Man

Luis Fernando Michea Acevedo

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Hormonal regulation of ion transport in renal and cardiovascular tissue. Pathophysiology of hypertension and vascular calcification in chronic kidney failure. Immunological mechanism in hypertension and hypertension- target- organ damage.

Educación

  •  CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 1996
  •  MD, UNIVERSIDAD DE CHILE. Chile, 1991
  •  Filosofía, UNIVERSIDAD DE LOS ANDES. Chile, 2006

Experiencia Académica

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE CHILE

    MEDICINA

    SANTIAGO, Chile

    2007 - 2010

  •   DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

    UNIVERSIDAD DE CHILE

    MEDICINA

    SANTIAGO, Chile

    2007 - 2013

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE LOS ANDES

    MEDICINA

    SANTIAGO, Chile

    1996 - 2002

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE LOS ANDES

    MEDICINA

    SANTIAGO, Chile

    2002 - 2006

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE CHILE

    MEDICINA

    SANTIAGO, Chile

    2010 - A la fecha

Experiencia Profesional

  •   VISITING SCIENTIST Full Time

    NATIONAL INSTITUTE OF HEALTH

    Bethesda, Maryland, Estados Unidos

    1998 - 2000

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE LOS ANDES

    Santiago, Chile

    1996 - 2002

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE LOS ANDES

    Santiago, Chile

    2002 - 2006

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2007 - 2010

  •   DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2007 - 2013

  •   PROFESOR ASOCIADO Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    2010 - A la fecha

Formación de Capital Humano


POSTDOCTORAL
Loreto Carrasco Alarcón. FONDECYT 3060026. Potential participation of vassopressin in cardiovascular damage induced by high salt intake and minerolcorticoids.

GRADUATE
Patricio Andrés Araos Salas. 2014. Renal dendritic cells are required for the development of arterial hypertension in response to Angiotensin II. PhD in Pharmacolgy. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
Pablo Andrés Diaz Molina Díaz. 2014. Role of the ?3 subunit of the Na+/K+ ATPase pump in sodium homeostasis and arterial hipertension PhD in Biochemistry. Universidad de Chile.
Daniel Enrique Hevia Magaña. 2014. Proinflammatory dendritic cells are required for damage induced by hipertension. PhD in Biomedical Sciences. Universidad de Chile.
Luis Alejandro Toro Cabrera. 2014. Protective effect of the FGF-23/Klotho/FGFR1 pathway in ischemic acute kidney injury. PhD in Biomedical Sciences and Speciality. Universidad de Chile.
Keigo Sugisawa. 2014. The Regulation of FGF23 in Acute Kidney Injury. Department of Human Pathology. Latin American Collaborative Research Center, Tokyo Medical and Dental University (TMDU), Clínica Las Condes- Universidad de Chile.
Daisuke Kawata. 2013. Role of FGFR1 Pathway in Acute Kidney Injury. Department of Human Pathology. Latin American Collaborative Research Center, Tokyo Medical and Dental University (TMDU),Clínica Las Condes- Universidad de Chile.
María Loreto Varela Morales. 2013. Effect of Angiotensin (1-9) in angiogenesis, via the AT2 receptor of Angiotensin II. Magister en Ciencias Biológicas y Médicas, mención Morfología. Universidad de Chile.
Juan Pedro Peña Mendez. 2013. Activation of Interleukin 17 via a mechanism of inflammation and cardiovascular damage induced by aldosterone. Magister en Ciencias Animales y Veterinarias. Mención Patología Animal. Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Cristián Alejandro Amador Carrasco. 2013. Activity of the mineralocorticoid receptor in cells from the immune system during cardiovascular and renal inflammation. PhD in Biomedical Sciences. Universidad de Chile.
Rafael Alonso Martínez Figueroa. 2012. Role of the inorganic phosphate cotransporter PiT-1 in the condroidea hypertrophy of ATDC5 cells exposed to synovial liquid of patients with osteoarthritis. PhD in Biomedical Sciences. Pontificia Universidad Católica de Chile.
Natalia Hilda Dünner Moreno. 2012. Studies on the mechanism of intracellular calcium levels and the proteolisis induced by the parathyroid hormone in uremic skeletal muscle. PhD in Biochemistry. Universidad de Chile.
Jessica Alejandra Díaz Elizondo . 2011. Aldosterone in peripheral blood mononuclear cells and cardiomyocytes: role of TNF-? and reactive oxygen species.PhD in Biochemistry. Universidad de Chile.
Alexis González Parra. 2009. Expression of the epithelial sodium channel (ENaC) in renin-angiotensin-aldosterone system and possible regulation mediated by Cox-2 in rat kidney. PhD in Physiological Sciences.

UNDERGRADUATE
Alvaro Plaza Valencia. 2014. Mineralocorticoid role in regulating subunit ?3 of the Na + / K + ATPase in rat ventricular myocardium. Biochemist . Universidad de Santiago de Chile.
María Ignacia Bunster Sobarzo. 2013. Activity of the mineralocorticoid receptor in cells from the immune system during cardiovascular and renal inflammation. Nutricionist. Universidad Andrés Bello de Chile.
María Paz Beltrán Salvo. 2011. Role of Connexin 43 in uremic rats. Biologist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.
Kathia Berczeller Nahum. 2007. Hormonal regulation of sodium-phospphate NaPi III cotransporter implicated in arteriosclerosis. Veterinary Doctor. Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Karla Carolina Pino Lemunao. 2006. Aldosterone effect on the expression of parathyroid hormone receptors in the cardiovascular system. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Andrea Alejandra Villagrán Torres. 2006. Potential aldosterone effect in the cardiovascular system of a experimental model for chronic renal failure. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Antonio Lisboa Galdames.2006. Hiperaldosteronism effect in experimental models for congestive heart failure over the imflamatory immune response.Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Andrés Enrique González Gutiérrez. 2006. Sodium ephitelial channel (ENaC) activity in rat cardiac tissue and its modulation by beta 1 adrenergic agonist. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Roderick Pérez Contreras. 2006. Endothelial sodium epithelial channel (ENAC) modulates the arterial contraction from vascular resistance arteries in the rat. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Rafael Rojas Díaz. 2004. Regulation of the expression of NKCC1 cotransporter by aldosterone in cardiac tissue. Veterinary Doctor, Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Ana María Delpiano Barriga. 2004. Mineralocorticoids regulate the expression of potassium-chloride KCC3 cotransporter in blood vessels but with no effect in arterial tissue. Biochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.
Natalia Dünner Moreno. 2003. Regulation by aldosterone of the genic expression of the NKCC1 cotransporter in cardiovascular tissueBiochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.
Nandy Carolina López Bartolucci. 2002. Expression and regulation by suprarenal steroids of the K+-Cl- cotransporters in arterial tissue. Biochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.


Premios y Distinciones

  •   Young Research Investigator Award

    Chilean Society of Nephrology

    Chile, 2013

    The fibroblast growth factor 23 presents early renal clearance and increase in experimental acute renal dysfunction.

  •   Best Clinical Work Award

    Chilean Society of Transplantation

    Chile, 2013

    Comparison of the diagnostic test of insulin resistance HOMA, ISI and TyG in pediatric renal transplantation

  •   Research Investigator Award

    Latin American Society of Nephrology and Hypertension and XVII Congress of the Colombian Association of Nephrology and Hypertension. 2012

    Colombia, 2012

    Stanniocalcin-1 increases expression in aorta of atherosclerotic animals and induce calcification in VSMC.

  •   Young Investigator Award

    XVth Congress of the International Society of Cardiovascular Pharmacotherapy

    Chile, 2011

    The blockade of interleukin-17 ameliorates the hypertension, and heart inflammation induced by Experimental hiperaldosteronism remodelation.

  •   Best Research Work

    Chilean Society of Transplantation

    Chile, 2011

    Mineral bone disease in renal transplantation : Role of FGF23-Klotho axis.

  •   Best Work Basic Sciences

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2011

    High phosphate and vitamin D induces the expression of Stanniocalcin-1, a new hormone procalcificante in endothelial cells

  •   Best Scientific Work

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2011

    Mineral bone disease in renal transplantation: Role of FGF23-Klotho axis

  •   Best Basic Research

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2010

    The activation of aldosterone receptor promotes the polarization of the Th17 inflammatory pathway in DOCA-salt rats and dendritic cells in vitro.

  •   Best Basic Research

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2009

    Aldosterone activates the inflammatory T helper17 pathway in DOCA-salt rats.

  •   Best Basic Research

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2008

    Aldosterone directly induce the expression of the sodium-phosphate cotransporter and the osteocondrogenic transdifferentiation of the arterial wall

  •   Young Investigator Award

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2007

    Sulprostone regulates expression of alpha - and ENaC -1 alpha subunit of the Na +, K +-ATPase pump in the renal medulla of rats infused with angiotensin II.

  •   Best Basic Research

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2007

    The activity of endothelial nitric oxide synthase is modulated by ENaC present in the endothelium of arteries resistance.

  •   Best Research Work

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2006

    Gene expression and activity of sodium-phosphate cotransporter in experimental vascular of CKD

  •   Best Research Work

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2005

    Spironolactone action in the cardiovascular system uremic rats

  •   Research Investigator Award

    XVII Congreso de la Sociedad Latinoamericana de Nefrología e Hipertensión Arterial SLANH / VIII Congreso Iberoamericano de Nefrología / XXXI Congreso Conjunto de Sociedades Chilenas de Nefrología e Hipertensión

    Chile, 2014

    Dendritic cells are necessary for the development of hypertension and tissue damage in response to angiotensin II and diet rich in salt.

  •   Research Investigator Award

    XVII Congreso de la Sociedad Latinoamericana de Nefrología e Hipertensión Arterial SLANH / VIII Congreso Iberoamericano de Nefrología / XXXI Congreso Conjunto de Sociedades Chilenas de Nefrología e Hipertensión

    Chile, 2014

    Fibroblast Growth Factor 23 has presented early renal clearance and increase in experimental acute renal failure

  •   Editorial Commentary

    Hypertension

    Estados Unidos, 2009

    The (F) low Down on the Endothelial Epithelial Sodium Channel. Epithelial Sodium Channel as a Brake on Flow-Mediated Vasodilation

  •   Invited Speaker

    Symposium New Mechanisms in the Regulation of Vascular Function. Sociedad Chilena de Ciencias Fisiológicas

    Chile, 2007

    Epithelial sodium channel (ENaC) located in the endothelium regulates the production of NO.

  •   Letter to the Editor

    Hypertension

    Estados Unidos, 2008

    Response to Spironolactone Attenuates Oxidative Stress in Patients With Chronic Kidney Disease

  •   Editorial Commentary

    Hypertension

    Estados Unidos, 2008

    Cardiac benefits of Mineralocorticoid Receptor Inhibition in Renal Failure.

  •   Invited Speaker

    World Congress Nephrology

    Brasil, 2007

    Receptor-mediated Endocytosis Symposium

  •   Editorial Commentary

    Hypertension

    Estados Unidos, 2005

    Microvascular Effects of Aldosterone and Angiotensin Type 2 Receptors

  •   Editorial Commentary

    Endocrinology

    Chile, 2005

    Nongenomic Cardiovascular Actions of Aldosterone: A Receptor for All Seasons?

  •   Latin American Scientist Award

    American Society of Nephrology

    Chile, 1998

    Latin American Scientist, 1998, American Society of Nephrology, Washington DC, USA.

  •   Young Investigator Award

    Chilean Societies of Nephrology, Hypertension and Transplant

    Chile, 2003

    Spironolactone and potassium homeostasis in hemodialysis patients

  •   Best Research Work

    XXXV Chilean Congress Internal Medicine

    Chile, 2014

    El factor de crecimiento fibroblástico 23 es un potencial biomarcador de injuria renal aguda en pacientes críticos con sepsis: resultados preliminares de una cohorte prospectiva

  •   The William E. Mitch, III, MD, FASN International Scholars

    American Society of Nephrology.Annual Meeting at Kidney Week 2014.

    Estados Unidos, 2014

    Ablation of Dendritic Cells Prevents Hypertension in Mice Infused with Angiotensin II plus High Salt Diet.

  •   Top Oral Abstracts by Trainees

    ASN Kidney Week 2014 Annual Meeting

    Chile, 2014

    Ablation of Dendritic Cells Prevents Hypertension in Mice Infused with Angiotensin II plus High Salt Diet


 

Article (61)

Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury
Myeloid CD11c(+) Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet
Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct
Tumor-induced osteomalacia: experience from a South American academic center
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species
Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake
Vascular mineralocorticoid receptor and blood pressure regulation
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes
Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial
Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients
Daño arterial asociado a la enfermedad renal crónica: evaluación mediante técnicas de laboratorio no invasivo en pacientes hemodializados
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney
Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons
A Randomized, Double-Blind, Placebo-Controlled Trial of Spironolactone on Carotid Intima-Media Thickness in Nondiabetic Hemodialysis Patients
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity
Cardiovascular assessment of non diabetic patients on hemodialysis
E Prostanoid-1 receptor regulates renal medullary alpha ENaC in rats infused with angiotensin II
Endothelial Epithelial Sodium Channel Inhibition Activates Endothelial Nitric Oxide Synthase via Phosphoinositide 3-Kinase/Akt in Small-Diameter Mesenteric Arteries
Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina
Increased free fetal DNA levels in early pregnancy plasma of women who subsequently develop preeclampsia and intrauterine growth restriction
Regulation of the Sodium-Phosphate Cotransporter Pit-1 and its Role in Vascular Calcification
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload
Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
Na+-K+-2Cl(-) cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels
High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries
Effect of spironolactone on K+ homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients
Estradiol-induced expression of Na+-K+-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors
cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels
Regulation of KCI cotransport (KCC) isoforms expression and activity by aldosterone in vascular tissue.
Toxicity of acetaminophen, salicylic acid, and caffeine for first-passage rat renal inner medullary collecting duct cells
Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells
Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture
Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells
Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells
Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells
p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication
Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat
Effect of casein-derived peptides on D-xylose absorption assessed by H-2 breath test in normal volunteers
Genomic and non-genomic effects of mineralocorticoids in vascular smooth muscle
Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation
Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin
Role of 11 beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries
Toxic effects, pharmacokinetics and clearance of saxitoxin, a component of paralytic shellfish poison (PSP), in cats
Adrenal-dependent modulation of the catalytic subunit isoforms of the Na+-K+-ATPase in aorta
Comparison of extra renal potassium disposal in hypertensive, diabetic and normal subjects
Biochemical evidence for adhesion-promoting role of major intrinsic protein isolated from both normal and cataractous human lenses
Lens major intrinsic protein (MIP) promotes adhesion when reconstituted into large unilamellar liposomes
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle.

Abstract (12)

BIOMARKERS IN ACUTE REJECTION IN PEDIATRIC KIDNEY TRANSPLANTATION
PROTOCOL BIOPSY AND BIOMARKERS OF ACUTE REJECTION IN PEDIATRIC KIDNEY TRANSPLANTATION
STEROID WITHDRAWAL IMMUNOSUPPRESSION IN FGF23/KLOTHO AND IGF-I/IGFBP3 AXIS IN PEDIATRIC KIDNEY TRANSPLANTATION
Biomarkers in Early Acute Rejection in Pediatric Renal Transplantation
Cardiovascular morbimortality in End Stage Renal Disease patients: Effect of spironolactone
Cardiac expression of degenerin/epithelial sodium channel proteins and potential modulation by mineralocorticoids
Effect of vasopressin and DOCA-salt in 11(beta)over-barhydroxysteroid deshydrogenase type 2 and mineralocorticoid receptor expression in cardiac tissue
Functional and structural cardiac responses to spironolactone in uremic rats
Non diabetic end stage renal disease patients in chronic hemodialysis have high prevalence of cardiovascular damage
Proinflammatory cytokines and cardiovascular damage in chronic hemodialysis patients
Adrenal steroids regulate the KCl cotransporter KCC4 isoform expression in cardiac muscle
Modulatory role of 11 beta-hydroxysteroid dehydrogenase on rapid effects of adrenocorticosteroids in vascular tissue

BookSection (3)

Fisiología de la mama en la era molecular
Sistema Renina Angiotensina Aldosterona
Sistema Renina Angiotensina Aldosterona: concepto clásico y nuevos paradigmas.

Letter (2)

Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure Reply
Response to Spironolactone Attenuates Oxidative Stress in Patients With Chronic Kidney Disease

Proyecto (28)

