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Romina Paola Bertinat

Technician

Universidad de Concepcion

Concepción, Chile

Diabetes; Resistencia a insulina; Secreción glucagón por célula alfa pancreática; Fármacos anti-diabéticos; Gluconeogénesis hepatica y renal; Localización subcelular de enzimas metabólicas

Biología celular y molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2010
Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2004

Technician Part Time

Universidad Austral de Chile

Valdivia, Chile

2003 - 2003
Research assistant Full Time

Universidad Austral de Chile

Valdivia, Chile

2003 - 2004
Research assistant Full Time

Universidad Austral de Chile

Valdivia, Chile

2010 - 2012
Principal investigator Full Time

Universidad Austral de Chile

Valdivia, Chile

2011 - 2014
Management consultant Part Time

Universidad de Concepcion

Concepción, Chile

2014 - 2015
Technician Part Time

Universidad de Concepcion

Concepción, Chile

2015 - 2015
Associated researcher Part Time

Universidad Austral de Chile

Chile

2015 - 2016
Technician Part Time

Universidad de Concepcion

Concepción, Chile

2015 - 2016
Principal investigator Full Time

Universidad de Concepcion

Concepción, Chile

2016 - 2019
Technician Part Time

Universidad de Concepcion

Concepción, Chile

2020 - 2021
Technician Part Time

Universidad de Concepcion

Concepción, Chile

2021 - A la fecha

Undergraduate students

1. Marianne Negrón Mardones. "Study of the expression of PEPCK-C in rat pancreas". Medical Technologist Undergraduate, Universidad de Concepción. 2018. Tutor
2. Ahilyn Escobar Verdugo. "Study of the expression of mitochondrial PEPCK in different human and rat tissues". Medical Technologist Undergraduate, Universidad de Concepción. 2019. Tutor
3. Paula Marín del Valle. "Standardization of a simple protocol for purification of antibodies from egg yolk to advance in the study of diabetes". Medical Technologist Undergraduate, Universidad de Concepción. 2020. Tutor
4. Paula Díaz Cuevas y Camila González Acevedo. "Detección de niveles de expresión de PCK1 en células mononucleares de sangre periférica (PBMCs) por qPCR como biomarcador en el diagnóstico de resistencia a insulina". Medical Technologist Undergraduates, Universidad de Concepción. 2020. Tutor


Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients Bertinat, Romina; Villalobos-Labra, Roberto; Hofmann, Lidija; Blauensteiner, Jennifer; Sepúlveda, Nuno; Westermeier, F Article WOS VASCULAR PHARMACOLOGY (2022)
Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients Blauensteiner, Jennifer; Bertinat, Romina; León, Luis E.; Riederer, Monika; Sepúlveda, Nuno; Westermeier, Francisco Article WOS Scientific Reports (2021)
Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas Westermeier, Francisco; Holyoak, Todd; Gatica, Rodrigo; Martínez, Fernando; Negrón, Marianne; Yáñez, Alejandro J.; Nahmias, Daniel; Nualart, Francisco; Burbulis, Ian; Bertinat, Romina Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice Forman, Katherine; Martinez, Fernando; Cifuentes, Manuel; Fernandez, Marcos; Bertinat, Romina; Torres, Pablo; Salazar, Katterine; Godoy, Alejandro; Nualart, Francisco Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Gluconeogenic Enzymes in beta-Cells: Pharmacological Targets for Improving Insulin Secretion Westermeier F., Holyoak T., Asenjo J., Gatica R., Nualart F., Burbulis I., Bertinat R. Article ISI SCOPUS TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)
The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice Bertinat, R; Westermeier, F; Silva, P; Gatica, R; Oliveira, JM; Nualart, F; Gomis, R; Yanez, AJ Article ISI SCOPUS JOURNAL OF DIABETES RESEARCH (2018)
Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney Forman K.; Martínez F.; Cifuentes M.; Bertinat R.; Salazar K.; Nualart F. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human Kidney Cells Bertinat R.; Westermeier F.; Silva P.; Shi J.; Nualart F.; Li X.; Yáñez A.J. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development Silva-Álvarez C.; Salazar K.; Cisternas P.; Martínez F.; Liour S.; Jara N.; Bertinat R.; Nualart F. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2017)
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies Salazar K.; Martínez F.; Pérez-Martín M.; Cifuentes M.; Trigueros L.; Ferrada L.; Espinoza F.; Saldivia N.; Bertinat R.; Forman K.; Oviedo M.J.; López-Gambero A.J.; Bonansco C.; Bongarzone E.R.; Nualart F. Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2017)
SGLT2 Inhibitors: Glucotoxicity and Tumorigenesis Downstream the Renal Proximal Tubule? Bertinat R.; Nualart, F.; Yáñez A.J. Article ISI SCOPUS Journal of Cellular Physiology (2016)
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling Salazar, K; Martinez, M; Ulloa, V; Bertinat, R; Martinez, F; Jara, N; Espinoza, F; Bongarzone, ER; Nualart, F Article ISI MOLECULAR NEUROBIOLOGY (2016)
In Vivo Sodium Tungstate Treatment Prevents E-Cadherin Loss Induced by Diabetic Serum in HK-2 Cell Line Bertinat, Romina; Silva, Pamela; Mann, Elizabeth; Li, Xuhang; Nualart, Francisco; Yáñez, Alejandro J. Article ISI SCOPUS Journal of Cellular Physiology (2015)
Over-expression of muscle glycogen synthase in human diabetic nephropathy Gatica, Rodrigo; Bertinat, Romina; Silva, Pamela; Kairath, Pamela; Slebe, Felipe; Pardo, Fabián; Ramírez, María J.; Slebe, Juan C.; Campistol, José M.; Nualart, Francisco; Caelles, Carme; Yáñez, Alejandro J. Article HISTOCHEMISTRY AND CELL BIOLOGY (2015)
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney Gatica, R; Bertinat R.; Silva P.; Carpio, D; Ramirez, MJ; Slebe, JC; Martin, RS; Nualart, F.; Campistol, JM; Caelles, C; Yanez, AJ Article ISI SCOPUS Journal of Cellular Biochemistry (2013)
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development Nualart, F.; Castro, T.; Low M; Henriquez, JP; Oyarce, K; Cisternas P.; Garcia, A.; Yanez, AJ; Bertinat R.; Montecinos, VP; Garcia-Robles, MA Article ISI SCOPUS Histochemistry and Cell Biology (2013)
Fructose 1,6-bisphosphatase and aldolase B location in organs of sheep supplemented with nonprotein nitrogen Noro, Mirela; Bertinat, Romina; Yáñez, Alejandro; SLEBE, Juan Carlos; Wittwer, Fernando Article SCOPUS Comparative Clinical Pathology (2013)
Non-protein nitrogen supplementation increases gluconeogenic capacity in sheep Noro M.; Bertinat R.; YaÃ±ez A.; Slebe J.C; Wittwer F. Article ISI SCOPUS Livestock Science (2012)
Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver Bertinat R.; Pontigo, J.P.; Perez M.; Concha I.I.; Martín R.S.; Guinovart J.J.; Slebe J.C; Yáñez A.J. Article ISI SCOPUS Journal of Cellular Biochemistry (2012)
Expression of key substrate cycle enzymes in rat spermatogenic cells: Fructose 1,6 bisphosphatase and 6 phosphofructose 1-kinase Yannez, AJ; Bustamante, X; Bertinat R.; Werner, E; Rauch MC; Concha, II; Reyes JG.; Slebe, JC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Different involvement for aldolase isoenzymes in kidney glucose metabolism: Aldolase B but not aldolase a colocalizes and forms a complex with FBPase Yanez, AJ; Ludwig, HC; Bertinat R.; Spichiger, C.; Gatica, R; Berlien, G; Leon, O.; Brito M.; Concha, II; Slebe, JC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas Yanez, AJ; Bertinat R.; Spichiger, C.; Carcamo, JG; Garcia, MDA; Concha, II; Nualart, F.; Slebe, JC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Subcellular localization of liver FBPase is modulated by metabolic conditions Yanez, AJ; Garcia-Rocha, M; Bertinat R.; Droppelmann C.; Concha, II; Guinovart, JJ; Slebe, JC Article ISI SCOPUS FEBS LETTERS (2004)
Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney Yanez, AJ; Nualart, F.; Droppelmann C.; Bertinat R.; Brito M.; Concha, II; Slebe, JC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Nuclear localization of liver FBPase isoenzyme in kidney and liver Yanez, AJ; Bertinat R.; Concha, II; Slebe, JC Article ISI SCOPUS FEBS LETTERS (2003)


