyphenyl) Amino-1,4-Naphthoquinone (Q7) on Vasomotion Is Mediated by the Vascular Endothelium, But Not Vascular Smooth Muscle Cell Metabolism
Mechanobiology of Autophagy: The Unexplored Side of Cancer
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability
Deciphering the Role of the Coagulation Cascade and Autophagy in Cancer-Related Thrombosis and Metastasis
Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division
Multi-Objective Optimization for Personalized Prediction of Venous Thromboembolism in Ovarian Cancer Patients
The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer
Chilean Registry for Neuroendocrine Tumors: A Latin American Perspective
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?
High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study
Targeted deep sequencing from multiple sources demonstrates increased NOTCH1 alterations in lung cancer patient plasma
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish
Using plasma cell-free DNA to monitor the chemoradiotherapy course of cervical cancer
Chilean Gastric Cancer Task Force A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues
Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio)
Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer
Simvastatin interferes with cancer stem-cell plasticity reducing metastasis in ovarian cancer
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Reprimo tissue-specific expression pattern is conserved between zebrafish and human
Reprimo tissue-specific expression pattern is conserved between zebrafish and human
Structural and functional identification of vasculogenic mimicry in vitro
The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
Escaping antioangiogenic therapy=> strategies employed by cancer cells
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage.
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats
Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats.
A snapshot of cancer in Chile: Analytical frameworks for developing a cancer policy
A snapshot of cancer in Chile: Analytical frameworks for developing a cancer policy.
Citosine-Adenine-Repeat Microsatellite of 11β-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children.
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells.
LEPTIN PROMOTES A MORE AGGRESIVE BEHAVIOR OF OVARIAN CANCER CELLS: A POTENTIAL EXPLANATION FOR A WORSE PROGNOSIS IN OBESE OVARIAN CANCER PATIENTS: IGCS-0095 Ovarian Cancer.
Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells=> an explanation for poor outcomes in obese women.
Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells
Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.
Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor
Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor.
The twisted survivin connection to angiogenesis.
2-methoxyestradiol and disorders of female reproductive tissues.
High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome
High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening
Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening.
Independent anti-angiogenic capacities of coagulation factors X and Xa.
Independent anti-angiogenic capacities of coagulation factors X and Xa.
LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids
LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids.
Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor
Antiangiogenic, antimigratory and antiinflammatory effects of 2-methoxyestradiol in zebrafish larvae
Antiangiogenic, antimigratory and antiinflammatory effects of 2-methoxyestradiol in zebrafish larvae.
Breaking through an epigenetic wall Re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors
Breaking through an epigenetic wall: re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors
Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats
Concanavalin-A induces granulosa cell death and inhibits FSH-mediated follicular growth and ovarian maturation in female rats.
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
Efectos de las estatinas en cáncer: Potencial rol en terapéutica y prevención
In vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment. Report of two cases
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells
Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells.
Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells
Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells
Potencial Herramienta en la personalización del tratamiento oncológico.
11 beta-Hydroxysteroid Dehydrogenase Type 2 Polymorphisms and Activity in a Chilean Essential Hypertensive and Normotensive Cohort
11β-hydroxysteroid dehydrogenase type 2 polymorphisms and activity in a chilean essential hypertensive and normotensive cohort.
PPAR alpha and PPAR gamma regulate the nucleoside transporter hENT1
PPARα and PPARγ regulate the nucleoside transporter hENT1.
Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1
Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1
The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer
The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer
Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction.
Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and beta cell dysfunction
Progesterone Utilizes Distinct Membrane Pools of Tissue Factor to Increase Coagulation and Invasion and These Effects are Inhibited by TFPI
Progesterone Utilizes Distinct Membrane Pools of Tissue Factor to Increase Coagulation and Invasion and These Effects are Inhibited by TFPI
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
2-methoxyestradiol inhibits progesterone mediated Tissue Factor expression and activity in breast cancer cells.
2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase
Lipophilic but not hydrophilic statins selectively induce cell death in gynecological cancers expressing high levels of HMGCoA reductase.
A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line
A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line
Glucose Transporters in Sex Steroid Hormone Related Cancer
2-Methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts.
2-Methoxyestradiol Mediates Apoptosis Through Caspase-Dependent and Independent Mechanisms in Ovarian Cancer Cells But Not in Normal Counterparts
Characterization and phenotypic variation with passage number of cultured human endometrial adenocarcinoma cells
Establishment and characterization through passage number of human endometrial cancer cells in culture
Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension
Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1) gene polymorphisms in arterial hypertension
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75.
Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters
Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters
The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium
TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract
In vivo and in vitro estrogenic and progestagenic actions of Tibolone
Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1
Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75
Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells
Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells
Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells
Origins and evolutionary diversification of the nuclear receptor superfamily
Convergence of progesterone with growth factor and cytokine signaling in breast cancer - Progesterone receptors regulate signal transducers and activators of transcription expression and activity
Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300
Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells - Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation

Abstract (24)

Leptin induces an IL-6 mediated interaction between macrophages and ovarian cancer cells that prompted invasiveness and migration
MATERNAL OBESITY IMPAIRS MIGRATION OF FETAL ENDOTHELIUM INVOLVING ENDOPLASMIC RETICULUM STRESS
2-METHOXYESTRADIOL REVERTS EPITHELIAL MESENCHYMAL TRANSITION IN OVARIAN CANCER-INITIATING CELLS REDUCING THEIR INVASIVE CAPABILITY AND SENSITIZING THEM TO CHEMOTHERAPY
Ovarian cancer cells treated with leptin contribute with a pro-tumoral phenotype in macrophages in vitro
Personalized cancer therapy for ovarian cancer patients
Platelet interaction induces Tissue Factor and a pro-metastatic phenotype in ovarian cancer cells
PROSPECTIVE OBSERVATIONAL STUDY TO ASSESS THE INFLUENCE OF OVERWEIGHT AND OBESITY OVER SURVIVAL FOR PATIENTS WITH OVARIAN CANCER.
Simvastatin modifies the expression of stemness and epithelial-mesenchymal transition (EMT) markers in ovarian cancer-initiating cells resulting in decreased cell migration
2-Methoxyestradiol induces differentiation of epithelial ovarian cancer-initiating cells sensitizing them to chemotherapy.
Combining chemotherapy and targeted therapies against resistance and recurrence in ovarian cancer
In situ estrogen metabolism in subgroups of obese women with differing potential risk for developing endometrial cancer
PERSONALIZED CANCER THERAPY FOR OVARIAN CANCER PATIENTS.
Simvastatin Inhibits Leptin-activated Signaling Pathways That Promote Migration and Invasiveness of Ovarian Cancer Cells
A Novel Polymorphism in 11 beta-Hydroxysteroid Dehydrogenase Type 2 Gene (HSD11B2) Is Associated with High Urinary Excretion of Tetrahydro-11-Deoxycortisol (THS) in Essential Hypertensive Patients.
Central Obesity and the Metabolic Syndrome Are Associated with Portal and Not Systemic Hypercortisolism Supported by the Raise of Urinary Corticosteroid Metabolites
Leptin increases the invasiveness and angiogenesis-mediated but not proliferation in human epithelial ovarian cancer cells
Progesterone regulation of breast cancer cell coagulative and invasive potential is dependent on the distinct membrane localization of tissue factor
Visceral Hypercortisolism Observed in Central Obesity and Metabolic Syndrome Is Associated with Insulin Resistance and Beta Cell Dysfunction.
Establishment and characterization of a human uterine sarcoma cell line sensitive to TNF-related apoptosis inducing ligand plus doxorubicin.
Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters.
2-methoxiestradiol induces apoptosis in gynecologic cancer cells but not in normal cell lines established from reproductive tissues.
2-Methoxyestradiol induces apoptosis in ovarian cancer cells but not in normal cells
Characterization and phenotypic variation with passage number of cultured human endometrial adenocarcinoma cells.
TNF-related apoptosis inducing ligand (TRAIL) induces apoptosis in endometrial cancer cells but not in normal cells.

BookSection (1)

Nuclear Receptor Genes: Evolution

ConferencePoster (4)

The Chilean Gastric Cancer Task Force: an update of results
Coagulation factor Xa promotes melanoma metastasis
Mímica vasculogénica en cáncer de ovario
Vasculogenic mimicry: an alternative model of tumour irrigation

Editorial (1)

Cancer's new Achilles' heel?

Errata (2)

Author Correction: The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish (Scientific Reports, (2019), 9, 1, (7131), 10.1038/s41598-019-43436-8)
TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract (vol 12, pg 73, 2007)

Patent (4)

Methods to identify inhibitors of 11β-HSD1
Process for obtaining cell culture to perform personalized medicine
Use of a FSH fraction in the control of cell proliferation
Use of coagulation Factor X and Xa in the treatment of angiogenic disorders

Proyecto (44)

