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Leonel Eduardo Rojo Castillo

Profesor Asociado

Universidad de Santiago de Chile

Estación Central, Chile

Metabolismo, Neurociencias, Farmacología, Biotecnología Médica, enfermedades crónicas, obesidad y diabetes, innovación y vinculación ciencia-empresa.

Quimica y Farmacia, UNIVERSIDAD DE CONCEPCION. Chile, 2001
Químico Farmacéutico , UNIVERSIDAD DE CHILE. Chile, 2001
Farmacología, UNIVERSIDAD DE CHILE. Chile, 2009

Académico Full Time

UNIVERSIDAD ARTURO PRAT

Ciencias de la Salud

Iquique, Chile

2002 - 2007
Visiting Scientist Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

Nueva York, Chile

2008 - 2009
Postdoctoral Associate Full Time

RUTGERS UNIVERSITY

New Brunswick, Chile

2009 - 2013
Associate Professor Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2016 - A la fecha

Concultor Part Time

Nutrasorb LLC

Estados Unidos

2010 - 2012
Consultor Part Time

Neuroinnovation Ltda

Chile

2014 - A la fecha
Miembro fundador Other

Instituto de Etnofarmacologia

Chile

2010 - 2013


African Journal of Agricultural Research Osmotic stress in Chenopodium quinoa Willd.: Variations in osmoprotectants at different phenological stages Rojas-Urrutia, J.; Graf, B. L. Article SCOPUS African journal of agricultural research (2019)
Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance Mascayano, C; Rojo, LE Article ISI SCOPUS FRONTIERS IN ENDOCRINOLOGY (2018)
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro Morales, Jonathan; Barrera-Avalos, Carlos; Castillo, Stephanie; Robles-Planells, Claudia; López, Ximena; Torres, Ernesto Article ISI SCOPUS Frontiers in immunology (2017)
From molecules to the clinic=> linking schizophrenia and metabolic syndrome through sphingolipids metabolism RI Castillo, LE Rojo; M Henriquez-Henriquez, H Silva; A Maturana, Villar M.J.; Fuentes M., Gaspar P.A Article Frontiers in Neuroscience (2016)
Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physico-chemical characteristics Graf, BL; Rojo, LE; Delatorre-Herrera, J; Poulev, A; Calfio, C; Raskin, I Article ISI SCOPUS JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2016)
Role of Anthocyanins in Skin Aging and UV-Induced Skin Damage Rojo, LE; Roopchand, DE; Graf, B; Cheng, DM; Ribnicky, D; Fridlender, B; Raskin, I Article ISI Anthocyanins in Health and Disease (2014)
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats Benites, J.; Bustos L.; Rios, D.; Bravo F.; Lopez, J.; Gajardo S.; Rojo L.; Buc Calderon, P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2013)
Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats [Efecto ansiolítico y antidepresivo del aceite esencial de Acantholippia deserticola phil en ratas hembras] Benites, J.; Bustos L.; Rios, D.; Bravo F.; Gajardo S.; Rojo L.; Buc-Calderon P. Article SCOPUS Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2013)
Evaluation of Analgesic Activities of Tremetone Derivatives Isolated from the Chilean Altiplano Medicine Parastrephia lepidophylla Benites, J.; Gutierrez, E.; Lopez, J.; Rojas M.; Rojo L.; Do Ceu Costa M.; Vinardelld M.P. Article ISI SCOPUS Natural Product Communications (2012)
CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF Xenophyllum poposum Benites, J.; Lopez, J.; Rojo, LE; Díaz P; Rojas M.; Fuentes R.; Moiteiro, C; Venancio, F Article ISI SCOPUS Chemistry of Natural Compounds (2011)
Molecular Targets in the Rational Design of AD Specific PET Tracers: Tau or Amyloid Aggregates? Rojo, LE; Gaspar, PA; Maccioni, RB Article ISI CURRENT ALZHEIMER RESEARCH (2011)
Selective Interaction of Lansoprazole and Astemizole with Tau Polymers: Potential New Clinical Use in Diagnosis of Alzheimer's Disease Rojo, LE; Alzate-Morales, J; Davies P.; Maccioni, RB Article ISI SCOPUS Journal of Alzheimer's Disease (2010)
Antioxidant capacity and polyphenolic content of twelve traditionally used herbal medicinal infusions from the South American Andes Rojo, LE; Benites, J.; Lopez, J.; Rojas M.; Díaz P; Ordoñez J.; Pastene, E. Article ISI SCOPUS BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2009)
COMPOSITION AND BIOLOGICAL ACTIVITY OF THE ESSENTIAL OIL OF PERUVIAN LANTANA CAMARA Benites, J.; Moiteiro, C; Miguel, G; Rojo L.; Lopez, J.; Venancio, F; Ramalho, L; Feio, S; Dandlen, S; Casanova, H.; et al. Article ISI SCIELO SCOPUS JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2009)
The Role of Neuroimmunomodulation in Alzheimer's Disease Maccioni, RB; Rojo, LE; Fernandez, JA; Kuljis, RO Article BREAST CANCER: FROM BIOLOGY TO THERAPY (2009)
THE ROLE OF NEUROIMMUNOMODULATION IN ALZHEIMERS DISEASE maccioni, ricardo; Rojo Leonel; Fernandez, Jorge; Kuljis, Rodrigo Article ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2009)
Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism Maccioni, R. B.; Rojo L.; Pastene, E.; Fuentes P.; Slachevsky, A Article SCOPUS NEUROPSYCHIATRIC DISEASE AND TREATMENT (2008)
COGNITIVE IMPAIRMENT AND ALZHEIMER´S DISEASSE : LINKS WITH OXIDATIVE STRESS AND CHOLESTEROL METABOLISM Sekler, Maria; Jimenez, Jose; Rojo Leonel; Pastene, Edgard; Fuentes, Patricio; Slachevsky, Andrea; maccioni, ricardo Article NEUROPSYCHIATRIC DISEASE AND TREATMENT (2008)
Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron Lavados M.; Guillon M.; Rojo, LE; Fuentes P.; Maccioni, RB Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2008)
Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line Benites, J.; Rojo L.; Taper, H.; CALDERON, PB Article ISI SCOPUS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines Benites, J.; Rivera, F; Rojo L.; Campos N.; Pedro, M; Nascimento, MSJ Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2008)
The damage signals hypothesis of Alzheimer's disease pathogenesis Maccioni, R. B.; Fernandez, J. A.; Rojo L. Article JOURNAL OF ALZHEIMERS DISEASE (2008)
THE DAMAGE SIGNALS HYPOTHESIS OF ALZHEIMERS DISEASE PATHOGENESIS Fernandez, Jorge; Rojo Leonel; Kuljis, Rodrigo; maccioni, ricardo Article JOURNAL OF ALZHEIMERS DISEASE (2008)
Composition and antimicrobial screening of the essential oil of Acantholippia deserticola (Phil.ex F. Phil.) moldenke Rojo L.; Benites, J.; Rodrigues, A; Venancio, F; Ramalho, L; Teixeira A.; Feio, S; Do Ceu Costa M. Article JOURNAL OF ESSENTIAL OIL RESEARCH


