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Julio Wilfredo Benites Vílchez

Profesor Titular

Universidad Arturo Prat

Iquique, Chile

Química de Quinonas y Química de Productos Naturales

Químico Farmacéutico, Universidad Nacional de Trujillo. Peru, 1994
Farmacia y Bioquímica, Universidad Nacional de Trujillo. Peru, 1994
Doctor en Ciencias Exactas con Mención en Química, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Profesor Titular Full Time

Universidad Arturo Prat

Ciencias de la Salud

Iquique, Chile

2001 - A la fecha

Académico Full Time

Universidad Nacional de Trujillo

Trujillo, Peru

1995 - 1995
Académico-Ayudante Other

Pontificia Universidad Católica de Chile

Santiago, Chile

1996 - 2000

He dirigido 17 tesis de pre-grado y 3 tesis de postgrado


A Review of the Actions of Endogenous and Exogenous Vasoactive Substances during the Estrous Cycle and Pregnancy in Rats Jaimes, Luisauris; Vinet, Raúl; Knox, Marcela; Morales, Bernardo; Benites, Julio; Laurido, Claudio; Martínez, José Article ISI SCOPUS Animals (2019)
Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-Bis(phenylamino)-1,4-benzoquinones on Cancer Cells Benites, Julio; VALDERRAMA, JAIME A; Ramos, Maryan; Valenzuela, Maudy; Guerrero-Castilla, Angélica; Muccioli, Giulio G.; Buc Calderon, Pedro Article ISI SCOPUS MOLECULES (2019)
Inhibition of Escherichia coli and Bacillus subtilis FtsZ Polymerization and Bacillus subtilis Growth by Dihydroxynaphtyl Aryl Ketones Araya, Gissela; Benites, Julio; Reyes, Juan S.; Marcoleta, Andrés E.; VALDERRAMA, JAIME A; Lagos, Rosalba; Monasterio, Octavio Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2019)
Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats Palacios, Javier; Miguel Fonseca, Jose; Ayavire, Fernando; Salas, Felipe; Ortiz, Mirko; Marcelo Sandoval, Juan; Benites, Julio; Nwokocha, Chukwuemeka R.; Zavala, Ewaldo; Paredes, Adrian; Barria, Ivan; Luis Vega, Jose; Cifuentes, Fredi Article ISI SCOPUS Oxidative Medicine and Cellular Longevity (2018)
Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta Martinez, Jose L.; Benites, Julio; Gomez, Harold; Vargas-Rueda, Silvia; Vinet, Raul; Jaimes, Luisauris; Laurido, Claudio Article ISI SCOPUS ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2018)
In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones Benites, J; Toledo, H; Salas, F; Guerrero, A; Rios, D; VALDERRAMA, JA; CALDERON, PB Article ISI Oxidative Medicine and Cellular Longevity (2018)
Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study Benites, J; Valderrama, JA; Ramos, M; Muccioli, GG; Calderon, PB Article ISI SCOPUS BIOMEDICINE & PHARMACOTHERAPY (2018)
Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate Valderrama, JA; Garrido, J; Delgado, V; Benites, J; Theoduloz, C Article ISI SCOPUS MOLECULES (2017)
Crystal structure of 11-(p-coumaroyloxy)tremetone, C22H20O5 Brito, Iván; Simirgiotis, Mario; Muñoz, Rubén; Benites, Julio; Pasten, Leyla; Bórquez, Jorge; Cárdenas, Alejandro Article ISI SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2017)
Metabolomic Analysis of the Lichen Everniopsis trulla Using Ultra High Performance Liquid Chromatography-Quadrupole-Orbitrap Mass Spectrometry (UHPLC-Q-OT-MS) Castro, Olivio N.; Benites, Julio; Rodilla, Jesus; Santiago, Julio C.; Simirgiotis, Mario; Sepulveda, Beatriz; Areche, Carlos Article ISI SCOPUS CHROMATOGRAPHIA (2017)
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones Valderrama, Jaime A.; Cabrera, Mónica; Benites, Julio; Ríos, David; Inostroza-Rivera, Ricardo; Muccioli, Giulio G.; Calderon, Pedro Buc Article ISI SCOPUS RSC ADVANCES (2017)
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones Valderrama, Jaime A.; Cabrera, Mónica; Benites, Julio; Ríos, David; Inostroza, Ricardo; Buc Calderón, Pedro Article RSC Advances (2017)
ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES JUANA ANDREA IBACACHE; JAIME A VALDERRAMA; VERÓNICA ARANCIBIA; Cristina Theoduloz; GIULIO G MUCCIOLI; Julio Benites Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2016)
Chemical composition and antimicrobial activity of essential oil of Peruvian Dalea strobilacea Barneby Benites, Julio; Moiteiro, Cristina; Figuereido, Ana Cristina; Rijo, Patricia; Buc-Calderon, Pedro; Bravo, Felipe; Gajardo, Sandra; Sanchez, Isidoro; Torres, Iván; Ganoza, Mayar. Article Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2016)
CRYSTAL STRUCTURE OF (1,4-DIHYDROXYNAPHTHALEN-2-YL) (4'-METHOXYPHENYL) METHANONE Julio Benites; JAIME A VALDERRAMA; DAVID RÍOS; ALEJANDRO CÁRDENAS; IVÁN BRITO Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2016)
Crystal structure of (2,5-dihydroxyphenyl)-(4-hydroxy-3,5-dimethoxyphenyl)methanone, C15H14O6 Benites, J.; VALDERRAMA, JA; Rios, D.; Cardenas, A; Brito, I Article ISI SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2016)
Crystal structure of (2,5-dihydroxyphenyl)-(4-methoxyphenyl)methanone, C14H12O4 Benites, J.; VALDERRAMA, JA; Rios, D.; Cardenas, A; Brito, I Article ISI SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2016)
Crystal structure of 5-hydroxy-4-((4-hydroxyphenyl)imino)naphthalen-1(4H)-one monohydrate, C16H11NO3 center dot 0.5H(2)O Benites, J.; VALDERRAMA, JA; Estela, C; Rios, D.; Cardenas, A; Brito, I Article ISI SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2016)
Determination of sun protection factor and antioxidant properties of six Chilean Altiplano plants Gajardo, Sandra; Aguilar, Marilú; Stowhas, Tamara; Salas, Felipe; López, José; Quispe, Cristina; Buc-Calderón, Pedro; Benites, Julio Article Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2016)
In vivo inhibition of tumor progression by 5-hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate Ourique, Fabiana; Kviecinski, Maicon Roberto; Zirbel, Guilherme; Castro, Luiza S.W; Castro, Allison J; Barreto, Fatima Regina M; Valderrama, Jaime A.; Rios, David; Benites, Julio; Buc Calderon, Pedro; Curi Pedrosa, Rozangela. Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones Benites, Julio; Valderrama, Jaime A.; Ríos, David; Lagos, Rosalba; Monasterio, Octavio; Calderon, Pedro Buc Article ISI SCOPUS Molecular and Cellular Toxicology (2016)
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones Benites Julio, Valderrama Jaime A., Ríos David, Lagos Rosalba, Monasterio Octavio and Buc Calderon Pedro Article Molecular & Cellular Toxicology (2016)
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta palacios, javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong, Mario; Cartes-Saavedra, Benjamín; Lafourcade, Carlos; Wyneken, Ursula; González, Pamela; Owen, Gareth I.; Pardo, Fabián; Sobrevia, Luis; Buc Calderon, Pedro Article ISI SCOPUS Oxidative Medicine and Cellular Longevity (2016)
Modulatory effect of 2-(4-hydroxyphenyl)amino-1,4-naphthoquinone on endothelial vasodilation in rat aorta Palacios, Javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong, Mario; Cartes-Saavedra, Benjamin; Lafourcade, Carlos; Wyneken, Ursula; González, Pamela; Owen, Gareth; Buc Calderon, Pedro M.; Pardo, Fabián and Sobrevia, Luis. Article Oxidative Medicine and Cellular Longevity (2016)
Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS Simirgiotis, MJ; Benites, J.; Areche, C; Sepúlveda B. Article ISI SCOPUS MOLECULES (2015)
Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly Gutierrez, E.; Benites, J.; VALDERRAMA, JA; CALDERON, PB; Verrax J.; NOVA, E; Villanelo, F; Maturana D.; Escobar C.; Lagos R.; Monasterio O. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2015)
DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate Ourique, F; Kviecinski, MR; Felipe, KB; Correia, JFG; Farias, MS; Castro, LSEPW; Grinevicius, VMAS; Valderrama J.; Rios, D.; Benites, J.; CALDERON, PB; Pedrosa, RC Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls Parra, T; Benites, J.; Ruiz, LM; Sepúlveda B.; Simirgiotis, M.; Areche, C Article ISI SCOPUS Bioorganic and Medicinal Chemistry Letters (2015)
Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b] quinazoline-7,12-quinones VALDERRAMA, JA; Rios, D.; Muccioli, GG; CALDERON, PB; Brito, I; Benites, J. Article ISI SCOPUS Tetrahedron Letters (2015)
Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium flabelliforme and Its Gastroprotective Effect in Mouse Model Areche, C; Benites, J.; Cornejo A.; Ruiz, LM; Garcia-Beltran, O; Simirgiotis, MJ; Sepúlveda B. Article ISI SCOPUS MARINE DRUGS (2015)
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch) Benites, J.; Tello V.; Flores, N.; Tapia, D; Lopez, J.; Rios, D.; Buc Calderon, P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2014)
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch) [Aceite esencial de Acantholippia deserticola como pesticida natural contra plagas agrícolas como mosquita blanca algodonosa [Aleurothrixus floccosus (Maskell)], falsa arañita de la vid (Brevipalpus chilensis Baker) y arañita bimaculada (Tetranychus urticae Koch)] Benites, J.; Tello V.; Flores, N.; Tapia, D; Lopez, J.; Rios, D.; Buc-Calderon P. Article SCOPUS Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2014)