Role of mitochondrial dynamics in the oxidative stress-induced invasion in human prostate cancer cells Francisco J. Roa Proyecto (2019)
PHOSPHOENOLPYRUVATE CARBOXYKINASE EXPRESSION IN PANCREATIC ?-CELLS MODULATES GLUCAGON SECRETION, CONTRIBUTING TO HYPERGLUCAGONEMIA DURING DIABETES FONDECYT (11160854) Proyecto 2016-2019 Inv. Responsable
CELLULAR POLARIZATION AND FUNCTIONAL ACTIVITY OF THE VITAMIN C TRANSPORTER,SVCT2,DURING CENTRAL NERVOUS SYSTEM DIFFERENTIATION (PRE- AND POST-NATAL) AND GLIOBLASTOMA PROGRESSION FONDECYT (1140477) Proyecto 2014-2018 Personal técnico y/o de apoyo
IIIG9 EXPRESSION AND FUNCTION IN NORMAL EPENDYMAL CELLS DIFFERENTIATION AND TUMORAL TRANSFORMATION. FONDECYT (11140405) Proyecto 2014-2017 Personal técnico y/o de apoyo
SODIUM TUNGSTATE A NEW TREATMENT FOR DIABETIC NEPHROPATHY=> EFFECT OF THIS DRUG IN INFLAMMATION, OXIDATIVE STRESS AND FIBROSIS DURING THE PROGRESSION OF THIS PATHOLOGY. FONDECYT (1131033) Proyecto 2013-2017 Personal técnico y/o de apoyo
ESTUDIO DEL EFECTO DE WOLFRAMATO DE SODIO SOBRE LA FUNCION DEL RECEPTOR DE GLUCOCORTICOIDES EN LA PROGRESION DE NEFROPATIA DIABETICA FONDECYT (3120144) Proyecto 2011-2014 Inv. Responsable
Producción de una vacuna oral contra piscirickettsia salmonis para disminuir la mortalidad en salmones y aumentar la competitividad y sustentabilidad de la industria salmonera INNOVA CORFO (07CN13PPT-256) Proyecto 2010-2012 Personal técnico y/o de apoyo
Study of nuclear translocation of human and rat fructose 1,6- bisphosphatase Universidad Austral de Chile (DID-UACh 2006-12) Proyecto 2006-2007 Inv. Principal
ESTUDIO DE NUEVOS MECANISMOS DE REGULACION DE LA FRUCTOSA 1,6-BISFOSFATASA=> FORMACION DE COMPLEJOS METABOLICOS, COMPARTIMENTACION CELULAR Y UNION ASIMETRICA DEL SUSTRATO Y DEL EFECTOR FRUCTOSA-2,6-BISFOSFATO A LOS SITIOS ACTIVOS FONDECYT (1051122) Proyecto 2005-2009 Tesista
RELACION DEL SINDROME DIABETICO CON LA EXPRESION Y LOCALIZACION CELULAR DE GLICOGENO SINTASA, FOSFOENOLPIRUVATO CARBOXIQUINASA Y FRUCTOSA-1, 6-BISFOSTASA, ENZIMAS CLAVES EN LA HOMEOSTASIS DE LA GLUCOSA FONDECYT (1051057) Proyecto 2005-2008 Tesista
MODULACION DE LA FUNCION DE LA FRUCTOSA-1,6 BISFOSFATASA DE RINON DE CERDO=> EFECTO DE LIGANDOS SOBRE LA ESTRUCTURA, PLEGAMIENTO INTERACCION PROTEINA Y LOCALIZACION SUBCELULAR COMO MECANISMOS REGULADORES DE SU ACTIVIDAD FONDECYT (1010720) Proyecto 2001-2004 Tesista


Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes? Bertinat R.; Westermeier F.; Gatica R.; Nualart F. Review ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Romina Bertinat

