Man

Pedro Miguel Buc Calderon

Profesor titular

UNIVERSITE CATHOLIQUE DE LOUVAIN

Iquique, Chile

Líneas de Investigación


bioquimica toxicologica; biologia del cancer; estrés oxidativo y radicales libres

Educación

  •  Doctorat en sciences pharmaceutiques, UNIVERSITE CATHOLIQUE DE LOUVAIN. Bélgica, 1987
  •  Quimica y Farmacia, UNIVERSIDAD DE CHILE. Chile, 1977

Experiencia Académica

  •   Profesor titular Full Time

    UNIVERSITE CATHOLIQUE DE LOUVAIN

    Bruselas, Bélgica

    2000 - 2016

  •   Profesor titular Part Time

    Universidad Arturo Prat

    Ciencias de la Salud

    Iquique, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Profesor Full Time

    Université catholique de Louvain

    Bruselas, Bélgica

    2000 - 2016

  •   Chargé de Cours Full Time

    Université catholique de Louvain

    Bruselas, Bélgica

    1992 - 2000

  •   Premier Assistant Full Time

    Université catholique de Louvain

    Bruselas, Bélgica

    1988 - 1992

  •   Profesor Titular Part Time

    Universidad Arturo Prat

    Iquique, Chile

    2016 - A la fecha

  •   VICERRECTOR DE INVESTIGACIÓN E INNOVACION Full Time

    UNIVERSIDAD ARTURO PRAT

    IQUIQUE , Chile

    2020 - A la fecha

Formación de Capital Humano


Dirección de Tesis de Doctorado

1.- Véronique Lefebvre (1989-1993): "Comportement métabolique des hépatocytes de rat soumis à l’hypoxie: effet protecteur du fructose et inhibition de la synthèse protéique". Doctorat en Sciences Pharmaceutiques.
2.- Sandrine Tinton (1991-1994): "Inhibition de la synthèse des protéines par les nucléotides adényliques. Rôle des récepteurs purinergiques et du métabolisme de l’adénosine". Doctorat en Sciences Pharmaceutiques.
3.- Isabelle Latour (1991-1996): "Effet de l'hydroperoxyde du tert-butyle sur l’intégrité de l’ADN et sur la synthèse protéique d’hépatocytes isolés". Doctorat en Sciences Pharmaceutiques.
4.- Jean Baptiste Demoulin (1996-1999): "Signal transduction by the Interleukin-9 receptor". Doctorat en Sciences Pharmaceutiques (co-director).
5.- Ekaterine Evdokimova (1995-2001): "Métabolisme des xénobiotiques lors d’une hypoxie froide suivie d’un réoxygénation à 37°C. Etude sur tranches de foie de rat". Doctorat en Sciences Pharmaceutiques.
6.- Valérie Wauthier (2000-2006): "Influence of ageing on drug metabolizing enzymes in male Wistar rats". Doctorat en Sciences Pharmaceutiques (co-director).
7.- Julien Verrax (2003-2006): "Study of the molecular mechanisms involved in cancer cell death following the exposure to the combination of ascorbate (vitamin C) and menadione (vitamin K3)". Doctorat en Sciences Pharmaceutiques.
8.- Raphaêl Beck (2006-2010): "Molecular mechanisms of oxidative stress-induced cancer cell death: hsp90 chaperone cleavage and consequences". Doctorat en Sciences Biomédicales.
9.- David Vasquez (2007-2009): "Design, synthesis and antitumor activity of aza-analogues of angucyclones and amino pyrimidoisoquinolinequinones derivatives". Doctorat en Cotutelle (WBI-Chile): Chimie (PUC-Chile) et Sciences Pharmaceutiques (UCL-Belgium).
10.- Juan Marcelo Sandoval (2007-2012): "Tellurite toxicity: from bacteria to eukaryotic cells". Doctorat en Cotutelle (WBI-Chile): Microbiologie (USACH-Chile) et Sciences Pharmaceutiques (UCL-Belgium).
11.- Christophe Glorieux (2010-2014): "Role and regulation of catalase and NAD(P)H:quinone oxidoreductase-1 in cancer cells". Doctorat en Sciences pharmaceutiques et Biomédicales.

Dirección de Tesis de pregrado

1.- Jean Louis Pregaldien (1988-1990): "Le fer ionique et le peroxyde d'hydrogène: Etude des effets de leur association sur la viabilité d'hépatocytes isolés". Licence en Technologie Biomédicale.
2.- Olivier Cousin (1988-1991): "Hépatocytes isolés et maintenus en survie en suspension: Etude comparative de l'effet cytotoxique des nucléotides". Licence en Toxicologie.
3.- Ennio De Ros (1988-1990): "Thiols et stress oxydatif. Etude sur hépatocytes isolés". Licence en Toxicologie.
4.- Martine Van Steenbrugge (1989-1991): "Modifications biochimiques lors de l'hypoxie-réoxygénation. Etude sur hépatocytes isolés". Licence en Technologie Biomédicale.
5.- Véronique Beckers (1990-1992): "Transport intracellulaire des acides aminés et inhibition de la synthèse des protéines en état d'hypoxie". Licence en Technologie Biomédicale.
6.- Amaya Leunda (1994-1996): "Implications énergétiques de l'activation de la poly(ADP-ribose) polymérase suite aux dommages de l'ADN par l'hydroperoxyde de tert-butyle". Licence en Technologie Biomédicale.
7.- Hervé Morales (1995-1996): "Influence du fructose sur la viabilité de tranches de foie de rat soumises à un processus d’hypoxie-réoxygénation. Etude biochimique et morphologique". Licence en Technologie Biomédicale.
8.- Agnès Brouet (1996-1997): "Activités d’oxydases à fonction mixte lors de la transition hypoxie froide (4°C)-réoxygénation normothermique (37°C). Etude sur tranches de foie de rats". Licence en Technologie Biomédicale.
9.- Anne-Cecile Massart (1996-1997): "Rôle de la S-thiolation dans l’inhibition de la biosynthèse protéique lors d’un stress oxydatif dans les hépatocytes isolés". Licence en Technologie Biomédicale.
10.- Christophe Lambeau (1996-1997): "Etude de la préservation de tranches de foie de rat lors d’une hypoxie froide suivie d’une réoxygénation normothermique. Etude biochimique et morphologique". Licence en Toxicologie.
11.- Florence Leconte (1997-1998): "Influence de la pression partielle en oxygène sur la synthèse protéique et sur la phosphorylation de résidus tyrosine dans les hépatocytes isolés de rat". Licence en Technologie Biomédicale.
12.- Severine Thielens (2000-2001): "Expression and activity of CYP3A isoforms in rat liver slices under hypoxia-reoxygenation". Licence en Sciences Biomédicales (VUB).
13.- Hong-Ngoc Ngo (2001-2002): "Mécanismes moléculaires impliquées dans la mort cellulaire induite par l'association des vitamines C et K3". Licence en Sciences Biomédicales, orientation Toxicologie.
14.- François Richir (2001-2002): "Influence du processus de vieillissement sur le cytochrome P450 2E1 (CYP2E1) chez le rat Wistar male". Licence en Sciences Biomédicales, orientation Toxicologie.
15.- Carole Marques (2001-2002): "Rôle des vitamines et des antioxydants dans la mort cellulaire induite par l'association des vitamines C et K3". Licence en Sciences Biomédicales, orientation Nutrition.
16.- Marianne Delvaux (2002-2003): "Etude in vitro et in vivo sur l’importance du cycle d’oxydo-réduction des vitamines C et K3 dans leur activité antitumorale". Licence en Sciences Biomédicales, orientation Nutrition.
17.- Pascaline Dubois (2003-2004): "Effet du vieillissement sur le profil sexe-dépendant des enzymes du cytochrome P450 et son influence sur la biotransformation". Licence en Sciences Biomédicales, orientation Toxicologie.
18.- Stéphanie Vanveber (2004-2005): "Rôle des vitamines dans le traitement du cancer: influence de l’état de phosphorylation sur la mort des cellules leucémiques induite par le cycle rédox entre l’ascorbate et la ménadione". Licence en Sciences Biomédicales, orientation Nutrition.
19.- Raphaël Beck (2005-2006): "Etude de l’association ascorbate/menadione sur la viabilité de cellules issues d’un carcinome mammaire (MCF7)". Licence en Sciences Biomédicales, orientation Toxicologie.
20.- Rathnavelu Mohanakumar (2006-2007): "Potential application of the association of vitamins C (sodium ascorbate) and K3 (menadione) as auxiliary therapy in cancer treatment". Master Thesis, Master Program in Medical and Pharmaceutical Research, Vrije Universiteit Brussel (VUB).
21.- Thomas Gonze (2006-2007): "Le clivage de la protéine chaperonne hsp90 par un stress oxydatif provoque la dégradation de la protéine oncogénique Bcr-Abl et mène à la mort des cellules de leucémie myéloïde chronique (K-562)". Licence en Sciences Biomédicales, orientation Nutrition.
22.- Mélanie Creton (2008-2010): "Etude des mécanismes impliqués dans le clivage de la protéine Hsp90 induit par un stress oxydatif". Licence en Sciences Biomédicales, orientation SBEX.
23.- Eva Jacobs (2011-2012): "Rôle du facteur de transcription Nrf2 dans la résistance des cellules cancéreuses à la chimiothérapie". Licence en Sciences Biomédicales, orientation SBEX.


Premios y Distinciones

  •   doctor honoris causa

    UNIVERSIDAD ARTURO PRAT

    Chile, 2009

    Reconocimiento al aporte entregado en los campos de docencia, investigacion y vinculacion.


 

Article (128)

Chemical Composition and Assessment of Antimicrobial, Antioxidant and Antiproliferative Activities of Essential oil from Clinopodium sericeum, a Peruvian Medicinal Plant
Vitamin C (Ascorbate) and Redox Topics in Cancer
In vitro inhibition of Hsp90 protein by benzothiazoloquinazolinequinones is enhanced in the presence of ascorbate. a preliminary in vivo antiproliferative study
New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and In Vitro Antiproliferative Activities on Breast and Prostate Human Cancer Cells
Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism
Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-Bis(phenylamino)-1,4-benzoquinones on Cancer Cells
Catalase down-regulation in cancer cells exposed to arsenic trioxide is involved in their increased sensitivity to a pro-oxidant treatment
Evaluation of Potential Mechanisms Controlling the Catalase Expression in Breast Cancer Cells
Glucose-regulated protein of 94 kDa contributes to the development of an aggressive phenotype in breast cancer cells
In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones
Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study
Catalase, a remarkable enzyme: Targeting the oldest antioxidant enzyme to find a new cancer treatment approach.
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones
Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones.
Use of a cocktail of spin traps for fingerprinting large range of free radicals in biological systems
Chemical composition and antimicrobial activity of essential oil of peruvian Dalea strobilacea Barneby
Chemical composition and antimicrobial activity of essential oil of Peruvian dalea strobilacea barneby [Composición química y actividad antimicrobiana del aceite esencial de la planta Peruana Dalea strobilaceae Barneby]
Chromatin remodeling regulates catalase expression during cancer cells adaptation to chronic oxidative stress
Determination of sun protection factor and antioxidant properties of six Chilean Altiplano plants
Determination of sun protection factor and antioxidant properties of six Chilean Altiplano plants [Determinación del factor de protección solar y propiedades antioxidante de seis plantas del Altiplano Chileno]
High hydrostatic pressure influences the in vitro response to xenobiotics in Dicentrarchus labrax liver
In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate
Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones
Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression.
Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells
Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives
Binding of dihydroxynaphthyl aryl ketones to tubulin colchicine site inhibits microtubule assembly
DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate
Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b] quinazoline-7,12-quinones
Regulation of catalase expression in healthy and cancerous cells
Acantholippia deserticola essential oil as a natural pesticide against agricultural plagues woolly whitefly [Aleurothrixus floccosus (Maskell)], Chilean false red mite (Brevipalpus chilensis Baker) and two-spotted mite (Tetranychus urticae Koch)
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway
Downregulation of Sox9 Expression Associates with Hepatogenic Differentiation of Human Liver Mesenchymal Stem/Progenitor Cells
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells
VALIDATION OF A METHOD TO DETECT CENTRAL NERVOUS SYSTEM ACTING DRUGS IN BLOOD BY GC/MS. APPLICATION IN CASES OF DEATH CAUSED BY PHENOTHIAZINES IN THE NORTH OF CHILE
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells
Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones
FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD
Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease
Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis
A comparative study of tellurite toxicity in normal and cancer cells
Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death
Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors
Biological Evaluation of 3-Acyl-2-Arylamino-1,4-Naphthoquinones as Inhibitors of Hsp90 Chaperoning Function
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells
Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: Implications for tumor recurrence
Precision-Cut Liver Slices To Investigate Responsiveness of Deep-Sea Fish to Contaminants at High Pressure
Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model
Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: A rationale for combination with radiation therapy
An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities
Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study
Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy
In Vitro Differentiated Adult Human Liver Progenitor Cells Display Mature Hepatic Metabolic Functions: A Potential Tool for In Vitro Pharmacotoxicological Testing
Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents
Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies
Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress
Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents
Comparison of methods for measuring oxygen consumption in tumor cells in vitro
Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells
Evaluation of the hepatotoxic and hepatoprotective effect of Rwandese herbal drugs on in vivo (guinea pigs barbiturate-induced sleeping time) and in vitro (rat precision-cut liver slices, PCLS) models
Studies on quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimidoisoquinolinequinones
Tellurite-induced oxidative stress leads to cell death of murine hepatocarcinoma cells
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
In Situ Modulation of Oxidative Stress: A Novel and Efficient Strategy to Kill Cancer Cells
Menadione Reduction by Pharmacological Doses of Ascorbate Induces an Oxidative Stress That Kills Breast Cancer Cells
Part 2: Influence of 2-Euryfuryl-1,4-naphthoquinone and Its peri-Hydroxy Derivatives on Both Cell Death and Metabolism of TLT Cells, a Murine Hepatoma Cell Line. Modulation of Cytotoxicity by Vitamin C
Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
Oxidative stress in the thyroid gland: From harmlessness to hazard depending on the iodine content
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line
The controversial place of vitamin C in cancer treatment
Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3 beta expression, while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation
Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis
Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells
The effect of ageing on cytochrome P450 enzymes: Consequences for drug biotransformation in the elderly
Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats
Botulinum toxin potentiates cancer radiotherapy and chemotherapy
Decreased CYP3A2 expression and activity in senescent male Wistar rats: Is there a role for HNF4 alpha?
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice
Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study
Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death
Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate : menadione treatment nuclear and DNA degradation
Inhibition of the development of metastases by dietary vitamin C : K-3 combination
The use of precision-cut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates
The association of vitamins C and K-3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use coadjuvants in anticancer therapy
Autoschizis: a novel cell death
Effects of bacterial endotoxin (lipopolysaccharides) on survival and metabolism of cultured precision-cut rat liver slices
Potential therapeutic application of the association of vitamins C and K-3 in cancer treatment
Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices
Cryopreservation of rat precision-cut liver slices by ultrarapid freezing - Influence on phase I and II metabolism and on cell viability upon incubation for 24 hours
Reoxygenation after cold hypoxic storage of cultured precision-cut rat liver slices: effects on cellular metabolism and drug biotransformation
Role of ATP and glycogen reserves in both paracetamol sulfation and glucuronidation by cultured precision-cut rat liver slices
Activation of poly(ADP-ribose)polymerase in rat hepatocytes does not contribute to their cell death by oxidative stress
Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes
Protein S-thiolation can mediate the inhibition of protein synthesis induced by tert-butyl hydroperoxide in isolated rat hepatocytes
Protective effect of fructose on survival and metabolic capacities of hepatocytes kept overnight under cold hypoxia before normothermic reoxygenation
Role of protein-phosphorylation events in the anoxia signal-transduction pathway leading to the inhibition of total protein synthesis in isolated hepatocytes
Adenosine stimulates calcium influx in isolated rat hepatocytes
Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs
DESFERAL PREVENTS AGAINST CELL-LYSIS INDUCED BY HYDROGEN-PEROXIDE TO HYPOXIC HEPATOCYTES - A ROLE FOR FREE IRON IN HYPOXIA-MEDIATED CELLULAR INJURY
HOMOCYSTEINE ENHANCES THE INHIBITORY EFFECT OF EXTRACELLULAR ADENOSINE ON THE SYNTHESIS OF PROTEINS IN ISOLATED RAT HEPATOCYTES
INHIBITION OF PROTEIN-SYNTHESIS INDUCED BY ADENINE-NUCLEOTIDES REQUIRES THEIR METABOLISM INTO ADENOSINE
OXIDATIVE DNA-DAMAGE BY T-BUTYL HYDROPEROXIDE CAUSES DNA SINGLE-STRAND BREAKS WHICH IS NOT LINKED TO CELL-LYSIS - A MECHANISTIC STUDY IN FRESHLY ISOLATED RAT HEPATOCYTES
FRUCTOSE METABOLISM AND CELL-SURVIVAL IN FRESHLY ISOLATED RAT HEPATOCYTES INCUBATED UNDER HYPOXIC CONDITIONS - PROPOSALS FOR POTENTIAL CLINICAL USE
ADENINE-NUCLEOTIDES AND INHIBITION OF PROTEIN-SYNTHESIS IN ISOLATED HEPATOCYTES INCUBATED UNDER DIFFERENT PO2 LEVELS
CYTOLYTIC EFFECTS AND BIOCHEMICAL-CHANGES INDUCED BY EXTRACELLULAR ATP TO ISOLATED HEPATOCYTES
IDENTIFICATION OF THE FREE-RADICAL FORMED BY ADDITION OF HYDROXYL RADICAL TO DEHYDROALANINE COMPOUNDS
CELL-DEATH AND LIPID-PEROXIDATION IN ISOLATED HEPATOCYTES INCUBATED IN THE PRESENCE OF HYDROGEN-PEROXIDE AND IRON SALTS
COMPARATIVE HEPATOTOXICITY OF CHOLIC-ACID, DEOXYCHOLIC-ACID AND LITHOCHOLIC ACID IN THE RAT - INVIVO AND INVITRO STUDIES
BIOCHEMICAL-CHANGES IN ISOLATED HEPATOCYTES EXPOSED TO TERT-BUTYL HYDROPEROXIDE - IMPLICATIONS FOR ITS CYTOTOXICITY
AD-5, A DEHYDROALANINE DERIVATIVE, DECREASES THE AMOUNT OF REACTIVE OXYGEN SPECIES FORMED DURING NITROFURANTION MICROSOMAL METABOLISM
INCREASE IN THE SURVIVAL-TIME OF MICE EXPOSED TO IONIZING-RADIATION BY A NEW CLASS OF FREE-RADICAL SCAVENGERS
N-ACYL DEHYDROALANINES SCAVENGE OXYGEN RADICALS AND INHIBIT INVITRO FREE-RADICAL MEDIATED PROCESSES
PREVENTION BY FREE-RADICAL SCAVENGER AD5 OF PROOXIDANT EFFECTS OF CHOLINE DEFICIENCY
INCREASING THERAPEUTIC EFFECT AND REDUCING TOXICITY OF DOXORUBICIN BY N-ACYL DEHYDROALANINES
INHIBITION OF RAT-LIVER MICROSOMAL LIPID-PEROXIDATION BY N-ACYLDEHYDROALANINES - AN INVITRO COMPARATIVE-STUDY
N-ACYL DEHYDROALANINES PROTECT FROM RADIATION TOXICITY AND INHIBIT RADIATION CARCINOGENESIS IN MICE
A NEW CLASS OF FREE-RADICAL SCAVENGERS REDUCING ADRIAMYCIN MITOCHONDRIAL TOXICITY
INHIBITION OF O-2-.-MEDIATED AND HO.-MEDIATED PROCESSES BY A NEW CLASS OF FREE-RADICAL SCAVENGERS - THE N-ACYL DEHYDROALANINES

Review (3)

Targeting hsp90 family members: A strategy to improve cancer cell death
Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach
Role of oxidative stress in the pathogenesis of alcohol-induced liver disease
131
Pedro Buc

Profesor titular

Quimica y Farmacia

UNIVERSITE CATHOLIQUE DE LOUVAIN

Iquique, Chile

19
Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

6
Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
David Vásquez

Profesor Asistente

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE

Santiago, Chile

3
ANGÉLICA GUERRERO

Directora de Carrera

Facultad de Medicina y Ciencias

Universidad San Sebastián

valdivia, Chile

2
Rosalba Lagos

Professor

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

2
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

2
Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

2
Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

1
Víctor Tello

ACADEMICO JORNADA COMPLETA

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

1
Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Maria Theoduloz

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

1
Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

1
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Elen Quispe

Académico

Facultad de Ciencias de la Salud

Universidad Arturo Prat

IQUIQUE, Chile