GREEN SYNTHETIC APPROACHES TO FUROYLNAPHTHOHYDROQUINONE AND JUGLONE Benites, J.; Cortes, M; Miranda L.; Estela, C; Rios, D.; Arenas, J; VALDERRAMA, JA Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Oxidative phenylamination of 5-substituted 1-hydroxynaphthalenes to N-phenyl-1,4-naphthoquinone monoimines by air and light on water Benites, J.; Meléndez J.; Estela, C; Rios, D.; Espinoza L.; Brito, I; VALDERRAMA, JA Article ISI SCOPUS BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2014)
Substituted 3-acyl-2-phenylamino-1,4-naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death Farias, MS; Pich, CT; Kviecinski, MR; Bucker, NCF; Felipe, KB; Da Silva, FO; Gunther, TMF; Correia, JF; Rios, D.; Benites, J.; VALDERRAMA, JA; CALDERON, PB; Pedrosa, RC Article ISI SCOPUS MOLECULAR MEDICINE REPORTS (2014)
Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones Rios, D.; Benites, J.; Torrejón F; Theoduloz, C; VALDERRAMA, JA Article ISI SCOPUS MEDICINAL CHEMISTRY RESEARCH (2014)
Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones Ibacache J.A.; Delgado, V; Benites, J.; Theoduloz, C; Arancibia, V; Muccioli, G. G.; Valderrama, J.A. Article ISI MOLECULES (2014)
VALIDATION OF A METHOD TO DETECT CENTRAL NERVOUS SYSTEM ACTING DRUGS IN BLOOD BY GC/MS. APPLICATION IN CASES OF DEATH CAUSED BY PHENOTHIAZINES IN THE NORTH OF CHILE Felipe Bravo; Roberto Ulloa; KARINA VENEGAS; MARIA CECILIA CONTZEN; DAVID RÍOS; MARGARITA BRICE; PEDRO BUC CALDERONI; Julio Benites Article SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2014)
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats Benites, J.; Bustos L.; Rios, D.; Bravo F.; Lopez, J.; Gajardo S.; Rojo L.; Buc Calderon, P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2013)
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats [Efecto ansiolítico y antidepresivo del aceite esencial de Acantholippia deserticola phil en ratas hembras] Benites, J.; Bustos L.; Rios, D.; Bravo F.; LÃ³pez J.; Gajardo S.; Rojo L.; Buc-Calderon P. Article SCOPUS Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2013)
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells Felipe, KB; Benites, J.; Glorieux C.; Sid, B.; Valenzuela,M.; Kviecinski, MR; PedrosaA, RC; VALDERRAMA, JA; Leveque, P; Gallez, B; Verrax J.; CALDERON, PB Article ISI SCOPUS Biochemical and Biophysical Research Communications (2013)
Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones Arenas, P; Peña A; Rios, D.; Benites, J.; Muccioli, GG; CALDERON, PB; VALDERRAMA, JA Article ISI SCOPUS MOLECULES (2013)
FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD Bravo, Felipe; ZAMBRA, CARMEN; VENEGAS, KARINA; Rios, David; Buc Calderon, Pedro; Benites, Julio Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2013)
Biological evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones as inhibitors of Hsp90 chaperoning function David Ríos; Julio Benites; Jaime A. Valderrama; Mirelle Farias; Rozangela C. Pedrosa; Pedro Buc Calderon ; Julien Verrax Article Current Topics in Medicinal Chemistry (2012)
Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine Parastrephia lepidophylla Benites, J.; Gutierrez, E.; Lopez, J.; Rojas M.; Rojo L.; Do Ceu Costa M.; Vinardelld M.P.; Calderon P.B. Article ISI SCOPUS Natural Product Communications (2012)
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells Kviecinski M.R.; Pedrosa R.C.; Felipe K.B.; Farias M.S.; Glorieux C.; Valenzuela,M.; Sid, B.; Benites, J.; Valderrama, J.A.; Verrax J.; Buc Calderon, P. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2012)
Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones Iribarra J.; Vásquez D.; Theoduloz, C; Benites, J.; Rios, D.; Valderrama, J.A. Article ISI SCOPUS MOLECULES (2012)
VALIDATION OF A METHOD TO DETECT COCAINE AND BENZOYLECGONINE IN HUMAN WHOLE BLOOD BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND APPLICATION IN BODY PACKERS AND STUFFERS CASES IN THE NORTH OF CHILE Bravo F.; Contzen M.C.; Mollo J.; Calderon P.B.; Benites, J. Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2012)
An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities Benites, J.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS Investigational New Drugs (2011)
CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF Xenophyllum poposum Benites, J.; Lopez, J.; Rojo, LE; Díaz P; Rojas M.; Fuentes R.; Moiteiro, C; Venancio, F Article ISI SCOPUS Chemistry of Natural Compounds (2011)
COMPOSITION AND ANTIMICROBIAL SCREENING OF THE ESSENTIAL OIL FROM THE LEAVES AND STEMS OF Senecio atacamensis Phil. FROM CHILE Benites, J.; Bravo F.; Rojas M.; Fuentes R.; Moiteiro, C; Venancio, F Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2011)
