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Paola Cecilia Casanello Toledo

Profesor Asociado

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Programación cardiometabólica e inmune del feto asociado a la trayectoria de crecimiento fetal, hipoxia, obesidad materna y condiciones nutricionales de la madre.

Educación

  •  Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Ciencias Fisiológicas, UNIVERSIDAD DE CONCEPCION. Chile, 2003
  •  Matrona, UNIVERSIDAD DE CONCEPCION. Chile, 1996
  •  Perinatología, UNIVERSIDAD DE CONCEPCION. Chile, 2000

Experiencia Académica

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2014 - A la fecha

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2016 - A la fecha

  •   Instructor Full Time

    UNIVERSIDAD DE CONCEPCION

    Medicina

    Concepción, Chile

    1998 - 2001

Experiencia Profesional

  •   Instructor Escuela de Medicina Part Time

    Universidad de Concepción

    Concepción, Chile

    1998 - 2001

  •   Profesor Asistente Escuela de Medicina Full Time

    Universidad de Concepción

    Concepción, Chile

    2002 - 2003

  •   Research Fellow Welcome Trust Full Time

    Universidad de Chile

    Santiago, Chile

    2004 - 2005

  •   Instructor Escuela de Medicina Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2005 - 2007

  •   Profesor Asistente Adjunto Escuela de Medicina Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2007 - 2010

  •   Profesor Asistente Escuela de Medicina Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - 2014

Formación de Capital Humano


TESISTAS DE PREGRADO

Catalina Correa (2020)
Efecto del ácido docosahexaenoico en la expresión de genes pro-inflamatorios en células endoteliales de arterias de cordón umbilical de mujeres con obesidad
pre-gestacional.
Bioquímico, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Estefanía Peñaloza (2017)
Efecto de la hipoxia sobre de los niveles de los micro-RNAs miR-21 y miR-126 en células endoteliales de cordón umbilical humano y su relación con la regulación de la actividad de eNOS. (Co-Tutor, Tutor Dr. Bernardo Krause)
Bioquímico, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Amanda Silva (2013)
Regulación reciproca de eNOS y arginasa-2 en endotelio placentario de fetos con RCIU.
Licenciada en Biología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Francisco Minaya (2010)
Regulación del transporte de adenosina por activación de purinoreceptores A2a y A1 en células endoteliales de vena umbilical humana.
Bioquímico, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Claudia Lavín (2010)
Participación de los aminoácidos L-citrulina y L-arginina en la vasodilatación mediada por óxido nítrico en arterias coriónicas de fetos con Restricción del Crecimiento Intrauterino.
Licenciada en Biología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Carlos Puebla (2008)
Regulación transcripcional del promotor del gen SLC29A1 para el transportador equilibrativo de nucleósidos tipo 1 (hENT1) por D-glucosa en endotelio fetal humano
Bioquímico, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

Catalina Prieto (2006)
Efecto de hipoxia sobre la expresión y actividad de eNOS y su regulación por arginasa en células endoteliales de vena umbilical humana.
Licenciada en Biología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile

TESISTAS DE POSTGRADO

Viviana Arroyo (en desarrollo desde Mayo 2018)
Participación de la leptina en la programación de la función de las células T reguladoras en hijos de madres con obesidad pregestacional.
Doctorado en Nutrición y Alimentos, INTA, Universidad de Chile.

Erika Castaño (en desarrollo desde Abril 2018)
The altered lipid metabolism in offspring of women with pregestational obesity and with Folate/Vitamin B12 imbalance, is reverted by maternal DHA supplementation.
Doctorado en Nutrición y Alimentos, INTA, Universidad de Chile.

Ángela Jaramillo (Mayo 2020)
Cantidad y calidad de la grasa corporal al nacimiento y a los 4 meses de edad en hijos de madres con obesidad pregestacional y suplementación con DHA durante la gestación.
Doctorado en Nutrición y Alimentos, INTA, Universidad de Chile.

Ivo Carrasco (Junio 2019)
Epigenetic programming of Nrf2?dependent genes in human umbilical artery endothelium in macrosomic babies from obese mothers.
Doctorado en Ciencias Biológicas, mención Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

Estefanía Muñoz (Marzo 2018)
Los fetos grandes para la edad gestacional presentan alteraciones en la función vascular placentaria y umbilical asociadas a niveles elevados de adiponectina en el plasma.
Doctorado en Nutrición y Alimentos, INTA, Universidad de Chile.

Ivo Carrasco (Enero 2015).
MicroRNAs en plasma como marcadores epigenéticos de disfunción metabólica temprana en niños prepuberales.
Magister en Ciencias Médicas, Mención Biología Celular y Molecular. Escuela de Medicina. Universidad de Valparaíso.

