Man

Juan Pedro Kusanovic Pivcevic

Jefe CIMAF

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Líneas de Investigación


Medicina materno-fetal; parto prematuro; rotura prematura de membranas; restricción de crecimiento fetal; preeclampsia; diabetes gestacional; enfermedad periodontal y embarazo; programación fetal; nutrición y embarazo.

Educación

  •  Médico Cirujano, Universidad de los Andes. Chile, 1998
  •  Obstetricia-Ginecología, Universidad de los Andes. Chile, 2001
  •  Medicina Materno-Fetal, Wayne State University - Perinatology Research Branch (NICHD/NIH/DHHS). Estados Unidos, 2010

Experiencia Académica

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2010 - A la fecha

  •   Profesor Asistente Full Time

    Wayne State Univeristy

    Medicina

    Detroit, Estados Unidos

    2005 - 2010

  •   Instructor Full Time

    Universidad de los Andes

    Medicina

    Santiago, Chile

    2001 - 2005

Experiencia Profesional

  •   Obstetra Full Time

    Universidad de los Andes/Hospital Parroquial de San Bernardo

    Santiago, Chile

    2001 - 2005

  •   Profesor Asociado Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - A la fecha

Premios y Distinciones

  •   Research Excellence Award - Department of Obstetrics and Gynecology

    Wayne State University

    Estados Unidos, 2008

    "Research Excellence Award" por producción en investigación

  •   Frederick P. Zuspan Award for clinical work

    International Society for the Study of Hypertension in Pregnancy

    Estados Unidos, 2008

    Frederick P. Zuspan Award for clinical work, presented at the 28th annual meeting of the International Society for the Study of Hypertension in Pregnancy, Washington D.C. Awarded to the abstract by Kusanovic JP, Erez O, Gotsch F, Chaiworapongsa T, Mazaki-Tovi S, Vaisbuch E, Gomez R, Hassan SS, Romero R. "Maternal Plasma Concentrations of Placental Growth Factor, Soluble Flt1 and Soluble Endoglin in Early Pregnancy and the Second Trimeseter in the Identification of Patients Destined to Develop Preterm Preeclampsia".

  •   Jacqueline and Marshall Lindheimer Award

    International Society for the Study of Hypertension in Pregnancy

    Estados Unidos, 2008

    Jacqueline and Marshall Lindheimer Award, presented at the 28th annual meeting of the International Society for the Study of Hypertension in Pregnancy, Washington D.C. Awarded to the abstract by Gostch F, Kim YM, Kim CJ, Edwin S, Hotra J, Tarca AL, Chaiworapongsa T, Kusanovic JP, Mor G, Redman CWG, Romero R. "A Link Between Inflammation/Infection and Anti-angiogenic State in Preeclampsia: Inflammaroty Mediators Mimic Effect of Hypoxia on Trophoblast by Increasing sFlt-1 and Decreasig Placental Growth Factor Production".

  •   Academic Excellence Award

    Perinatology Research Branch, NICHD/NIH/DHHS

    Estados Unidos, 2009

    "Academic Excellence Award" por producción en investigación y difusión

  •   Distinguished Service Award

    Perinatology Research Branch, NICHD/NIH/DHHS

    Estados Unidos, 2009

    "Distinguished Service Award" por producción en investigación y difusión.

  •   Research Excellence Award

    3rd BIRTH Congress

    Brasil, 2015

    Research Excellence Award. 3rd BIRTH Congress, Fortaleza, Brazil, March 5-7, 2015. Chaemsaithong P, Romero R, Korzeniewski SJ, Kusanovic JP, Dong Z, Martinez-Varea A, Yoon BH, Hassan SS, Chaiworapongsa T, Yeo L. "Clinical Chorioamnionitis at Term I: Microbiology of the Amniotic Cavity Using Cultivation and Molecular Techniques".