DEVELOPMENT AND VALIDATION OF A SOLID-PHASE EXTRACTION GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF OPIOID DRUGS IN HUMAN WHOLE BLOOD AND PLASMA Bravo F.; González D; Benites, J. Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2011)
Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents Jaime A. Valderrama; Andrea Ibacache; Jaime A. Rodriguez; Cristina Theoduloz; Julio Benites Article European Journal of Medicinal Chemistry (2011)
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress Verrax J.; Beck R.; Dejeans N.; Glorieux C.; Sid, B.; Calderon P.B.; Pedrosa R.C.; Benites, J.; Vásquez D.; Valderrama, J.A. Article ISI SCOPUS Anti-Cancer Agents in Medicinal Chemistry (2011)
Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents VALDERRAMA, JA; Ibacache, A.; Rodriguez JA.; Theoduloz, C; Benites, J. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
The solar-chemical photo-Friedel-Crafts heteroacylation of 1,4-quinones Benites, J.; Rios, D.; Díaz P; Valderrama, J.A. Article ISI SCOPUS Tetrahedron Letters (2011)
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents Benites, J.; VALDERRAMA, JA; Bettega, K; Pedrosa, RC; CALDERON, PB; Verrax J. Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
DEVELOPMENT AND VALIDATION OF A GC-NPD/micro-ECD METHOD USING DUAL COLUMN FOR THE DETERMINATION OF BENZODIAZEPINE IN HUMAN WHOLE BLOOD AND PLASMA Bravo F.; Lobos, C; Venegas K.; Benites, J. Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2010)
Antioxidant capacity and polyphenolic content of twelve traditionally used herbal medicinal infusions from the South American Andes Rojo, LE; Benites, J.; Lopez, J.; Rojas M.; Díaz P; Ordoñez J.; Pastene, E. Article ISI SCOPUS BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2009)
Comparative study on the antioxidant effects and phenolic content of twelve highly consumed medicinal plants from SouthAmerican Andes Leonel E. Rojo; Julio Benites; José López; Mauricio Rojas; Pilar Diaz; Edgar Pastene; Jose Ordoñez Article Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (BLACPMA) (2009)
COMPOSITION AND BIOLOGICAL ACTIVITY OF THE ESSENTIAL OIL OF PERUVIAN LANTANA CAMARA Benites, J.; Moiteiro, C; Miguel, G; Rojo L.; Lopez, J.; Venancio, F; Ramalho, L; Feio, S; Dandlen, S; Casanova, H.; Torres, I Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2009)
Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C Benites, J.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS CHEMICAL PHARMACEUTICAL BULLETIN (2009)
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line Benites, J.; Rojo L.; VALDERRAMA, JA; Taper, H.; CALDERON, PB Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines Benites, J.; VALDERRAMA, JA; Rivera, F; Rojo L.; Campos N.; Pedro, M; Nascimento, MSJ Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Time course of endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats Farias, JG; Bustos-Obregon, E; Tapia, PJ; Gutierrez, E.; Zepeda, A; Juantok, C; Cruz, G.; Soto G.; Benites, J.; Reyes JG. Article ISI SCOPUS JOURNAL OF REPRODUCTION AND DEVELOPMENT (2008)
Composition and antimicrobial screening of the essential oil of Acantholippia deserticola (Phil.ex F. Phil.) Moldenke Rojo L.; Benites, J.; Rodrigues, A; Venancio, F; Ramalho, L; Teixeira A.; Feio, S; Costa, MDC Article ISI SCOPUS JOURNAL OF ESSENTIAL OIL RESEARCH (2006)
Mild and rapid method for the generation of o-quinone methide intermediates. Synthesis of puupehedione analogues Barrero, AF; del Moral, JFQ; Herrador, MM; Arteaga P.; Cortes, M; Benites, J.; Rosellon, A Article ISI SCOPUS TETRAHEDRON (2006)
New cyclic acetals related to Ambergris and their olfactory evaluation Benites, J.; Armstrong, V; Cortes, M Article ISI SCOPUS JOURNAL OF CHEMICAL RESEARCH-S (2006)
THE PREPARATION OF OXYGENATED DERIVATIVES OF AMBROX AND ISOAMBROX FROM DRIMENOL Benites, J.; Lopez, J.; Farias, JG; Cortes, M Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2006)
Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones VALDERRAMA, JA; Benites, J.; Cortes, M; Pessoa-Mahana H.; Prina, E; Fournet, A Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Studies on quinones. Part 35: Access to antiprotozoal active euryfurylquinones and hydroquinones VALDERRAMA, JA; Benites, J.; Cortes, M; Pessoa-Mahana D.; Prina, E; Fournet, A Article ISI SCOPUS TETRAHEDRON (2002)
Conversion of (+)-confertifolin into 11,12-bisnordriman-9-one and (+)-8 alpha H,9 alpha H-11,12-diacetoxydrimane Benites, J.; Preite, MD.; Cortes, M Article ISI SYNTHETIC COMMUNICATIONS (2001)
Regiospecific Michael reaction of (+)-euryfuran with activated 1,4-benzoquinones VALDERRAMA, JA; Cortes, M; Pessoa-Mahana D.; Preite, M; Benites, J. Article ISI SCOPUS TETRAHEDRON LETTERS (2000)


