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Juan Pedro Kusanovic Pivcevic

Jefe CIMAF

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Medicina materno-fetal; parto prematuro; rotura prematura de membranas; restricción de crecimiento fetal; preeclampsia; diabetes gestacional; enfermedad periodontal y embarazo; programación fetal; nutrición y embarazo.

Médico Cirujano, Universidad de los Andes. Chile, 1998
Obstetricia-Ginecología, Universidad de los Andes. Chile, 2001
Medicina Materno-Fetal, Wayne State University - Perinatology Research Branch (NICHD/NIH/DHHS). Estados Unidos, 2010

Profesor Asociado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2010 - A la fecha
Profesor Asistente Full Time

Wayne State Univeristy

Medicina

Detroit, Estados Unidos

2005 - 2010
Instructor Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2001 - 2005

Obstetra Full Time

Universidad de los Andes/Hospital Parroquial de San Bernardo

Santiago, Chile

2001 - 2005
Profesor Asociado Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2010 - A la fecha

Research Excellence Award - Department of Obstetrics and Gynecology

Wayne State University

Estados Unidos, 2008

"Research Excellence Award" por producción en investigación
Frederick P. Zuspan Award for clinical work

International Society for the Study of Hypertension in Pregnancy

Estados Unidos, 2008

Frederick P. Zuspan Award for clinical work, presented at the 28th annual meeting of the International Society for the Study of Hypertension in Pregnancy, Washington D.C. Awarded to the abstract by Kusanovic JP, Erez O, Gotsch F, Chaiworapongsa T, Mazaki-Tovi S, Vaisbuch E, Gomez R, Hassan SS, Romero R. "Maternal Plasma Concentrations of Placental Growth Factor, Soluble Flt1 and Soluble Endoglin in Early Pregnancy and the Second Trimeseter in the Identification of Patients Destined to Develop Preterm Preeclampsia".
Jacqueline and Marshall Lindheimer Award

International Society for the Study of Hypertension in Pregnancy

Estados Unidos, 2008

Jacqueline and Marshall Lindheimer Award, presented at the 28th annual meeting of the International Society for the Study of Hypertension in Pregnancy, Washington D.C. Awarded to the abstract by Gostch F, Kim YM, Kim CJ, Edwin S, Hotra J, Tarca AL, Chaiworapongsa T, Kusanovic JP, Mor G, Redman CWG, Romero R. "A Link Between Inflammation/Infection and Anti-angiogenic State in Preeclampsia: Inflammaroty Mediators Mimic Effect of Hypoxia on Trophoblast by Increasing sFlt-1 and Decreasig Placental Growth Factor Production".
Academic Excellence Award

Perinatology Research Branch, NICHD/NIH/DHHS

Estados Unidos, 2009

"Academic Excellence Award" por producción en investigación y difusión
Distinguished Service Award

Perinatology Research Branch, NICHD/NIH/DHHS

Estados Unidos, 2009

"Distinguished Service Award" por producción en investigación y difusión.
Research Excellence Award

3rd BIRTH Congress

Brasil, 2015

Research Excellence Award. 3rd BIRTH Congress, Fortaleza, Brazil, March 5-7, 2015. Chaemsaithong P, Romero R, Korzeniewski SJ, Kusanovic JP, Dong Z, Martinez-Varea A, Yoon BH, Hassan SS, Chaiworapongsa T, Yeo L. "Clinical Chorioamnionitis at Term I: Microbiology of the Amniotic Cavity Using Cultivation and Molecular Techniques".


