PDI - Resultado de Búsqueda

Bernardo Javier Krause Leyton

Assistant Professor

Universidad de O'Higgins

Rancagua, Chile

Vascular physiology; Fetal programming; Epigenetics; Hypoxia; Obesity

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004

Assistant Professor of Chemistry Other

UNIVERSIDAD DEL BIO-BIO

Health and Food Sciences

Chillán, Chile

2007 - 2007
Assistant Professor of Physiology Other

UNIVERSIDAD DE CHILE

Health and Food Sciences

Chillán, Chile

2007 - 2007
Ajunct Researcher Other

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2010 - 2010
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2017 - 2020
Assistant Professor Full Time

Universidad de O'Higgins

Instituto de Ciencias de la Salud

Rancagua, Chile

2020 - A la fecha

Welcome Trust Fellow Research Full Time

Fetal and Developmental Physiology Laboratory, Faculty of Medicine, Universidad de Chile.

Santiago, Chile

2004 - 2007
Fellow Research Full Time

Faculty of Medicine Pontificia Universidad Católica de Chile

Santiago, Chile

2007 - 2007

Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Estefanía Peñaloza Pezoa. Title: Micro-RNAs 21 y 126 en la respuesta a hypoxia en células endoteliales de arteria umbilical (Micro-RNA 21 and 126 in the response to hypoxia in HUAEC). September 2016- in progress

Director PhD Biomedical Science research unit. Pontificia Universidad Católica de Chile. Student: Fabián Vega. Title: Leptin as a modulator of the epigenetic programming of monocyte-derived macrophages in neonates. January 2017 - in progress

Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Isidora Lefever Medina. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016

Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Catalina Letelier. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016

Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Francisca Cifuentes Zuñiga. Title: EFECTO DE LA OBESIDAD MATERNA SOBRE LA EXPRESIÓN DE MEDIADORES INFLAMATORIOS EN MACRÓFAGOS FETALES: POTENCIAL PROGRAMACIÓN DE LA FUNCIÓN INMUNE (Effect of maternal obesity on the expression of inflammatory mediators in fetal macrophages). July 2015-June 2016

Co-director Medical Veterinary thesis, University of Chile. Student: René Alegría. Title: CARACTERIZACIÓN DE LA FUNCIÓN VASCULAR DE UN MODELO DE RESTRICCIÓN DE CRECIMIENTO INTRA-UTERINO POR OCLUSIÓN PROGRESIVA DE ARTERIAS UTERINAS EN COBAYAS (Vascular function characterization in a guinea pig model of intrauterine growth restriction by gradual uterine artery occlusion) March - December 2014.

Lecturer on the III Workshop on Maternal Fetal Interaction - University of São Paulo, February 14 – 17, 2013, São Paulo, Brasil

Tutorial. Molecular Cell Biology. Faculty of Odontology, Pontificia Universidad Católica de Chile. First semester 2010.

Undergrade Fellowship

UNIVERSIDAD DE CHILE

Chile, 1997

Academic performance based scholarship for undergraduate studies.
Internship Fellowship

European Union, Alfa Project Nº II-0379-FCD

Francia, 2005

Fellowship for reasearch visit to University of Milano. Training in proteomic analysis
Meeting atendance Fellowship

SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

Chile, 2006

Meeting atendance Fellowship
Internship Fellowship.

Alfa Project Nº II-0379-FCD, European Union.

Francia, 2006

Research exchange program.
Meeting atendance Fellowship

SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

Chile, 2007

Meeting atendance Fellowship
Y.W. Loke New Investigator Travel Award

International Federation of Placenta Associations

Australia, 2009

For support for New Investigators in Placentology to attend IFPA meetings.The awards are based on a review of abstracts submitted for an IFPA-designated meeting.
Young Investigator Travel Award

International Society for Developmental Origins of Health and Disease (DOHaD)

Estados Unidos, 2011

Meeting atendance Fellowship for Junior Investigators are merit-based awards given to the primary authors (all countries) of accepted abstracts (oral and poster)
Y.W. Loke New Investigator travel award