Mechanism of resistance to immunotherapy based on checkpoint inhibitors in metastatic gastric cancer
THE EXTRACELLULAR MATRIX PROMOTES THE PROCESS OF VASCULOGENIC MIMICRY AND THUS DELIVERS AN ADVANTAGE TO OVARIAN CANCER PROGRESSION.
BMS
Estudio de la relación entre los parámetros de difusión obtenida mediante imágenes de resonancia magnética (DW RM) y el número de Células clonogénicas en un tumor o muestra
Estudio De La Relación Entre Los Parámetros De Difusión Obtenidos Mediante Imágenes De Resonancia Magnética (Dwrm) Y El Número De Células Clonogénicas En Un Tumor O Muestra
Instituto Milenio de Inmunología e Inmunoterapia
Advanced Center for Chronic Diseases (ACCDIS)
Consorcio Tecnólogico en Biomedicina aplicada para el desarrollo de nuevas estrategias de prevención, diagnóstico y tratamiento; P6: Terapia oncológica personalizada: desarrollo de un servicio de diagnóstico para predecir individualmente en cada paciente cual tratamiento de quimioterapia entregará una respuesta clínica favorable en cáncer de ovario y cáncer del tracto gastrointestinal
Modulation of the process of Angiogenesis by Coagulation Factor X
MODULATION OF THE PROCESS OF ANGIOGENESIS BY COAGULATION FACTOR X
TERAPIA ONCOLÓGICA PERSONALIZADA
Advanced Center for Chronic Diseases (ACCDiS)
Ensayo de medicina personalizada para pacientes con cáncer de ovario y su expansión como servicio clínico nacional e internacional
Ensayo de medicina personalizada para pacientes con cáncer de ovario y su expansión como servicio clínico nacional e internacional
Identificación y desarrollo de inhibidores de la enzima 11beta-HSD1 para el tratamiento de la hipertensión arterial y el síndrome metabólico
Effects of statins in the maintenance, differentiation and drug sensitivity of cancer-initiating cells in ovarian cancer
Primary aldosteronism and HSD11B2 enzyme activity defects in pediatric population and its empact on the generation of endotelial injury, oxidative stress and arterial hypertension
The identification of subgroups of obese women with differing potential risk for developing endometrial carcinoma
The identification of subgroups of obese women with differing potential risk for developming endometrial carcinoma
Generación y desarrollo de nuevos fármacos para el tratamiento de cánceres dependientes de EGFR
Generación y desarrollo de nuevos fármacos para el tratamiento de cánceres dependientes del EGFR
Primary aldosteronism and HSD11B2 enzyme activity defects in pediatric population and its impact on the generation of endothelial injury, oxidative stress and arterial
STUDY OF A NOVEL HUMAN FOLLICLE STIMULATING HORMONE (FSH) VARIANT: ELUCIDATION OF THE PHYSIOLOGICAL ROLE AND PATHOLOGICAL IMPLICATIONS
Study of a novel human follicle stimulating hormone (FSH) variant=> Elucidation of the physiological role and pathological implications.
Nuevo test Diagnóstico molecular para identificar causas de hipertensión arterial esencial con y sin síndrome metabólico
Nuevo test diagnóstico molecular para identificar causas de hipertensión arterial esencial con y sin síndrome metabólico
Efectos de las estatinas en la capacidad metastásica y la sensibilidad a agentes inductores de apoptosis en el cáncer de ovario
Efectos de las estatinas en la capacidad metastásica y la sensibilidad a agentes inductores de apoptosis en el cáncer de ovario
Terapia Oncológica Personalizada (TOP): Desarrollo de métodos de diagnóstico molecular para ayudar en la elección del tratamiento más adecuado para cada paciente con cáncer
Terapia Oncológica Personalizada (TOP)=> Desarrollo de métodos de diagnóstico molecular para ayudar en la elección del tratamiento más adecuado para cada paciente con cáncer.
Desarrollo de una nueva droga anti tumoral para el tratamiento de cánceres del tracto reproductivo femenino
Desarrollo de una nueva droga anti-tumoral para el tratamiento de cánceres del tracto reproductivo femenino
Evaluación clínico- molecular del rol de las deshidrogenasas tipo 1 y 2 (11BHSD1 y 11BHSD2) en la génesis de la hipertensión arterial hiporrennemica
Evaluación clínico-molecular del rol de las deshidrogenasas tipo 1 y 2 (11BHSD1 y 11BHSD2) en la génesis de la hipertensión arterial hiporrennemica
Elucidation of the regulation and pathophysiological actions of tissue factor in breast and endometrial cancer.
ELUCIDATION OF THE REGULATION AND PATHOPHYSIOLOGICAL ACTIONS OF TISSUE FACTOR IN BREAST AND ENDOMETRIAL CANCER.
Differential Regulation of Tissue Factor expression in breast and endometrial cells
Differential regulation of Tissue Factor expression in breast and endometrial cells
PAPEL PARADOJICO DE LA PROGESTERONA EN LA MAMA Y EL ENDOMETRIO UTERINO: ELUCIDACION DE LA "CROSS-TALK" ENTRE LA PROGESTERONA Y LA VIA DE SENAL DEL EGF
Papel paradójico de la progesterona en la mama y el endometrio uterino=> Elucidación de la "Cross-Talk" entre la progesterona y la vía de señal del EGF.
Elucidation of the differential regulation of breast and endometrial cells by oestrogen and progesterone and their interaction with the EGF signal transduction pathway.
Equipment Grant=> To establish and maintain a cell line model system of the breast and endometrium.
Respuesta de Tibolona (Tinox) en células de mama y útero
Extending palliative care reach from secondary to primary health care level and from urban to rural communities

