Man

Francisco Javier Valenzuela Melgarejo

Academico

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

Líneas de Investigación


Fisiologia; Endocrinología; Sistema Circadiano; Biología Celular y Molecular

Educación

  •  Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Academico Full Time

    UNIVERSIDAD DEL BIO-BIO

    Ciencias

    Chillán, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Asistente Investigación Fondecyt (1110883) Full Time

    Universidad de los Andes

    Santiago, Chile

    2011 - 2012

  •   Director Alterno Proyecto CORFO (11IDL2-10487) Other

    Universidad de los Andes

    Santiago, Chile

    2011 - 2012

Formación de Capital Humano


He dirigido 3 tesis de Pregrado: “MELATONINA Y SU ROL SOBRE EL SISTEMA CIRCADIANO DE LA PLACENTA HUMANA”, Ped. Ciencias, 2014, Marcela Pradenas ; “HIGH LEVEL OF CLOCK GENE PER1 IS DETECTED IN PLACENTAS FROM PREECLAMPSIA”. Ped. Ciencias, 2014, Karen Muñoz, Sara Muñoz, Solange Oyarce; “PAPEL DEL SISTEMA CIRCADIANO Y DE MELATONINA EN LAS PATOLOGÍAS DEL EMBARAZO” Bachillerato, 2013. Fabiola Pino.

He dirigido 1 tesis de Postgrado: “EL SISTEMA CIRCADIANO MODULA EL CICLO CELULAR DE LA PLACENTA: MECANISMO MOLECULAR DEL CONTROL CELULAR”, Magister en Cs. Biológicas, 2015. Carlos Venegas.



 

Article (29)

Effect of metal in Schiff bases of chitosan adsorbed on glassy carbon electrode in the inhibition of sphingomyelinase C toxin
Preliminary evaluation of the up-conversion emission of Y2O3=>Er-Yb thin films prepared by a solid state photochemical deposition method
Study on the photochemical preparation of nickel gallium oxide spinel doped with Eu(III) ions from carboxylate and beta-diketonate complexes and the evaluation of its optical properties
"Deciphering the function of the blunt circadian rhythm of melatonin in the newborn lamb=> Impact on adrenal and heart.", # en.2017-00254R2
Carriage of Staphylococcus aureus among food service workers
Mechanistic characterization and inhibition of sphingomyelinase C over substituted Iron Schiff bases of chitosan adsorbed on glassy carbon electrode
PORTACIÒN DE STAPHYLOCOCCUS AUREUS ENTEROTOXIGÈNICO TIPO A, EN FROTIS NASOFARINGEOS EN MANIPULADORAS DE ALIMENTOS
Oxidation of melatonin on a glassy carbon electrode modified with metallic glucosamines.
Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature
Oxidation of melatonin on a glassy carbon electrode modified with metallic glucosamines. Synthesis and characterization
Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy
Impact of maternal melatonin suppression on amount and functionality of brown adipose tissue (BAT) in the newborn sheep
Increased placental angiogenesis in late and early onset pre-eclampsia is associated with differential activation of vascular endothelial growth factor receptor 2
Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms
Circadian rhythms in the fetus.
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia
Pathogenesis of preeclampsia: The genetic component
Melatonin Exerts Direct Inhibitory Actions on ACTH Responses in the Human Adrenal Gland
Cryptochrome 2 Expression Level Is Critical for Adrenocorticotropin Stimulation of Cortisol Production in the Capuchin Monkey Adrenal
Circadian cortisol secretion and circadian adrenal responses to ACTH are maintained in dexamethasone suppressed capuchin monkeys (Cebus apella)
Clock gene expression in adult primate suprachiasmatic nuclei and adrenal: Is the adrenal a peripheral clock responsive to melatonin?
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland
La melatonina reduce la respuesta de cortisol al ACTH en humanos
Melatonin reduces cortisol response to ACTH in humans
Melatonin reduces cortisol response to ACTH in humans La melatonina reduce la respuesta de cortisol al ACTH en humanos
Maternal melatonin effects on clock gene expression in a nonhuman primate fetus
Maternal melatonin stimulates growth and prevents maturation of the capuchin monkey fetal adrenal gland
La melatonina reduce la respuesta de cortisol al ACTH en humanos (2009)
Melatonin reduces cortisol response to ACTH in humans.

Abstract (7)

The RNA Levels of Keys Enzimes for the Methionine-Homocysteine Metabolism Are Elevated in Placenta of Preeclamptic (PE) Patients
A Different Temporal Order between Fetal Atrium and Ventricle? Identification of Adrenergic Receptor Beta 1 (ADRB1), Atrial Natriuretic Peptide (ANP), Clock Genes and Melatonin Receptor 1 (MT1) in Fetal Capuchin Monkey Heart. Preliminary Results
Interactions between Melatonin and ACTH in the Human Adrenal Gland: Adrenal Clockwork Inhibition?.
Different effects of melatonin on PER2 expression in the adrenal gland of fetal and adult Capuchin monkey
Differential expression of the clock gene Cry2 in capuchin monkey fetal tissues
Maternal melatonin inhibits 30-hydroxysteroid-dehydrogenase expression in the primate fetal adrenal gland.
Regulation of 3b-hydroxysteroid dehydrogenase (3b-HSD) expression in the capuchin monkey fetal adrenal gland by maternal melatonin.

BookSection (1)

The role of placenta in the fetal programming associated to gestational diabetes

Proyecto (10)

ESTUDIO DE FLUJO DE SANGRE, LA INHIBICIÓN Y LA CINÉTICA DE LA ESFINGOMIELINASA C CON COMPLEJO DE QUITOSÁN Y GLUCOSAMINAS DE HIERRO Y DE COBALTO SOBRE EL ELECTRODO DE CARBONO VÍTREO. EFECTO DE TAMAÑOS COMPLEJOS
PROYECTO SUIZAGUA ANDINA CHILE
ROLE OF ANGIOGENESIS MEDIATED BY THE A2AAR/VEGF SIGNALING PATHWAY IN THE GENERATION OF HYPERTENSION IN OFFSPRING BORN FROM PRE-ECLAMPTIC PREGNANCIES
“Prevalencia de Staphylococcus aureus enterotoxigénicos en frotis nasofaríngeo de manipuladores en servicios de alimentación de escuelas municipalizadas de la comuna de Chillán”.
“FORTALECIMIENTO DE LA INVESTIGACION EN BIOMEDICINA EN LA UNIVERSIDAD DEL BIO BIO”
"Desarrollo de un test de diagnóstico molecular predictivo de parto prematuro en mujeres embarazadas" (Director Alterno)
THE METHIONINE-HOMOCYSTEINE CYCLE AND ITS EFFECTS ON THE METABOLISM OF 2-METHOXYOESTRADIOL. THE ROLE OF CATECHOL-O-METHYLTRANSFERASE IN THE ETIOPATHOGENESIS OF PREECLAMPSIA
"Mecanismo Molecular de la inhibición por melatonina sobre la producción de cortisol estimulada por ACTH"
EL SISTEMA CIRCADIANO FETAL=>¿UNA JERARQUIA DE RELOJES PERIFERICOS CIRCADIANOS COORDINADOS POR LA MELATONINA MATERNA?
LA MELATONINA MATERNA COMO SENAL CIRCADIANA EN EL FETO DE PRIMATES-ACCION SOBRE EL OSCILADOR FETAL CENTRAL(NUCLEO SUPRAQUIASMATICO) Y POSIBLES OSCILADORES PERIFERICOS FETALES (HIPOFISIS Y GLANDULA SUPRARRENAL)

Review (2)

Potential Crosstalk between Fructose and Melatonin: A New Role of Melatonin-Inhibiting the Metabolic Effects of Fructose
Circadian rhythms in the fetus
31
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

18
Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Lorena Abarzúa

Investigador

Medicina

Universidad de los Andes

Santiago, Chile

2
Gerardo Cabello

Academico

Departamento de Ciencias Básicas

Universidad del Bio-Bio, Chile

Chillán, Chile

2
Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Claudia Caro

UNIVERSIDAD DEL BÍO-BÍO

Chillán, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

1
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Tamara Sáez

Postdoctoral fellow

Obstetrics and Gynecology

University of Alberta

Edmonton, Canada