 

Article (72)

Neonates from women with pregestational maternal obesity show reduced umbilical vein endothelial response to insulin
Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis
Clinical chorioamnionitis at term IX: In vivo evidence of intra-amniotic inflammasome activation
Effectiveness on maternal and offspring metabolic control of a home-based dietary counseling intervention and DHA supplementation in obese/overweight pregnant women (MIGHT study): A randomized controlled trial-Study protocol
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus
Transabdominal collection of amniotic fluid sludge and identification of Candida albicans intra-amniotic infection
Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response
Clinical chorioamnionitis at term III: how well do clinical criteria perform in the identification of proven intra-amniotic infection?
Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile
Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response
Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity
Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia
Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue
Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques
Effectiveness of a normative nutrition intervention (diet, physical activity and breastfeeding) on maternal nutrition and offspring growth: the Chilean maternal and infant nutrition cohort study (CHiMINCs)
Intrahepatic Cholestasis of Pregnancy (ICP) in US Latinas and Chileans: Clinical features, Ancestry Analysis, and Admixture Mapping
Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes
Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor
Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial
Characterization of the Fetal Blood Transcriptome and Proteome in Maternal Anti-Fetal Rejection: Evidence of a Distinct and Novel Type of Human Fetal Systemic Inflammatory Response
Conceptual basis for prescriptive growth standards from conception to early childhood: present and future
Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia
Trophoblast islands of the chorionic connective tissue (TICCT): A novel placental histologic feature
Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome
Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
Hematologic profile of the fetus with systemic inflammatory response syndrome
Interleukin-19 in fetal systemic inflammation
A molecular signature of an arrest of descent in human parturition
A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d
An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome
Circulating angiogenic and antiangiogenic factors in women with eclampsia
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Increases Risk for Preeclampsia
Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study
Maternal HLA Panel-Reactive Antibodies in Early Gestation Positively Correlate with Chronic Chorioamnionitis: Evidence in Support of the Chronic Nature of Maternal Anti-fetal Rejection
Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia
miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines Siderosis of Interstitial Trophoblasts as a Novel Pathology of Preterm Preeclampsia and Small-for-Gestational-Age Pregnancies
Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia
Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age
Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis
A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)
Allergy-induced preterm labor after the ingestion of shellfish
Could alterations in maternal plasma visfatin concentration participate in the phenotype definition of preeclampsia and SGA?
Evidence for a Spatial and Temporal Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion in Term and Preterm Parturition
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes
Isobaric labeling and tandem mass spectrometry: A novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation
Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate
Maternal Plasma Concentration of the Pro-Inflammatory Adipokine Pre-B-Cell-Enhancing Factor (PBEF)/Visfatin Is Elevated In Pregnant Patients with Acute Pyelonephritis
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery
Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods
Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses
Sex Differences in Fetal Growth Responses to Maternal Height and Weight
Should Bilateral Uterine Artery Notching Be Used in the Risk Assessment for Preeclampsia, Small-for-Gestational-Age, and Gestational Hypertension?
Surfactant Protein-A as an Anti-Inflammatory Component in the Amnion: Implications for Human Pregnancy
The clinical significance of eosinophils in the amniotic fluid in preterm labor
The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth
The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD)
Early Rapid Growth, Early Birth: Accelerated Fetal Growth and Spontaneous Late Preterm Birth
Growth Perturbations in a Phenotype with Rapid Fetal Growth Preceding Preterm Labor and Term Birth
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate
Downward percentile crossing as an indicator of an adverse prenatal environment
First-trimester maternal serum PP13 in the risk assessment for preeclampsia
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
Twin-to-twin transfusion syndrome: an antiangiogenic state?
Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor
Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor
The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes
A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery
A role of the anti-angiogenic factor sVEGFR-1 in the 'mirror syndrome' (Ballantyne's syndrome)

Abstract (15)