Dihydroxynaphthyl aryl ketones as tubulin polymerization and cancer cell growth inhibitors Monasterio O.; Gutierrez, E.; Benites, J.; VALDERRAMA, JA; CALDERON, PB; Verrax J.; NOVA, E; Villanelo, F; Maturana D.; Lagos R. Abstract ISI FEBS JOURNAL (2014)


Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function Rios, D.; Benites, J.; Valderrama, J.A.; Farias M.; Pedrosa R.C.; Verrax J.; Calderon P.B. Review ISI CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

Pedro Buc

Profesor titular

Quimica y Farmacia

Universidad Arturo Prat

Iquique, Chile

Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Jorge Farias

Full Professor

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

MARIO SIMIRGIOTIS

full professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Juana Ibacache

académico

Ciencias del ambiente

Universidad de Santiago de Chile

Santiago, Chile

Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

David Vásquez

Profesor Asistente

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE

Santiago, Chile

Victor Tello

ACADEMICO JORNADA COMPLETA

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

Juan Sandoval

Profesor Asistente

UNIVERSIDAD ARTURO PRAT

Iquique, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Luis Espinoza

Assistant Professor

Chemistry

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

Raul Vinet

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Jorge Borquez

Académico

Química

Universidad de Antofagasta

Antofagasta, Chile

ANGÉLICA GUERRERO

Directora de Carrera

Facultad de Medicina y Ciencias

Universidad San Sebastián

valdivia, Chile

PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Felipe Villanelo

Investigador

Fundacion Ciencia y Vida

Santiago, Chile

Iván Barría

Investigador Post doctoral

Centro Interdisciplinario de Neurociencia de Valparaíso

Valparaíso, Chile

Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

Andrés Marcoleta

Profesor Asistente

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

Andrea Zepeda

Docente/Investigador

Universidad Autónoma de Chile

Temuco, Chile

Marcelo Preite

Associate Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Julio Wilfredo Benites Vílchez

Líneas de Investigación

Educación

Químico Farmacéutico, Universidad Nacional de Trujillo. Peru, 1994

Farmacia y Bioquímica, Universidad Nacional de Trujillo. Peru, 1994

Doctor en Ciencias Exactas con Mención en Química, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

Profesor Titular Full Time

Experiencia Profesional

Académico Full Time

Académico-Ayudante Other

Formación de Capital Humano

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