Ernesto Muñoz (Diciembre 2013)
Participación del estrés oxidativo en la disfunción placentaria observada en Restricción del Crecimiento Fetal.
Magister en Ciencias Biológicas, mención Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

Bernardo Krause (Noviembre 2012)
Mecanismos epigenéticos implicados en la programación de la función endotelial en fetos con Restricción del Crecimiento Intrauterino.
Doctorado en Ciencias Biológicas, mención Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

Catalina Prieto (Marzo 2012)
Determinación de la expresión y regulación funcional de Arginasa II y eNOS en células endoteliales de la vena umbilical humana en hipoxia.
Doctorado en Ciencias Biológicas, mención Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

Carlos Puebla (Octubre 2011)
Papel del transporte y metabolismo de D-glucosa en la expresión y actividad del transportador equilibrativo de nucleosidos 1 (hENT1) en endotelio de vena umbilical humana.
Doctorado en Ciencias Biológicas, mención Ciencias Fisiológicas, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.

Victoria Gallardo (Enero 2008)
Regulación de la actividad de la ruta L-arginina /óxido nítrico por heme oxigenasa-1 en el endotelio fetal humano.
Magister en Bioquímica, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile


Difusión y Transferencia


Solicitud de Patente 2014-02403, PCT/CL2015/050035 Chile. (11/09/2014) "Procedimiento para la síntesis enantioselectiva y purificación del ácido 2(S)-Amino-6-Boronohexanoico (ABH) e intermedios claves sintéticos." Preite Marcelo, Manríquez Juan, Correa Jordán, Iturriaga Rodrigo, Casanello Paola, Krause Bernardo.

Solicitud de Patente 2016-02951, PCT/CL2016/050062 Chile. (18/11/2016) “Combinación farmacéutica para el tratamiento y prevención de la hipertensión arterial y disfunción vascular” Preite Marcelo, Del Río Rodrigo, Iturriaga Rodrigo, Casanello Paola, Krause Bernardo.


Premios y Distinciones

  •   Mejor Investigador Junior 2012 de la Escuela de Medicina de la Pontificia Universidad Católica de Chile

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2013

    Premio al mejor investigador joven en la Escuela de Medicina de la Pontificia Universidad Católica el año 2012. Es una distinción importante y competitiva dentro de la carrera académica de la Escuela de Medicina.

  •   Best poster presentation in DOHaD World Congress

    DOHaD International Society

    Singapur, 2013

    El trabajo presentado en proteoma de endotelio placentario de fetos con restricción de crecimiento vs fetos con trayectorias de crecimiento normal ganó el premio a uno de los mejores 10 trabajos presentados (de cerca de 600) en este congreso, que se celebra cada dos años. Este trabajo fue luego publicado en la revista de la especialidad Placenta.

  •   Ex-alumna distinguida

    UNIVERSIDAD DE CONCEPCION

    Chile, 2019

    Exalumna distinguida, invitada a dictar la conferencia central de la ceremonia de conmemoración de 95 años de la Facultad de Medicina, Universidad de Concepción

  •   Expositora en Congreso del Futuro, Comisión del Senado, Chile

    CONGRESO NACIONAL

    Chile, 2017

    Expositora en Congreso del Futuro, Comisión del Senado, Chile

  •   Invitación reunión expertos OMS

    ORGANIZACION MUNDIAL DE LA SALUD

    Suiza, 2016

    Invitación a “Expert meeting on avoidable Early Environmental Exposures” de la Organización Mundial de la Salud, 13-14 de Junio, Ginebra, Suiza.

  •   DOHaD Directive Council member

    UNIVERSITY OF SOUTHAMPTON

    Reino Unido

    Nombrada Miembro del Consejo Directivo Internacional de DOHaD, representando a las Ciencias Biomédicas (activa entre 2013 y 2017).

  •   Ciencia de Frontera

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2012

    Miembro del Programa “Ciencia de Frontera 2012-2014” de la Academia Chilena de Ciencias

  •   DOHaD Recognized Health Educator Award

    International DOHaD Society

    Estados Unidos

    DOHaD Recognized Health Educator Award to attend DOHaD 7th Word Congress, Portland, Oregon, USA.

  •   Distinción Máxima Tesis Doctoral

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2007

    Distinción Máxima Tesis Doctoral: “Caracterización de las vías de señalización involucradas en la disminución de la actividad de la ruta L-arginina/óxido nítrico endotelial en restricción del crecimiento intrauterino e hipoxia”

  •   Travel Award

    Physiological Society

    Reino Unido, 2004

    Beca Physiological Society para viaje y participación en Reunión conjunta Sociedad Chilena de Ciencias Fisiológicas y Physiological Society, UK (Diciembre 2004)

  •   Research Visit Award

    Wellcome Trust

    Chile, 2003

    Beca Wellcome Trust para Visita de Investigación al Kings College London, University of London, UK – Microarreglos de genes en endotelio de vena umbilical de fetos con RCF (Enero - Abril 2003)

  •   Best presentation I Latin American Symposium on Maternal-Fetal interaction

    I Latin American Symposium on Maternal-Fetal Interaction & Placenta (SLIMP)

    Brasil, 2003

    Premio al mejor trabajo presentado. I Simposio Latinoamericano sobre Interacción Materno-Fetal Placenta, Sao Paulo, Brasil.