International Federation of Placenta Associations

Francia, 2014

Scientific merit based award for young investigator in Placental Physiology


EFFECT OF FETAL GROWTH RESTRICTION ON THE BIOMECHANICAL AND STRUCTURAL PROPERTIES IN HUMAN UMBILICAL AND CHORIONIC ARTERIES Arenas, G.; Gonzalez, J; Saavedra, H; Navarrete, A; Castillo-Galan, S; Garcia-Herrera, C; Krause, B Abstract ISI PLACENTA (2019)
Novel Gasotransmitter Protection against Fetal Origins of Vascular Disease: The Role of Hydrogen Sulphide. Krause, BJ; Garrud, TA; Ford, SG; Niu Y.; Giussani, DA Abstract ISI REPRODUCTIVE SCIENCES (2019)
PROGRESSIVE UTERINE ARTERY OCCLUSION IN GUINEA PIGS INCREASES OXIDATIVE STRESS LEVELS AND DISRUPTS GLYCOGEN METABOLISM IN THE MATERNAL DECIDUA Candia, AA; Lopez-Tello, J; Herrera, EA; Krause, BJ; Sferruzzi-Perri, AN Abstract ISI PLACENTA (2019)
DNA Methylation of nos3 Promoter in IUGR Guinea Pig Fetuses Does Not Predict Endothelial Function and DNA Methylation Later in Life Krause, BJ; Penaloza, E; Hernandez, C; Soto-Carrasco, G; Casanello, P; Uauy, R; Herrera, EA Abstract ISI REPRODUCTIVE SCIENCES (2018)
Role of Leptin in M1 Programming of Monocyte-Derived Macrophages from Newborns of Obese Mothers. Vega, F; Soto-Carrasco, G; Lefever, I; Letelier C.; Casanello, P; Castro-Rodriguez, J; Krause, BJ Abstract ISI REPRODUCTIVE SCIENCES (2018)
ADIPONECTIN RECEPTOR 1 EXPRESSION IN HUMAN UMBILICAL ARTERY ENDOTHELIAL CELLS (HUAEC) FROM LARGE FETUSES (LGA) OF OBESE WOMEN IS RELATED TO eNOS ACTIVATION Munoz-Munoz, EC; Krause, B; Uauy R.; Casanello, P Abstract ISI PLACENTA (2015)
EPIGENETICS AND ENDOTHELIAL HETEROGENEITY IN THE UMBILICOPLACENTAL UNIT: A LANDSCAPE FOR EPIGENETIC PROGRAMMING OF VASCULAR FUNCTION Krause, B; Carrasco-Wong, I; Hernandez C.; Uauy R.; Casanello, P Abstract ISI PLACENTA (2015)
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION Herrera, EA; Schneider D.; Alegría R.; Figueroa, E.; Villanueva C.; Farias M.; Casanello, P; Krause, BJ Abstract ISI PLACENTA (2015)
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS Scheneider, D; Alegría R.; Herrera, E; Farias M.; Casanello, P; Krause, B Abstract ISI PLACENTA (2014)
HISTONE DEACETYLASE ACTIVITY AND NITRIC OXIDE CONTROL THE EXPRESSION OF ENOS AND ARGINASE-2 IN HUMAN UMBILICAL ARTERY ENDOTHELIUM IN INTRAUTERINE GROWTH RESTRICTION Krause, B; Hernandez C.; Schneider D.; Casanello, P Abstract ISI PLACENTA (2014)
ROLE OF OXIDATIVE STRESS STATUS ON THE IMPAIRED ENOS-DEPENDENT RELAXATION IN PLACENTAL CHORIONIC ARTERIES OF INTRAUTERINE GROWTH RESTRICTED (IUGR) AND MACROSOMIC FETUSES FROM OBESE MOTHERS (FMOM) Schneider D.; Hernandez C.; Krause, B; Casanello, P Abstract ISI PLACENTA (2014)
Epigenetic mechanisms implicated in endothelial programming associated to IUGR: Insights from umbilical endothelium Krause, BJ; Carrasco-Wong, I; Casanello, P Abstract PLACENTA (2013)
RhoA/ROCK Signaling Pathway Is Not Implicated in the Regulation of eNOS Activation and arginase-2 Expression in Human Umbilical Vein Endothelial Cells Exposed to Hypoxia. Prieto, CP; Krause, BJ; Sobrevia L.; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2012)
The Hypoxic Phenotype of IUGR Placental Endothelial Cells Is Reverted by DNMT1 Silencing. Evidence for Altered Epigenetic Vascular Programming. Krause, BJ; Sobrevia L.; Hanson, MA; Casanello, P Abstract ISI REPRODUCTIVE SCIENCES (2012)
Abnormal Expression of L-Arginine/NO-Related Enzymes in HUVEC Is Associated with Altered Vascular Reactivity of Umbilical Vein from IUGR Placentae Krause, BJ; Muñoz E.; Prieto, CP; Sobrevia L.; Casanello, P Abstract Journal of Developmental Origins of Health and Disease (2011)
