Man

Alejandro Samuel Godoy Sánchez

Associate Professor

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Dr. Godoy's Lab focuses on the study of: 1) the role of the tumor microenvironment, specifically the vasculature, in the progression of prostate cancer, and 2) the role of fructose in the development and progression of prostate cancer.

Educación

  •  Medical Technology, UNIVERSIDAD DE LA FRONTERA. Chile, 1996
  •  Physiology, UNIVERSIDAD DE CONCEPCION. Chile, 2000
  •  Cellular and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2005

Experiencia Académica

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Biological Sciences

    Santiago, Chile

    2012 - 2019

  •   Adjunct Professor of Oncology Other

    ROSWELL PARK CANCER INSTITUTE

    Buffalo, Estados Unidos

    2012 - A la fecha

  •   HRI Scientist (Junior Faculty) Other

    ROSWELL PARK CANCER INSTITUTE

    Buffalo, Estados Unidos

    2010 - 2012

  •   Profesor Asociado Full Time

    UNIVERSIDAD SAN SEBASTIAN

    Medicina y Ciencia

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   HRI Scientist (Junior Faculty) Full Time

    Roswell Park Comprehensive Cancer Center

    Buffalo, Estados Unidos

    2010 - 2012

  •   Adjunct Professor of Oncology Other

    Roswell Park Comprehensive Cancer Center

    Buffalo, Chile

    2012 - A la fecha

  •   Associate Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2012 - A la fecha

Formación de Capital Humano


MENTORING-UNDERGRADUATE

1. BIOCHEMISTRY
Jaime Lizama, 2014 (University of Valparaiso)
Catalina Asencio, 2017-present (PUC)
Carolina Gaete, 2018-present (University of Chile).

2. BIOLOGY
Hugo Muñoz, 2015 (PUC)
Catalina Garay, 2016 (University of Valparaiso)
Marcia Arredondo, 2016 (PUC)
Carla Cembrano, 2016 (PUC).

3. MEDICAL TECHNOLOGY
Aaron Claveria, 2014 (UNAB)
Nicolás Durán, 2014 (UNAB)
Diego Saavedra, 2014 (UNAB)
Edson Reyes, 2015 (UNAB)
Daniel Silva, 2015 (UNAB)
Guillermo Delgado, 2015 (UNAB)
Paula Venegas, 2015 (2015)
Carolina Acha, 2017 (UNAB)
Arantxa Urrestarazu, 2017 (UNAB)
Marta Verdugo, 2017 (UNAB).
Maria José Vives, 2018 (UNAB)
Gissella Reyes, 2018 (UNAB)
Romina Labrin, 2018 (UNAB)
Nicole Martinez, 2018 (UNAB)
Carolina Ipanaque, 2018 (UNAB)
Andrea Meneses, 2019-present (UNAB)
Florencia Benito, 2019-present (UNAB)
Miguel Alarcón, 2019-present (UNAB)

MENTORING-GRADUATE

Dr. Daniela Carreño (Postdoctoral, PUC), 2016-present.
Dr. (C) Veronica Torres (PhD in Physiology, PUC), 2015-present.
Dr. (C) Nestor Corro (PhD in Physiology, PUC), 2016-present.
Dr. (C) Viviana Orellana (PhD in Medical Sciences, UDD), 2018-present


Difusión y Transferencia


MEETING ORGANIZATION

2014: Workshop: Prostate Cancer Research: New Determinant of Tumor Progression.
2015: Workshop: Cancer Biology: New Advances in Angiogenesis.
2017: Symposium: Preclinical Models of Human Cancer.
2018: Workshop: Mechanisms of Intercellular Communication in Cancer.
2018: Symposium, Chilean Society for Cell Biology: Tumor Microenvironment and Cancer Biology.

PATENTS

1. “Use of 5-alpha-reductase type 3 In Diagnosis of Malignant Prostate”
61/254,329 US Patent awarded
J. Mohler, M. Titus, A. Godoy, O. Kozyreva, E. Kawinski, Y. Li.

2. “anti-angiogenic peptides from endogenous PSA protein”
Provisional 61/368,406 US Patent Pending
G. Smith, K. Chadha, A. Godoy, V. Montecinos, R. Zou.


Premios y Distinciones

  •   Academic Excellence Award

    UNIVERSIDAD DE LA FRONTERA

    Chile, 1992

    Academic Excellence Fellowship 100%. Funded by the Government of Chile and the University of La Frontera.

  •   CONICYT Graduate Fellowship (M.Sc.)

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 1998

    CONICYT Fellowship for Master of Biological Science mention Physiology. From 1998 to 2000.

  •   CONICYT Pre-Doctoral Fellowship (Ph.D.)

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2000

    Fellowship for PhD in Biological Sciences mention Cellular and Molecular Biology. From 2000 to 2004.

  •   MECESUP Travel and Research Award

    UNIVERSIDAD DE CONCEPCION

    Chile, 2003

    Research Training at the Center for Research in Reproductive Physiology, Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, USA.

  •   SBUR Travel Award

    Society of Basic Urologic Research

    Estados Unidos, 2007

    Travel Award to Present at the Annual Meeting of the Society for Basic Urologic Research, USA. Selected as Oral Expositor.

  •   Prostate Cancer Training Award-Postdoctoral

    U.S. Department of Defense

    Chile, 2008

    Fellowship to complete Post-Doctoral training at Roswell Park Cancer Institute. From 2008 to 2010.

  •   Attraction and Integration Program for Advanced Human Capital in the Academia

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2011

    Awarded by the Goverment of Chile. This Fellowship was declined.

  •   Visiting Professor

    UNIVERSIDAD DE LA FRONTERA

    Chile, 2013

    Awarded by the University of la Frontera, PhD Program in Applied Cellular and Molecular Biology.

  •   Travel Award UNESCO/ICRO

    Escuela de Neurociencia

    Uruguay, 1999

    Meeting of the Escuela Latinoamericana de Neurociencia.

  •   Travel Award ICGEB

    INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS

    Venezuela, 2000

    Travel award to assist to an international course on cell death and cancer.

  •   Travel Award UNESCO/ICRO

    Universidad Federal de Rio de Janeiro

    Brasil

    Travel Award to assist to an international course on cellular proliferation.


 

Article (62)

Dietary fructose promotes prostate cancer growth
Hexose Transporters in Cancer: From Multifunctionality to Diagnosis and Therapy
Advantages in Wound Healing Process in Female Mice Require Upregulation A(2A)-Mediated Angiogenesis under the Stimulation of 17 beta-Estradiol
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Deletion of the adenosine A(2A)receptor increases the survival rate in a mice model of polymicrobial sepsis
Recapitulation of prostate tissue cell type-specific transcriptomes by anin vivoprimary prostate tissue xenograft model
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
Fructose and prostate cancer: toward an integrated view of cancer cell metabolism
Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure
Androgens modulate male-derived endothelial cell homeostasis using androgen receptor-dependent and receptor-independent mechanisms
Combination of the histone deacetylase inhibitor vorinostat with bevacizumab in patients with clear-cell renal cell carcinoma: a multicentre, single-arm phase I/II clinical trial
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
Pro-angiogenic Role of Insulin: From Physiology to Pathology
Anti-angiogenic activity of PSA-derived peptides
Selective targeting of bioengineered platelets to prostate cancer vasculature: new paradigm for therapeutic modalities
5 alpha-Reductase Type 3 Enzyme in Benign and Malignant Prostate
Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population
Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population.
Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population.
Androgen-responsive Serum Response Factor target genes regulate prostate cancer cell migration
Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer.
Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer
Human Choroid Plexus Papilloma Cells Efficiently Transport Glucose and Vitamin C
Human choroid plexus papilloma cells efficiently transport glucose and vitamin C.
Prostate Cancer Cells Differ in Testosterone Accumulation, Dihydrotestosterone Conversion, and Androgen Receptor Signaling Response to Steroid 5 alpha-Reductase Inhibitors
Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5 alpha-reductase inhibitors
Role of Androgen and Vitamin D Receptors in Endothelial Cells from Benign and Malignant Human Prostate
Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate.
Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression
Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue
Primary Xenografts of Human Prostate Tissue as a Model to Study Angiogenesis Induced by Reactive Stroma
Primary Xenografts of Human Prostate Tissue as a Model to Study Angiogenesis Induced by Reactive Stroma
The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases
5 alpha-Reductase Type 3 Expression in Human Benign and Malignant Tissues: A Comparative Analysis During Prostate Cancer Progression
5alpha-reductase type 3 expression in human benign and malignant tissues: a comparative analysis during prostate cancer progression
Androgen deprivation induces rapid involution and recovery of human prostate vasculature
Androgen deprivation induces rapid vascular involution and recovery in the short-term prostate primary xenograft model
Biochemical characterization of nuclear receptors for vitamin D3 and glucocorticoids in prostate stroma cell microenvironment.
Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblast and paracrine signaling to prostate cancer
Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities
Enzymatic Activity of Free-Prostate-SpecificAntigen (f-PSA) Is Not Required for Some of its Physiological Activities
Histidine Residues in the Na+-coupled Ascorbic Acid Transporter-2 (SVCT2) Are Central Regulators of SVCT2 Function, Modulating pH Sensitivity, Transporter Kinetics, Na+ Cooperativity, Conformational Stability, and Subcellular Localization
Histidine Residues in the Na+-coupled Ascorbic Acid Transporter-2 (SVCT2) Are Central Regulators of SVCT2 Function, Modulating pH Sensitivity, Transporter Kinetics, Na+ Cooperativity, Conformational Stability, and Subcellular Localization
ABCG2-Mediated dyecycle violet efflux defined side population in benign and malignant prostate
Nutritional channels in breast cancer
Nutritional channels in breast cancer
Oct4A is expressed by a subpopulation of prostate neuroendocrine cells
Androgen receptor is causally involved in the homeostasis of the human prostate endothelial cell
Mechanistic insights and functional determinants of the transport cycle of Na+-ascorbic acid cotransporter SVCT2: Activation by Sodium and Absolute dependence on bivalent cations.
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2
Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer
Stromal-epithelial cell interactions and AR-coregulator recuitment is altered in the tissue microenvironment of prostate cancer
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess survival of glutathione
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
Differential subcellular distribution of glucose transporters GLUT1-GLUT6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissue.
Redefining the facilitated transport of mannose in human cells: Absence of a glucose-insensitive, high-affinity facilitated mannose transport system
Redefining the facilitated transport of mannose in human cells: Absence of a glucose-insensitive, high-affinity facilitated mannose transport system.
Recycling of vitamin C by a bystander effect
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier
Elevated expression of the glucose transporter-1 in hypotalamic ependymal cells not involved in barrier function.
Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain.