Neonates from women with pregestational maternal obesity show reduced umbilical vein endothelial response to insulin Westermeier, Francisco; Pizarro, Carolina; Toledo, Fernando; Kusanovic, Juan P; Mardones, Francisco Article ISI SCOPUS PLACENTA (2019)
Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis MÃ¶nckeberg M.; Kusanovic J.P.; Schepeler M.; Nien, J. K.; Illanes, S. E. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2019)
Clinical chorioamnionitis at term IX: In vivo evidence of intra-amniotic inflammasome activation Maymon E.; Kusanovic J.P.; Miller D.; Pacora P.; Motomura K.; Erez O.; Jung E. Article SCOPUS Journal of Perinatal Medicine (2018)
Effectiveness on maternal and offspring metabolic control of a home-based dietary counseling intervention and DHA supplementation in obese/overweight pregnant women (MIGHT study): A randomized controlled trial-Study protocol Casanello, Paola; Araya, Marcela; Flores, Marcela; Bravo, Alfredo; Kusanovic, Juan Pedro; Olmos, Pablo; Uauy, Ricardo Article ISI SCOPUS CONTEMPORARY CLINICAL TRIALS (2018)
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus Chaparro, Alejandra; Zúñiga, Edgardo; Albers, Daniela; Kusanovic, Juan P Article ISI SCOPUS Journal of Periodontology (2018)
Transabdominal collection of amniotic fluid sludge and identification of Candida albicans intra-amniotic infection Silva K.; Erez O.; Maymon E.; Ferrer F.; Le Cerf P. Article ISI JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2018)
Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response Romero R.; Chaemsaithong P.; Korzeniewski S.J.; Tarca A.L.; Bhatti G.; Xu, ZH; Dong Z.; Docheva, N; Martinez-Varea A.; Yoon B.H.; et al. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2016)
Clinical chorioamnionitis at term III: how well do clinical criteria perform in the identification of proven intra-amniotic infection? Romero R.; Chaemsaithong P.; Korzeniewski S.J.; Docheva, N; Martinez-Varea A.; Yoon B.H.; Hassan S.S.; Chaiworapongsa T.; Yeo L. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2016)
Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile Romero R.; Chaemsaithong P.; Docheva, N; Korzeniewski S.J.; Tarca A.L.; Bhatti G.; Xu, ZH; Dong Z.; Chaiyasit, N; Yoon B.H.; et al. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2016)
Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response Romero R.; Chaemsaithong P.; Docheva, N; Korzeniewski S.J.; Tarca A.L.; Bhatti G.; Xu, ZH; Chaiyasit, N; Dong Z.; Yoon B.H.; et al. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2016)
Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity Romero R.; Chaemsaithong P.; Docheva, N; Korzeniewski S.J.; Yoon B.H.; Kim J.S.; Chaiyasit, N; Qureshi, F; Jacques, SM; Kim C.J.; et al. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2016)
Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia Chaparro A.; Gaedechens D.; Ramirez V.; Zuniga E.; Kusanovic J.P.; Inostroza C.; Silva K.; Salomon C.; Rice G.; Illanes, S. E. Article ISI SCOPUS PRENATAL DIAGNOSIS (2016)
Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue Mazaki-Tovi S.; Vaisbuch E.; Tarca A.L.; Than, NG; Chaiworapongsa T.; Dong Z.; Hassan S.S.; Romero R. Article ISI SCOPUS PLOS ONE (2015)
Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques Romero R.; Miranda J.; Kusanovic J.P.; Chaiworapongsa T.; Chaemsaithong P.; Martinez A.; Gotsch F.; Dong Z.; Ahmed A.I.; Shaman, M; et al. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2015)
Effectiveness of a normative nutrition intervention (diet, physical activity and breastfeeding) on maternal nutrition and offspring growth: the Chilean maternal and infant nutrition cohort study (CHiMINCs) Corvalan C.; Araya M.; Casanello P.; Uauy R. Article ISI SCOPUS BMC Pregnancy and Childbirth (2015)
Intrahepatic Cholestasis of Pregnancy (ICP) in US Latinas and Chileans: Clinical features, Ancestry Analysis, and Admixture Mapping Bull, LN; Hu, DL; Shah S.; Temple, L; Silva K.; Huntsman S.; Melgar, J; Geiser, MT; Sanford, U; Lee, RH; et al. Article ISI SCOPUS PLOS ONE (2015)
Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes Romero R.; Miranda J.; Chaemsaithong P.; Chaiworapongsa T.; Dong Z.; Shaman, M; Lannaman K.; Yoon B.H.; Hassan S.S.; Kim C.J.; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2015)
Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor Maddipati, KR; Romero R.; Chaiworapongsa T.; Zhou, SL; Xu, ZH; Tarca A.L.; Munoz H.; Honn, KV Article ISI SCOPUS FASEB JOURNAL (2014)
Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial Bosquiazzo, LM; Bruna, JA; Fabrica, MC; Mascotti, C; Bertin, MS; Castaldi, JL; Mendoza, SJ; Partida, LY; Zyla, A; Castilla, L; et al. Article ISI LANCET (2013)
Characterization of the Fetal Blood Transcriptome and Proteome in Maternal Anti-Fetal Rejection: Evidence of a Distinct and Novel Type of Human Fetal Systemic Inflammatory Response Lee J.; Romero R.; Chaiworapongsa T.; Dong Z.; Tarca A.L.; Xu Y.; Chiang, PJ; Hassan S.S.; Yeo L.; Yoon B.H.; et al. Article ISI SCOPUS American Journal of Reproductive Immunology (2013)
Conceptual basis for prescriptive growth standards from conception to early childhood: present and future Uauy R.; Casanello P.; Krause B.; Kuzanovic, JP; Corvalan C. Article ISI SCOPUS BJOG: An International Journal of Obstetrics and Gynaecology (2013)
Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia Chaiworapongsa T.; Romero R.; Korzeniewski S.J.; Soto E.; Lám, J; Dong Z.; Than, NG; Yeo L.; Hernandez-Andrade E.; Conde-Agudelo, A; et al. Article ISI SCOPUS American Journal of Obstetrics and Gynecology (2013)
Trophoblast islands of the chorionic connective tissue (TICCT): A novel placental histologic feature Hong, JS; Romero R.; Kim J.S.; Lee J.; Jin M.; El Azzamy, H; Topping, V; Ahn S.; Jacques, S; Qureshi, F; et al. Article ISI SCOPUS Placenta (2013)
Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome Romero R.; Soto E.; Berry S.M.; Hassan S.S.; Yoon B.H.; Edwin, S; Mazor M.; Chaiworapongsa T. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2012)
Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE Romero R.; Chaiworapongsa T.; Savasan, ZA; Hussein, Y; Dong Z.; Kim C.J.; Hassan S.S. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2012)
Hematologic profile of the fetus with systemic inflammatory response syndrome Romero R.; Savasan, ZA; Chaiworapongsa T.; Berry S.M.; Hassan S.S.; Yoon B.H.; Edwin, S; Mazor M. Article ISI SCOPUS Journal of Perinatal Medicine (2012)
Interleukin-19 in fetal systemic inflammation Savasan, ZA; Chaiworapongsa T.; Romero R.; Hussein, Y; Xu Y.; Dong Z.; Kim C.J.; Hassan S.S. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2012)
A molecular signature of an arrest of descent in human parturition Mittal, P; Romero R.; Draghici, S; Chaiworapongsa T.; Hotra, J; Kusanovic J.P.; Lee D.C.; Gomez R. Article ISI SCOPUS American Journal of Obstetrics and Gynecology (2011)
A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d Lee J.; Romero R.; Xu Y.; Topping, V; Kusanovic J.P.; Chaiworapongsa T.; Kim, J. S.; Yoo, W Article ISI SCOPUS PLOS ONE (2011)
An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome Vaisbuch E.; Romero R.; Gomez R.; Mazaki-Tovi S.; Chaiworapongsa T.; Hassan S.S. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2011)
Circulating angiogenic and antiangiogenic factors in women with eclampsia Vaisbuch E.; Whitty, JE; Hassan S.S.; Romero R.; Cotton, DB; Sorokin, Y; Karumanchi, SA Article ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2011)
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1 Romero R.; Chaiworapongsa T.; Savasan, ZA; Xu Y.; Hussein, Y; Dong Z.; Kim C.J.; Hassan S.S. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2011)
Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia Hill, LD; York, TP; Gomez R.; Eaves, LJ; Romero R.; Strauss J.F. Article ISI SCOPUS PLOS ONE (2011)
Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study Hill, LD; Hilliard, DD; York, TP; Srinivas S.; Gomez R.; Elovitz, MA; Romero R.; Strauss J.F. Article ISI SCOPUS BMC Medical Genetics (2011)
Maternal HLA Panel-Reactive Antibodies in Early Gestation Positively Correlate with Chronic Chorioamnionitis: Evidence in Support of the Chronic Nature of Maternal Anti-fetal Rejection Lee J.; Romero R.; Xu Y.; Kim J.S.; Park J.Y.; Chaiworapongsa T.; Hassan S.S.; Kim C.J. Article ISI SCOPUS American Journal of Reproductive Immunology (2011)
Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia Chaiworapongsa T.; Romero R.; Savasan, ZA; Ogge, G; Soto E.; Dong Z.; Tarca A.; Gaurav B.; Hassan S.S. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2011)
miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines Siderosis of Interstitial Trophoblasts as a Novel Pathology of Preterm Preeclampsia and Small-for-Gestational-Age Pregnancies Romero R.; Kim J.S.; Tarca A.L.; Montenegro D.; Pineles, BL; Kim E.; Lee J.; Kim S.Y.; Draghici, S; Mittal, P; et al. Article ISI AMERICAN JOURNAL OF PATHOLOGY (2011)
Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia Ogge, G; Chaiworapongsa T.; Romero R.; Hussein, Y; Yeo L.; Kusanovic J.P. Article ISI SCOPUS Journal of Perinatal Medicine (2011)
Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age Romero R.; Kusanovic J.P.; Mazaki-Tovi S.; Vaisbuch E.; Erez O.; Chaiworapongsa T.; Tromp, G; Menon R.; Bartlett J.; Gomez R.; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2011)
Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis Conde-Agudelo, A; Romero R.; Hassan S.S. Article ISI SCOPUS American Journal of Obstetrics and Gynecology (2011)
A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia Chaiworapongsa T.; Romero R.; Tarca A.L.; Gotsch F.; Mittal, P; Kim, SK; Vaisbuch E.; Erez O.; Dong Z.; Kim C.J.; et al. Article ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2010)
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) Romero R.; Friel, LA; Edwards, DRV; Hassan S.S.; Mazaki-Tovi S.; Vaisbuch E.; Kim C.J.; Erez O.; Chaiworapongsa T.; Pearce, BD; et al. Article ISI SCOPUS American Journal of Obstetrics and Gynecology (2010)
Allergy-induced preterm labor after the ingestion of shellfish Romero R.; Munoz H.; Gomez R.; Lamont, RF; Yeo L. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA? Mazaki-Tovi S.; Romero R.; Kim, SK; Vaisbuch E.; Erez O.; Chaiworapongsa T.; Gotsch F.; Mittal, P; Nhan-Chang C.L.; Than, NG; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
Evidence for a Spatial and Temporal Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion in Term and Preterm Parturition Romero R.; Kim J.S.; Yoo, W; Lee J.; Mittal, P; Hassan S.S.; Yoon B.H.; Kim C.J. Article ISI JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes Romero R.; Edwards, DRV; Hassan S.S.; Mazaki-Tovi S.; Vaisbuch E.; Kim C.J.; Chaiworapongsa T.; Pearce, BD; Friel, LA; Bartlett J.; et al. Article ISI SCOPUS American Journal of Obstetrics and Gynecology (2010)
Isobaric labeling and tandem mass spectrometry: A novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation Romero R.; Gotsch F.; Erez O.; Vaisbuch E.; Mazaki-Tovi S.; Moser, A; Tam, S; Leszyk, J; Master, SR; Juhasz, P; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate Mazaki-Tovi S.; Vaisbuch E.; Romero R.; Chaiworapongsa T.; Kim, SK; Nhan-Chang C.L.; Gomez R.; Savasan, ZA; Madan, I; Yoon B.H.; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis Mazaki-Tovi S.; Vaisbuch E.; Romero R.; Chaiworapongsa T.; Kim, SK; Nhan-Chang C.L.; Gomez R.; Yoon B.H.; Yeo L.; Mittal, P; et al. Article ISI SCOPUS American Journal of Reproductive Immunology (2010)
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery Romero R.; Mazaki-Tovi S.; Vaisbuch E.; Chaiworapongsa T.; Gomez R.; Nien J.K.; Yoon B.H.; Mazor M.; Luo, JQ; Banks, D; et al. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods DiGiulio, DB; Gervasi M.; Romero R.; Mazaki-Tovi S.; Vaisbuch E.; Seok, KS; Gomez R.; Mittal, P; Gotsch F.; Chaiworapongsa T.; et al. Article ISI SCOPUS Journal of Perinatal Medicine (2010)
Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses DiGiulio, DB; Gervasi M.T.; Romero R.; Vaisbuch E.; Mazaki-Tovi S.; Seok, KS; Gomez R.; Mittal, P; Gotsch F.; Chaiworapongsa T.; et al. Article ISI SCOPUS Journal of Perinatal Medicine (2010)
Sex Differences in Fetal Growth Responses to Maternal Height and Weight Lampl, M; Gotsch F.; Gomez R.; Nien J.K.; Frongillo, EA; Romero R. Article ISI SCOPUS AMERICAN JOURNAL OF HUMAN BIOLOGY (2010)
Should Bilateral Uterine Artery Notching Be Used in the Risk Assessment for Preeclampsia, Small-for-Gestational-Age, and Gestational Hypertension? Espinoza J.; Bahado-Singh, R; Gervasi M.T.; Romero R.; Lee W.; Vaisbuch E.; Mazaki-Tovi S.; Mittal, P; Gotsch F.; Erez O.; et al. Article ISI SCOPUS Journal of Ultrasound in Medicine (2010)