DETECTION OF CD63+MICRO-VESICLES, PLACENTAL ALKALINE PHOSPHATASE AND ANGIOGENIC MARKERS IN GINGIVAL CREVICULAR FLUID IN PREECLAMPTIC PATIENTS
Intrahepatic Cholestasis of Pregnancy (ICP) in US Latinas and Chileans: Ancestry Analysis, Admixture Mapping, and Biochemical Features
MATERNAL OBESITY AND NEONATAL INSULIN RESISTANCE IN THE ORIGIN OF METABOLIC SYNDROME IN CHILDHOOD
Reduced Insulin Response in Human Umbilical Vein Endothelial Cells from Pregnancies with Maternal Obesity Is Associated with Activation of PERK Branch of Endoplasmic Reticulum Stress Pathway
Epistasis between COMT and MTHFR in Maternal-Fetal Dyads Is Associated with Increased Risk for Preeclampsia
ERAP2 and Preeclampsia: Racial/Ethinic-Specific Associations
A molecular investigation of the microbial diversity and burden in preterm PROM reveals a high rate of infection with a broad range of organisms including gastrointestinal tract microbiota
The molecular signature of an arrest of descent in human parturition
Does a Perturbation in Visfatin Homeostasis Participate in the Phenotype Definition of Preeclampsia and SGA?
Maternal Plasma Concentrations of Placental Growth Factor, Soluble Flt1 and Soluble Endoglin in Early Pregnancy and the Second Trimester in the Identification of Patients Destined to Develop Preterm Preeclampsia
The adipokine visfatin participates in the host response to intra-amniotic infection
Differences and similarities in the plasma cytokine profile (pro- and anti-inflammatory) in SGA and preeclampsia
The myometrial transcriptome in spontaneous labor at term and in failure to progress in labor (arrest of dilatation and arrest of descent)
A role for the anti-angiogenic factor sVEGFR-1 in the Mirror Syndrome" (Ballantine Syndrome)"
MMP-8 PLT: A rapid bedside test for the detection of intra-amniotic inflammation can identify patients at risk for preterm delivery within 7 days

EditorialMaterial (1)

Placental Lesions Associated With Maternal Underperfusion Are More Frequent in Early-Onset Than in Late-Onset Preeclampsia EDITORIAL COMMENT

Review (15)

Detection of Anti-HLA Antibodies in Maternal Blood in the Second Trimester to Identify Patients at Risk of Antibody-Mediated Maternal Anti-Fetal Rejection and Spontaneous Preterm Delivery
Nifedipine in the management of preterm labor: a systematic review and metaanalysis
Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection
Preterm premature rupture of the membranes: current approaches to evaluation and management
The Transcriptome of the Fetal Inflammatory Response Syndrome
A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: Evidence of an increased thrombin generation
Adiponectin multimers in maternal plasma
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition
Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: The use of a novel computational method to analyze mass spectrometric profiling
The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10
Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition
Adiponectin in severe preeclampsia
Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
Resistin: a hormone which induces insulin resistance is increased in normal pregnancy
103
Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

4
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Camila Corvalan

Assistant Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

3
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Valeria Ramirez

Profesor asistente

Universidad de Los Andes

Santiago, Chile

2
Maria Garmendia

Academic

Institute of Nutrition and Food Technology (INTA)

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
marcela araya

Profesor Asistente

Departamento de Promoción de la Salud de la Mujer y el Recién Nacido

UNIVERSIDAD DE CHILE

Santiago, Chile

1
carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

1
Pia Venegas

Asesora Técnica

Enfermedades No Transmisibles

Ministerio de Salud

Santiago, Chile

1
Francisco Westermeier

Universidad de Chile

Santiago, Chile

1
José Poblete

Jefe de Deparatmento

Departamento Obstetricia y Ginecologia

HOSPITAL CLÍNICO UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcela Flores

Encargada Unidad de Investigación

Salud

Corporación Municipal de Puente Alto

Santiago, Chile

1
Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

1
Fernando Abarzua

Assitant researcher

Universidad de La Frontera

Temuco, Chile

1
Claudio Vera

Assitant Professor

Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

1
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile