Man

Andrew Frederick Geoffery Quest Minikus

Full Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Caveolin-1 as a tumor suppressor and metastasis promoter/Helicobacter pylori in gastric cancer/inflammation-associated changes in Caveolin-1 function

Educación

  •  Biochemistry, ETH Zuerich. Suiza, 1988

Experiencia Académica

  •   Prof. Titular Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    Enero 2005 - A la fecha

Experiencia Profesional

  •   Full Professor Full Time

    Facultad de Medicina, Universidad de Chile

    Santiago, Chile

    Enero 2005 - A la fecha

Formación de Capital Humano


Post-doctoral fellows
1) Mauricio Henríquez (2006-2009 : Universidad de Chile). Working on alternative forms of cell death induced by ceramides (FONDAP 15010006). Fondecyt post-doctoral fellow award Nr. 3050037 (2007-2009) to study role of P2X7 receptors and ATP in FasL-induced necrosis. Position as Assistant Professor at the ICBM, Universidad de Chile since January 2009.
2) Vicente Torres (2009-2013: Universidad de Chile). Short additional post-doctoral training period working on effects of caveolin-1 as a tumor suppressor (FONDAP 15010006). As of 2010 funded by Fondecyt Chile Project Nr. 79090021 (2010-2012) “Renovacion academica para el desarollo de la medicina molecular“ financial support to promote integration of young scientists (post-doctoral fellows) into academia. Position as Assistant Professor at the Faculty of Odontology, Universidad de Chile since March 2011.
3) Manuel Valenzuela (2009-2011: Universidad de Chile). Continuation of Ph.D. thesis project working on mechanisms underlying cell death induced by Helicobacter Pylori in gastric epithelial cells for over a year. Subsequently, post-doctoral position in the laboratory of Dr. Pedro Buc Calderon, Université Catholique de Louvain, Belgium.
4) Denisse Bravo (2009-2011: Universidad de Chile). Continuation from Manuel working on mechanisms underlying cell death induced by Helicobacter Pylori in gastric epithelial cells. Position as assistant professor at the Faculty of Odontology, Universidad de Chile since March 2011.
5) Jimena Castillo (2013-2015: Universidad de Chile). Continuation from Carlos Sanhueza and Maria Ines Diaz’s work evaluating CAveolin-1 translocation to ER in hypoxia, the regulation there of eNOS and the connection to HIF-1a inhibition.
6) Simon Guerrero (2013-2015: Universidad de Chile). Collaboration with Marcelo Kogan from the Fcultad de Odontologia, Universidad de Chile, evaluating the potential of gold nanoparticles to track melanoma metastasis in vivo.

PhD thesis students (finished)
1. Diego Rodriguez (April 2009): “Caveolina-1 inhibe la proliferación y promueve muerte celular mediante la regulación negativa de ciclooxigenasa-2 y survivina” (AQ thesis director/LLeyton co-director).
2. Manuel Valenzuela (May 2009): “Estudio del papel de survivina y caveolina-1 en la apoptosis inducida por Helicobacter pylori en celulas gastricas” (AQ thesis director/HToledo co-director).
3. Jorge Gutierrez (June 2009): “Rol de PKCalfa en la regulación de la expresión de caveolina-1 en celulas de cancer de endometrio, mama y colon“ (AQ thesis director/SLavandero co-director)
4. Rodrigo Herrera-Molina (August 2009) “La interaccion molecular integrina aVb3/Thy-1 en el contacto celula-celula entre astrositos y neuronas participa en la inhibición del crecimiento de neuritas y la retraccion de procesos neuronales s traves de una via de señalización que involucra a src“(AQ thesis codirector/LL director).
5. Alejandra Valdivia (June 2010): “Transduccion de senales mediada por Thy-1 en astrocitos: Participación secuencial de la integrina avb3 y sindican-4 en la formación de adhesiones focales y fibras de estrés” (AQ thesis codirector/LL director).
6. Adam Aguirre (June 2011) : “FasL promueve muerte celular en celulas linfoides via liberacion de ATP y activacion de receptores P2X7” (AQ thesis director/Mauricio Henriquez co-director).
7) Lorena Lobos (June 2011) :”La E-cadherina potencia a Caveolina-1 como supresor de tumores y reduce su efecto promotor de metastasis” ” (AQ thesis director/Lisette Leyton co-director).
8) Paulina Ormazabal (December 2011) “Evaluacion de moleculas relacionadas con la via metabolica de la insulina en celulas endometriales y en endometrio de mujeres con syndrome de ovario poliquistico“ Ph.D. advisor Margarita Vega, AQ co-advisor.
9) Jaime Gonzalo Fernandez (Jan 2012) “Survivina promueve la actividad transcripcional de b-catenina favoreciendo de esta manera angiogenesis” (AQ thesis director, co-advisor Julio Tapia).
10) Lorena Aguilar (Nov. 2012) “La terapia experimental conjunta de Calreticulina de Trypanosoma Cruzi y la inmunizacion con Survivina inhibe el crecimiento in vivo de un melanoma experimental murino” (AQ and Arturo Ferreira thesis advisors).
11) Sergio Nunez (Dec 2012) “Caveolina-1 sensibiliza a las células Min6 a la muerte inducida por ácidos grasos libres” (AQ director).
12) Carlos Sanhueza (Sept. 2013) “Caveolina-1 reduce la transcripcion dependiente de HIF-1a en un mecanismo dependiente del oxido nitrico en celulas tumorales” (AQ thesis advisor/ LL co-advisor).
13) Milene Kong (Jan 2014). “Thy-1 induce la migración de los astrocitos activando vías de señalización que involucran a FAK, PI3K, Tiam1 y Rac1” (LL thesis advisor/ AQ co-advisor).

PhD thesis students (in progress)
14) Ph. D. Advisor of Rina Ortiz (Oct 2010 – April 2014) Ph.D. in Farmacology (funded by CONICYT/FONDAP; Mecesup travel fellowship) “Caveolin-1 expression promotes migration of B16F10 mouse melanoma cells in vitro and metastasis in vivo in C56BL6 mice in manner that requires phosphorylation on tyrosine by src family kinases” Thesis co-advisor Lisette Leyton, ICBM, Universidad de Chile. Teaching position at the Universidad de Valparaiso.
15) Ph. D. Co-advisor of Alvaro Alvarez (Oct 2010 – April 2014) Ph.D. in Farmacology (funded by CONICYT/FONDAP; Mecesup travel fellowship) “Role of the receptor P2X7 in astrocyte responses triggered by Thy-1 in an inflammatory environment” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile. Teaching position at private university.
16) Ph. D. Co-advisor of Roberto Bravo (Oct 2011 – April 2015) Ph.D. in Biochemistry (funded by CONICYT/FONDAP) “Compartmentalizacion of physical and metabolic coupling between ER and mitochondria in cancer cells” Thesis advisor Sergio Lavandero, ICBM, Universidad de Chile.
17) Ph. D. Co-advisor of Horacio Maldonado (Oct 2011 – April 2015) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; PhD travel fellowship) “Study of signaling mechanisms associated with retraction/inhibition of neurite outgrowth mediated by ?v?3/Thy-1 interaction in neuronal cells in culture” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile.
18) Adviser Unidad de Investigación (Ph.D. program Biochemistry) of Jorge Diaz (March 2011 – July 2011) “Caveolin-1 enhances migration of metastatic tumor cell vai a Rab5-dependent pathway” Co-advisor Vicente Torres, Facultad de Odontologia, Universidad de Chile.
19) Ph. D. Advisor of Jorge Diaz (Dec 2011 – April 2014) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; MECESUP travel fellowship) “Caveolin-1 enhanced migration of metastatic tumor cells requires phosphorylation on tyrosine-14 and activation of the Rab5/Tiam-1/Rac1 axis” Thesis co-advisor Vicente Torres, Facultad de Odontologia, Universidad de Chile.
20) Ph. D. Advisor of Jimena Canales (Oct 2012 – April 2016) Ph.D. in Farmacology (funded by CONICYT/FONDAP; xxxxx travel fellowship) “Helicobacter pylori induced iNOS expression and NO production enhances HIF-1?-dependent transcription transition to a more mobile cell phenotype” Thesis co-advisor Denisse Bravo, ICBM, Universidad de Chile.
21) Ph. D. Advisor of Yeniffer Avalos (Oct 2012 – April 2016) Ph.D. in Farmacology (funded by CONICYT/FONDAP; PhD travel fellowship) “Caveolin-1-enhanced autophagy via reduced iNOS signaling favors caveolin-1-mediated tumor suppression”
22) Ph. D. Advisor of Natalia Diaz (Oct 2012 – April 2016) Ph.D. in Biochemistry (funded by CONICYT/FONDAP; proyecto REDES travel fellowship) “Inhibition of Caveolin-1 enhanced migration of metastatic tumor cells by E-cadherin involves suppression of phosphorylation on tyrosine-14 and the Rab5/Tiam-1/Rac1 axis” Thesis co-advisor Lisette Leyton, ICBM, Universidad de Chile.
23) Ph. D. Co-advisor of Cesar Oyarce (Mar 2013 – April 2015) Ph.D. in Biomedical Sciences (funded by CONICYT/FONDAP) “Caveolin-1 promotes dendritic cell maturation by inhibiting b-catenin/Tcf-Lef-dependent transcription” Thesis advisor Alvaro Lladser, Fundacion Ciencia y Vida.
24) Ph. D. Advisor of Victor Diaz (Jan 2014 – April 2017) Ph.D. in Biochemistry (funded by CONICYT/ANILLO/FONDAP) “Development of nanoparticles based on Quantum Dots to stady CAV1-enhanced metastasis of B16F10 cells in vivo” Thesis co-advisor Jose Miguel Perez, Universidad Andres Bello.
25) Ph. D. Co-advisor of Francesca Burgos (April 2014 – April 2017) Ph.D. in Biochemistry (funded by CONICYT) “The astrocyte proteoglycan Syndecan-4 participates in the inhibition of neuronal process outgrowth induced by engagement of neuronal Thy-1 and astrocyte avb3 integrin” Thesis advisor Lisette Leyton, ICBM, Universidad de Chile.

Masters thesis students (finished)
1) Master’s thesis Co-advisor of Astrid Schmied (Mar 2011 – Nov 2013) “Caracterizacion del tipo de murte cellular enn linfocitos de sujetos con historia de cancer de piel y probable enfermedades de alzheimer” Thesis advisor Dr. Maria Isabel Behrens.

Undergraduate thesis students (finished)
1) Thesis co-advisor for Hery Urra (Jan 2007 – May 2009) “Rol de caveolina-1 en migracion cellular de celulas metastaticas de cancer de mama y astrocitos” (Universidad de Valparaiso, Chile)
2) Thesis advisor for Natalia Diaz (May 2008 – March 2010) “Regulacion de la re-expresion de caveolina-1 en celulas tumorales” (Universidad de Valparaiso, Chile)
3) Visiting student, Tania Yareli (August-September, 2009) from Universidad Autonoma de Sinaloa, Mexico.
4) Visiting student, Cristina Gomez (October-December, 2009) from Universidad de Medellín, Colombia
5) Visiting student Stefan Brueck (March-June, 2010) from the Institute of Biochemistry and Molecular Biology of the Medical School of the RWTH Aachen University, Germany.
6)Thesis advisor for Hernan Huerta (August 2010 – May2012) “Estudio del rol de la proteina PKC? en la re-expresion de Caveolin-1 inducida por el ester de forbol 4?-TPA” (Universidad de Santiago, Chile)
7) Adviser for Unidad de Investigacion of 2nd year pre-medical students Victor Vicencio and Ruben Valenzuela (May-Dec 2010) “Estudio de los mecanismos moleculares de angiogenesis y metastasis en celulas tumorales” (Universidad de Chile, Chile)
8) Adviser for Unidad de Investigacion of 2nd year pre-medical students Mackarenna Norambuena Guamparito and Constanza Segura Rios (May-Dec 2011) “Caveolina-1 reduce la actividad de HIF-1 inducida por hipoxia en
células de melanoma B16F10” (Universidad de Chile, Chile)
9) Adviser for Unidad de Investigacion of 2nd year pre-medical students Wendy Soruco Guamparito and Konnie Yanez (May-Dec 2012) “El rol de Survivina y ?-Catenina en proliferación celular, apoptosis y resistencia a drogas en células de Leucemia Linfoblástica” (Universidad de Chile, Chile).
10) Masters thesis co-adviser for Samantha Gonzalez (May 2012- April 2013) “Rol de la proteina survivina en la inhibicion de la apoptosis por Porphyromonas gingivalis” (Universidad de Chile, Chile)
11) Adviser for Unidad de Investigacion of 2nd year pre-medical students Diego Urbina – Andrés Vargas (May-Dec 2013) “Rol de la proteína caveolina-1 en la migración e invasión de células metastásicas” (Universidad de Chile, Chile).
12) Adviser for one month summer research stage of Students in Biochemistry (Dec 2013 – Mar 2014) Ana Victoria Rojas, Eliseo Parra, Francisco Cornejo.
13) Adviser for Unidad de Investigacion of 2nd year pre-medical students xxxxxxxxxxx (May-Dec 2014) “Estudio del eje Caveolina-1/Rab5 en la migración e invasion de células metastásicas” (Universidad de Chile, Chile).

Undergraduate courses
1) Curso de Fisiológica y Patológia Integrada de la Facultad de Química Farmaceutica: Bases Moleculares del Cancer (Marzo 2009, 3 horas directa, 125 alumnos).
2) “Unidades de Investigación 2010” para estudiantes del 2ndo ano de la carrera de medicina.
3) Clase magistral para estudiantes del 1er ano de medicina “Bases celulares y moleculares del cancer” (Nov. 2010, 2 horas directas, 125 alumnos)
4) “Unidades de Investigación 2010” para estudiantes del 2ndo ano de la carrera de medicina
5) “Unidades de Investigación 2011/2012” para estudiantes del 2ndo ano de la carrera de medicina
6) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2011/2012).
7) “Unidades de Investigación 2012” para estudiantes del 2ndo ano de la carrera de medicina
8) Curso de Bioquímica de la Facultad de Química Farmaceutica: Compartmentalizacion en transduccion de senales (May 2012, 2 horas directa, 20 alumnos).
9) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2012).
10) Bases Científicas de Medicina I: Capitulo Biología Celular y Molecular (Nov-Dec 2013).

Post-graduate courses
essentially the same courses every year since 2009 - listed here courses in 2014

1) Co-organizer (together with Sergio Lavandero) of an interfaculty post-graduate Course, “Basic Concepts in Cell Signalling” (April - May, 2014) and “Signalling in Biomedicine” (June-July, 2014). Lecturer for the following topics; “Ras-Raf-MAPK pathway”, “PKC- PI3K”, “Mechanisms underlying compartmentalisation of signal transduction molecules”, “Lipid second messengers”, “Protein Motifs mediating Lipid Interactions”, “Signalling in cell death”, “Signalling in Cancer” ICBM, Facultad de Medicina, U. de Chile. These two modules are taught to students at the Facultad de Ciencias Químicas y Farmacéuticas as well as Ciencias. This course represents a contribution of the anillo group NEMESIS(CEMC) to post-graduate education in four faculties of the Universidad de Chile.

2) Co-organizer (together with Vicente Torres and Mario Chiong) of an interfaculty post-graduate course of the University of Chile, “Advanced Cell and Molecular Biology” (April - May, 2014). Coordinator of the section “Dynamics of Cytoplasm, Cytoskeleton, and cell migration”. Lecturer for the following topics; “Organization of the plasma membrane – microdomains - cell migration”. This course is taught to students primarily from the Facultad de Ciencias, Ciencias Químicas y Farmacéuticas, Farmacología and Medicine. This course represents a contribution of the anillo group NEMESIS(CEMC) to inter-faculty post-graduate education at the Universidad de Chile.

3) Lecturer in post-graduate course entitled “Advanced Molecular Pharmacology” organized by Guillermo Diaz (August 2014), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Topic: “Cancer”

4) Lecturer in post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2014), at Facultad de Medicina, Universidad de Chile.

5) Lecturer and organizer of post-graduate course entitled “Reading and Discussing papers in English” organized by Lisette Leyton (Oct-Nov 2014), at Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile.


Premios y Distinciones

  •   Niemeyer Lecture

    Sociedad Espanola de Bioquimica y Biologia Molecular

    España, 2014

    Niemeyer Conference - "Caveolin-1, a pleiotropic molecular switch in cancer progression" SEBBM (Sociedad Espanola de Bioquimica y Bioloiaa Molecular) 9-12 Sept. 2014, Granada, Spain.

  •   Editorial board member

    Current Molecular Medicine

    Estados Unidos, 2014

    Just recently appointed as editorial board member. Still not mentioned in web of the journal.


 

Article (80)

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.
and Gastric Cancer=> Adaptive Cellular Mechanisms Involved in Disease Progression.
in human health and disease=> Mechanisms for local gastric and systemic effects.
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients.
Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines.
Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis.
Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells.
Intracellular Ca Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.
Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells.
Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins.
?V?3 Integrin regulates astrocyte reactivity
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells
Calcium Transport and Signaling in Mitochondria.
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells
Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology.
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis
Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy.
Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children
Hypoxia-induced Rab5 activation promotes tumor cell migration, invasion and metastasis
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.
mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.
Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients.
Regulation of cardiomyocyte autophagy by calcium.
Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024.
The Porphyromonas gingivalis O antigen is required for inhibition of apoptosis in gingival epithelial cells following bacterial infection.
Therapeutic targeting of autophagy in myocardial infarction and heart failure.
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins.
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells.
ER-to-mitochondria miscommunication and metabolic diseases.
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer.
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome?
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren’s syndrome?
The twisted survivin connection to angiogenesis.
Cavolin-1 in cell migration and metastasis
Editorial: Signaling in cell migration and disease.
Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy Against a Murine Melanoma In Vivo
Molecular insights to a novel Caveolin-1-Rab5-Rac-1 signaling pathway important for metastatic cancer cell migration and invasion
Organelle communication: signaling crossroads between homeostasis and disease.
Splice variants and polymorphisms of MUC1 related to Xerostomia and inflammatory responses in Salivary Glands from Sjörgren's Syndrome Patients
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription
Tumor suppression and promotion by autophagy
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Decreased Phosphorylation of Y14Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells
Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration
Helicobacter pylori induced loss of survivin by gamma glutamyl tranpeptidase activity in gastric cells
Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors
Loss of Salivary Gland Acinar Cell Architecture and targeted secretion could be an initiator for Sjögren's Syndrome
Oral dryness in Sjögren's syndrome patients. Not just a question of water.
Rab5 Activation Promotes Focal Adhesion Turnover, Migration and Invasiveness of Tumor Cells
Sjögren's syndrome and the epithelial target: A comprehensive review
Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells.
The caveolin-1 connection to cell death and survival
Thy-1-interacting molecules and cellular signaling in both Cis and Trans.
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopic mucin secretion
Age-Dependent increases in Apoptosis/Necrosis Ratios in Human Lymphocytes exposed to oxidative stress
ATP release due to Thy-1–integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation
Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction
Is survivin the potential archilles’ heel of cancer?
Mechanotransduction and epigenetic control in autoimmune diseases
Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production
Helicobacter pylori—Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells
Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA
Caveolin-1, an ambiguous partner in cell signaling and cancer
Cell Death by Necrosis, a Regulated Way to Go
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
Direct Thy-1/Alphav Beta3 integrin interaction mediates neuron to astrocyte communication
Reduced sulfation of Muc5B is linked to Xerostomia in Sjoegrens syndrome patients
E-cadherin is required for caveolin-1 mediated down-regulation of the inhibiutor of apoptosis protein survivin via reduced b-catenin/Tcf-Lef-dependent transcription
Casein Kinase 2 (CK2) increases survivin expression via enhanced b-catenin/T-cell factor/lymphoid enhancer binding factor-dependent transcription
Caveoln-1 levels are down-regulated in human colon tumors and ectopic caveolin-1 expression in colon carcinoma cell lines reduces tumorigenicity
GFP-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol in living cells