Surfactant Protein-A as an Anti-Inflammatory Component in the Amnion: Implications for Human Pregnancy Romero R.; Kim C.J.; Chaiworapongsa T.; Tarca A.L.; Lee J.; Suh, YL; Vaisbuch E.; Mittal, P; Draghici, S; Erez O.; et al. Article ISI JOURNAL OF IMMUNOLOGY (2010)
The clinical significance of eosinophils in the amniotic fluid in preterm labor Romero R.; Gomez R.; Lamont, R; Bytautiene, E; Garfield, RE; Mittal, P; Hassan S.S.; Yeo L. Article ISI SCOPUS Journal of Maternal-Fetal and Neonatal Medicine (2010)
The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth Kim C.J.; Romero R.; Yoo, W; Dong Z.; Topping, V; Gotsch F.; Yoon B.H.; Chi, JG; Kim J.S. Article ISI MODERN PATHOLOGY (2010)
The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD) Kim, SK; Romero R.; Erez O.; Vaisbuch E.; Mazaki-Tovi S.; Gotsch F.; Mittal, P; Chaiworapongsa T.; Pacora P.; Ogge, G; et al. Article ISI SCOPUS Journal of Perinatal Medicine (2010)
Early Rapid Growth, Early Birth: Accelerated Fetal Growth and Spontaneous Late Preterm Birth Lampl, M; Erez O.; Espinoza J.; Gotsch F.; Gonçalves, L; Hassan S.; Gomez R.; Nien J.K.; Frongillo, EA; Romero R. Article ISI SCOPUS AMERICAN JOURNAL OF HUMAN BIOLOGY (2009)
Growth Perturbations in a Phenotype with Rapid Fetal Growth Preceding Preterm Labor and Term Birth Lampl, M; Erez O.; Gotsch F.; Espinoza J.; Gonçalves, L; Lee W.; Gomez R.; Nien J.K.; Frongillo, EA; Romero R. Article ISI SCOPUS AMERICAN JOURNAL OF HUMAN BIOLOGY (2009)
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for Romero R.; Nien J.K.; Espinoza J.; Todem, D; Fu W.; Chung H.; Gotsch F.; Erez O.; Mazaki-Tovi S.; Gomez R.; et al. Article JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate Romero R.; Nien J.K.; Espinoza J.; Todem, D; Fu W.; Chung H.; Gotsch F.; Erez O.; Mazaki-Tovi S.; Gomez R.; et al. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
Downward percentile crossing as an indicator of an adverse prenatal environment Lampl, M; Gotsch F.; Espinoza J.; Gonçalves, L; Gomez R.; Nien J.K.; Frongillo, EA; Romero R. Article ISI SCOPUS ANNALS OF HUMAN BIOLOGY (2008)
First-trimester maternal serum PP13 in the risk assessment for preeclampsia Romero R.; Than, NG; Erez O.; Gotsch F.; Espinoza J.; Edwin, S; Chefetz, I; Gomez R.; Nien J.K.; Sammar, M; et al. Article ISI SCOPUS AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2008)
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry Bujold, E; Romero R.; Erez O.; Gotsch F.; Chaiworapongsa T.; Gomez R.; Espinoza J.; Vaisbuch E.; Kim Y.M.; Edwin, S; et al. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age Erez O.; Romero R.; Espinoza J.; Fu, WJ; Todem, D; Gotsch F.; Edwin, S; Nien J.K.; Chaiworapongsa T.; Mittal, P; et al. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
Twin-to-twin transfusion syndrome: an antiangiogenic state? Romero R.; Espinoza J.; Nien J.K.; Kim C.J.; Mittal, P; Edwin, S; Erez O.; Gotsch F.; Mazaki-Tovi S.; Than, NG; et al. Article ISI SCOPUS AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2008)
Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor Espinoza J.; Romero R.; Nien J.K.; Gomez R.; Goncalves, LF; Medina L.; Edwin, S; Hassan S.; Carstens, M; Gonzalez R. Article ISI SCOPUS AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2007)
Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor Espinoza J.; Romero R.; Hoppensteadt, D; Nien J.K.; Kim C.J.; Erez O.; Soto E.; Fareed, J; Edwin, S; Chaiworapongsa T.; et al. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2007)
The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes Friel, LA; Romero R.; Edwin, S; Nien J.K.; Gomez R.; Chaiworapongsa T.; Tolosa J.E.; Hassan S.S.; Espinoza J. Article ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2007)
A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery Nien J.K.; Yoon B.H.; Espinoza J.; Erez O.; Soto E.; Richani, K; Gomez R.; Hassan S.; Mazor M.; Edwin, S; et al. Article ISI SCOPUS AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2006)
A role of the anti-angiogenic factor sVEGFR-1 in the 'mirror syndrome' (Ballantyne's syndrome) Espinoza J.; Romero R.; Nien J.K.; Richani, K; Gomez R.; Kim C.J.; Mittal, P; Gotsh, F; Erez O.; Chaiworapongsa T.; et al. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2006)