Technician

Farmacología

Universidad de Concepcion

Concepción, Chile

Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Pamela Silva

Lab Manager

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

KATHERINE FORMAN

Profesor Asociado

nutrition and dietetics

universidad de concepción

concepción, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

Marcos Fernandez

Profesor Asociado

Farmacia

FACULTAD DE FARMACIA, UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

María Rauch

ACADEMICO

INSTITUTO DE BIOQUÍMICA Y MICROBIOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

Juan Pontigo

Academico-Investigador

Medicina Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

Ian Burbulis

Academic Professor Regular

Medicina

Universidad San Sebastian

Puerto Montt, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Francisca Espinoza

Investigadora postdoctoral

Facultad de Medicina

Universidad Católica de la Santisima Concepción

Concepción, Chile

Enrique Werner

Académico

Ciencias Básicas

UNIVERSIDAD DEL BIO-BIO

Chillán, Chile

Marcela Low

Docente INvestigador

Universidad San Sebastián

Valdivia, Chile

Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile

Romina Paola Bertinat

Líneas de Investigación

Educación

Biología celular y molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2010

Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2004

Experiencia Profesional

Technician Part Time

Research assistant Full Time

Research assistant Full Time

Principal investigator Full Time

Management consultant Part Time

Technician Part Time

Associated researcher Part Time

Technician Part Time

Principal investigator Full Time

Technician Part Time

Technician Part Time

Formación de Capital Humano

Article (25)

Proyecto (11)

PHOSPHOENOLPYRUVATE CARBOXYKINASE EXPRESSION IN PANCREATIC ?-CELLS MODULATES GLUCAGON SECRETION, CONTRIBUTING TO HYPERGLUCAGONEMIA DURING DIABETES

CELLULAR POLARIZATION AND FUNCTIONAL ACTIVITY OF THE VITAMIN C TRANSPORTER,SVCT2,DURING CENTRAL NERVOUS SYSTEM DIFFERENTIATION (PRE- AND POST-NATAL) AND GLIOBLASTOMA PROGRESSION

IIIG9 EXPRESSION AND FUNCTION IN NORMAL EPENDYMAL CELLS DIFFERENTIATION AND TUMORAL TRANSFORMATION.

SODIUM TUNGSTATE A NEW TREATMENT FOR DIABETIC NEPHROPATHY=> EFFECT OF THIS DRUG IN INFLAMMATION, OXIDATIVE STRESS AND FIBROSIS DURING THE PROGRESSION OF THIS PATHOLOGY.

ESTUDIO DEL EFECTO DE WOLFRAMATO DE SODIO SOBRE LA FUNCION DEL RECEPTOR DE GLUCOCORTICOIDES EN LA PROGRESION DE NEFROPATIA DIABETICA

Producción de una vacuna oral contra piscirickettsia salmonis para disminuir la mortalidad en salmones y aumentar la competitividad y sustentabilidad de la industria salmonera

Study of nuclear translocation of human and rat fructose 1,6- bisphosphatase

ESTUDIO DE NUEVOS MECANISMOS DE REGULACION DE LA FRUCTOSA 1,6-BISFOSFATASA=> FORMACION DE COMPLEJOS METABOLICOS, COMPARTIMENTACION CELULAR Y UNION ASIMETRICA DEL SUSTRATO Y DEL EFECTOR FRUCTOSA-2,6-BISFOSFATO A LOS SITIOS ACTIVOS

RELACION DEL SINDROME DIABETICO CON LA EXPRESION Y LOCALIZACION CELULAR DE GLICOGENO SINTASA, FOSFOENOLPIRUVATO CARBOXIQUINASA Y FRUCTOSA-1, 6-BISFOSTASA, ENZIMAS CLAVES EN LA HOMEOSTASIS DE LA GLUCOSA

MODULACION DE LA FUNCION DE LA FRUCTOSA-1,6 BISFOSFATASA DE RINON DE CERDO=> EFECTO DE LIGANDOS SOBRE LA ESTRUCTURA, PLEGAMIENTO INTERACCION PROTEINA Y LOCALIZACION SUBCELULAR COMO MECANISMOS REGULADORES DE SU ACTIVIDAD

Review (1)