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Julio Wilfredo Benites Vílchez

Profesor Titular

Universidad Arturo Prat

Iquique, Chile

Líneas de Investigación


Química de Quinonas y Química de Productos Naturales

Educación

  •  Químico Farmacéutico, Universidad Nacional de Trujillo. Peru, 1994
  •  Farmacia y Bioquímica, Universidad Nacional de Trujillo. Peru, 1994
  •  Doctor en Ciencias Exactas con Mención en Química, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

  •   Profesor Titular Full Time

    Universidad Arturo Prat

    Ciencias de la Salud

    Iquique, Chile

    2001 - A la fecha

Experiencia Profesional

  •   Académico Full Time

    Universidad Nacional de Trujillo

    Trujillo, Peru

    1995 - 1995

  •   Académico-Ayudante Other

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    1996 - 2000

Formación de Capital Humano


He dirigido 17 tesis de pre-grado y 3 tesis de postgrado



 

Article (73)

A Review of the Actions of Endogenous and Exogenous Vasoactive Substances during the Estrous Cycle and Pregnancy in Rats
Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-Bis(phenylamino)-1,4-benzoquinones on Cancer Cells
Inhibition of Escherichia coli and Bacillus subtilis FtsZ Polymerization and Bacillus subtilis Growth by Dihydroxynaphtyl Aryl Ketones
Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats
Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta
In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones
Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study
Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate
Crystal structure of 11-(p-coumaroyloxy)tremetone, C22H20O5
Metabolomic Analysis of the Lichen Everniopsis trulla Using Ultra High Performance Liquid Chromatography-Quadrupole-Orbitrap Mass Spectrometry (UHPLC-Q-OT-MS)
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones
ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
Chemical composition and antimicrobial activity of essential oil of Peruvian Dalea strobilacea Barneby
CRYSTAL STRUCTURE OF (1,4-DIHYDROXYNAPHTHALEN-2-YL) (4'-METHOXYPHENYL) METHANONE
Crystal structure of (2,5-dihydroxyphenyl)-(4-hydroxy-3,5-dimethoxyphenyl)methanone, C15H14O6
Crystal structure of (2,5-dihydroxyphenyl)-(4-methoxyphenyl)methanone, C14H12O4
Crystal structure of 5-hydroxy-4-((4-hydroxyphenyl)imino)naphthalen-1(4H)-one monohydrate, C16H11NO3 center dot 0.5H(2)O
Determination of sun protection factor and antioxidant properties of six Chilean Altiplano plants
In vivo inhibition of tumor progression by 5-hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Modulatory effect of 2-(4-hydroxyphenyl)amino-1,4-naphthoquinone on endothelial vasodilation in rat aorta
Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS
Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly
DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate
Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls
Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b] quinazoline-7,12-quinones
Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium flabelliforme and Its Gastroprotective Effect in Mouse Model
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch)
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch) [Aceite esencial de Acantholippia deserticola como pesticida natural contra plagas agrícolas como mosquita blanca algodonosa [Aleurothrixus floccosus (Maskell)], falsa arañita de la vid (Brevipalpus chilensis Baker) y arañita bimaculada (Tetranychus urticae Koch)]
GREEN SYNTHETIC APPROACHES TO FUROYLNAPHTHOHYDROQUINONE AND JUGLONE
Oxidative phenylamination of 5-substituted 1-hydroxynaphthalenes to N-phenyl-1,4-naphthoquinone monoimines by air and light on water
Substituted 3-acyl-2-phenylamino-1,4-naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death
Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones
Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones
VALIDATION OF A METHOD TO DETECT CENTRAL NERVOUS SYSTEM ACTING DRUGS IN BLOOD BY GC/MS. APPLICATION IN CASES OF DEATH CAUSED BY PHENOTHIAZINES IN THE NORTH OF CHILE
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats [Efecto ansiolítico y antidepresivo del aceite esencial de Acantholippia deserticola phil en ratas hembras]
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells
Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones
FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
Biological evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones as inhibitors of Hsp90 chaperoning function
Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine Parastrephia lepidophylla
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells
Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones
VALIDATION OF A METHOD TO DETECT COCAINE AND BENZOYLECGONINE IN HUMAN WHOLE BLOOD BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND APPLICATION IN BODY PACKERS AND STUFFERS CASES IN THE NORTH OF CHILE
An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities
CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF Xenophyllum poposum
COMPOSITION AND ANTIMICROBIAL SCREENING OF THE ESSENTIAL OIL FROM THE LEAVES AND STEMS OF Senecio atacamensis Phil. FROM CHILE
DEVELOPMENT AND VALIDATION OF A SOLID-PHASE EXTRACTION GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHOD FOR THE SIMULTANEOUS QUANTIFICATION OF OPIOID DRUGS IN HUMAN WHOLE BLOOD AND PLASMA
Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress
Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents
The solar-chemical photo-Friedel-Crafts heteroacylation of 1,4-quinones
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents
DEVELOPMENT AND VALIDATION OF A GC-NPD/micro-ECD METHOD USING DUAL COLUMN FOR THE DETERMINATION OF BENZODIAZEPINE IN HUMAN WHOLE BLOOD AND PLASMA
Antioxidant capacity and polyphenolic content of twelve traditionally used herbal medicinal infusions from the South American Andes
Comparative study on the antioxidant effects and phenolic content of twelve highly consumed medicinal plants from SouthAmerican Andes
COMPOSITION AND BIOLOGICAL ACTIVITY OF THE ESSENTIAL OIL OF PERUVIAN LANTANA CAMARA
Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines
Time course of endocrine changes in the hypophysis-gonad axis induced by hypobaric hypoxia in male rats
Composition and antimicrobial screening of the essential oil of Acantholippia deserticola (Phil.ex F. Phil.) Moldenke
Mild and rapid method for the generation of o-quinone methide intermediates. Synthesis of puupehedione analogues
New cyclic acetals related to Ambergris and their olfactory evaluation
THE PREPARATION OF OXYGENATED DERIVATIVES OF AMBROX AND ISOAMBROX FROM DRIMENOL
Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones
Studies on quinones. Part 35: Access to antiprotozoal active euryfurylquinones and hydroquinones
Conversion of (+)-confertifolin into 11,12-bisnordriman-9-one and (+)-8 alpha H,9 alpha H-11,12-diacetoxydrimane
Regiospecific Michael reaction of (+)-euryfuran with activated 1,4-benzoquinones

Abstract (1)

Dihydroxynaphthyl aryl ketones as tubulin polymerization and cancer cell growth inhibitors

Review (1)

Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function
66
Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

19
Pedro Buc

Profesor titular

Quimica y Farmacia

UNIVERSITE CATHOLIQUE DE LOUVAIN

Iquique, Chile

9
Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

6
Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

5
Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

4
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

4
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

4
Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

3
MARIO SIMIRGIOTIS

Associate professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Juana Ibacache

académico

Ciencias del ambiente

Universidad de Santiago de Chile

Santiago, Chile

3
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

2
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

2
Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

2
David Vásquez

Profesor Asistente

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Víctor Tello

ACADEMICO JORNADA COMPLETA

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

1
Andrés Marcoleta

Profesor Asistente

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Luis Espinoza

Assistant Professor

Chemistry

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

1
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Jorge Borquez

Académico

Química

Universidad de Antofagasta

Antofagasta, Chile

1
ANGÉLICA GUERRERO

Directora de Carrera

Facultad de Medicina y Ciencias

Universidad San Sebastián

valdivia, Chile

1
Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

1
Felipe Villanelo

Investigador

Fundacion Ciencia y Vida

Santiago, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Iván Barría

Investigador Post doctoral

Centro Interdisciplinario de Neurociencia de Valparaíso

Valparaíso, Chile

1
Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

1
Andrea Zepeda

Docente/Investigador

Universidad Autónoma de Chile

Temuco, Chile

1
Marcelo Preite

Associate Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile