
Bernardo Javier Krause Leyton
Assistant Professor
Universidad de O'Higgins
Rancagua, Chile
Vascular physiology; Fetal programming; Epigenetics; Hypoxia; Obesity
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Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2012
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Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
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Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004
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Assistant Professor of Chemistry Other
UNIVERSIDAD DEL BIO-BIO
Health and Food Sciences
Chillán, Chile
2007 - 2007
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Assistant Professor of Physiology Other
UNIVERSIDAD DE CHILE
Health and Food Sciences
Chillán, Chile
2007 - 2007
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Ajunct Researcher Other
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Medicine
Santiago, Chile
2010 - 2010
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Assistant Professor Full Time
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Medicine
Santiago, Chile
2017 - 2020
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Assistant Professor Full Time
Universidad de O'Higgins
Instituto de Ciencias de la Salud
Rancagua, Chile
2020 - A la fecha
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Welcome Trust Fellow Research Full Time
Fetal and Developmental Physiology Laboratory, Faculty of Medicine, Universidad de Chile.
Santiago, Chile
2004 - 2007
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Fellow Research Full Time
Faculty of Medicine Pontificia Universidad Católica de Chile
Santiago, Chile
2007 - 2007
Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Estefanía Peñaloza Pezoa. Title: Micro-RNAs 21 y 126 en la respuesta a hypoxia en células endoteliales de arteria umbilical (Micro-RNA 21 and 126 in the response to hypoxia in HUAEC). September 2016- in progress
Director PhD Biomedical Science research unit. Pontificia Universidad Católica de Chile. Student: Fabián Vega. Title: Leptin as a modulator of the epigenetic programming of monocyte-derived macrophages in neonates. January 2017 - in progress
Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Isidora Lefever Medina. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016
Director Nutritionist thesis, Pontificia Universidad Católica de Chile. Student: Catalina Letelier. Title: Efecto in vitro de la leptina recombinante en la respuesta inflamatoria de macrófagos derivados de monocitos del cordón umbilical de recién nacidos de madres obesas (In vitro effect of leptin on the inflammatory response in monocyte-derived macrophages from neonates born to obese mothers). March - December 2016
Director Biochemist thesis, Pontificia Universidad Católica de Chile. Student: Francisca Cifuentes Zuñiga. Title: EFECTO DE LA OBESIDAD MATERNA SOBRE LA EXPRESIÓN DE MEDIADORES INFLAMATORIOS EN MACRÓFAGOS FETALES: POTENCIAL PROGRAMACIÓN DE LA FUNCIÓN INMUNE (Effect of maternal obesity on the expression of inflammatory mediators in fetal macrophages). July 2015-June 2016
Co-director Medical Veterinary thesis, University of Chile. Student: René Alegría. Title: CARACTERIZACIÓN DE LA FUNCIÓN VASCULAR DE UN MODELO DE RESTRICCIÓN DE CRECIMIENTO INTRA-UTERINO POR OCLUSIÓN PROGRESIVA DE ARTERIAS UTERINAS EN COBAYAS (Vascular function characterization in a guinea pig model of intrauterine growth restriction by gradual uterine artery occlusion) March - December 2014.
Lecturer on the III Workshop on Maternal Fetal Interaction - University of São Paulo, February 14 – 17, 2013, São Paulo, Brasil
Tutorial. Molecular Cell Biology. Faculty of Odontology, Pontificia Universidad Católica de Chile. First semester 2010.
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Undergrade Fellowship
UNIVERSIDAD DE CHILE
Chile, 1997
Academic performance based scholarship for undergraduate studies.
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Internship Fellowship
European Union, Alfa Project Nº II-0379-FCD
Francia, 2005
Fellowship for reasearch visit to University of Milano. Training in proteomic analysis
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Meeting atendance Fellowship
SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS
Chile, 2006
Meeting atendance Fellowship
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Internship Fellowship.
Alfa Project Nº II-0379-FCD, European Union.
Francia, 2006
Research exchange program.
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Meeting atendance Fellowship
SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS
Chile, 2007
Meeting atendance Fellowship
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Y.W. Loke New Investigator Travel Award
International Federation of Placenta Associations
Australia, 2009
For support for New Investigators in Placentology to attend IFPA meetings.The awards are based on a review of abstracts submitted for an IFPA-designated meeting.
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Young Investigator Travel Award
International Society for Developmental Origins of Health and Disease (DOHaD)
Estados Unidos, 2011
Meeting atendance Fellowship for Junior Investigators are merit-based awards given to the primary authors (all countries) of accepted abstracts (oral and poster)
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Y.W. Loke New Investigator travel award
International Federation of Placenta Associations
Francia, 2014
Scientific merit based award for young investigator in Placental Physiology
Time-course modeling of the vascular epigenetic programming by fetal growth restriction=> role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses |
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals: Experiments, Modelling, Numerical Simulation and Validation |
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals=> Experiments, Modelling, Numerical Simulation and Validation |
Fetal programming of inflammatory responses and body fat by maternal obesity: Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease |
Fetal programming of inflammatory responses and body fat by maternal obesity=> Role of DHA in the modulation of epigenetic markers of obesity and metabolic disease |
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo |
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION |
EARLY RISK OF ASTHMA IN CHILDREN EXPOSED TO IN-UTERO MATERNAL OBESITY. AN EPIGENETIC-MEDIATED PROGRAMMING OF IMMUNE FUNCTION |
Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the intrauterine growth restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction |
MODELING THE EPIGENETIC PROGRAMMING OF VASCULAR DYSFUNCTION BY OXIDATIVE STRESS IN THE INTRAUTERINE GROWTH RESTRICTED FETUS=> ROLE OF PRENATAL ANTIOXIDANTS IN PREVENTING LONG-TERM VASCULAR DYSFUNCTION |
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular: Respuesta integrada a una patología multifactorial |
Nueva formulación farmacológica para el tratamiento y la prevención de la hipertensión arterial y disfunciónvascular=> Respuesta integrada a una patología multifactorial |
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES=> EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION. |
PAPEL DE ARGINASAS I Y II EN LA DISFUNCION ENDOTELIAL DE LA UNIDAD FETO-PLACENTARIA EN EMBARAZOS CON RESTRICCION DEL CRECIMIENTO INTRAUTERINO Y EN HIPOXIA |
EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL. |
Effects of chronic hipoxia on fetal cardiovascular and endocrine functions in the sheep |
INTRAUTERINE PROGRAMMING OF HIPOXIA- AND OXIDATIVE STRESS-INDUCED VASCULAR RESPONSES IN PLACENTAL ENDOTHELIUM FROM IUGR AND MACROSOMIC FETUSES: EARLY EVIDENCE FOR EPIGENETIC-DRIVEN VASCULAR DYSFUNCTION |
N-acetyl cysteine and the hypoxia induced vascular dysfunction in chick embryo |
Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction |
LA ALIMENTACIÓN DE LA MADRE, EL BEBÉ Y EL NIÑO |
Programación epigenética placentaria en restricción del crecimiento intrauterino |

Bernardo Krause
Assistant Professor
Insituto de Ciencias de la Salud
Universidad de O'Higgins
Rancagua, Chile

Paola Casanello
Profesor Asociado
División de Obstetricia y Ginecología
Pontificia Universidad Católica de Chile
Santiago, Chile

LUIS SOBREVIA
Professor
Division of Obstetrics and Gynaecology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile

Marcelo Farias
Assistant Professor
Division of Obstetrics and Gynecology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA
Santiago, Chile

Jorge Llanos
PROFESOR TITULAR
FISIOPATOLOGÍA
UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA
Santiago, Chile

German Ebensperger
PROFESOR ASISTENTE
INSTITUTO DE CIENCIAS BIOMEDICAS
UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA
Santiago, Chile

Claudia Torres
Full Professor
Instituto de Anatomía, Histología y Patología
UNIVERSIDAD AUSTRAL DE CHILE
Valdivia, Chile

Lorena Garcia
Assistant Professor
Bioquimica y Biologia Molecular
UNIVERSIDAD DE CHILE
Santiago, Chile

Enrique Guzman
Profesor Asistente
Bioquímica Clínica e Inmunología
Universidad de Concepción
Concepción, Chile

Claudio Aguayo
Profesor Asociado
Bioquimica Clinica e Inmunologia
UNIVERSIDAD DE CONCEPCIÓN
Concepción, Chile

Rodrigo Iturriaga
Chairman of the Department of Physiology
Physiology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Andrea Vecchiola
Profesor Asistente
Endocrinologia
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Rodrigo Del Rio
Assistant Professor
Physiology
Pontificia Universidad Católica de Chile
Santiago, Chile

Salesa Barja
Médico Nutrióloga pediátrica
Gastroenterología y Nutrición Pediátrica
Pontificia Universidad Católica de Chile
Santiago, Chile

Sebastian San Martin
Associate Professor
Biomedical Sciences
Universidad de Valparaiso
Valparaiso, Chile
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Claudia Quezada
Full Professor
Institute of Biochemistry and Microbiology
Universidad Austral de Chile
Valdivia, Chile

Jose Castro
Profesor Asociado
Cardiologia y Neumologia Pediatrica
Pontificia Universidad Catolica de Chile
Santiago, Chile

Jorge Carvajal
Chief of Department
Obstetrics
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Juan Kusanovic
Jefe CIMAF
Obstetricia y Ginecología
SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO
Santiago, Chile

Estefania Nova
Assistant Professor
Clinical Biochemistry & Immunology
University of Concepcion
Concepción , Chile

Víctor Reyes
Profesor Asociado
Instituto de Ciencias Biomédicas
UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA
Santiago, Chile

José Suazo
Profesor Asociado
Instituto de Investigación en Ciencias Odontológicas
Universidad de Chile
Santiago, Chile

Jose Suazo
Profesor Asociado
Instituto de Investigación en Ciencias Odontológicas
Facultad de Odontologia, Universidad de Chile
Santiago, Chile

Claudio Garcia
Associate Professor
Departamento de Ingenieria Mecanica
UNIVERSIDAD DE SANTIAGO DE CHILE
Santiago, Chile