Man

Carlos D Figueroa Valverde

Head

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Inflammation Kinin receptors Breast cancer Keratinocyte differentiation

Educación

  •  Pharmacology, UNIVERSITY OF BRISTOL. Reino Unido, 1990

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Faculty of Medicine

    Valdivia, Chile

    1983 - A la fecha

Experiencia Profesional

  •   Profesor Ayudante Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    1983 - 1987

  •   Profesor Instructor Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    1987 - 1990

  •   Profesor Auxiliar Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    1990 - 1995

  •   Profesor Asociado Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    1995 - 2001

  •   Profesor Titular Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2001 - A la fecha

Formación de Capital Humano


“La activación del receptor B1 de cininas induce la secreción de los factores angiogénicos IL-4 y VEGF en queratinocitos humanos” Postgraduate Student Astrid Johana Mejía. Doctorado en Ciencias, mención Biología Celular y Molecular; Universidad Austral de Chile. 2012.

“La estimulación del receptor B2 de cininas en células renales antagoniza la transición epitelio-mesenquimática y la vía de señalización Smad activada por TGF-?“ Co-Patrocinante Postgraduate Student Areli Cárdenas. Doctorado en Ciencias, mención Biología Celular y Molecular; Universidad Austral de Chile. 2012.

“La transactivación del receptor del factor de crecimiento epidérmico, inducida por el agonista B1 de cininas, regula la migración del queratinocito humano” Postgraduate Student Carola Elizabeth Matus Velásquez. Doctorado en Ciencias, mención Biología Celular y Molecular; Universidad Austral de Chile. 2012.

“La Degradación de Cininas ¿Genera fragmentos inactivos?”. Postgraduate Student Angel Alejandro Astroza Constanzo. Doctorado en Ciencias, mención Biología Celular y Molecular; Universidad Austral de Chile. 2012.



 

Article (56)

Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the expression of Mac-1, LFA-1 and ICAM-1
Pre-stimulation of the kallikrein system in cisplatin-induced acute renal injury: An approach to renoprotection
Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria
Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration
Expression of HER2 and bradykinin B1 receptors in precursor lesions of gallbladder carcinoma
Activation of kinin B-1 receptor increases the release of metalloproteases-2 and-9 from both estrogen-sensitive and -insensitive breast cancer cells
The Splice Variant of the V2 Vasopressin Receptor Adopts Alternative Topologies
Canine perianal furunculosis and interdigital lesions: Probable systemic lupus erythematosus
Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects
Kinin B-1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family
New potential targets to modulate neutrophil function in inflammation
Nutritional channels in breast cancer
Stimulation of the bradykinin B-1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway
Activation of kinin B(1) receptor triggers differentiation of cultured human keratinocytes
Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Kinin B1 receptor triggers tyrosine phosphorylation, epidermal growth factor receptor transactivation and cell differentiation in human keratinocytes
Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways
Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4
Cellular expression of plasma prekallikrein in human tissues
Comparison of kinin B-1 and B-2 receptor expression in neutrophils of asthmatic and non-asthmatic subjects
Activation of kinin B-1 receptors induces chemotaxis of human neutrophils
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
Modulation of renal kallikrein by a high potassium diet in rats with intense proteinuria
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif
Differential distribution of the vasopressin V-2 receptor along the rat nephron during renal ontogeny and maturation
Kinin B2 receptor-coupled signal transduction in human cultured keratinocytes
Kinin-induced filaggrin expression is enhanced after blocking EGF receptor transactivation in human keratinocytes
Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer
Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice
Stimulated human neutrophils form biologically active kinin peptides from high and low molecular weight kininogens
Bradykinin B-2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro
Evidence for modulation of human epidermal differentiation and remodelling by CD40
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization
Effect of mycophenolate mofetil on kallikrein expression in the kidney of 516 nephrectomized rats
Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes
Differential distribution of bradykinin B-2 receptors in the rat and human cardiovascular system
Differential distribution of bradykinin B2 receptors in the rat and human cardiovascular system
DIFFERENTIAL DISTRIBUTION OF BRADYKININ B2 RECEPTORS IN THE RAT HUMAN CARDIOVASCULAR SYSTEM
Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells
Renal kallikrein-kinin system (KK) compromise in a 5/6 renal ablation model modulated by mycophenolate mofetil (MMF).
Temporospatial changes of kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus
Tissue kallikrein and bradykinin B2 receptor in human uterus in luteal phase and in early and late gestation
Tissue kallikrein in human placenta in early and late gestation
Expression and co-localization of cytokeratin 1 and urokinase plasminogen activator receptor on the membrane of endothelial cells.
Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse
VASOPRESSIN AND BRADYKININ RECEPTORS IN THE KIDNEY: IMPLICATIONS FOR TUBULAR FUNCTION
Vasopressin stimulates tyrosine phosphorylation by activation of PKC in the rat smooth muscle cell line, A-10
Autoradiographic and immunological techniques to analyse kinin receptor distribution in rat and human tissues
The kallikrein-kinin system along the different stages of gestation: Experimental and clinical findings
Estrogen and luminal stimulation of rat uterine kallikrein
Immunolocalization of V1 vasopressin receptors in the rat kidney using anti-receptor antibodies
Alpha 1-antitrypsin expression in human thyroid papillary carcinoma
Localization of the fructose 1,6-bisphosphatase at the nuclear periphery
Temporospatial changes of kallikrein-like enzymes during the estrous cycle and pregnancy in the rat uterus
EXPRESSION OF KALLIKREIN, BRADYKININ B2 RECEPTOR, AND ENDOTHELIAL NITRIC OXIDE SYNTHASE IN PLACENTA IN NORMAL GESTATION, PREECLAMPSIA, AND PLACENTA ACCRETA

Abstract (7)

Kinin B1 but not B2 receptor agonists induce human neutrophil chemotaxis
Expression of CD40 and the mitogenic peptide hormone receptors vasopressin V1 and kinin B1 and B2 receptors in psoriatic epidermis
Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes.
Kinin B2 receptors during the estrous cycle and pregnancy in the rat uterus
Placental kinin B2 receptors in early and late human pregnancy.
Translocation of MAPKs to the nucleus induced by vasopressin in a vascular smooth muscle cell line.
Characterization and distribution of renal bradykinin and vasopressin receptors

ConferencePaper (4)

Renal kallikrein-kinin system damage and salt sensitivity: Insights from experimental models
Hydrolysis of kininogens by degranulated human neutrophils and analysis of bradykinin as chemotactic factor for cells isolated from peripheral blood
Localization of the bradykinin B2 receptor in uterus, bladder and madin- darby canine kidney cells
Rat bradykinin B2 receptor: Immunochemical characterization and immunovizualization in epithelial and smooth muscle cells

Errata (1)

Participation of kinins in the captopril-induced inhibition of intimal hyperplasia caused by interruption of carotid blood flow in the mouse (vol 130, pg 1076, 2000)

Review (2)

Discovery and therapeutic potential of kinin receptor antagonists
Kinin receptors as targets for cancer therapy
76
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

18
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

10
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

6
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

5
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

4
Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

3
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

3
Leopoldo Ardiles

Profesor Titular

Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
MARIANNE BRENET

Investigador

SymbiOx Inc.

Macul, Chile

2
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

2
Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

2
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

2
Isabel Cornejo

Investigadora

Biología

Centro de Estudios Científicos

Valdivia, Chile

2
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

2
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

2
Cesar Toledo

Estudiante de posgrado Doctorado en Ciencias Agropecuarias

Ciencias Agropecuarias y Acuícolas

Universidad Católica de Temuco

Temuco, Chile

1
PATRICIA BURGOS

Associate Professor & Sub-Director CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Javier Ojeda

Docente instructor en el INstituto de Ciencias Clínicas Veterinarias.

Universidad Austral de Chile

Valdivia, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
César Trigo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

1
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

1
Ivan Conejeros

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Gaspar Peña

Profesor Asistente

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

1
Lida Fuentes

Researcher

Centro Regional de Estudios en Alimentos Saludables

Valparaiso, Chile

1
Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

1
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
CAROLINA AÑAZCO

Associate Professor

Preclinical Sciences

Universidad Católica del Maule

TALCA, Chile