Altered Expression of L-Arginine/NO-Related Enzymes in Cultured Endothelial Cells from IUGR Placenta Is Accompanied by Specific DNA Methylation Changes Krause, BJ; Costello, P; Garrat, ES; Lillycrop, KA; Sobrevia L.; Hanson, MA; Casanello, P Abstract Journal of Developmental Origins of Health and Disease (2011)
ADENOSINE TRANSPORT IS MEDIATED BY DIFFERENT NUCLEOSIDE TRANSPORTERS IN NON-DIFFERENTIATED AND DIFFERENTIATED HUMAN ENDOTHELIAL PROGENITOR CELLS Guzman, E; Lamperti, L; Salomon, C; Krause, B; Sobrevia L.; Aguayo, C. Abstract PLACENTA (2010)
Hypoxia-Reduced eNOS Activity Could Be Explained by Higher Arginase II Activity and Cellular Redistribution in Human Umbilical Vein Endothelial Cells Prieto, CP; Krause, B; Sobrevia L.; Casanello, P Abstract REPRODUCTIVE SCIENCES (2010)
PARTICIPATION OF ARGINASES IN THE VASCULAR TONE IN UMBILICAL VEIN FROM IUGR PLACENTAE: ROLE OF THE ENDOTHELIUM AND HYPOXIA Muñoz E.; Krause, B; Prieto, C; Lavin C.; Sobrevia L.; Casanello, P Abstract PLACENTA (2010)
Role of Arginase II in the Vascular Function of Umbilical Arteries and Veins: Effect of Hypoxia Krause, B; Prieto, C; Sobrevia L.; Casanello, P Abstract REPRODUCTIVE SCIENCES (2010)
THE REDUCED NOS-DEPENDENT VASODILATION IN IUGR CHORIONIC ARTERIES IS IMPROVED BY ARGINASE INHIBITION Krause, BJ; Muñoz E.; Lavin C.; Sobrevia L.; Casanello, P Abstract ISI PLACENTA (2010)
Upregulation of Arginase II in Hypoxia Counteracts Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells Prieto, C; Krause, B; Torres E.; Sobrevia L.; Casanello, P Abstract REPRODUCTIVE SCIENCES (2009)
Hypoxia upregulates the expression of arginase II in human umbilical vein endothelial cells. Regulating the nitric oxide synthase activity Prieto, CP; Krause, BJ; Torres E.; Sobrevia L.; Casanello, P Abstract PLACENTA (2008)
Persistent pulmonary hypertension of the newborn even following transient exposure of the pregnancy to high altitude Herrera, EA; Ebensperger G.; Riquelme, RA; Reyes,RV; Krause, BJ; Giussani, DA; Llanos, AJ Abstract REPRODUCTIVE SCIENCES (2008)
Preeclampsia is associated with increased adenosine transport via the human equilibrative nucleoside transporter 2 in placental microvascular endothelial cells. Escudero, c; Krause, B; Casanello, R; Sobrevia L. Abstract PLACENTA (2007)
Cardiovascular responses to acute hypoxemia in low altitude(LA)and high altitude (HA) fetal sheep (FS) Ebensperger G.; Herrera, EA; Ebensperger, R; Riquelme, RA; Sanhueza, EM; Krause, B; Galvez, P; Valdez, E; Llanos, AJ Abstract PLACENTA (2006)
Differential femoral and pulmonary adrenergic vascular reactivity in high and low altitude newborn lambs Galvez, P; Krause, B; Casanello, P; Herrera, EA; Llanos, AJ Abstract PLACENTA (2006)
Hemoxygenase expression in lung tissue from high and low altitude newborn lambs Martinez, G; Ebensperger G.; Krause, B; Casanello, P; Reyes, VR; Llanos, AJ Abstract PLACENTA (2006)
Melatonin blocks noradrenaline-induced vasoconstriction in middle cerebral artery in lowland fetal sheep Krause, B; Torres-Farfan, C; Galvez, P; Martinez, G; Herrera, EA; Seron-Ferre, MJ; Llanos, AJ Abstract PLACENTA (2006)
Melatonin restrains cortisol production in sheep fetal adrenal in late gestation Torres-Farfan, C; Riquelme, B; Krause, B; Herrera, EA; Campino C.; Llanos, AJ; Seron-Ferre, M Abstract PLACENTA (2006)
The ET-1 system in the pulmonary circulation from newborn lambs submitted to chronic hypoxia Valenzuela, I.; Krause, B; Riquelme R.; Herrera, E; Sanhueza E.; Reyes, VR; Llanos A. Abstract PLACENTA (2006)


Epigenetic mechanisms activated by childhood adversity Krause, Bernardo J.; Artigas, Rocio; Sciolla, Andres F.; Hamilton, James Article EPIGENOMICS (2020)
Adult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation Krause B.J.; PeÃ±aloza E.; Candia, A.; CaÃ±as D.; HernÃ¡ndez C.; Arenas G.A.; Peralta-Scholz M.J.; Valenzuela R.; GarcÃa-Herrera C.; Herrera, E. A. Article ISI SCOPUS ACTA PHYSIOLOGICA (2019)
Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction Paz, Adolfo A.; Arenas, German A.; Castillo-Galan, Sebastian; Penaloza, Estefania; Caceres-Rojas, Gabriela; Suazo, Jose; Herrera, Emilio A; Krause, Bernardo J. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition Krause, BJ; Casanello, P; Dias, AC; Arias, P; Velarde, V; Arenas, GA; Preite, MD; Iturriaga, R Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries Munoz-Munoz, E; Krause, BJ; Uauy, R; Casanello, P Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2018)
Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth Lopez-Tello, Jorge; Angeles Jimenez-Martinez, Maria; Herrera, Emilio A; Krause, Bernardo J.; Sferruzzi-Perri, Amanda N. Article ISI SCOPUS PLACENTA (2018)
Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells Krause, BJ; Hernandez C.; Caniuguir, A; Vasquez-Devaud, P; Carrasco-Wong, I; Uauy R.; Casanello, P Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2016)
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs Herrera, E. A.; Alegría R.; Farias M.; Díaz-López F.; Hernandez C.; Uauy R.; Regnault T.R.H.; Casanello, P; Krause, B. J. Article ISI SCOPUS Journal of Physiology (2016)
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano Herrera, EA; Rojas, RT; Krause, BJ; Ebensperger G.; Reyes,RV; Giussani, DA; Parer, JT; Llanos, AJ Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2016)
Markers of early endothelial dysfunction in intrauterine growth restriction-derived human umbilical vein endothelial cells revealed by 2D-DIGE and mass spectrometry analyses Caniuguir, A; Krause, B. J.; Hernandez C.; Uauy R.; Casanello, P Article ISI SCOPUS Placenta (2016)
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses Krause, B. J.; Herrera, E. A.; Díaz-López, F. A.; Farías, M.; Uauy, R.; Casanello, P. Article ISI SCOPUS Journal of Developmental Origins of Health and Disease (2016)
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia Krause, B. J.; Del Rio R.; Moya E.A.; Marquez-Gutierrez M.; Casanello, P; Iturriaga R. Article ISI SCOPUS Journal of Hypertension (2015)
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children Krause, BJ; Carrasco-Wong, I; Dominguez A.; Arnaiz P.; Farias M.; Barja S.; Mardones F.; Casanello, P Article ISI SCOPUS PLOS ONE (2015)
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA Schneider D.; Hernandez C.; Farias M.; Uauy R.; Krause, BJ; Casanello, P Article ISI SCOPUS Placenta (2015)
The placental pursuit for an adequate oxidant balance between the mother and the fetus Emilio A Herrera, Bernardo J Krause, German Ebensperger, Roberto V. Reyes, Paola Casanello, Mauro Parra-Cordero and Anibal J. Llanos Article SCOPUS FRONTIERS IN PHARMACOLOGY (2014)
Conceptual basis for prescriptive growth standards from conception to early childhood: present and future Uauy R.; Casanello, P; Krause, B; Kuzanovic, JP; Corvalán C. Article ISI SCOPUS BJOG: An International Journal of Obstetrics and Gynaecology (2013)
Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels Krause, BJ; Carrasco-Wong, I; Caniuguir, A; Carvajal, J.; Farias M.; Casanello, P Article ISI SCOPUS Placenta (2013)
Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses Krause, BJ; Costello, PM; Munoz-Urrutia, E; Lillycrop, KA; Hanson, MA; Casanello, P Article ISI SCOPUS Epigenetics (2013)
Role of arginase-2 and eNOS in the differential vascular reactivity and hypoxia-induced endothelial response in umbilical arteries and veins Krause, B. J.; Prieto C.P.; Munoz-Urrutia, E; San Martin, S; Sobrevia L.; Casanello, P Article ISI SCOPUS Placenta (2012)
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium Prieto, CP; Krause, BJ; Quezada C.; San Martín R.; Sobrevia L.; Casanello, P Article ISI SCOPUS Placenta (2011)
Differential expression of functional nucleoside transporters in non-differentiated and differentiated human endothelial progenitor cells Guzman-Gutierrez, E; Sandoval C.; Nova, E; CASTILLO, JL; Vera, JC; Lamperti, L; Krause, B; Salomon, C; Sepulveda, C; Aguayo, C.; Sobrevia L. Article ISI SCOPUS PLACENTA (2010)
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level Herrera, EA; Riquelme, RA; Ebensperger G.; Reyes,RV; Ulloa, CE; Cabello, G; Krause, BJ; Parer, JT; Giussani, DA; Llanos, AJ Article ISI SCOPUS American Journal of Physiology - Regulatory Integrative and Comparative Physiology (2010)
Epigenetics: New Concepts of Old Phenomena in Vascular Physiology Krause, B; Sobrevia L.; Casanello, P Article ISI Current Vascular Pharmacology (2009)
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia Casanello, P; Krause, B; Torres E.; Gallardo V.; Gonzalez, M.; Prieto, C; Escudero, c; Farias M.; Sobrevia L. Article ISI SCOPUS PLACENTA (2009)
TGF-beta 1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium Vega, JL; Puebla, C; Vasquez R.; Farias M.; Alarcon J.; Pastor-Anglada, M; Krause, B; Casanello, P; Sobrevia L. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2009)
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland Torres-Farfan, C; Valenzuela, FJ; Mondaca, M.; Valenzuela GJ; Krause, B; Herrera, EA; Riquelme R.; Llanos, AJ; Seron-Ferre, M Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2008)
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium Puebla, C; Farias M.; Gonzalez, M.; Vecchiola, A; Aguayo, C.; Krause, B; Pastor-Anglada, M; Casanello, P; Sobrevia L. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease Maldonado, H.; Ortiz-Riano, E; Krause, B; Barriga, A.; Medina, F; Pando, ME; Alberti C.; Kettlun, AM; Collados, L; Garcia, L.; Cartier, L; Valenzuela, MA. Article ISI SCIELO BIOLOGICAL RESEARCH (2008)
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep Herrera, EA; Ebensperger G.; Krause, BJ; Riquelme, RA; Reyes,RV; Capetillo, M; Gonzalez S.; Parer, JT; Llanos, AJ Article ISI SCOPUS PEDIATRIC RESEARCH (2008)
Evolving in thin air - Lessons from the llama fetus in the altiplano Llanos, AJ; Riquelme, RA; Herrera, EA; Ebensperger G.; Krause, B; Reyes,RV; Sanhueza, EA; Pulgar VM; Behn, C; Cabello, G; Parer, JT; Giussani, DA; Blanco, CE; Hanson, MA Article ISI SCOPUS RESPIRATORY PHYSIOLOGY NEUROBIOLOGY (2007)


Time-course modeling of the vascular epigenetic programming by fetal growth restriction=> role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses FONDECYT (1181341) Proyecto 2018-2021 Inv. Principal
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals: Experiments, Modelling, Numerical Simulation and Validation Garcia, Claudio; Krause, Bernardo; Celentano, Diego; Herrera, Emilio; Cruchaga, M Proyecto (2017)
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals=> Experiments, Modelling, Numerical Simulation and Validation FONDECYT (1170608) Proyecto 2017-2020 Coinvestigador(a)
Fetal programming of inflammatory responses and body fat by maternal obesity: Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease Casanello, Paola; Krause, Bernardo; Garmedia, María; Uauy, Ricardo; Kusanovic, Juan Pedro; Castro, Jose Proyecto (2017)
Fetal programming of inflammatory responses and body fat by maternal obesity=> Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease FONDECYT (1171406) Proyecto 2017-2021 Coinvestigador(a)
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo Society for Reproductive Investigation, United States (In training grant - 2017) Proyecto 2017-2017 Inv. Principal
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION FONDECYT (1141195) Proyecto 2014-2018 Coinvestigador(a)
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION Castro, José; Krause, Bernardo; Casanello. Paola; Garmedia, Maria; Uauy, Ricardo Proyecto (2014)
Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the intrauterine growth restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction Krause, Bernardo; Casanello, Paola; Herrera, Emilio; Iturriaga, Rodrigo; Farías, Marcelo Proyecto (2013)
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION FONDECYT (1130801) Proyecto 2013-2017 Inv. Responsable
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular: Respuesta integrada a una patología multifactorial Iturriaga, Rodrigo; Casanello, Paola; Krause, Bernardo; Preite, Marcelo Proyecto (2013)
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular=> Respuesta integrada a una patología multifactorial FONDEF (D11I1098) Proyecto 2013-2015 Investigador(a)
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES=> EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION. FONDECYT (1120928) Proyecto 2012-2016 Coinvestigador(a)
PAPEL DE ARGINASAS I Y II EN LA DISFUNCION ENDOTELIAL DE LA UNIDAD FETO-PLACENTARIA EN EMBARAZOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO Y EN HIPOXIA FONDECYT (1080534) Proyecto 2008-2012 Tesista
EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL. FONDECYT (1050479) Proyecto 2005-2009 Personal técnico y/o de apoyo
Effects of chronic hipoxia on fetal cardiovascular and endocrine functions in the sheep . The Welcome Trust, UK (CRIG 072256/2/03/2) Proyecto 2004-2007 Investigador(a)
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES: EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION Casanello, Paola; Krause, Bernardo; Kusanovic, Juan Pedro; Sobrevia, Luis Proyecto (0)
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo Krause, Bernardo; Giussani, Dino Proyecto (0)


Mechanical characterization of arteries affected by fetal growth restriction in guinea pigs (Cavia porcellus). Cañas, Daniel; García-Herrera, Claudio M; Herrera, Emilio A; Celentano, Diego J; Krause, Bernardo J Article Journal of the mechanical behavior of biomedical materials (2018)
Fetal Growth Restriction Induces Heterogeneous Effects on Vascular Biomechanical and Functional Properties in Guinea Pigs (Cavia porcellus). Cañas, Daniel; Herrera, Emilio A; García-Herrera, Claudio; Celentano, Diego; Krause, Bernardo J Article Frontiers in Physiology (2017)
Fetal Growth Restriction Induces Heterogeneous Effects on Vascular Biomechanical and Functional Properties in Guinea Pigs (Cavia porcellus). Cañas, Daniel; Herrera, Emilio A; García-Herrera, Claudio; Celentano, Diego; Krause, Bernardo J Article Frontiers in physiology (2017)
IL-10 Expression in Macrophages from Neonates Born from Obese Mothers Is Suppressed by IL-4 and LPS/INFÎ³. Cifuentes-Zúñiga, Francisca; Arroyo-Jousse, Viviana; Soto-Carrasco, Gustavo; Casanello, Paola; Uauy, Ricardo; Krause, Bernardo J; Castro-Rodríguez, José A Article JOURNAL OF CELLULAR PHYSIOLOGY (2017)
IL-10 Expression in Macrophages from Neonates Born from Obese Mothers Is Suppressed by IL-4 and LPS/INFÎ³. Cifuentes-Zúñiga, Francisca; Arroyo-Jousse, Viviana; Soto-Carrasco, Gustavo; Casanello, Paola; Uauy, Ricardo; Krause, Bernardo J; Castro-Rodríguez, José A Article Journal of cellular physiology (2017)
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs. Herrera, Emilio A; Cifuentes-Zúñiga, Francisca; Figueroa, Esteban; Villanueva, Cristian; Hernández, Cherie; Alegría, René; Arroyo-Jousse, Viviana; Peñaloza, Estefania; Farías, Marcelo; Uauy, Ricardo; Casanello, Paola; Krause, Bernardo J Article The Journal of Physiology (2017)
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs. Herrera, Emilio A; Cifuentes-Zúñiga, Francisca; Figueroa, Esteban; Villanueva, Cristian; Hernández, Cherie; Alegría, René; Arroyo-Jousse, Viviana; Peñaloza, Estefania; Farías, Marcelo; Uauy, Ricardo; Casanello, Paola; Krause, Bernardo J Article The Journal of physiology (2017)
Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells. Krause, Bernardo J; Hernandez, Cherie; Caniuguir, Andres; Vasquez-Devaud, Paola; Carrasco-Wong, Ivo; Uauy, Ricardo; Casanello, Paola Article Biochemical pharmacology (2016)
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs. Herrera, Emilio A; Alegría, René; Farias, Marcelo; Díaz-López, Farah; Hernández, Cherie; Uauy, Ricardo; Regnault, Timothy R H; Casanello, Paola; Krause, Bernardo Article The Journal of physiology (2016)
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano. Herrera, Emilio A; Rojas, Rodrigo T; Krause, Bernardo J; Ebensperger, Germán; Reyes, Roberto V; Giussani, Dino A; Parer, Julian T; Llanos, Aníbal J Article The Journal of physiology (2016)
Markers of early endothelial dysfunction in intrauterine growth restriction-derived human umbilical vein endothelial cells revealed by 2D-DIGE and mass spectrometry analyses. Caniuguir, Andres; Krause, Bernardo J; Hernandez, Cherie; Uauy, Ricardo; Casanello, Paola Article Placenta (2016)
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia. Krause, Bernardo J; Del Rio, Rodrigo; Moya, Esteban A; Marquez-Gutierrez, Monica; Casanello, Paola; Iturriaga, Rodrigo Article Journal of hypertension (2015)
Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children. Krause, Bernardo J; Carrasco-Wong, Ivo; Dominguez, Angélica; Arnaiz, Pilar; Farías, Marcelo; Barja, Salesa; Mardones, Francisco; Casanello, Paola Article PloS one (2015)
Oxidative stress as common trait of endothelial dysfunction in chorionic arteries from fetuses with IUGR and LGA. Schneider, D; Hernández, C; Farías, M; Uauy, R; Krause, B J; Casanello, P Article Placenta (2015)
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses. Krause, B J; Herrera, E A; Díaz-López, F A; Farías, M; Uauy, R; Casanello, P Article Journal of developmental origins of health and disease (2015)
Role of nitric oxide in placental vascular development and function. Krause, B J; Hanson, M A; Casanello, P Article Placenta (2011)


Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic Morrison J.L.; Botting K.J.; Darby J.R.T.; David A.L.; Dyson R.M.; Gatford K.L.; Gray C.; Herrera, E. A.; Hirst J.J.; Kim B.; Kind K.L.; Krause B.J.; Matthews S.G.; Palliser H.K.; Regnault T.R.H.; Richardson B.S.; Sasaki A.; Thompson L.P.; Berry M.J. Review ISI SCOPUS (2018)
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity Casanello, P; Schneider D.; Herrera, EA; Uauy R.; Krause, BJ Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2014)
Role of nitric oxide in placental vascular development and function Krause, BJ; Hanson, MA; Casanello, P Review ISI SCOPUS Placenta (2011)


Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction Casanello, Paola; Herrera, Emilio; Krause, Bernardo; Jing Zheng; Chi Zhou BookSection (2017)
LA ALIMENTACIÓN DE LA MADRE, EL BEBÉ Y EL NIÑO Muñoz, Estefanía; Casanello, Paola; Krause, Bernardo; Uauy, Ricardo; Gutiérrez Navas, Manual BookSection (2015)


Programación epigenética placentaria en restricción del crecimiento intrauterino Casanello, P; Castro-Rodríguez J.A.; Uauy R.; Krause, B. J. Actualizacion SCIELO SCOPUS REVISTA CHILENA DE PEDIATRIA-CHILE (2016)

Bernardo Krause

Assistant Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

ivo carrasco

encargado investigación

Universidad de Valparaíso

Valparaíso, Chile

Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Sebastian San Martin

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

Catalina Prieto

Postdoctor

Biología

Universidad de Chile

Santiago, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Santiago, Chile

Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

Sebastian San Martin

Associate Professor

Biomedical Sciences

Universidad de Valparaiso

Valparaiso, Chile

Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

Jorge Carvajal

Chief of Department

Obstetrics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Camila Corvalan

Assistant Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

Claudio Garcia

Associate Professor

Departamento de Ingenieria Mecanica

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

Fabián Vega

Investigador postdoctoral

Oftalmología

Universidad de Chile

Santiago, Chile

Bernardo Javier Krause Leyton

Líneas de Investigación

Educación

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

Assistant Professor of Chemistry Other

Assistant Professor of Physiology Other

Ajunct Researcher Other

Assistant Professor Full Time

Assistant Professor Full Time

Experiencia Profesional

Welcome Trust Fellow Research Full Time

Fellow Research Full Time

Formación de Capital Humano

Premios y Distinciones

Undergrade Fellowship

Internship Fellowship

Meeting atendance Fellowship

Internship Fellowship.

Meeting atendance Fellowship

Y.W. Loke New Investigator Travel Award

Young Investigator Travel Award

Y.W. Loke New Investigator travel award

Abstract (31)

Article (30)

Proyecto (18)

Time-course modeling of the vascular epigenetic programming by fetal growth restriction=> role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses

Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals=> Experiments, Modelling, Numerical Simulation and Validation

Fetal programming of inflammatory responses and body fat by maternal obesity=> Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease

N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo

EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION

MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION

Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular=> Respuesta integrada a una patología multifactorial

INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES=> EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION.

PAPEL DE ARGINASAS I Y II EN LA DISFUNCION ENDOTELIAL DE LA UNIDAD FETO-PLACENTARIA EN EMBARAZOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO Y EN HIPOXIA

EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL.

Effects of chronic hipoxia on fetal cardiovascular and endocrine functions in the sheep

Article (16)

Review (3)

BookSection (2)

Actualizacion (1)