 

Article (157)

Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile
Effectiveness of a normative nutrition intervention in Chilean pregnant women on maternal and neonatal outcomes: the CHiMINCs study
Evaluation of the Stability of Fatty Acids in Erythrocytes from Human Umbilical Cord
Human umbilical artery endothelial cells from Large-for-Gestational-Age newborn have increased antioxidant efficiency and gene expression
Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by -Acetylcysteine Supplementation and Arginase Inhibition.
Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition
Effectiveness on maternal and offspring metabolic control of a home-based dietary counseling intervention and DHA supplementation in obese/overweight pregnant women (MIGHT study): A randomized controlled trial-Study protocol
LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries
LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries.
Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer.
IL-10 expression in macrophages from neonates born from obese mothers is suppressed by IL-4 and LPS/INFγ.
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs.
Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells
Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells.
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs.
Epigenetics in allergic diseases and asthma
General concepts of epigenetics: Projections in paediatrics
Markers of early endothelial dysfunction in intrauterine growth restriction-derived human umbilical vein endothelial cells revealed by 2D-DIGE and mass spectrometry analyses
Markers of early endothelial dysfunction in intrauterine growth restriction-derived human umbilical vein endothelial cells revealed by 2D-DIGE and mass spectrometry analyses.
Placental epigenetic programming in intrauterine growth restriction (IUGR)
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia.
Effectiveness of a normative nutrition intervention (diet, physical activity and breastfeeding) on maternal nutrition and offspring growth: the Chilean maternal and infant nutrition cohort study (CHiMINCs)
Effectiveness of a normative nutrition intervention (diet, physical activity and breastfeeding) on maternal nutrition and offspring growth: the Chilean maternal and infant nutrition cohort study (CHiMINCs).
Fetal programming of chronic diseases: Current concepts and epigenetics
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA.
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses.
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity.
Long-term impact of early life events on physiology and behaviour.
The placental pursuit for an adequate oxidant balance between the mother and the fetus.
5 '-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
Conceptual basis for prescriptive growth standards from conception to early childhood: present and future
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels
Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses
The International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). Conceptual basis for prescriptive growth standards from conception to early childhood: present and future.
Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins.
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes
Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium.
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes
Role of Nitric Oxide in Placental Vascular Development and Function.
ACTIVITY AND EXPRESSION OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IS REGULATED BY D-GLUCOSE UPTAKE AND METABOLISM IN UMBILICAL VEIN ENDOTHELIUM
Antagonic Role of Adenosine A(2A) and A(2B) Receptors on L-Arginine/Nitric Oxide Pathway in Human Placental Microvascular Endothelial Cells from Pre-Eclampsia
DIFFERENTIAL MODULATION OF INSULIN RECEPTOR ISOFORMS EXPRESSION AND NOS ACTIVITY BY INSULIN IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES
Expression and Activity of Human Equilibrative Nucleoside Transporter 1 Depends on D-Glucose Uptake in Umbilical Vein Endothelial Cells.
Functional evidences of fetal endothelial dysfunction as a programmed phenomenon in pregnancy diseases
HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS EXHIBIT GLUTS-LIKE TRANSPORT ACTIVITY MODULATED BY INSULIN
Hypoxia-Reduced eNOS Activity Could Be Explained by Higher Arginase II Activity and Cellular Redistribution in Human Umbilical Vein Endothelial Cells
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP alpha in human umbilical vein endothelial cells from gestational diabetes
Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBP? in human umbilical vein endothelial cells from gestational diabetes
PARTICIPATION OF ARGINASES IN THE VASCULAR TONE IN UMBILICAL VEIN FROM IUGR PLACENTAE: ROLE OF THE ENDOTHELIUM AND HYPOXIA
RHOA/ROCK SIGNALLING PATHWAY IS NOT IMPLICATED IN ENOS INACTIVATION BY HYPOXIA IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Role of Arginase II in the Vascular Function of Umbilical Arteries and Veins: Effect of Hypoxia
THE REDUCED NOS-DEPENDENT VASODILATION IN IUGR CHORIONIC ARTERIES IS IMPROVED BY ARGINASE INHIBITION
Adenosine A(2B) Receptors Are Involved in the Regulation of Nitric Oxide Synthesis in Placental Microvascular Endothelial Cells from Preeclamptic Pregnancies
Brain natriuretic peptide (BNP) produced by the human chorioamnion may mediate pregnancy myometrial quiescence.
Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
Epigenetics: new concepts of old phenomena in vascular physiology.
Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia
Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia.
TGF-?1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
Upregulation of Arginase II in Hypoxia Counteracts Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells
Adenosine, L-Arginine and Nitric Oxide Pathway in Human Placental Microvascular Endothelial Cells Derived from Preeclampsia.
Brain natriuretic peptide (BNP) decreases expression and activity of eNOS and iNOS in primary human myometrial cell cultures
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
Characterization of adenosine, L-arginine, and nitric oxide pathway in human placental microvascular endothelial cells derived from preeclampsia
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium
Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A(2B) adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A(2B) adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia
Hypoxia upregulates the expression of arginase II in human umbilical vein endothelial cells. Regulating the nitric oxide synthase activity
TGF-beta 1 inhibits adenosine transport in human fetal endothelium
The transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose rfsponses to transcription factor Sp1 and ZBP-89 in human foetal endothelium
Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium
ALANO pathway in the feto-placental endothelium from gestational diabetes
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
D-Glucose stimulation of L-arginine transport and nitric oxicle synthesis results from activation of mitogen-activated protein kinases p42/44 and smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium
D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-? receptors in human umbilical vein endothelium
DISMINUCION DEL FLUJO PLACENTARIO EN PREECLAMPSIA SEVERA: ¿ESTA INVOLUCRADA ADENOSINA EN ESTE FENOMENO?
Equilibrative nucleoside (ENTs) and cationic amino acid (CATs) transporters: Implications in foetal endothelial dysfunction in human pregnancy diseases
Expression and activty of HENT1 and HENT2 are regulated by adenosine receptors in placenta microvascular endothelium from preeclampsia
Insulin increases adenosine transport via equilibrative nucleoside transporter 2 in human umbilical vein endothelium under normoxia or hypoxia.
Lower activity of L-arginine-nitric oxide pathway is related to PKCA activation in human umbilical vein endothelium from intruterine growth restriction.
Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium
Transforming growth factor beta 1 reduces expression and activity of equilibrative nucleoside transporter 1 in human fetal endothelium
Adenosine receptor A2A stimulation decreases nitric oxide synthesis in placental microvascular endothelial cells from women with preeclampsia and intrauterine growth restriction
Adenosine transport via Equilibrative Nucleoside Transporters 1 and 2 are not modulated by insulin in human umbilical vein endothelium under hypoxia
Alano pathway in human umbilical vein endothelium
Carbon monoxide (CO): A key vasodilator in the pulmonary circulation in the llama neonate
D-GLUCOSE stimulates nitric oxide synthase via a mechanism that involves TGF-beta 1 in human foetal endothelium
Differential femoral and pulmonary adrenergic vascular reactivity in high and low altitude newborn lambs
Differential regulation of adenosine transport by activation of A(2a) and A(1) purinoceptors in human umbilical vein endothelium
Effect of insulin on L-arginine transport through system y(+)L in human umbilical vein endothelium
Effects of insulin on the expression and activity of system y(+)L-mediated L-arginine transport in human umbilical vein endothelium
Hemoxygenase expression in lung tissue from high and low altitude newborn lambs
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium
Hypoxia represses carbon monoxide/heme oxygenase (Co/Ho) system and downregulates L-arginine/nitric oxide (No) pathway in human umbilical vein endothelial cells (Huvec).
Hypoxia-induced heme oxygenase-1 regulates the L-arginine/nitric oxide pathway in human umbilical vein endothelium
Inhibition of L-arginine transport and nitric oxide activity in human umbilical vein endothelium of newborn with intrauterine growth restriction: role of hypoxia and PKC
Insulin restores D-glucose reduced adenosine transport in human umbilical vein endothelium
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium
Modulation of adenosine transport by insulin in human foetal endothelium
Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endotheliurn from gestational diabetes
Post-translational modulation of equilibrative nucleoside transporter 1 by D-glucose in human umbilical vein endothelium
Short-, but not long-term stimulation of L-arginine transport by D-glucose involves TGF-beta 1 in human foetal endothelium
Effect of transforming growth factor beta 1 on L-arginine/nitric oxide pathway in human umbilical vein endothelium exposed to high D-glucose
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
Equilibrative nucleoside transporter 1 is downregulated by activation of A(2a) adenosine receptors in human umbilical vein endothelium.
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia
Gestational diabetes increases L-arginine transport via a P13-K-independent mechanism in human foetal endothelium
Heme oxygenase 1 regulates the L-arginine/nitric oxide pathway in hypoxia in human umbilical vein endothelium
Insulin restores the elevated adenosine transport in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies
Role of nitric oxide in the pulmonary circulation in high- and low-altitude newborn lambs.
CELL SIGNALLING-MEDIATING INSULIN INCREASE OF MRNA EXPRESSION FOR CATIONIC AMINO ACID TRANSPORTERS-1 AND-2 AND MEMBRANE HYPERPOLARIZATION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and-2 and membrane hyperpolarization in human umbilical vein endothelial cells
Expression of equilibrative nucleoside transporters 1 is modulated by hypoxia in human umbilical vein endothelial cells
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium
Transforming growth factor beta 1 increases L-arginine transport and expression of the human cationic amino acid transporter 1 mRNA in human umbilical vein endothelial cells
Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium
Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium
Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y(+)L in human umbilical vein endothelium
Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y(+)L in human umbilical vein endothelium
Rapid stimulation of L-arginine transport by D-glucose involves P42/44(mapk) and nitric oxide in human umbilical vein endothelium
Rapid stimulation of L-arginine transport by D-glucose involves P42/44(mapk) and nitric oxide in human umbilical vein endothelium
Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P-2Y2 purinoceptors in human umbilical vein endothelial cells
Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P-2Y2 purinoceptors in human umbilical vein endothelial cells
Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated elevated D-glucose involves activation of P 2Y2 purinoceptors in human umbilical vein endothelial cells
Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y(+)/hCAT-1 and y(+)/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells
Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y(+)/hCAT-1 and y(+)/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells
Intra-uterine growth retardation is associated with reduced activity and expression of cationic amino acid transporters (system y(+)/CAT) and nitric oxide synthase in human umbilical vein endothelial cells
NITRIC OXIDE REDUCES ADENOSINE TRANSPORTER ENT1 GENE (SLC29A1) PROMOTER ACTIVITY IN HUMAN FETAL ENDOTHELIURN FROM GESTATIONAL DIABETES