Validación de un Biomarcador Combinado para el Diagnóstico Precoz de Injuria Renal Aguda: Estudio Clínico Prospectivo Multicéntrico
DIETARY CHLORIDE IN THE DEVELOPMENT OF HYPERTENSION: A NEW PLAYER REGULATING INTRARENAL RENIN-ANGIOTENSIN SYSTEM AND DENDRITIC CELL ACTIVITY?
Dietary chloride in the development of hypertension=> a new player regulating intrarenal renin-angiotensin system and dendritic cell activity?
REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION.
ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES=> REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP.
Instituto Milenio Inmunología e Inmunoterapia
Instituto Milenio Inmunología e Inmunoterapia
THE INCRETIN GLUCAGON-LIKE PEPTIDE I=> STUDY OF NEW METABOLIC MECHANISMS IN VASCULAR REMODELING
ANGIOTENSIN-(1-9)=> A NEW PEPTIDE REGULATOR OF BLOOD PRESSURE THAT DECREASES CARDIOVASCULAR REMODELING AND RENAL INJURY
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases
MECANISMOS DE ARTERIOESCLEROSIS EN LA INSUFICIENCIA RENAL CRONICA=> REGULACION DE LOS TRANSPORTADORES DE FOSFATO Y TRANSDIFERENCIACION DEL MUSCULO LISO POR ALDOSTERONA Y LEPTINA
Millennium Nucleus on Immunology and Immunotherapy
Centro FONDAP, Centro Estudios Moleculares de la Célula
Centro FONDAP, Centro Estudios Moleculares de la Célula
ESTADO INMUNOLOGICO PROINFLAMATORIO MEDIADO POR ALDOSTERONA. ESTUDIO CLINICO Y EXPERIMENTAL DE LA FUNCION INMUNE Y ENDOTELIAL EN EL DANO CARDIOVASCULAR INDUCIDO POR HIPERALDOSTERONEMIA
MECANISMOS DE CARDIOPROTECCION DE ANTAGONISTAS DE ALDOSTERONA Y SU ACCION EN EL DANO CARDIOVASCULAR DE LA IRC=>ESTUDIOS CLINICOS Y EXPERIMENTALES.
POTENCIAL PARTICIPACION DE VASOPRESINA EN EL DANO CARDIOVASCULAR INDUCIDO POR ALTA INGESTA DE SAL Y MINERALOCORTICOIDES.
MECANISMOS DE CARDIOPROTECCION DE ANTAGONISTAS DE ALDOSTERONA Y SU ACCION EN EL DAÑO CARDIOVASCULAR DE LA INSUFICIENCIA RENAL CRONICA=>ESTUDIOS CLINICOS Y EXPERIMENTALES.
REGULACION HORMONAL DE TRANSPORTADORES IONICOS DEL MUSCULO LISO VASCULAR Y SU EFECTO EN LA CONTRACTILIDAD Y PROLIFERACION CELULAR.
REGULACION HORMONAL DE LOS TRANSPORTES VASCULARES DE SODIO Y SU RELACION CON LA REACTIVIDAD VASCULAR
SEPARACION Y PURIFICACION DE FRACCIONES DE POLIPEPTIDOS DE LA CASEINA, ESTUDIO DE SU EFECTO EN LA ABSORCION, MOTILIDAD Y TRANSITO DEL INTESTINO DELGADO
PURIFICACION DE DOS PROTEINAS INTRINSECAS DE MEMBRANA PRESENTES EN CRISTALINOS DE MAMIFEROS.
ACOPLAMIENTO ESTIMULO-PERMEABILIDAD=> ROL DE HORMONAS POLIPEPTIDICAS Y DE MENSAJEROS CELULARES.
ANGIOTENSIN-(1-9): A NEW PEPTIDE REGULATOR OF BLOOD PRESSURE THAT DECREASES CARDIOVASCULAR REMODELING AND RENAL INJURY
REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION
ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES: REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP
THE INCRETIN GLUCAGON-LIKE PEPTIDE I: STUDY OF NEW METABOLIC MECHANISMS IN VASCULAR REMODELING

Review (3)

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system
Influence of glucose metabolism on vascular smooth muscle cell proliferation
Aldosterone as a modulator of immunity: implications in the organ damage
93
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Cristián Amador

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

6
Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

5
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

4
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

3
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

3
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

3
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

3
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile

3
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

3
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Francisco Espinoza

Profesor Asistente

Medicina Interna

Universidad de los Andes

Santiago, Chile

2
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

2
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

2
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

2
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

2
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

2
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

2
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

2
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

2
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

2
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

2
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Nestor Lagos

Full Professor

Fisiología y Biofísica

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

2
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Patricio Araos

Estudiante Doctorado

Fisiología

University of Chile

Santiago, Chile

1
Viola Pinto

Jefe

Hospital de niños Dr. Exequiel González Cortés

Santiago, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

1
Andrés Tittarelli

Investigador

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Alvaro Gonzalez

Chief Technology Officer

Cellter

Santiago, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Edio Maldonado

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Pablo Florenzano

Instructor

Endocrinologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

1
Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

1
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

1
Alejandro Arriagada

Coordinador y docente

Núcleo de Ciencias Biológicas

Universidad Mayor de Chile

Santiago, Chile

1
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Alvaro Becerra

Coordinador Academico

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gilberto González

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

1
Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

1
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carlos Romero

Medico Intensivista

Medicina

Hospital Clinico Universidad de Chile

Santiago, Chile