Article (44)

Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors
Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts
The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis
A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE(2) Signaling Axis
The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1 alpha in Gastric Cells
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress
Curcumin-loaded nanoemulsion: A new safe and effective formulation to prevent tumor reincidence and metastasis
Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential
Hypoxia-induced caveolin-1 expression promotes migration and invasion of tumor cells
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer
Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
A novel caveolin-1/p85?/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion
Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models
Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity
Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion
FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X7
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion
Astrocytic alpha(V)beta(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1
Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer
Activation of kinin B-1 receptor increases the release of metalloproteases-2 and-9 from both estrogen-sensitive and -insensitive breast cancer cells
Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren's Syndrome
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction
DAI (DLM-1/ZBP1) as a Genetic Adjuvant for DNA Vaccines That Promotes Effective Antitumor CTL Immunity
Progesterone Utilizes Distinct Membrane Pools of Tissue Factor to Increase Coagulation and Invasion and These Effects are Inhibited by TFPI
TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure
Caveolin-1-mediated suppression of cyclooxygenase-2 via a ?-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin e 2 production and survivin expression
EXTRACELLULAR ATP MEDIATES FASL-INDUCED NECROSIS OF LYMPHOID CELLS VIA P2X7 ACTIVATION
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with ?v?3 integrin that activates PKC? and RhoA
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome
Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells

Proyecto (22)

Caveolina-1 induce cambios metabólicos en células de cáncer que favorecen la metástasis
Advanced Center for Chronic Diseases (ACCDiS)
Rol del ambiente inflamatorio en la expresión de CAV1 y la progresión del Cáncer de Vesícula Biliar
The role of the ” Angiotensin II type 2 receptor in the molecular pathogenesis of human gastric carcinoma
Phosphatases and exosomes in caveolin-1-mediated metastasis
The role of PKR-like ER kinase (PERK) in Helicobacter pylori induced gastric cell death and progression of precancerous lesions to gastric cancer
Role of helicobacter pylori gamma-glutamyl transpeptidase in autophagy of human gastriccells and the progression of precancerous lesions to gastric cancer
THE THY-1 RECEPTORS αVβ3 INTEGRIN AND SYNDECAN-4 ON ASTROCYTES CONTROL MITOCHONDRIAL LOCATION AS WELL AS ATP RELEASE AND THEREBY CONTRIBUTE TO THE NEUROTOXIC EFFECTS OF REACTIVE ASTROCYTES.
Advanced Center for Chronic Diseases (ACCDiS)
CAVEOLIN-1-DEPENDENT MIGRATION AND METASTASIS OF CANCER CELLS REQUIRES TYR14 PHOSPHORYLATION, SEQUESTRATION OF P85A AND ACTIVATION OF THE RAB5-RAC1 PATHWAY, WHICH ARE INHIBITED BY EXPRESSION OF E-CADHERIN
ESTUDIO DE LOS CAMBIOS EN LA LOCALIZACION INTRACELULAR DE CAVEOLINA-1 DURANTE LA HIPOXIA Y SU RELACION CON LA INHIBICION DE LA SINTASA DE OXIDO NITRICO ENDOTELIAL (eNOS) Y EL FACTOR INDUCIDO POR HIPOXIA, HIF-1a.
TRÁFICO DE NANOPARTÍCULAS DENTRO DE CÉLULAS METASTÁSICAS, UN ACERCAMIENTO AL MARCAJE CELULAR PARA SU POSTERIOR SEGUIMIENTO IN VIVO
Metabolic Stress Signaling in Cancer, Cardiovascular Diseases and Diabetes
PRO-INFLAMMATORY STIMULI INCREASE ALPHAVBETA3 INTEGRIN EXPRESSION IN ASTROCYTES, WHICH UPON ENGAGEMENT OF NEURONAL THY-1 TRIGGERS BIDIRECTIONAL-SIGNALING EVENTS REQUIRED FOR ASTROCYTE MIGRATION AND AXONAL RETRACTION.
SUPPRESSION OF TUMOR GROWTH BY CAVEOLIN-1 INVOLVES INHIBITION OF THE UNFOLDED PROTEIN RESPONSE
ASOCIACION INVERSA ENTRE CANCER Y ENFERMEDAD DE ALZHEIMER=> UN POSIBLE MECANISMO BIOLOGICO COMUN.
ASOCIACION INVERSA ENTRE CANCER Y ENFERMEDAD DE ALZHEIMER=> UN POSIBLE MECANISMO BIOLOGICO COMUN.
ROL AUTOCRINO DE ATP COMO FORMA ALTERNATIVA DE MUERTE CELULAR=> PARTICIPACION DE P2X7 DETERMINA NECROSIS INDUCIDA POR FAS-L EN LINFOCITOS NEOPLASICOS.
EL SUPRESOR DE TUMORES CAVEOLINA-1 INTERACTUA CON LA CICLOOXIGENASA-2 E INHIBE SU ACTIVIDAD CATALITICA, PROMOVIENDO LA APOPTOSIS EN CELULAS DE CANCER DE COLON.
CENTER FOR MOLECULAR STUDIES OF THE CELL
ELUCIDATION OF MECHANISMS UNDERLYING CAVEOLIN-1 TUMOR SUPPRESSOR ACTIVITY IN HUMAN COLON CARCINOMA CELLS AND PROTEIN KINASE C-DEPENDENT PATHWAYS CONTROLLING CAVEOLIN-1 EXPRESSION.
PROTEIN KINASE C ISOFORMS IN THE CONTROL OF CELL GROWTH=> ROLE OF LIPID SECOND MESSENGERS AND COMPARTMENTALIZATION OF PKC ISOFORMS.

JournalWhole (18)

Caveoin-1 in cell migration and metastasis
Caveolin-1 is a risk factor for post-surgery metastasis in a preclinical melanoma model
Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy Against a Murine Melanoma In Vivo
Organelle communication: signaling crossroads between homeostasis and disease.
Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Decreased Phosphorylation of Y 14 Caveolin-1 in Endometrial Tissue of Polycystic Ovary Syndrome Patients may be Related with an Insulin Resistant State in this Tissue
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells
Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration
Helicobacter pylori induced loss of survivin by gamma glutamyl transpeptidase activity in gastric cells
hy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4
Local control of nuclear Ca2+ signaling in cardiac myocytes by perinuclear sarcolemmal microdomains
ORAL DRYNESS IN SJÖGREN’S SYNDROME PATIENTS. NOT JUST A QUESTION OF WATER
Rab5 Activation Promotes Focal Adhesion Turnover, Migration and Invasiveness of Tumor Cells.
Sjögren’s syndrome and the epithelial target: A comprehensive review
Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells
The caveolin-1 connection to cell death and survival
Thy-1-interacting molecules and cellular signaling in both Cis and Trans

Review (9)

Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis
Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Organic and inorganic nanoparticles for prevention and diagnosis of gastric cancer
Is Survivin the Potential Achilles' Heel of Cancer?
Mechanotransduction and epigenetic control in autoimmune diseases
Beyond apoptosis: Nonapoptotic cell death in physiology and disease
Supramolecular complex formation in cell signaling and disease: an update on a recurrent theme in cell life and death
Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1

Abstract (6)

Extracellular vesicles containing Caveolin-1 from metastatic breast cancer cells are enriched in adhesion proteins and enhance migration and invasion of recipient cells
Anti-neoplastic drugs at sub lethal doses augment caveolin-1 expression and caveolin-1 dependent migration and invasion of cancer cells.
Csk-Binding-Protein mediates Thy-1 signaling and neurite retraction caused by astrocyte alpha v beta 3 integrin in neuronal cultures.
Protein kinase CK2 enhances colorectal cancer malignancy by upregulating the expression of cyclooxygenase-2 through the canonical Wnt signaling pathway
E-cadherin is a molecular switch for Caveolin-1 function in melanoma cells that synergizes in tumor suppression and blocks Caveolin-1-enhanced metastasis
Do adult skeletal muscle traverse tubules contain caveola?

Editorial (3)

Meet our associate editor
Signaling in cell death, survival, proliferation and degeneration
Is there a link between dementia and cancer?

Errata (2)

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress (vol 26, pg 1195, 2019)
Erratum: Decreased phosphorylation of Y14Caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may be related with an insulin resistant state in this tissue (Hormone and Metabolic Research)

EditorialMaterial (1)

Cellular Signaling

BookSection (1)

Caveolin-1 in Melanoma Progression
84
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

14
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

9
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

8
Claudio Molina

Director Investigación

Investigación

Universidad San Sebastián

Santiago, Chile

7
Sergio González

Profesor titular

Patología General y Oral

Universidad Mayor

Santiago, Chile

7
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

6
Ulises Urzúa

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

5
Lorena Lobos-Gonzalez

Principal Investigator-Prosesor Asociado

Facultad de Medicina - Clinica Alemana

Universidad Del Desarrollo

santiago, Chile

5
Isabel Castro

Profesor Asistente

Tecnología Médica

Universidad de Chile

Santiago, Chile

5
Alvaro Lladser

Associate Researcher / Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

4
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

3
Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

3
Rodrigo Herrera Molina

Group Leader (staff member)

Neurochemistry and Molecular Biology

Leibniz Institute for Neurobiology

Magdeburg, Alemania

3
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

2
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

2
Paula Díaz

POSTDOCTORAL RESEARCH FELLOW

UNIVERSIDAD DE CHILE

Chile

2
Mónica Silva

Lab Manager

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

2
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Lorena Aguilar

Assistant Professor

Pathology

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Maria Diaz

Part time Professor

Ciencias Quimicas y Biologicas

Universidad Bernado O´higgins

Santiago , Chile

2
Felipe Salech

Investigador

Universidad de Chile / Facultad de Medicina

Santiago, Chile

2
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

2
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

2
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

2
Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

2
Maritza Garrido

Bioquímico

Obstetricia y Ginecología

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

2
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Eugenia Diaz

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Sergio Aguilera

Reumatólogo

CLÍNICA INDISA

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

1
Virginia Monardes

Bioquímico

Hematologia

SSMO Hospital del Salvador

Santiago, Chile

1
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

1
Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

1
Christian Palavecino

Profesor asistente

Universidad Central de Chile

Santiago, Chile

1
Felipe Oyarzún

Profesor Asistente

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paz Robert

Prof. Titular

Ciencia de los Alimentos y Tecnología Química

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Rina Ortiz

Profesor auxiliar

Física

Universidad Técnica Federico Santa María

Valparaiso, Chile

1
María Barrera

Profesor Asistente

Odontología

Universidad San Sebastián, Facultad de Odontología

Santiago, Chile

1
Flavio salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
SOLEDAD BOLLO

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

1
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Mariana Sinning

Medico Staff

Neurología Psiquiatria y Oncología

Clinica Alemana Santiago

Santiago, Chile

1
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mercedes Lopez

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

1
Denisse Bravo

Assistant Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Igor Osorio

Director del Doctorado en Ciencias de Materiales Avanzados

Universidad Mayor

Santiago, Chile

1
Ivan Conejeros

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

1
Margarita Montoya

Profesor Asistente

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Andrés Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Ricardo Armisen

Profesor Investigador

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Luisa Herrera

Profesor Asociado

Incstituto de Ciencias Biomédicas, Programa de Genética Humana

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM

Santiago, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Ethel Velásquez

investigador

Departamento de Tecnologías Nucleares

Comisión Chilena de Energía Nuclear

Santiago, Chile

1
Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Daniel Peña

Investigador postdoctoral

Instituto de Ciencias Odontológicas

Universidad de Chile

Santiago, Chile