Role of Anthocyanins in Skin Aging and UV-induced Skin Damage, Rojo LE, Graf B, Roopchand DE, Cheng D, Ribnicky D, Ilya Raskin; Taylor W, Giusti M BookSection


Olanzapine-induced steatosis in and mitochondrial dysfunction are inhibited by dietary anthocyanins Rojo L E, ConferencePaper (2017)
Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer's Disease and Their Diagnostic and Therapeutic Implications Rojo, LE; Fernández J; Jimenez, J.; Maccioni, AA; Sekler, A; Kuljis, RO; Maccioni, RB ConferencePaper ISI SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)
What Have We Learned from the Tau Hypothesis? Maccioni, RB; Rojo, LE; Sekler, MA; Kujis, RO ConferencePaper ISI SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)


NUEVOS COMPUESTOS DERIVADOS DE PIRIDINMETILSULFINILBENZOXAZOLES Y PIRIDINMETILSULFINIBENZOTIAZOLES, MARCADOS RADIACTIVAMENTE O CON FLUORESCENCIA Y SUS COMPOSICIONES, COMO BIOMARCADORES ESPECIFICOS PARA EL DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS Y PATOLOGÍAS INVOLUCRADAS CON LA PROTEÍNA TAU Maccioni R.M. Patent (2019)
BENZIMIDAZOLES COMPOUNDS AS MARKERS FOR NEURODEGENERATIVE DISEASES Maccioni, RB; Kuljis, RO; Rojo, LE Patent (2016)
BENZIMIDAZOLES COMO MARCADORES DE ENFERMEDADES NEURODEGENERATIVAS Maccioni, RB; KULJIS RORIGO; Leonel Rojo Patent (2015)
METHODS OF PRODUCING AND USING BRASSIONOSTEROIDS TO PROMOTE GROWTH REPAIR, MAINTAINANCE OF SKELETAL MUSCLES AND SKIN ILYA RASKIN; DEBORA ESPOSITO; SLAVKO KOMARNTSKY; Leonel Rojo; RATHINASABAPATHY, Thirumurugan Patent (2012)
PREPARATION AND USE OF POULTERIA LUCUMA EXTRACT ILYA RASKIN; SCHMIDT, Barbara; VILLANO KAREN; Leonel Rojo Patent (2012)


Effect Secnod Generation Antipsychotic on Mitochondrial Function Proyecto (2018)
Evaluation of Athocyanins from Maqui Berry in the prevention of Clozapine-Induced Hepatic Lipid Accumulation, Activation of SREBP1c Target Genes and Obesity Leonel Rojo Proyecto (2014)
In the search of tau binding molecules with biomedical interest as potential radiotracers Maccioni, RB; Leonel Rojo Proyecto (2008)
Development of anxiolytic and antidepressive herbal mixtures of Acantholippia deserticola Phil and Aloysia triphylla Leonel Rojo Proyecto (2007)
International Center for Biomedicine, Chilean Bicentennial Program (PBCT) & CONICYT Maccioni, RB; Leonel Rojo Proyecto (2007)
Medicinal Plants from Chilean Highlands protect Erythrocytes from AAPH Oxidative Damage Leonel Rojo Proyecto (2004)
Synthesis and Antiproliferative of Furylquinones DGI-UNAP Research Grant Julio Benites; Leonel Rojo Proyecto (2002)
Design of software for cognitive stimulation of AD and MCI patients R Maccioni; Rojo Leonel Proyecto (0)
Generación de Capacidades de Transferencia Tecnológica en Corporación de Desarrollo de la Universidad Arturo Prat Leonel Rojo Proyecto (0)
Phytochemistry & Biological Activities of Acantholippia sp. from the Chilean Highlands Julio Benites; Rojo Leonel Proyecto (0)
Radiopharmaceuticals to visualize neurofibrillary tangles in vivo CORFO Chile, Con-investigator HAMARAL H, MACCIONI RB; Maccioni, RB Proyecto (0)


From Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids Metabolism Castillo, RI Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2016)
Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.) Graf, BL; Rojas-Silva, P; Rojo, LE; Delatorre-Herrera, J; Baldeon, ME; Raskin, I Review ISI SCOPUS Comprehensive Reviews in Food Science and Food Safety (2015)
Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology Rojo, LE; Gaspar, PA; Silva H.; Risco, L.; Arena, P; Cubillos-Robles, K; Jara, B. Review ISI SCOPUS Pharmacological Research (2015)
Insulin Resistance and Alzheimer's Disease: Molecular Links & Clinical Implications Neumann KF; Rojo L.; Navarrete, LP; Farías G.; Reyes, P; Maccioni, RB Review ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2008)
Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease Rojo, LE; Fernandez, JA; Maccioni, AA; Jimenez, JM; Maccioni, RB Review ISI ARCHIVES OF MEDICAL RESEARCH (2008)
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease Rojo L.; Sjoberg, MK; Hernández P; Zambrano C.; Maccioni, RB Review ISI SCOPUS JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2006)

Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

Jaime Valderrama

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

Marcelo Cortez

Académico

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

Hernán Silva

CLÍNICA PSIQUIÁTRICA UNIVERSITARIA - UNIVERSIDAD DE CHILE

Santiago, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

Julio Benites

Profesor Titular

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

Gonzalo Farías

Profesor Asistente

Departamento de Neurología y Neurocirugía Norte y Departamento de Neurociencias

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Rodrigo Kuljis

Founder and President

Office of the President

Zdrav Mozak Limitada

Santiago, Chile

Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

Pedro Buc

Profesor titular

Quimica y Farmacia

Universidad Arturo Prat

Iquique, Chile

Marcela Sjoberg

Assistant professor

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Pablo Gaspar

Profesor Asociado

Psiquiatria Norte

Universidad de Chile

santiago, Chile

Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

Maria Sekler

Investigadora

Neuroinnovation Ltda

Santiago, Chile

Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Alejandro Maturana

PROFESOR ASISTENTE DE PSIQUIATRIA

PSIQUIATRIA

Universidad de Chile

SATIAGO, Chile

Karen Neumann

PhD

Producción Animal

Universidad de Chile

Santiago, Chile

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

Stephanie Castillo

Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

Camila Calfío

Investigador PhD/Jefe de Proyectos

Corp. Centro Internacional de Biomedicina ICC

Santiago, Chile

José Jiménez

Postdoc

Investigación

Fundacion Ciencia y Vida

Santiago, Chile

Rolando Castillo

PROFESOR ASISTENTE

PSIQUIATRÍA NORTE

Universidad de Chile

SANTIAGO, Chile

Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

Leonel Eduardo Rojo Castillo

Líneas de Investigación

Educación

Quimica y Farmacia, UNIVERSIDAD DE CONCEPCION. Chile, 2001

Químico Farmacéutico , UNIVERSIDAD DE CHILE. Chile, 2001

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

Académico Full Time

Visiting Scientist Full Time

Postdoctoral Associate Full Time

Associate Professor Full Time

Experiencia Profesional

Concultor Part Time

Consultor Part Time

Miembro fundador Other

Article (24)

BookSection (1)

ConferencePaper (3)

Patent (5)

Proyecto (11)

Review (6)