Img_4265.jpg_thumb90

Marcelo Catalan Gaete

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Electrofisiología; Fisiología epitelial; Transporte de iones

Educación

  •  Bioquimica, UNIVERSIDAD DE CHILE. Chile, 1999
  •  Ciencias Biomedicas, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Staff Scientist Full Time

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos

    2010 - 2017

  •   Research Assistant Professor Full Time

    University of Rochester

    Rochester, NY, Estados Unidos

    2009 - 2010

Experiencia Profesional

  •   Staff Scientist Full Time

    National Institutes of Health

    Besthesda, MD, Estados Unidos

    2010 - 2017

  •   Research Assistant Professor Full Time

    University of Rochester

    Rochester, NY, Estados Unidos

    2009 - 2010

  •   Profesor Asociado Full Time

    Universidad Arturo Prat

    Iquique, Chile

    2017 - 2018

  •   Profesor Auxiliar Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2019 - A la fecha

Premios y Distinciones

  •   Best poster

    11th International Symposium on Exocrine Secretion

    Japón, 2009

    NaCl reabsorption in mouse submandibular gland ductal epithelium requires apical Cftr and ENaC channels.

  •   Nominado a la competencia Hatton

    International Association for Dental Research/Unilever.

    Estados Unidos, 2010

    Enhanced Dental Caries in a Mouse Model of Cystic Fibrosis


 

Article (34)

A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons
Nocturnal Light Pollution Induces Weight Gain in Mice and Reshapes the Structure, Functions, and Interactions of Their Colonic Microbiota
Novel Oxime Synthesized from a Natural Product of Senecio nutans SCh. Bip. (Asteraceae) Enhances Vascular Relaxation in Rats by an Endothelium-Independent Mechanism
Activation of the Ae4 (Slc4a9) cation-driven Cl -/HCO 3- exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells
Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action
Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3
Physiological cAMP-elevating secretagogues differentially regulate fluid and protein secretions in mouse submandibular and sublingual glands
A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion
The Insensitivity of TASK-3 K2P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure
Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction
The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice
Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger
A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland
Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells
Functional Differences in the Acinar Cells of the Murine Major Salivary Glands
Ca2+-dependent K+ channels in exocrine salivary glands
Association of Bone Morphogenetic Protein 6 With Exocrine Gland Dysfunction in Patients With Sjogren's Syndrome and in Mice
A quantitative analysis of electrolyte exchange in the salivary duct
Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels
Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjogren's syndrome
TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation
Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration
Elevated Incidence of Dental Caries in a Mouse Model of Cystic Fibrosis
Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland
Tmem16A Encodes the Ca2+-activated Cl- Channel in Mouse Submandibular Salivary Gland Acinar Cells
Purinergic P2X(7) Receptors Mediate ATP-induced Saliva Secretion by the Mouse Submandibular Gland
A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif
The voltage-dependent CIC-2 chloride channel has a dual gating mechanism
A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the CIC-2 chloride channel
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization
Nonselective cation channels as effecters of free radical-induced rat liver cell necrosis

Abstract (5)

Exploring the Transport Mechanism of the Human AE4 (SLC4A9) CL-/HCO3- Exchanger
Functional Analysis of the ClC-2 hyperpolarization-activated Cl-channel in Mouse Colon.
Basolateral ClC-2 chloride channels in surface colon epithelium: Regulation by a direct effect of intracellular chloride
Magnesium inhibition of single cardiac RyR channels
Sodium influx through non-selective cation channels: an effector mechanism for necrotic cell death

Proyecto (3)

Ion-transporting pathways in beta-adrenergic receptor stimulated fluid secretion in salivary glands.
Role of the Clcn2 Cl- Channel in Intestinal Fluid Secretion
Proyecto Regular Fondecyt 1171135: Ion-transporting pathways in beta-adrenergic receptor stimulated fluid secretion in salivary glands
40
Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

7
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

7
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

6
Gaspar Peña

Profesor Asistente

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

6
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

5
Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

5
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

2
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

2
Isabel Cornejo

Investigadora

Biología

Centro de Estudios Científicos

Valdivia, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

1
DINKA MANDAKOVIC

Assistant Professor

GEMA Center

Universidad Mayor

Santiago, Chile

1
Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

1
Omar Porras

Associate professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rafael Zúñiga

Investigador

Facultad de Ingeniería

Universidad de Talca

Talca, Chile

1
Angel Cayo

ACADÉMICO INVESTIGADOR

MEDICINA TRASLACIONAL

Universidad Católica del Maule

TALCA, Chile