DETECTION OF CD63+MICRO-VESICLES, PLACENTAL ALKALINE PHOSPHATASE AND ANGIOGENIC MARKERS IN GINGIVAL CREVICULAR FLUID IN PREECLAMPTIC PATIENTS Chaparro A.; Zuniga E.; Gaedechens D.; Ramirez V.; Inostroza C.; Silva K.; Rice G.E.; Illanes S.E. Abstract ISI PLACENTA (2015)
Intrahepatic Cholestasis of Pregnancy (ICP) in US Latinas and Chileans: Ancestry Analysis, Admixture Mapping, and Biochemical Features Bull L.; Hu, DL; Shah S.; Temple, L; Silva K.; Huntsman S.; Melgar, J; Geiser, M; Sanford, U; Ortiz J.; et al. Abstract ISI HEPATOLOGY (2015)
MATERNAL OBESITY AND NEONATAL INSULIN RESISTANCE IN THE ORIGIN OF METABOLIC SYNDROME IN CHILDHOOD Farias M.; Villalobos R.; Saez P.; Westermeier F.; Poblete J.; Mardones-Santander, F; Sobrevia L. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)
Reduced Insulin Response in Human Umbilical Vein Endothelial Cells from Pregnancies with Maternal Obesity Is Associated with Activation of PERK Branch of Endoplasmic Reticulum Stress Pathway Westermeier F.; Mardones F.; Sobrevia L. Abstract ISI REPRODUCTIVE SCIENCES (2013)
Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Is Associated with Increased Risk for Preeclampsia Hill, LD; York, TP; Gomez R.; Eaves, LJ; Romero R.; Strauss J.F. Abstract ISI REPRODUCTIVE SCIENCES (2011)
ERAP2 and Preeclampsia: Racial/Ethinic-Specific Associations Hill, LD; York, TP; Srinivas S.; Gomez R.; Elovitz, MA; Romero R.; Strauss J.F. Abstract ISI REPRODUCTIVE SCIENCES (2011)
A molecular investigation of the microbial diversity and burden in preterm PROM reveals a high rate of infection with a broad range of organisms including gastrointestinal tract microbiota Digiulio, D; Romero R.; Gomez R.; Kim C.J.; Seok, K; Gotsch F.; Mazaki-Tovi S.; Vaisbuch E.; Sanders K.; Bik E; et al. Abstract AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2009)
The molecular signature of an arrest of descent in human parturition Mittal, P; Romero R.; Tarca A.L.; Nhan-Chang C.L.; Chaiworapongsa T.; Hotra, J; Gomez R.; Kim J.S.; Kim C.J.; Hassan S.S. Abstract AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2009)
Does a Perturbation in Visfatin Homeostasis Participate in the Phenotype Definition of Preeclampsia and SGA? Kim, SK; Romero R.; Mazaki-Tovi S.; Vaisbuch E.; Erez O.; Than, N; Gotsch F.; Nhan-Chang C.L.; Chiaworapongsa, T; Gomez R.; et al. Abstract Hypertension in Pregnancy (2008)
Maternal Plasma Concentrations of Placental Growth Factor, Soluble Flt1 and Soluble Endoglin in Early Pregnancy and the Second Trimester in the Identification of Patients Destined to Develop Preterm Preeclampsia Erez O.; Gotsch F.; Chaiworapongsa T.; Mazaki-Tovi S.; Vaisbuch E.; Gomez R.; Hassan S.; Romero R. Abstract Hypertension in Pregnancy (2008)
The adipokine visfatin participates in the host response to intra-amniotic infection Mazaki-Tovi S.; Romero R.; Erez O.; Gotsch F.; Mittal, P; Than, NG; Nhan-Chang C.L.; Hamill, N; Vaisbuch E.; Edwin, SS; et al. Abstract ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2007)
Differences and similarities in the plasma cytokine profile (pro- and anti-inflammatory) in SGA and preeclampsia Espinoza J.; Hassan S.; Edwin, SS; Gotsch F.; Kim C.J.; Than, NG; Pineles, BL; Erez O.; Friel, L; Nien J.K.; et al. Abstract ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2006)
The myometrial transcriptome in spontaneous labor at term and in failure to progress in labor (arrest of dilatation and arrest of descent) Mittal, P; Tarca A.L.; Draghici, S; Espinoza J.; Nien J.K.; Gomez R.; Yoon B.H.; Hassan S.; Romero R.; Tromp, G Abstract ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2006)
A role for the anti-angiogenic factor sVEGFR-1 in the Mirror Syndrome" (Ballantine Syndrome)" Espinoza J.; Nien J.K.; Richani, K; Gomez R.; Kim C.J.; Mittal, P; Chaiworapongsa T.; Romero R. Abstract ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2005)
MMP-8 PLT: A rapid bedside test for the detection of intra-amniotic inflammation can identify patients at risk for preterm delivery within 7 days Nien J.K.; Yoon B.H.; Espinoza J.; Erez O.; Soto E.; Richani, K; Gomez R.; Romero R. Abstract ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2005)


Placental Lesions Associated With Maternal Underperfusion Are More Frequent in Early-Onset Than in Late-Onset Preeclampsia EDITORIAL COMMENT Ogg G.; Chaiworapongsa T.; Romero R.; Hussein, Y; Yeo L.; Kim C.J.; Hassan S.S. EditorialMaterial OBSTETRICAL & GYNECOLOGICAL SURVEY (2012)


Detection of Anti-HLA Antibodies in Maternal Blood in the Second Trimester to Identify Patients at Risk of Antibody-Mediated Maternal Anti-Fetal Rejection and Spontaneous Preterm Delivery Lee J.; Romero R.; Xu Y.; Miranda J.; Yoo, W; Chaemsaithong P.; Chaiworapongsa T.; Tarca A.L.; Korzeniewski S.J.; Hassan S.S.; et al. Review ISI SCOPUS American Journal of Reproductive Immunology (2013)
Nifedipine in the management of preterm labor: a systematic review and metaanalysis Romero R. Review ISI AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2011)
Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection Mazaki-Tovi S.; Romero R.; Vaisbuch E.; Chaiworapongsa T.; Erez O.; Mittal, P; Kim, SK; Gotsch F.; Lamont, R; Ogge, G; et al. Review ISI SCOPUS Journal of Perinatal Medicine (2010)
Preterm premature rupture of the membranes: current approaches to evaluation and management DiGiulio, DB; Romero R.; Gomez R.; Kim C.J.; Seok, KS; Gotsch F.; Mazaki-Tovi S.; Vaisbuch E.; Sanders K.; Bik, EM; et al. Review ISI SCOPUS American Journal of Reproductive Immunology (2010)
The Transcriptome of the Fetal Inflammatory Response Syndrome Madsen-Bouterse, SA; Romero R.; Tarca A.L.; Espinoza J.; Kim C.J.; Kim J.S.; Edwin, SS; Gomez R.; Draghici, S Review ISI SCOPUS American Journal of Reproductive Immunology (2010)
A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia Romero R.; Chaiworapongsa T.; Erez O.; Mittal, P; Vaisbuch E.; Mazaki-Tovi S.; Gotsch F.; Edwin, SS; Gomez R.; Yeo L.; et al. Review ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2009)
Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: Evidence of an increased thrombin generation Erez O.; Romero R.; Vaisbuch E.; Chaiworapongsa T.; Mazaki-Tovi S.; Gotsch F.; Gomez R.; Maymon E.; Pacora P.; Edwin, SS; et al. Review ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2009)
Adiponectin multimers in maternal plasma Mazaki-Tovi S.; Romero R.; Erez O.; Vaisbuch E.; Gotsch F.; Mittal, P; Than, GN; Nhan-Chang, C; Chaiworapongsa T.; Edwin, S; et al. Review ISI JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition Chaiworapongsa T.; Erez O.; Vaisbuch E.; Mazaki-Tovi S.; Gotsch F.; Than, NG; Mittal, P; Kim Y.M.; Camacho N.; Edwin, S; et al. Review ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: The use of a novel computational method to analyze mass spectrometric profiling Romero R.; Espinoza J.; Rogers, WT; Moser, A; Nien J.K.; Gotsch F.; Erez O.; Gomez R.; Edwin, S; Hassan S.S. Review ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10 Gotsch F.; Romero R.; Erez O.; Espinoza J.; Kim C.J.; Vaisbuch E.; Than, NG; Mazaki-Tovi S.; Chaiworapongsa T.; Mazor M.; et al. Review ISI JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2008)
Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition Mazaki-Tovi S.; Romero R.; Erez O.; Gotsch F.; Mittal, P; Than, NG; Nhan-Chang C.L.; Hamill, N; Vaisbuch E.; Chaiworapongsa T.; et al. Review ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2008)
Adiponectin in severe preeclampsia Nien J.K.; Mazaki-Tovi S.; Romero R.; Erez O.; Gotsch F.; Pineles, BL; Gomez R.; Edwin, S; Mazor M.; Espinoza J.; et al. Review ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2007)
Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women Nien J.K.; Mazaki-Tovi S.; Romero R.; Erez O.; Gotsch F.; Pineles, BL; Gomez R.; Edwin, S; Mazor M.; Espinoza J.; et al. Review ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2007)
Resistin: a hormone which induces insulin resistance is increased in normal pregnancy Nien J.K.; Shali, T; Romero R.; Erez O.; Gotsch F.; Pineles, BL; Friell, LA; Espinoza J.; Gonçalves, L; Santolaya, J; et al. Review ISI SCOPUS JOURNAL OF PERINATAL MEDICINE (2007)