Review (8)

The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties
Angiogenesis inhibitors in early development for gastric cancer
The twisted survivin connection to angiogenesis
2-Methoxyestradiol and Disorders of Female Reproductive Tissues
Efectos de las estatinas en cáncer: ¿potencial rol en terapéutica y prevención?
Effects of statins in cancer
Glucose Transporters in Sex Steroid Hormone Related Cancer
Glucose transporters: expression, regulation and cancer
137
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

16
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

12
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

11
Andres Carvajal

Investigador

INIA

Osorno, Chile

10
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

7
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

6
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Enrique Castellón

Profesor Titular. Director

Oncología Básico-Clínica

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Rafaela Erices

Postdoctorante

Ginecología y Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Javiera Sateler

Profesor instructor

Ciencias Clínicas

Universidad Católica del Maule

Talca, Chile

5
Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile

5
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

4
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
RENAN ORELLANA

Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

4
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

4
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Javiera Cornejo

Academica

Medicina Preventiva

FAVET, Universidad de Chile

Santiago, Chile

3
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

3
Ana Meneses

Académico

Universidad Diego Portales

Santiago, Chile

3
jose dominguez

Profesor Asistente

Endocrinologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

3
Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

2
Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

2
Yolanda Vargas

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

2
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

2
FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Ethel Velásquez

investigador

Departamento de Tecnologías Nucleares

Comisión Chilena de Energía Nuclear

Santiago, Chile

2
María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Lorena Abarzúa

Investigador

Medicina

Universidad de los Andes

Santiago, Chile

2
María Rodríguez

Profesora Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Julio Amigo

Assistant Professor

Physiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carolina Bizama

Profesor Asistente

Anatomía Patológica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

2
Betty San Martin

Directora

Ciencias Clínicas

UNIVERSIDAD DE CHILE, FAC. CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

2
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Pablo Lois

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
Pedro Buc

Profesor titular

Quimica y Farmacia

UNIVERSITE CATHOLIQUE DE LOUVAIN

Iquique, Chile

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Maria Gago

Profesor Asistente

Facultad de Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Benjamin Garcia

Director

Facultad de Estudios Interdisciplinarios

Universidad Mayor de Chile

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
German Reig

Investigador Principal

Centro integrativo de Biología y Química Aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Paul Vöhringer

Profesor Asociado

Psyquiatría

CLINICA PSIQUIÁTRICA UNIVERSITARIA

Santiago, Chile

1
Juan Opazo

Profesor Titular

Instituto de Ciencias Ambientales y Evolutivas

Universidad Austral de Chile

Valdivia, Chile

1
Pia Villarroel

Docente investigador

UNIVERSIDAD MAYOR

Santiago, Chile

1
Gabriel Bastias

Profesor Asociado

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ignacio Espinoza

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Oscar Lazo

Research Fellow

UK Dementia Research Institute and Department of Neuromuscular diseases

UCL Queen Square Institute of Neurology

London, Reino Unido

1
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Pereira

Jefe

Hematología-Oncología

ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

1
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Paula Solar

Académico Investigador

Universidad SEK

Santiago, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

1
Erica Koch

Oncólogo Médico

Red de Salud UC Christus

Santiago, Chile

1
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
EVA BUSTAMANTE

JEFE DE COORDINACION CIENTIFICA

INVESTIGACION Y DOCENCIA

FUNDACION ARTURO LOPEZ PEREZ

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
María Villarroel

Médico Anátomo-Patólogo

Anatomía Patológica

Red de Salud UC Christus / Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
MARIA DURAN

Estudiante

Universidad Mcgill

Montreal, Canada

1
Eugenia Ortiz

Instructor

Medicina Interna

UNIVERSIDAD DE LA FRONTERA. FACULTAD DE MEDICINA

Temuco, Chile

1
NATALIA LANDEROS

Postdoctoral Research Assistant

Hematología y Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Franz Villarroel

Jefe Laboratorio - PI

Unidades de Diagnóstico

Fundación Arturo López Pérez

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
German Osorio

Especialista en Microscopia

Biologia Celular

Universidad de Concepción

Concepción, Chile