Abstract (81)

DNA Methylation of nos3 Promoter in IUGR Guinea Pig Fetuses Does Not Predict Endothelial Function and DNA Methylation Later in Life
Changes in the M1/M2 Responses and Epigenetic Markers in Neonatal Monocyte-Derived Macrophages from Women with Pre-Gestational Obesity.
INTRAUTERINE GROWTH TRAJECTORIES MODIFY THE EPIGENETIC PROGRAMMING OF VASCULAR-RELATED GENES IN HUMAN UMBILICAL ARTERY ENDOTHELIUM AND CORD ADIPONECTIN LEVELS
Antioxidant and Angiotensin AT1 Receptor Antagonist Treatment Reduced the Hypertension Induced by Chronic Intermittent Hypoxia in rats, but had Different Effects on Endothelial Dysfunction
ADIPONECTIN RECEPTOR 1 EXPRESSION IN HUMAN UMBILICAL ARTERY ENDOTHELIAL CELLS (HUAEC) FROM LARGE FETUSES (LGA) OF OBESE WOMEN IS RELATED TO eNOS ACTIVATION
EPIGENETICS AND ENDOTHELIAL HETEROGENEITY IN THE UMBILICOPLACENTAL UNIT: A LANDSCAPE FOR EPIGENETIC PROGRAMMING OF VASCULAR FUNCTION
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION
MATERNAL OBESITY IMPAIRS MIGRATION OF FETAL ENDOTHELIUM INVOLVING ENDOPLASMIC RETICULUM STRESS
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS
HISTONE DEACETYLASE ACTIVITY AND NITRIC OXIDE CONTROL THE EXPRESSION OF ENOS AND ARGINASE-2 IN HUMAN UMBILICAL ARTERY ENDOTHELIUM IN INTRAUTERINE GROWTH RESTRICTION
MATERNAL OBESITY IS ASSOCIATED WITH AN ALTERED ANTIOXIDANT SYSTEM IN THE UMBILICAL ARTERY ENDOTHELIUM: NEW INSIGHTS INTO VASCULAR FETAL PROGRAMMING BY MATERNAL OBESITY?
ROLE OF OXIDATIVE STRESS STATUS ON THE IMPAIRED ENOS-DEPENDENT RELAXATION IN PLACENTAL CHORIONIC ARTERIES OF INTRAUTERINE GROWTH RESTRICTED (IUGR) AND MACROSOMIC FETUSES FROM OBESE MOTHERS (FMOM)
Epigenetic mechanisms implicated in endothelial programming associated to IUGR: Insights from umbilical endothelium
The increase in oxidative stress in umbilical endothelium from IUGR pregnancies involves changes in GTPCH and DHFR expression
Maternal Supraphysiological Hypercholesterolemia Leads to Reduced Endothelium-Dependent Vasodilation of Human Umbilical Vein and Reduced Nitric Oxide Production in HUVEC.
RhoA/ROCK Signaling Pathway Is Not Implicated in the Regulation of eNOS Activation and arginase-2 Expression in Human Umbilical Vein Endothelial Cells Exposed to Hypoxia.
SREBP-1C AND HCHOP-C/EBP alpha INVOLVEMENT IN INSULIN MODULATION OF HENT2 ACTIVITY IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIUM FROM GESTATIONAL DIABETES
The Hypoxic Phenotype of IUGR Placental Endothelial Cells Is Reverted by DNMT1 Silencing. Evidence for Altered Epigenetic Vascular Programming.
Abnormal Expression of L-Arginine/NO-Related Enzymes in HUVEC Is Associated with Altered Vascular Reactivity of Umbilical Vein from IUGR Placentae
Altered Expression of L-Arginine/NO-Related Enzymes in Cultured Endothelial Cells from IUGR Placenta Is Accompanied by Specific DNA Methylation Changes
Differential Expression of A and B Isoforms of Insulin Receptor Are Involved in the Insulin-Mediated Recovery of Gestational Diabetes to Normal Phenotype in Human Placental Microvascular Endothelium
INSULIN ACTIVATES EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 INVOLVING INSULIN RECEPTOR A IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES
INSULIN RECEPTOR A IS INVOLVED IN GESTATIONAL DIABETES-REDUCED ADENOSINE TRANSPORT VIA HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Insulin Reverses Gestational Diabetes-Increased L-Arginine Transport Via A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium
Maternal Supraphysiological Hypercholesterolemia Leads to Reduced Endothelium-Dependent Vasodilation of Umbilical Vein and Increased L-Arginine Transport in HUVEC
ACTIVITY AND EXPRESSION OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 IS REGULATED BY D-GLUCOSE UPTAKE AND METABOLISM IN UMBILICAL VEIN ENDOTHELIUM
Antagonic Role of Adenosine A(2A) and A(2B) Receptors on L-Arginine/Nitric Oxide Pathway in Human Placental Microvascular Endothelial Cells from Pre-Eclampsia
DIFFERENTIAL MODULATION OF INSULIN RECEPTOR ISOFORMS EXPRESSION AND NOS ACTIVITY BY INSULIN IN HUMAN PLACENTA MICROVASCULAR ENDOTHELIAL CELLS FROM GESTATIONAL DIABETES
Expression and Activity of Human Equilibrative Nucleoside Transporter 1 Depends on D-Glucose Uptake in Umbilical Vein Endothelial Cells.
Functional evidences of fetal endothelial dysfunction as a programmed phenomenon in pregnancy diseases
HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS EXHIBIT GLUTS-LIKE TRANSPORT ACTIVITY MODULATED BY INSULIN
Hypoxia-Reduced eNOS Activity Could Be Explained by Higher Arginase II Activity and Cellular Redistribution in Human Umbilical Vein Endothelial Cells
PARTICIPATION OF ARGINASES IN THE VASCULAR TONE IN UMBILICAL VEIN FROM IUGR PLACENTAE: ROLE OF THE ENDOTHELIUM AND HYPOXIA
RHOA/ROCK SIGNALLING PATHWAY IS NOT IMPLICATED IN ENOS INACTIVATION BY HYPOXIA IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
Role of Arginase II in the Vascular Function of Umbilical Arteries and Veins: Effect of Hypoxia
THE REDUCED NOS-DEPENDENT VASODILATION IN IUGR CHORIONIC ARTERIES IS IMPROVED BY ARGINASE INHIBITION
VASOCONSTRICTION INDUCED BY SEROTONIN IS REDUCED BY ADENOSINE IN HUMAN UMBILICAL VEINS FROM GESTATIONAL DIABETES
Adenosine A(2B) Receptors Are Involved in the Regulation of Nitric Oxide Synthesis in Placental Microvascular Endothelial Cells from Preeclamptic Pregnancies
Upregulation of Arginase II in Hypoxia Counteracts Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells
Adenosine, L-Arginine and Nitric Oxide Pathway in Human Placental Microvascular Endothelial Cells Derived from Preeclampsia.
Brain natriuretic peptide (BNP) decreases expression and activity of eNOS and iNOS in primary human myometrial cell cultures
Characterization of adenosine, L-arginine, and nitric oxide pathway in human placental microvascular endothelial cells derived from preeclampsia
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium
Gestational diabetes mellitus is associated with NO and PKC-dependent repressor effect of hCHOP-C/EBPalpha on equilibrative nucleoside transporter 1 expression human umbilical vein endothelium
Hypoxia upregulates the expression of arginase II in human umbilical vein endothelial cells. Regulating the nitric oxide synthase activity
TGF-beta 1 inhibits adenosine transport in human fetal endothelium
The transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose rfsponses to transcription factor Sp1 and ZBP-89 in human foetal endothelium
Transforming growth factor beta 1 is involved in the inhibitory effect of high D-glucose on human equilibrative nucleosidie transporter 1 in human fetal endothelium
ALANO pathway in the feto-placental endothelium from gestational diabetes
Expression and activty of HENT1 and HENT2 are regulated by adenosine receptors in placenta microvascular endothelium from preeclampsia
Insulin increases adenosine transport via equilibrative nucleoside transporter 2 in human umbilical vein endothelium under normoxia or hypoxia.
Lower activity of L-arginine-nitric oxide pathway is related to PKCA activation in human umbilical vein endothelium from intruterine growth restriction.
Transcriptional repression of equilibrative nucleoside transporter 1 by D-glucose involves nitric oxide and Sp1 in human foetal endothelium
Transforming growth factor beta 1 reduces expression and activity of equilibrative nucleoside transporter 1 in human fetal endothelium
Adenosine receptor A2A stimulation decreases nitric oxide synthesis in placental microvascular endothelial cells from women with preeclampsia and intrauterine growth restriction
Adenosine transport via Equilibrative Nucleoside Transporters 1 and 2 are not modulated by insulin in human umbilical vein endothelium under hypoxia
Alano pathway in human umbilical vein endothelium
Carbon monoxide (CO): A key vasodilator in the pulmonary circulation in the llama neonate
D-GLUCOSE stimulates nitric oxide synthase via a mechanism that involves TGF-beta 1 in human foetal endothelium
Differential femoral and pulmonary adrenergic vascular reactivity in high and low altitude newborn lambs
Differential regulation of adenosine transport by activation of A(2a) and A(1) purinoceptors in human umbilical vein endothelium
Effect of insulin on L-arginine transport through system y(+)L in human umbilical vein endothelium
Effects of insulin on the expression and activity of system y(+)L-mediated L-arginine transport in human umbilical vein endothelium
Hemoxygenase expression in lung tissue from high and low altitude newborn lambs
Hypoxia increases equilibrative nucleoside transporter 2 activity by a transcriptional independent mechanism in human umbilical vein endothelium
Hypoxia represses carbon monoxide/heme oxygenase (Co/Ho) system and downregulates L-arginine/nitric oxide (No) pathway in human umbilical vein endothelial cells (Huvec).
Hypoxia-induced heme oxygenase-1 regulates the L-arginine/nitric oxide pathway in human umbilical vein endothelium
Inhibition of L-arginine transport and nitric oxide activity in human umbilical vein endothelium of newborn with intrauterine growth restriction: role of hypoxia and PKC
Insulin restores D-glucose reduced adenosine transport in human umbilical vein endothelium
Modulation of adenosine transport by insulin in human foetal endothelium
Post-translational modulation of equilibrative nucleoside transporter 1 by D-glucose in human umbilical vein endothelium
Short-, but not long-term stimulation of L-arginine transport by D-glucose involves TGF-beta 1 in human foetal endothelium
Effect of transforming growth factor beta 1 on L-arginine/nitric oxide pathway in human umbilical vein endothelium exposed to high D-glucose
Equilibrative nucleoside transporter 1 is downregulated by activation of A(2a) adenosine receptors in human umbilical vein endothelium.
Gestational diabetes increases L-arginine transport via a P13-K-independent mechanism in human foetal endothelium
Heme oxygenase 1 regulates the L-arginine/nitric oxide pathway in hypoxia in human umbilical vein endothelium
Insulin restores the elevated adenosine transport in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies
Role of nitric oxide in the pulmonary circulation in high- and low-altitude newborn lambs.
Expression of equilibrative nucleoside transporters 1 is modulated by hypoxia in human umbilical vein endothelial cells
Transforming growth factor beta 1 increases L-arginine transport and expression of the human cationic amino acid transporter 1 mRNA in human umbilical vein endothelial cells
Intra-uterine growth retardation is associated with reduced activity and expression of cationic amino acid transporters (system y(+)/CAT) and nitric oxide synthase in human umbilical vein endothelial cells

Actualizacion (1)

Programación epigenética placentaria en restricción del crecimiento intrauterino

BookSection (4)

Adenosine receptors: A novel therapeutic alternative for diabetic nephropathy
Multidrug Resistance Proteins
Role of equilibrative nucleoside transporters in fetal endothelial dysfunction in gestational diabetes
Mecanismos moleculares asociados a la regulación del transporte y metabolismo de adenosina y L-arginina por hipoxia en endotelio fetal humano

ConferencePaper (2)

Intervention Strategies for Preventing Low Birthweight in Developing Countries: Importance of Considering Multiple Interactive Factors
Role of equilibrative nucleoside transporters in endothelial dysfunction: Adenosine/L-arginine/nitric oxide pathway

Proyecto (17)

Early origins of Allergy and Asthma
DOCOSAHEXAENOIC ACID (DHA) SUPPLEMENTATION DURING PREGNANCY TO PREVENT DEEP PLACENTATION DISORDERS=> A RANDOMIZED CLINICAL TRIAL AND A STUDY OF THE MOLECULAR PATHWAYS OF ABNORMAL PLACENTATION PREVENTION
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION
EFFECTIVENESS OF A NORMATIVE INTERVENTION (DIET, PHYSICAL ACTIVITY AND BREASTFEEDING) ON MATERNAL NUTRITION AND OFFSPRING GROWTH AND DEVELOPMENT=> NUTRITION IN THE FIRST 1000 DAYS KEY TO HEALTHY GROWTH AND LONG-TERM HEALTH.
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION
New pharmacologic formulation for the treatment and prevention of arterial hypertension and vascular dysfunction=> an integrated response to a multifactorial disease.
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES=> EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION.
ROLE OF ADENOSINE IN INSULIN RESPONSE OF MACRO AND MICROVASCULAR HUMAN PLACENTAL ENDOTHELIUM FROM GESTATIONAL DIABETES MELLITUS VIA INSULIN RECEPTOR SUBTYPES A AND B.
Caracterización de mecanismos fisiopatológicos y detección de blancos terapéuticos comunes en la disfunción placentaria en patologías del embarazo humano. (Investigador Principal Alterno)
ROL PARACRINO DEL PEPTIDO NATRIURETICO CEREBRAL (BNP) EN LA MANTENCION DE LA QUIESCENCIA MIOMETRIAL DEL EMBARAZO. ESTUDIO DE SUS VIAS DE SEQALIZACION CELULAR EN EL MIOMETRIO HUMANO
PAPEL DE ARGINASAS I Y II EN LA DISFUNCION ENDOTELIAL DE LA UNIDAD FETO-PLACENTARIA EN EMBARAZOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO Y EN HIPOXIA
REGULACION DE LA EXPRESION Y ACTIVIDAD DE LOS TRANSPORTADORES EQUILIBRADOS DE NUCLEOSIDOS TIPO 1 (HENT1) Y 2 (HENT2) POR INSULINA EN EL ENDOTELIO MICRO Y MACROVASCULAR FETAL HUMANO EN DIABETES MELLITUS GESTACIONAL.
EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL.
REGULACION DE LA RUTA DE SENALIZACION L-ARGINIA/OXIDO NITRICO EN ENDOTELIO DE VENA UMBILICAL DE FETOS CON RESTRICCION DEL CRECIMIENTO INTARUTERINO (RCIU)
REGULACION DE LA RUTA DE SENALIZACION L-ARGINIA/OXIDO NITRICO EN ENDOTELIO DE VENA UMBILICAL DE FETOS CON RESTRICCION DEL CRECIMIENTO INTARUTERINO (RCIU)
REGULACION DE LA RUTA DE SENALIZACION L-ARGININA/OXIDO NITRICO EN ENDOTELIO DE VENA UMBILICAL DE FETOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO (RCIU)
REGULACION TRANSCRIPCIONAL DEL TRANSPORTADOR EQUILIBRATIVO DE NUCLEOSIDOS ENT1 POR D-GLUCOSA EN ENDOTELIO HUMANO.

Review (8)

Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity
Long-Term Impact of Early Life Events on Physiology and Behaviour
The placental pursuit for an adequate oxidant balance between the mother and the fetus
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Role of nitric oxide in placental vascular development and function
Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia
Equilibrative nucleoside (ENTs) and cationic amino acid (CATs) transporters: Implications in foetal endothelial dysfunction in human pregnancy diseases
146
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

58
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

45
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

35
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

17
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

13
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

12
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

10
Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

9
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

8
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

7
Francisco Westermeier

Universidad de Chile

Santiago, Chile

6
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

5
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

5
ivo carrasco

encargado investigación

Universidad de Valparaíso

Valparaíso, Chile

5
CATALINA PRIETO

Postdoctor

Biología

Universidad de Chile

Santiago, Chile

4
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

4
Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

4
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

4
Camila Corvalan

Assistant Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

3
Maria Garmendia

ACADEMICO

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LSO ALIMENTOS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

3
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

3
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

3
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

2
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

2
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

2
marcela araya

Profesor Asistente

Departamento de Promoción de la Salud de la Mujer y el Recién Nacido

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

2
Marco Ramirez

Associate Professor

Universidad de Antofagasta

Antofagasta, Chile

2
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Natalia Rodriguez

Colaboradora Académica

Obstetricia y Puericultura

Universidad de Concepción

Concepción, Chile

1
Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rómulo Melo

Neurosurgeon

Department of Neurosurgery

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

1
Carlos Oyarzún

Profesor Adjunto Asociado

Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Sebastián Alarcón

Profesor Adjunto a Honorarios

Facultad Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Marcela Flores

Encargada Unidad de Investigación

Salud

Corporación Municipal de Puente Alto

Santiago, Chile

1
Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

1
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

1
Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Karina Carrasco

Coordinadora de Estudios Clínicos

Obstetricia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
carolina iturriaga

Sub Directora Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

1
Carolina Serrano

Profesor Asistente Adjunto

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

1
Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

1
Caroll Hernández

Investigador Postdoctoral

Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica de Chile

Santiago , Chile

1
Carlos Jara

Jefe de Laboratorio - Estrés Oxidativo

Universidad de Valparaíso

Reñaca, Chile