José Poblete

Jefe de Deparatmento

Departamento Obstetricia y Ginecologia

HOSPITAL CLÍNICO UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Emma Hernandez

Directora

Servicio de Anatomía Patológica

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Camila Corvalan

Full Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

Claudio Vera

Assitant Professor

Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

103

Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Maria Garmendia

Academic

Institute of Nutrition and Food Technology (INTA)

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

marcela araya

Profesor Asistente

Departamento de Promoción de la Salud de la Mujer y el Recién Nacido

UNIVERSIDAD DE CHILE

Santiago, Chile

Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Fernando Abarzua

medico staff

obstetricia

Hospital Hernan Henriquez Aravena

Temuco, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Francisco Westermeier

Universidad de Chile

Santiago, Chile

MANUEL VARAS

Associated Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcela Flores

Encargada Unidad de Investigación

Salud

Corporación Municipal de Puente Alto

Santiago, Chile

Valeria Ramirez

PROFESOR TITULAR

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

Max Monckeberg

Profesor Investigador Asistente.

Ginecología Obstetricia y Biología de la Reproducción.

Universidad de Los Andes.

Santiago, Chile

Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

Pia Venegas

Asesora Técnica

Dirección de salud

Desafío Levantemos Chile

Santiago, Chile

Roberto Villalobos

Académico

Facultad de Medicina

Universidad de Valparaíso

San Felipe, Chile

daniela albers

Profesor Asistente Extraordinario

Ciencias biomédicas, ética, investigación y educación

Universidad Los Andes

Santiago, Chile

Juan Pedro Kusanovic Pivcevic

Líneas de Investigación

Educación

Médico Cirujano, Universidad de los Andes. Chile, 1998

Obstetricia-Ginecología, Universidad de los Andes. Chile, 2001

Medicina Materno-Fetal, Wayne State University - Perinatology Research Branch (NICHD/NIH/DHHS). Estados Unidos, 2010

Experiencia Académica

Profesor Asociado Full Time

Profesor Asistente Full Time

Instructor Full Time

Experiencia Profesional

Obstetra Full Time

Profesor Asociado Full Time

Premios y Distinciones

Research Excellence Award - Department of Obstetrics and Gynecology

Frederick P. Zuspan Award for clinical work

Jacqueline and Marshall Lindheimer Award

Academic Excellence Award

Distinguished Service Award

Research Excellence Award

Article (72)

Abstract (15)

EditorialMaterial (1)

Review (15)