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Clemente Javier Palacios Díez

Académico

Universidad Arturo Prat

Iquique, Chile

Efecto vascular y cardiovascular de extractos de plantas medicinales y sus metabolitos. Estudio de los mecanismos fisiológicos involucrados y rol del estrés oxidativo.

Ciencias Ph.D., Universidad de Navarra. España, 2001
Bioquímico, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1987

académico e investigador Part Time

UNIVERSIDAD DE LOS ANDES

Medicina

Santiago, Chile

1997 - 2004
académico e investigador Part Time

UNIVERSIDAD CATOLICA DEL NORTE

Ciencias

Antofagasta, Chile

2004 - 2008
Profesor Asociado Full Time

Universidad del Mar

Iquique, Chile

2009 - 2012
Profesor Titular Full Time

UNIVERSIDAD ARTURO PRAT

Facultad Ciencias de la Salud

Iquique, Chile

2013 - A la fecha

Académico Full Time

Universidad Arturo Prat

IQUIQUE, Chile

2013 - A la fecha


A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization Palacios, Javier; Paredes, Adrian; Cifuentes, Fredi; Luis Garcia-Villalon, Angel; Borquez, Jorge; Foster, Amy; Greensmith, David J. Article ISI SCOPUS Journal of Ethnopharmacology (2023)
Alterations of the Oestrous Cycle and Increase in the Blood Pressure in Normotensive Female Rats by Continuous Exposure to Light Palacios, Javier; Rios, Miguel; Escobar, Jorge Article ISI SCOPUS Pakistan Veterinary Journal (2023)
Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (Drimys winteri J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits Cifuentes, Fredi; Palacios, Javier; Romero-Jola, Nestor Jaime; Paredes, Adrian Article ISI SCOPUS Foods (2023)
UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries Ramos, Lucia Cuesta; Palacios, Javier; Castagnini, Juan Manuel; Barba, Francisco J.; Tapia, Alejandro; Paredes, Adrian; Cifuentes, Fredi Article ISI SCOPUS Foods (2023)
Artocarpus Altilis (Breadfruit) could Reverse Myocardial Infarction Through the Normalization of the Oxygen Haemoglobin Dissociation Curve Anderson, Tanya; James-Green, Tameika; Pepple, Dagogo Article SCOPUS Cardiovascular and Hematological Agents in Medicinal Chemistry (2022)
Lepidium meyenii Walp (red maca) Supplementation Prevents Acrylamide-Induced Oxidative Stress and Liver Toxicity in Rats: Phytochemical Composition by UHPLC-ESI-MS/MS Palacios, Javier; Duarte Galhardo de Albuquerque, Ricardo Diego Article ISI SCOPUS Plant Foods for Human Nutrition (2022)
Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism Palacios, Javier; Paredes, Adrian; Cifuentes, Fredi Article ISI SCOPUS Molecules (2022)
Phenolic Fingerprinting and Bioactivity Profiling of Extracts and Isolated Compounds from Gypothamnium pinifolium Phil. Paredes, Adrian; Cifuentes, Fredi; Palacios, Javier; Borquez, Jorge Article ISI SCOPUS Antioxidants (2022)
High-performance thin-layer chromatography for rutin, chlorogenic acid, caffeic acid, ursolic acid, and stigmasterol analysis in periploca aphylla extracts Orfali R.; Perveen S.; Aati H.Y.; Alam P.; Noman O.M.; Palacios J.; Al-Kurbi B.S.S.; Al-Taweel A.M.; Khan A.; Mehmood R.; et al. Article SCOPUS Separations (2021)
Impact of the Potential Antitumor Agent 2-(4-Hydroxyphenyl) Amino-1,4-Naphthoquinone (Q7) on Vasomotion Is Mediated by the Vascular Endothelium, But Not Vascular Smooth Muscle Cell Metabolism Palacios, Javier; Chiong, Mario; Paredes, Adrian; Cifuentes, Fredi Article ISI SCOPUS Journal of Cardiovascular Pharmacology (2021)
Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude Palacios, Javier Article ISI SCOPUS Reproductive Medicine and Biology (2021)
Blood pressure-reducing activity of Gongronema latifolium Benth. (Apocynaeceae) and the identification of its main phytochemicals by UHPLC Q-Orbitrap mass spectrometry Beshel J.A.; Beshel F.N.; Nku C.O.; Owu D.U. Article SCOPUS Journal of Basic and Clinical Physiology and Pharmacology (2020)
Chemical Fingerprinting, Isolation and Characterization of Polyphenol Compounds fromHeliotropium taltalense(Phil.) IM Johnst and Its Endothelium-Dependent Vascular Relaxation Effect in Rat Aorta Simirgiotis, Mario J.; Palacios, Javier; Paredes, Adrian; Borquez, Jorge; Cifuentes, Fredi Article ISI SCOPUS Molecules (2020)
Fast Isolation of Flavonoids from the Endemic Species Nolana ramosissima IM Johnst and Its Endothelium-Independent Relaxation Effect in Rat Aorta Cifuentes, Fredi; Palacios, Javier; Borquez, Jorge; Paredes, Adrian; Simirgiotis, Mario J. Article ISI SCOPUS Molecules (2020)
Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats Palacios, Javier; Paredes, Adrian; Cifuentes, Fredi Article ISI SCOPUS Scientific Reports (2020)
Metabolomic Profiling of Mango (Mangifera indica Linn) Leaf Extract and Its Intestinal Protective Effect and Antioxidant Activity in Different Biological Models Palacios, Javier; Borquez, Jorge; Simirgiotis, Mario J.; Cifuentes, Fredi; Paredes, Adrian Article ISI SCOPUS Molecules (2020)
Protective effects of apocynin against cadmium toxicity and serum parameters; evidence of a cardio-protective influence Rattray V.R.; McCalla G.; McGrowder D. Article ISI SCOPUS Inorganica Chimica Acta (2020)
Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat Cifuentes, Fredi; Palacios, Javier; Borquez, Jorge; Simirgiotis, Mario J.; Chiong, Mario; Paredes, Adrian Article ISI SCOPUS ANTIOXIDANTS (2019)
8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx Cifuentes, Fredi; Palacios, Javier; Paredes, Adrian Article ISI SCOPUS MOLECULES (2018)
Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats Palacios, Javier; Miguel Fonseca, Jose; Marcelo Sandoval, Juan; Paredes, Adrian; Luis Vega, Jose; Cifuentes, Fredi Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats Cifuentes, Fredi; Palacios, Javier; Kuzmicic, Jovan; Quispe, Cristina; Morales, Glauco; Chiong, Mario; Paredes, Adrian Article ISI SCOPUS PHYTOMEDICINE (2018)
Aqueous extract from leaf of Artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: Negative chronotropic and inotropic effects Nwokocha, Chukwuemeka; Thomas, Jemesha; Nwokocha, Magdalene; Young, Lauriann; Thompson, Rory; Delgoda, Rupika Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2017)
Hydroalcoholic extract and pure compounds from Senecio nutans Sch Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms Nwokocha, Chukwuemeka R. Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2016)
Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch Bip. (Compositae) in mice: Chronotropic and negative inotropic effect, a nifedipine-like action Cifuentes F.; Paredes Ã.; Palacios J.; Munoz F.; Carvajal L.; Nwokocha C.R.; Morales G. Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2016)
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta González, Constanza; Cartes-Saavedra, Benjamín Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide Cifuentes F.; Palacios J.; Nwokocha C.R. Article ISI SCOPUS CARDIOVASCULAR TOXICOLOGY (2016)
Effect of phenylephrine and endothelium on vasomotion in rat aorta involves potassium uptake Palacios J.; Vega J.L.; Paredes Ã.; Cifuentes F. Article ISI SCOPUS Journal of Physiological Sciences (2013)
Exposure to Low Level of Arsenic and Lead in Drinking Water from Antofagasta City Induces Gender Differences in Glucose Homeostasis in Rats Palacios J.; Román, D; Cifuentes F. Article ISI SCOPUS Biological Trace Element Research (2012)
Chronic Exposure to Arsenic in Tap Water Reduces Acetylcholine-induced Relaxation in the Aorta and Increases Oxidative Stress in Female Rats Cifuentes F.; Bravo J.; Norambuena M.; Stegen, S; Ayavire, A; Palacios J. Article ISI SCOPUS INTERNATIONAL JOURNAL OF TOXICOLOGY (2009)
Na+-K+-2Cl(-) cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine Palacios J.; Espinoza F.; Munita C.; Cifuentes F.; Michea L. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2006)
Estradiol-induced expression of Na+-K+-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors Palacios J.; Marusic, ET; González, M.; Michea L. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)


The Role of NADP(H) Oxidase Inhibition and Its Implications in Cardiovascular Disease Management Using Natural Plant Products Reid, Melissa. Spence, Janson. Nwokocha, Magdalene. Palacios, Javier. Nwokocha, Chukwuemeka.; Atta-ur-Rahman BookSection (2018)


Oxidant-induced disruption of vascular K+ channel function: implications for diabetic vasculopathy Nwokocha C.; Palacios J.; Ojukwu V.E.; Nna V.U.; Owu D.U.; Nwokocha M.; McGrowder D.; Orie N.N. Review ISI SCOPUS Archives of Physiology and Biochemistry (2024)