Proyecto (12)

Consorcio Tecnológico IFAN=> Desarrollo Sinérgico de Ingredientes funcionales y Aditivos Naturales. P4. Desarrollo de un ingrediente funcional para el tratamiento del cáncer de próstata
PARACRINE EFFECT OF THE ENDOTHELIUM ON PROSTATE CANCER CELLS AND ITS ROLE DURING TUMOR PROGRESSION
Predictive test of prostate cancer progression based on stromal expression signature
ROL DE FRUCTOSA EN CÁNCER DE PRÓSTATA
Rol del Receptor de Andrógeno en Hiperplasia Prostática Benigna y su Utilidad como Nuevo Blanco Terapéutico en Hombres Mayores de 65 años con Falla a Tratamiento Médico
VEGF-A SIGNALING IN CARCINOMA-ASSOCIATED FIBROBLASTS=> ROLE IN REACTIVE STROMA GENERATION AND METASTATIC POTENTIAL"
Apoyo a la Formación de Redes Internacionales entre Centros de Investigación
Role of Fructose in Prostate Cancer
Busqueda del estado del arte para patentamiento/licenciamiento
ROLE OF ADRENAL ANDROGENS IN PROSTATE VASCULATURE
Clinical Relevance of Androgen Regulators in Castration Resistant Prostate Cancer
Androgen Effects on Human Prostate Endothelial Cells

Review (3)

Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer
Exercise and prostate cancer: From basic science to clinical applications
Androgen receptor in human endothelial cells
36
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

12
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

10
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

9
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

8
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

6
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

3
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

3
Alexis Salas

Assistant Professor

Pharmacology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

2
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

2
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
Maria Escobar

Postdoctorado

Biología Molecular Vegetal

Universidad de Chile

Santiago , Chile

2
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

2
Lorena Mardones

ASSOCIATED PROFESSOR

BASIC SCIENCES AND MORPHOLOGY

UNIVERSIDAD CATOLICA DE LA SANTISIMA CONCEPCION

CONCEPCION, Chile

2
MARCELO VILLAGRAN

Profesor asociado

Departamento de Ciencias Básicas

Universidad Catolica de la Santísima Concepción

Concepcion, Chile

2
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Valeska Ormazabal

Profesor asistente

Farmacología

Universidad de Concepción

Concepción, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alberto Martin

Assistant professor

Centro de Genómica y Bioinformática

Universidad Mayor

Santiago, Chile

1
Rafaela Erices

Postdoctorante

Ginecología y Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

1
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Tapia

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

1
Claudio Morales

Bioquímico

Hospital Dr. Félix Bulnes Cerda

Santiago, Chile

1
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ignacio San Francisco

URÓLOGO, PROFESOR ASOCIADO

UROLOGÍA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE MEDICINA, DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

Santiago, Chile

1
Javier Cerda Infante

Graduate Student

Biología Celular y Molecular

Pontifica Universidad Católica de Chile

Santiago, Chile

1
PAULA GUZMÁN

Profesional Bioquímico

Laboratorio Clínico

Hospital Clínico Regional de Concepción Guillermo Grant Benavente

Concepción, Chile

1
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

1
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Verónica Torres

Coordinador Academico

Ciencias Químicas y biológicas

Universidad Bernardo O'Higgins

Santiago , Chile

1
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

1
KATHERINE FORMAN

Profesor Asociado

nutrition and dietetics

universidad de concepción

concepción, Chile

1
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

1
CAROLINA DELGADO

Encargado de calidad Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
Marcos Fernandez

Profesor Asociado

Farmacia

FACULTAD DE FARMACIA, UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Romina Bertinat

Investigador asociado

Centro de Microscopía Avanzada, CMA BIO BIO

Universidad de Concepcion

Concepción, Chile

1
Nicolás Santander

Investigador Postdoctoral

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
RENAN ORELLANA

Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile