Man

Rody San Martín

Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Líneas de Investigación


Nucleoside metabolism; Pharmacology and signaling properties of adenosine receptor; Pathology of diabetic kidney disease; Multiple Drug Resistance transporters; Endothelial dysfunction, renal fibrosis, diabetic kidney disease

Educación

  •  Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1998
  •  Molecular and Cellular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2004
  •  Bachelor in Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1998

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Sciences Faculty

    Valdivia, Chile

    2010 - 2016

  •   Assistant Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Sciences Faculty

    Valdivia, Chile

    2005 - 2010

  •   Professor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Sciences Faculty

    Valdivia, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Member of the biology group 3 of Fondecyt Other

    Conicyt/Fondecyt

    Chile

    2011 - 2013

  •   Director Magister in Biochemistry Biochemistry Other

    Universidad Austral de Chile

    Chile

    2012 - 2014

  •   Director PhD Program in Sciences mention Cellular and Molecular Biology Other

    Universidad Austral de Chile

    Chile

    2014 - A la fecha

  •   Coordinator Commission for Accreditation of the Doctoral Program in Sciences mention Cell and Molecular Biology Other

    Universidad Austral de Chile

    Valdivia, Chile

    2016 - A la fecha

Formación de Capital Humano


Undergraduate Formation Sponsorship(23) :

-2019 Muñoz K. “Papel de los péptidos ang 2-7, Ang 2-8 y Ang 2-10 en el desarrollo de fibrosis glomerular mediado por el receptor AT1 en un modelo de nefropatía diabética en ratas”. BIOQUÍMICA. Universidad Austral de Chile.
-2018 Tellez A. “La señalización de TGF-ß1 promueve cambios epigenéticos en las modificaciones post-traduccionales de las histonas asociadas al promotor del gen CD73 para aumentar su expresión génica”. BIOQUÍMICA. Universidad Austral de Chile.
-2018 Concha D. “Estudio cuantitativo del efecto de diabetes sobre la actividad de aminopeptidasa a en ratas”. BIOQUÍMICA. Universidad Austral de Chile.
-2017 Huentelican S. “Caracterización de Péptidos del Sistema Renina Angiotensina (RAS) generados por la Hidrósis de Aminopeptidasa A (APA) en Nefropatía Diabética (ND) y su efecto sobre cardiomiocitos de Rata”. TECNOLOGÍA MÉDICA. Universidad Austral de Chile.
-2017 Salinas C. “Actividad de Ecto 5' nucelotidasa (CD73) en pacientes diabéticos su relación con nefropatía diabética”. BIOQUÍMICA. Universidad Austral de Chile.
-2017. Barrientos S. '' Diabetes and their role in the activity of the glomerular ENT2 transporter ''. BIOCHEMISTRY. Universidad Austral de Chile.
-2016. Catalan J. Role of the kinases CK2 and PKA on the activity of the equilibrating transporters of Nucleosides 1 and 2 (hENT1 and hENT2) in HK-2 "renal epithelial cells. BIOCHEMISTRY. Universidad Austral de Chile.
-2015. Pérez G. '' Study of the factors that affect the expression of the A2B adenosine receptor in Glomeruli of rats ". BIOCHEMISTRY. Universidad Austral de Chile.
-2015. Ojeda A. "Effect of adenosine on expression of aminopeptidase A in renal glomeruli." BIOCHEMISTRY. Universidad Austral de Chile.
-2015. Vega G. Effect of D-Glucose and Insulin on Expression and Activity of Conveyors Equilibrating nucleoside type 1 (rENT1) and type 2 (rENT2) in glomerulus and rat mesangial cells ''.BIOCHEMISTRY. Universidad Austral de Chile.
-2014. Herrera D. '' Evaluation of the interaction of adenosine signaling with the Renin system Angiotensin (RAS) ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2014. Ross T. Generation of a plasmid vector for the overexpression of the A2B adenosine receptor in Renal cell lines ". Bachelor of Science in Biological Sciences. Universidad Austral de Chile.
-2014. Villablanca C. '' Role of the ectoenzyme CD73 on the maintenance of the epithelial phenotype of the cells of Proximal renal tubule ''. BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Fuentealba V. '' Changes in the Glomerular Adenosine balance associated with the function of the Equilibrating nucleoside transporters in mesangial cells ". BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Kretschmar C. '' Role of adenosine receptors on epithelial-mesenchymal transdifferentiation In HK-2 "human proximal tubule cells. BIOCHEMISTRY. Universidad Austral de Chile.
-2013. Toledo C. '' Signaling pathways involved in the production of vascular endothelial growth factor Mediated by adenosine in glomeruli of rats ". BIOCHEMISTRY. Universidad Austral de Chile.
-2011. Montecinos P. Characterization of adenosine receptors in rat coronary endothelial cells. BIOCHEMISTRY. Universidad Austral de Chile.
-2011. Guaiquil O. Role of adenosine receptors in myofibroblastic transdifferentiation of cells Mesangial. " MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2011. Cárdenas Á. '' Evaluation of the effect of an A2B adenosine receptor antagonist on production of vascular endothelial growth factor in the development of diabetic nephropathy in an in vivo model. MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2009. Roa H. Role of adenosine receptors on the production of TGF-B1 and PKC activity in Rat renal glomeruli ". Bachelor of Science in Biological Sciences. Universidad Austral de Chile.
-2008. Gajardo C. Effect of diabetes on the extracellular bioavailability of adenosine and the expression of its Receptors on the rat renal glomeruli ". BIOCHEMISTRY. Universidad Austral de Chile.
-2007. Valladares D. Role of adenosine receptors on the production of growth factor Vascular endothelium (VEGF) in rat renal glomeruli. BIOCHEMISTRY. Universidad Austral de Chile.
-2007. Tejeda C. '' Role of adenosine on the expression of protein components of the filtration barrier Glomerular: Implications in diabetic nephropathy ". BIOCHEMISTRY. Universidad Austral de Chile

Undergraduate Formation Co-Sponsorship (8) :

-2017. Huentelican S. Activity of Ecto 5 'nuecleotidase (CD73) in diabetic patients its relation with Diabetic nephropathy ". MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2017. Uribe C. 'Characterization of Peptides of the Renin Angiotensin System (RAS) generated by the Hydrosis Of Aminopeptidase A (APA) in Diabetic Nephropathy (ND) and its effect on rat cardiomyocytes. MEDICAL TECHNOLOGY. Universidad Austral de Chile.
-2015. Salinas C. '' Characterization of the activity and expression of the CD73 ectonucleotidase in renal tubules of Diabetic rats during the progression of diabetic nephropathy. " BIOCHEMISTRY. Universidad Austral de Chile.
-2014. Dellarossa A. '' Role of adenosine in multiple drug resistance in glioma-starter cells of high grade''. BIOCHEMISTRY. Universidad Austral de Chile.
-2012. Muñoz M. '' Tacrolimus modulates the expression and activity of drug resistance transporters in Brain tumors ". CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2011. Geoffroy C. Effect of sodium tungstate on the expression and activation of glycogen 3? kinase Synthase in diabetic kidney ". BIOCHEMISTRY. Universidad Austral de Chile.
-2011. Salinas J. Effect of the inhibition of the MRP1 transporter on the chemoresistance in glioblastoma Human multiforme ". CHEMISTRY AND PHARMACY. Universidad Austral de Chile.
-2009. Alarcón S. '' Effect of diabetic syndrome on the expression and activity of ABC proteins ''. BIOCHEMISTRY. Universidad Austral de Chile.

Postgrade formation Sponsorship (8) :

-2020. Mendoza P. Estudio de la Señalización del Receptor de Adenosina A2B en la Adhesión de Podocitos: Implicancias en la Nefropatía Diabética. Doctorado en Ciencias M/ Biología Celular y Molecular (en ejecución), Universidad Austral de Chile, Valdivia, Chile.
-2020. Suarez R. Estudio de la Regulación de la Actividad del transportador ENT2 y sus implicancias en la glomerulopatía Diabética. Doctorado en Ciencias M/ Biología Celular y Molecular (en ejecución), Universidad Austral de Chile, Valdivia, Chile.
-2019. Ojeda A. Efecto de adenosina sobre el equilibrio del sistema renina angiotensina durante el desarrollo de la nefropatía diabética. Magister en Biotecnología Bioquímica (en ejecución), Universidad Austral de Chile, Valdivia, Chile.
-2018. García J. Identificación de las vías metabólicas y de señalización reguladas por el receptor de adenosina A2B en la glomerulopatía diabética. Magister en Genética (en ejecución), Universidad Austral de Chile, Valdivia, Chile.
-2016. Alarcón S. Efecto de insulina y alta concentración de glucosa sobre la disponibilidad extracelular de adenosina en podocitos de rata, posibles implicancias en la producción de VEGF. Doctorado en Ciencias M/ Biología Celular y Molecular, Universidad Austral de Chile, Valdivia, Chile.
-2015 Jaramillo C., "Effect of adenosine on cytoarchitecture, filtration diaphragm conformation and podocyte adhesion: implication in diabetic nephropathy". Doctoral Program in Sciences, mention Cellular and Molecular Biology, Universidad Austral de Chile.
-2015 Oyarzún C, "Evaluation of adenosine and the ecto-CD73 enzyme as new markers of diabetic nephropathy". Magister Program in Pathology. Universidad Austral de Chile
-2015 Santander L. "Evaluation of human PEG-ADA treatment in an experimental model of diabetic nephropathy". Magister Program in Pathology. Universidad Austral de Chile

Postgrade formation Co-sponsorship (2):
-2017. Torres A. '' Generation of a model of high-grade brain tumor in rats. In vivo study of Multiple drug resistance chemosensitizers ". DOCTORATE IN VETERINARY SCIENCES. Sponsor: Dra. Claudia Quezada
Universidad Austral de Chile.
-2013 Wallys Garrido "Role of nucleoside adenosine in the chemoresistance and angiogenesis of human glioblastoma multiforme". Doctoral Program in Sciences, mention Cellular and Molecular Biology, Universidad Austral de Chile. Sponsor: Dra. Claudia Quezada

Posdoc (2):

- 2018 – 2021. Proyecto FONDECYT POSTDOCTORADO 3180749 “Rol del receptor de adenosina A2B en la capacidad de infiltración y diferenciación miofibroblástica de monocitos/macrófagos en la gloméruloesclerosis diabética”. (Principal Researcher: Angelo Torres) ''. Sponsor Researcher
-2017 - 2020, FONDECYT POSTDOCTORADO 3170812. '' TGF-beta and adenosine signaling Converge to induce the transcriptional activation of cd73 and support the pro-fibrotic trans-differentiation of Renal epithelial cells. (Principal Researcher: Claudio Cappelli Leon) ''. Sponsor Researcher
-2015 - 2017, FONDECYT POSTDOCTORADO 3150548. '' Study of purinergic signaling that mediates fibrosis Renal failure in diabetic nephropathy. " (Principal Research: Wallys Garrido). Sponsor Researcher.


Difusión y Transferencia


Technological Transfer Projects:

-2019 – 2021. Proyecto FIC19-70 Región de Los Ríos “Biomarkers in gallbladder cancer”. Alternate Director
-2017 - 2018. FONDEF VIU16E0107 “Development of a prototype enzyme kit to assess cardiovascular risk in diabetics”. Universidad Austral de Chile. Tutor
-2015-2016, FONDEF VIU15P0054. '' Sensor for the early detection of Diabetic Nephropathy. (First stage)''. Sponsoring Researcher. 2 years.
-2016-2017, FONDEF VIU15P0054. '' Sensor for the early detection of Diabetic Nephropathy. (Second stage)''. Sponsoring Researcher. 2 years.
-2013-2016, CORFO 13IDL2-23502. '' Identification of new early diagnosis and progression markers Of diabetic nephropathy for the development of a molecular diagnostic kit. " Alternate Director. 3 years.

Management Projects:
-2015. FONDEQUIP EQM130208. In vivo animal image analysis platform for the study of Pathogenesis of diseases. Responsible Researcher.
-2013 - 2015, REDES130102. '' Team research projects in science and technology ACT-73 and University rings Medical Center Groningen (UCMG), University of Groningen (UG) Netherlands ''. Investigator. 2 years.

Diffusion:
-2019 The link between metabolic imbalance and the pathogenesis of kidney disease in diabetes, R. San Martín. Symposium "Recent Advances in Metabolism and Disease". 21 de Marzo 2019, Auditorio Hugo Campos, Universidad Austral de Chile.
-2018 Loss of adenosine homeostasis leads to kidney injury, R San Martín. Symposium "Chronic Kidney Disease: Pathogenesis and interventio”. 22 de Marzo 2018, Auditorio Hugo Campos, Universidad Austral de Chile.
-2017 "Pathogenesis of diabetic nephropathy: loss of adenosine homeostasis" R San Martín, Seminar "Diabetic Nephropathy: new trends in diagnosis and therapy. 21 de Diciembre 2017, Auditorio Nahmías, Universidad Austral de Chile.
-2016 “The nucleoside adenosine is a link between the metabolic imbalance in diabetes and kidney damage. " Symposium Metabolism in Health and Disease, Austral University of Chile, Valdivia 11 de abril 2016, Auditorio Hugo Campos, Edificio Emilio Pugin, Facultad de Ciencias, Universidad Austral de Chile.
-2015. Alterations of adenosine signaling in diabetic kidney disease. I Workshop in Molecular Pathology: "Cancer Stem cells biology and nucleoside metabolism in diseases. "Universidad Austral de Chile, Valdivia, Chile
-2014. Adenosine and its use as a potential marker of diabetic nephropathy. Attention Teaching Center Comprehensive Ambulatory (CENAIA) of the Universidad Austral de Chile. Valdivia, Chile.
-2013. Chat. "Effect of Complications of Diabetes", 1000 Scientists 1000 Classes .. San Luis de Alba College. Responsable.
-2011. Role of adenosine on the dysfunction of podocytes and mesangial cells in diabetic rats. Institute of Biomedicine, University of Barcelona. Barcelona, ??Spain.
2011. Adenosine-induced changes in glomerular function: implications in diabetic nephropathy. Symposium "Role of adenosine in pathologies". Universidad Austral de Chile. Valdivia, Chile.
-2010. Course. School of Talents of the Universidad Austral de Chile ALTA-UACH. Southern University of Chile. Responsable
-2010. Role of adenosine in diabetic nephropathy. University of Antofagasta. Antofagasta, Chile.
-2009. Role of Adenosine Receptors in Complications of Diabetes. Department of Biochemistry and Molecular Biology, University of Barcelona. Barcelona, ??Spain.
-2008. Finding new therapeutic targets to treat nephropathy associated with diabetes. Cycle Seminars Institute of Histology and Pathology, Universidad Austral de Chile. Valdivia, Chile.
-2008. Regulation of the production of VEGF by adenosine and its receptors in the renal glomerulus. Workshop "Effect of diabetes in metabolism and tissue damage". Universidad Austral de Chile. Valdivia, Chile.
-2008. Role of Adenosine in Diabetic Nephropathy. Symposium "Role of nucleoside transporters in Pathologies ". Universidad Austral de Chile. Valdivia, Chile.
-2006. Effect of adenosine and its receptors on the expression and activity of the nucleoside transporter ENT-1 in Fetal endothelium. Workshop "Role of nucleoside transporters in diabetes and cancer". University of Bío-Bío. Concepción, Chile.
-2006. New actors in the pathogenesis and treatment of diabetic nephropathy. Cycle of SeminarsInstitute of Biochemistry, Universidad Austral de Chile. Valdivia, Chile.
-2005. Transcriptional repression of the equilibrative nucleoside transporter 1 in human umbilical vein endothelium From gestational diabetes. II Latin-American Symposium on Fetal-Maternal Interaction and Placenta (SLIMP Chile 2005) and XIX Annual Meeting of the Chilean Society of Physiological Sciences (SCHCF). Santiago, Chile

RESEARCH AGREEMENTS
2015 to date. Participation Agreement in the STUDENT RESEARCH DEVELOPMENT CENTER Program, University Metropolitan, San Juan, Puerto Rico for research stays at the Laboratory of Molecular Pathology of the UACH.
2013 to date. Scientific Research Agreement with the Center for Primary Care CESFAM-CENAIA de Valdivia.
2010 to date. Research agreement with Fundación Puigvert. Barcelona, Spain.


Premios y Distinciones

  •   Award for Scientific Research "Cure and Prevention of Cancer".

    Santander Universia-El Mercurio

    Chile, 2013

    Coinvestigator. Integrant research team Award for Scientific Research University Santander-El Mercurio "Cure and Prevention of Cancer". Topic: Chemical resistance in Glioblastoma multiforme. . Banco Santander - El Mercurio. Chile. Principal Research: Dra. Claudia Quezada

  •   Research Grant to Stay

    International Union of Biochemistry and Molecular Biology (IUBMB)

    Canada, 2009

    Scholarship for Research Stays of the International Union of Biochemistry and Molecular Biology (IUBMB).

  •   Distinguished Achievement Award

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 2004

    Distinction Award to the academic merit 2004 to the best student of Doctorate. Doctorate in Sciences Mention Cellular Biology and Molecular. School of Graduates of the Faculty of Sciences. Austral University of Chile. Chile.


 

Article (63)

Intraglomerular Monocyte/Macrophage infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy is regulated by A2B Adenosine Receptor
The TGF-beta profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.
Adenosine depletion as a new strategy to decrease glioblastoma stem-like cells aggressiveness.
Blockade of the adenosine A3 receptor attenuates caspase 1 activation in renal tubule epithelial cells and decreases interleukins IL-1beta and IL-18 in diabetic rats
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A(3) Adenosine Receptor activation under hypoxia
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A3 Adenosine Receptor activation under hypoxia
Role of extracellular vesicles in glioma progression.
The Adenosine A3 Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia.
Adenosine Contribution to Normal Renal Physiology and Chronic Kidney Disease
Adenosine contribution to normal renal physiology and chronic kidney disease.
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme.
Current Therapeutic Alternatives and New Perspectives in Glioblastoma Multiforme.
DEFICIENT INSULIN-MEDIATED UPREGULATION OF THE EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 CONTRIBUTES TO CHRONICALLY INCREASED ADENOSINE IN DIABETIC GLOMERULOPATHY
Deficient insulin-mediated upregulation of the equilibrative nucleoside transporter 2 contributes to chronically increased adenosine in diabetic glomerulopathy.
High plasma adenosine levels in overweight/obese pregnant women
High plasma adenosine levels in overweight/obese pregnant women
Insulin/adenosine axis linked signalling
Insulin/adenosine axis linked signalling.
Insulin/adenosine axis linked signalling.
Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling
Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling.
Multidrug resistance in glioblastoma stem-like cells=> Role of the hypoxic microenvironment and adenosine signaling.
The Adenosine A3 Receptor regulates differentiation of Glioblastoma Stem-like Cells to Endothelial Cells under Hypoxia
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
Pro-apoptotic and anti-angiogenic properties of the ? /?-thujone fraction from Thuja occidentalis on glioblastoma cells
Pro-apoptotic and Anti-angiogenic Properties of the alpha/beta Thujone Fraction from Thuja occidentalis on Glioblastoma Cells
Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells.
Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy
The cellular and signalling alterations conducted by TGF-β contributing to renal fibrosis
The cellular and signalling alterations conducted by TGF-β contributing to renal fibrosis.
Increased levels of adenosine and CD73 activity precedes renal dysfunction in diabetic rats
Increased levels of adenosine and ecto 5 '-nucleotidase (CD73) activity precede renal alterations in experimental diabetic rats
Chemoresistance in High-Grade Gliomas: Relevance of Adenosine Signalling in Stem-Like Cells of Glioblastoma Multiforme
5 '-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
Adenosine A(2B) receptor-mediated VEGF induction promotes diabetic glomerulopathy
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney
Targeting Adenosine Signaling to Treatment of Diabetic Nephropathy
Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver
Combined Use of Anticancer Drugs and an Inhibitor of Multiple Drug Resistance-Associated Protein-1 Increases Sensitivity and Decreases Survival of Glioblastoma Multiforme Cells In Vitro
FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1
Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme
Tacrolimus Confers Chemosensitivity to Anticancer Drugs in Glioblastoma Multiforme Cells by Decreasing the Expression of the Multiple Resistance-Associated Protein-1.
Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
Do adenosine receptors offer new therapeutic options for diabetic nephropathy?
Adenosine A(2B) receptor mediates an increase on VEGF-A production in rat kidney glomeruli
Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 (ABCA5) proteins in hematoencephalic barrier cells
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
Gene structure and seasonal expression of carp fish prolactin short receptor isoforms
Genomic organization of nucleolin gene in carp fish: Evidence for several genes
Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia
Seasonal modulation of growth hormone mRNA and protein levels in carp pituitary: evidence for two expressed genes
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium
Seasonal environmental changes modulate the prolactin receptor expression in an eurythermal fish
Gene structure of the carp fish ribosomal protein L41: seasonally regulated expression

Abstract (20)

Adenosine and its role in stemness of glioblastoma stem-like cells
Low-affinity adenosine receptors contribute to chemoresistance in glioblastoma stem-like cells under hypoxia
D-glucose and insulin regulate the activity of equilibrative nucleoside transporters in renal glomerular cells
Reversion of glioblastoma stem-like cells chemoresistance by adenosine A(3) receptor blockage
Adenosine affects the slit diaphragm and podocyte cytoarchitecture
Hypoxia impacts on adenosine metabolism and chemoresistance in glioblastoma stem like cells
Adenosine induces markers of epithelial to mesenchymal transition in renal proximal epithelial tubule cells
Study of the role of extracellular adenosine on chemoresistance in glioblastoma stem-like cells
Adenosine metabolism and physiological effects in podocytes.
Expression of FPBase and PEPCK during the progression of tubular damage in diabetic nephropathy
THE ACTIVITY OF MRP1 MEMBRANE TRANSPORTER CONFERS RESISTANCE TO ANTICANCER DRUGS IN GLIOBLASTOMA MULTIFORME CELLS
Alano pathway in human umbilical vein endothelium
Cloning and seasonal expression of short prolactin receptor isoforms in a teleost fish
Differential regulation of adenosine transport by activation of A(2a) and A(1) purinoceptors in human umbilical vein endothelium
High D-glucose reduces promoter activity of human equilibrative nucleoside transporter 1 in human umbilical vein endothelium
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium
Transcriptional repression of the equilibrative nucleoside transporter I in human umbilical vein endothelium from gestational diabetes
Equilibrative nucleoside transporter 1 is downregulated by activation of A(2a) adenosine receptors in human umbilical vein endothelium.
Molecular mechanisms involved in the modulation of nucleolar gene expression during the acclimatization of the carp fish
Growth hormone expression in carp pituitary during acclimatisation

BookSection (1)

Adenosine receptors: A novel therapeutic alternative for diabetic nephropathy

Proyecto (45)

Several mechanisms of therapeutic resistance are regulated through adenosine signaling in glioblastoma stem-like cells
Biomarcadores en cáncer de vesícula biliar”
Rol del receptor de adenosina A2B en la capacidad de infiltración y diferenciación miofibroblástica de monocitos/macrófagos en la gloméruloesclerosis diabética
Rol del receptor de adenosina A2B en la capacidad de infiltración y diferenciación miofibroblástica de monocitos/macrófagos en la gloméruloesclerosis diabética
Desarrollo de un prototipo de kit enzimático para evaluar riesgo cardiovascular en diabéticos
Desarrollo de un prototipo de kit enzimático para evaluar riesgo cardiovascular en diabéticos
LA SEÑALIZACIÓN DE TGF-BETA Y ADENOSINA CONVERGEN PARA INDUCIR LA ACTIVACIÓN TRANSCRIPCIONAL DE CD73 Y SUSTENTAR LA TRANS-DIFERENCIACIÓN PRO-FIBRÓTICA DE CÉLULAS DE EPITELIO RENAL.
La señalización de TGF-beta y adenosina convergen para inducir la activación transcripcional de CD73 y sustentar la trans-diferenciación pro-fibrótica de células de epitelio renal
Study of equilibrative nucleotide transporter 2 regulation by insulin and fibrosis mediated by adenosine signaling in diabetic nephrophathy
Study of the Equilibrative Nucleoside Transporter-2 regulation by insulin and fibrosis mediated by adenosine signaling in diabetic nephropathy
''Role of hypoxia and adenosine on chemoresistance mediated by multidrug resistance-associated proteins 1 and 3 in glioblastoma stem like cells''
'Role of hypoxia and adenosine on chemoresistance mediated by multidrug resistance-associated proteins 1 and 3 in glioblastoma stem like cells
'Sensor para la detección temprana de la Nefropatía Diabética
ROLE OF HYPOXIA AND ADENOSINE ON CHEMORESISTANCE MEDIATED BY MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS 1 AND 3 IN GLIOBLASTOMA STEM LIKE CELLS
Sensor para la detección temprana de la Nefropatía Diabética
Estudio de la señalización purinérgica que media fibrosis renal en la nefropatía diabética
Plataforma de análisis de imágenes en animales in vivo para el estudio de la patogénesis de enfermedades
Sensor para la detección temprana de la Nefropatía Diabética.
''Estudio de la señalización purinérgica que media fibrosis renal en la nefropatía diabética''. Investigador Patrocinante.
''Identificación de nuevos marcadores de diagnóstico temprano y progresión de la nefropatía diabética para el desarrollo de kit de diagnóstico molecular'
''Team research projects in science and technology Anillos ACT-73 and University Medical Center Groningen (UCMG), University of Groningen (UG) Paises Bajos
''Team research projects in science and technology Anillos ACT-73 and University Medical Center Groningen (UCMG), University of Groningen (UG) Paises Bajos
'Pathogenic role of adenosine in diabetic nephropathy: mechanisms and intervention''. Investigador Responsable
'Sodium tungstate a new treatment for diabetic nephropathy: effect of this drug in inflammation, oxidative stress and fibrosis during the progression of this pathology
Identificación de nuevos marcadores de diagnóstico temprano y progresión de la nefropatía diabética para el desarrollo de kit de diagnóstico molecular
Identificación de nuevos marcadores de diagnóstico temprano y progresión de la nefropatía diabética para el desarrollo de kit de diagnóstico molecular
Identificación de nuevos marcadores de diagnóstico temprano y progresión de la nefropatía diabética para el desarrollo de kit de diagnóstico molecular”
PATHOGENIC ROLE OF ADENOSINE IN DIABETIC NEPHROPATHY=> MECHANISMS AND INTERVENTION.
Plataforma de análisis de imágenes en animales in vivo para el estudio de la patogénesis de enfermedades
SODIUM TUNGSTATE A NEW TREATMENT FOR DIABETIC NEPHROPATHY=> EFFECT OF THIS DRUG IN INFLAMMATION, OXIDATIVE STRESS AND FIBROSIS DURING THE PROGRESSION OF THIS PATHOLOGY.
'Study of the role of multiple resistance associated protein 1 on chemoresitance of glioblastoma stem-like cells and evaluation of inhibitors
STUDY OF THE ROLE OF MULTIPLE RESISTANCE ASSOCIATED PROTEIN 1 ON CHEMORESISTANCE OF GLIOBLASTOMA STEM-LIKE CELLS AND EVALUATION OF INHIBITORS
''Role of adenosine receptors on progression of proteinuria and fibrosis in the diabetic kidney disease
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy
Characterization of the pathohysiological mechanisms, and detection of common therapeutic targets in placental dysfunction in pathologies of the human pregnancy'
ROLE OF ADENOSINE RECEPTORS ON PROGRESSION OF PROTEINURIA AND FIBROSIS IN THE DIABETIC KIDNEY DISEASE.
'Regulation of kidney glucose and glycogen metabolism by insulin and tungstate in long term diabetic and control rats
REGULATION OF KIDNEY GLUCOSE AND GLYCOGEN METABOLISM BY INSULIN AND TUNGSTATE IN LONG TERM DIABETIC AND CONTROL RATS.
''Regulación de la expresión y actividad de los transportadores equilibrados de nucleosidos tipo 1(hent1) y 2 (hent2) por insulina en el endotelio micro y macrovascular fetal humano en diabetes mellitus gestacional'
ALTERACIONES DE LA FUNCION CELULAR EN EL GLOMERULO RENAL INDUCIDAS POR ADENOSINA=> IMPLICANCIAS EN LA PATOGENESIS Y EL TRATAMIENTO DE LA NEFROPATIA DIABETICA.
Alteraciones de la función celular en el glomérulo renal inducidas por adenosina: implicancias en la patogénesis y el tratamiento de la neuropatía diabética
Alteraciones de la función celular en el glomérulo renal inducidas por adenosina=> implicancias en la patogénesis y el tratamiento de la nefropatía diabética
REGULACION DE LA EXPRESION Y ACTIVIDAD DE LOS TRANSPORTADORES EQUILIBRADOS DE NUCLEOSIDOS TIPO 1 (HENT1) Y 2 (HENT2) POR INSULINA EN EL ENDOTELIO MICRO Y MACROVASCULAR FETAL HUMANO EN DIABETES MELLITUS GESTACIONAL
'Papel de los receptores de adenosina en la producción del factor de crecimiento de endotelio vascular en células del glomérulo renal de ratas diabéticas'
“Regulación por adenosina de la expresión del factor de crecimiento de endotelio vascular (VEGF) y sus receptores en células de glomérulo renal en un modelo de nefropatía diabética

Review (2)

Do adenosine receptors offer new therapeutic options for diabetic nephropathy?
Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endotheliurn
111
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

23
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

16
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

16
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

14
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

11
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

9
Carlos Oyarzún

Profesor Adjunto Asociado

Ciencias

Universidad Austral de Chile

Valdivia, Chile

8
Sebastián Alarcón

Bioquímico - COVID19

Facultad Medicina

Universidad Atacama

Copiapo, Chile

6
Rómulo Melo

Neurosurgeon

Department of Neurosurgery

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

6
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

5
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

4
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

4
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

3
Marco Alvarez

Full Professor

Department of Biological Science

Universidad Andres Bello

Viña del Mar, Chile

2
Romina Bertinat

Investigador asociado

Centro de Microscopía Avanzada, CMA BIO BIO

Universidad de Concepcion

Concepción, Chile

2
Denisse Valladares

Assistant Professor

Universidad de O'Higgins

Rancagua, Chile

2
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

2
Genesis Vega

Investigador

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

2
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

2
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

2
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
José Rocha

Research Assistant

Evolutionary Biology

Centro de investigación i-mar

Puerto Montt, Chile

2
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Claudio Flores

Académico

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

1
Lucia Podesta

Directora

Facultad de Medicina

CENTRO DE DOCENCIA DE ATENCIÓN INTEGRAL AMBULATORIA

Valdivia, Chile

1
Juan Pontigo

Academico-Investigador

Medicina Veterinaria

Universidad San Sebastián

Puerto Montt, Chile

1
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

1
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

1
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Constanza Salinas

Tesista de Postgrado

Centro Interdisciplinario de Estudios del Sistema Nervioso (CISNe)

Universidad Austral de Chile

Valdivia, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Cristopher Villablanca

Investigador post doctoral

Centro de Gerociencia, Salud Mental y Metabolismo (GERO)

Santiago, Chile

1
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile