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Manuel Valenzuela Valderrama

Académico Investigador

Universidad Central de Chile

santiago, Chile

Helicobacter pylori-associated gastric cancer, Inflammation and oxidative stress, Translational control of the antiapoptotic protein Survivin, Photodynamic therapy.

Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2015
Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Académico Investigador Full Time

Universidad Central de Chile

Facultad de Ciencias de la Salud

Santiago, Chile

2016 - A la fecha

Post-doctorado

Universidad Católica de Lovaina

Bélgica

2011 - 2013
Postdoctorado

Universidad de Chile

Chile

2009 - 2011
Investigador Fondap AccDis Part Time

Universidad de Chile

santiago, Chile

2014 - A la fecha
Academico Investigador

Universidad Central de Chile

Chile

2016 - A la fecha

2018-2020 Co-Director tesis post-grado estudiante de Doctorado en Bioquímica, Universidad de Chile: Esteban Palacios. "Papel de Nrf2 en la reactividad de astrocitos inducida por OMVs de Helicobacter pylori".

2018 Director tesis de pregrado estudiante de Tecnología Médica Universidad Central de Chile:

Alejandra Neculman (TM) :"Evaluación in vitro del efecto bactericida y citotóxico de Leptocarpina extraída desde Leptocarpha rivularis (Palo negro) sobre la viabilidad de Helicobacter pylori y células gástricas"
Cecilia Sandoval (TM): "Efecto antimicrobiano del compuesto fotosensible (Ir(F2ppy)2NOHpplPF6) contra Helicobacter pylori".

2017-2018. Director tesis de pregrado estudiantes de Tecnología Médica Universidad Central de Chile:
-Karina Álvarez “Papel de la ureasa de Helicobacter pylori en la inducción de HIF-1? en células gástricas humanas”
-Francisca Andrade “Estudio del efecto protector de Nrf2 frente a la citotoxicidad e inflamación inducidas por Helicobacter pylori en células gástricas”
-Claudio Vega “Estudio del efecto protector de Nrf2 frente a la citotoxicidad e inflamación inducidas por Helicobacter pylori en células gástricas”
-Jenny Hormazábal“Asociación del grado de susceptibilidad antibiótica con la expresión de factores de patogenicidad de
Klebsiella pneumoniae y evaluación de una terapia fotodinámica alternativa contra los bacilos Gram negativos Klebsiella pneumoniae y Helicobacter pylori”,
-Karla Alvarez “Asociación del grado de susceptibilidad antibiótica con la expresión de factores de patogenicidad deKlebsiella pneumoniae y evaluación de una terapia fotodinámica alternativa contra los bacilos Gram negativos Klebsiella pneumoniae y Helicobacter pylori”,

Difusión:

2016
Diario El Lector de Linares http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=38556916&idT=700547&org=no&carp=universidadcentral&ve=0
Portal web Radio Polar http://www.radiopolar.com/noticia_125059.html
Portal web Revo http://revo30.com/especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-chile/
Diario Austral de Atacama http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=38545329&idT=700547&org=no&carp=universidadcentral&ve=0
Portal web Gigante de Atacama http://gigantedeatacama.cl/doctor-en-ciencias-biomedicas-una-alimentacion-sana-es-clave-para-prevenir-el-cancer-gastrico-en-chile/
Portal web Espacios FM http://espaciosfm.cl/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/
Portal Austral de Valdivia http://www.australvaldivia.cl/impresa/Sociedad/2016/10/13/423462/Especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-Chile/ciudad/
Portal El Acontecer http://www.elacontecer.cl/index.php/u-s/item/1106-cancer-gastrico
Portal web Es Noticia http://esnoticia.cl/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/
Portal web Belleza y Alma https://www.bellezayalma.com/una-alimentacion-sana-clave-prevenir-cancer-gastrico-chile/
Portal web Entorno Inteligente http://www.entornointeligente.com/articulo/9086302/Una-alimentacion-sana-es-clave-para-prevenir-el-cancer-gastrico-en-Chile-13102016
Portal web Soy Chile http://www.soychile.cl/Santiago/Sociedad/2016/10/13/423462/Especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-Chile.aspx
Portal web Reporte Chile https://reportechile.net/2016/10/especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-chile/
Portal web FM Dos http://www.fmdos.cl/noticias/atentos-estos-alimentos-ayudan-prevenir-cancer-gastrico/
Portal web Soy Chile TV https://www.youtube.com/watch?v=DCrcce7hqik
Portal Solución Web http://solucionweb.cl/2016/10/13/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/

2017
Diario La Prensa de Curicó http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=39581542&idT=700547&org=no&carp=universidadcentral&ve=0

2018
-Canal Chilevisión, programa ‘CHV Noticias Central’ https://www.litoralpress.cl/deposito/videosm/7921373.mp4
-Canal CNN Chile, programa ‘Mirada Central’ "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Portal Canal Chilevisión, programa ‘CHV Noticias Central’ https://www.litoralpress.cl/deposito/videosm/7921373.mp4
-Portal Canal CNN Chile, programa ‘Mirada Central’ "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Canal CNN Chile, programa ‘Mirada Central’ (Repetición) "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Canal CNN Chile, programa ‘Mirada Central’ (Repetición) "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Docente Evaluador en evento Expociencias Nacional (17-19 Noviembre)

Congresos:
1. Antibacterial and antitumorigenic effects of organic extracts from the Chilean medicinal plant leptocarpha rivularis gainst Helicobacter pylori and gastric cancer cells, respectively. A. Neculman; N. Carrasco N; I. Montenegro; J. Villena; M. Valenzuela. EHMSG XXXIst International Workshop on Helicobacter & Microbiota in Inflammation & Cancer. 12-14 Septiembre 2018, Kaunas, Lituania.
2. Urease virulence factor of Helicobacter pylori induces HIF-1? activity in gastric cells. Valenzuela M, Cerda P, Canales J, Bravo D and Quest AFG. European Helicobacter and Microbiota Study Group – EHMSG XXXth International Workshop on Helicobacter & Microbiota in Inflammation & Cancer. 7-9 Septiembre, Bordeaux, Francia.
3. HIF-1? activation following Helicobacter pylori infection reduces Cyclin D1 to promote cell cycle arrest in gastric cells. Canales J, Valenzuela M, Bravo D, Toledo H, Quest AFG. AccDis Cancer Spring Symposium, 7-9 de Septiembre 2016. Olmué, Chile.

F.R.S.-FNRS-Télévie postdoctoral fellow

KATHOLIEKE UNIVERSITEIT LEUVEN (KUL)

Bélgica, 2011

beca postdoctoral
Becas Chile postdoctoral fellow

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2011

Becas postdoctoral en el extranjero
Collaborator Researcher

FONDAP

Chile, 2014

Collaborator researcher Fondap ACCDis


Caveolin-1-mediated tumor suppression is linked to reduced HIF1α S-nitrosylation and transcriptional activity in hypoxia Lobos Lorena Article WOS, Scopus CANCERS (2020)
Photodynamic treatment with cationic Ir(III) complexes induces a synergistic antimicrobial effect with imipenem over carbapenem-resistant Klebsiella pneumoniae Bustamante V.; Carrasco N.; Palavecino C. Article WOS, Scopus Photodiagnosis and photodinamic therapy (2020)
Synergistic effect of combined imipenem and photodynamic treatment with the cationic Ir(III) complexes to polypyridine ligand on carbapenemresistant Klebsiella pneumoniae Palavecino, Christian Erick Article PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2020)
The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon Palavecino C.E.; Carrasco-VÃ©liz N. Article SCOPUS Biochemical and Biophysical Research Communications (2020)
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells MartÃnez-Meza S.; Sandoval-BÃ³rquez A.; Huilcaman, R.; Ocaranza M.P. Article ISI SCOPUS CANCERS (2019)
NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE(2) Signaling Axis Salvatierra R.; Selman A. Article ISI SCOPUS CANCERS (2019)
Photodynamic treatment for multidrug-resistant Gram-negative bacteria: Perspectives for the treatment of Klebsiella pneumoniae infections Palavecino C.E. Article ISI SCOPUS PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2019)
The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1 alpha in Gastric Cells Backert S; Jorquera-Cordero C; Wehinger, S Article ISI SCOPUS CANCERS (2019)
Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells Valenzuela, M; Bastias, L; Montenegro, I; Werner, E; Madrid, A; Godoy, P; Parraga, M; Villena, J Article EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)
Synthesis and Antiproliferative Activity of New Cyclodiprenyl Phenols against Select Cancer Cell Lines Said, Bastian; Valenzuela, Manuel; Caro, Nelson; Godoy, Patricio Article ISI SCOPUS MOLECULES (2018)
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1 alpha to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells Cerda-Opazo P. Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1 alpha to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells Canales J., Valenzuela M.; Bravo J., Cerda-Opazo P.; Jorquera C., Toledo H.; Bravo D., Quest A.F.G. Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis Costantino, VV; Lobos-Gonzalez, L.; Ibáñez J.; Fernández, D.; Cuello-Carrion, FD; Valenzuela, MA.; Semino, SN; Jahn, GA; Quest, AFG Article ISI SCOPUS CANCER LETTERS (2016)
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis Costantino VV, Lobos-Gonzalez L, Ibañez J, Fernandez D, Cuello-Carrión FD, Manuel A. Valenzuela, Barbieri MA, Semino SN, Jahn GA, Quest AF, Lopez LA. Article CANCER LETTERS (2016)
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis Manuel Valenzuela, Jimena Canales, Alejandro H. Corvalán and Andrew Quest Article WORLD JOURNAL OF GASTROENTEROLOGY (2015)
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells Wehinger, S; Ortiz, R.; Díaz M.I., Aguirre A.; Valenzuela,M.; Llanos P., Mc Master C.; Leyton, L; Quest, A.F.G. Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
Phosphorylation of Caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher McMaster, Lisette Leyton, Andrew F.G. Quest Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
The twisted survivin connection to angiogenesis Carlos Sanhueza, Sergio Wehinger, Jimena Castillo, Manuel Valenzuela, Gareth Owen and Andrew Quest Article Molecular Cancer (2015)
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells Sid, B.; Glorieux C., Valenzuela; M., Rommelaere; G, Najimi; M., Dejeans N.; Renard, P; Verrax J., Calderon Article Biochemical Pharmacology (2014)
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells Brice Sid, Christophe Glorieux, Manuel Valenzuela, Guillaume Rommelaere, Mustapha Najimi, Nicolas Dejeans, Patricia Renard, Julien Verrax, Pedro Buc Calderon Article BIOCHEMICAL PHARMACOLOGY (2014)
Characterization of the arginine decarboxylase gene (ORF HP0422) involved in acid tolerance in Helicobacter pylori Valenzuela M, Cáceres A., Almarza O., Bravo D., Soto S., Cerda O. and Toledo H Article HELICOBACTER (2014)
Characterization of the Arginine Decarboxylase Gene (ORF HP0422, speA) Involved in Acid Tolerance in Helicobacter pylori Valenzuela,M.; Cáceres A., Almarza O.; Bravo D., Soto; S, Cerda O.; Toledo, H Article HELICOBACTER (2014)
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells Valenzuela,M.; Glorieux C., Stockis; J, Sid; B., Sandoval; JM, Felipe; KB, Kviecinski; MR, Verrax J.; Calderon, PB Article British Journal of Cancer (2014)
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells M Valenzuela, C Glorieux, J Stockis, B Sid, J M Sandoval, K B Felipe, M R Kviecinski, J Verrax, P Buc Calderon Article BRITISH JOURNAL OF CANCER (2014)
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription Fernandez, JG; Rodriguez, DA; Valenzuela,M.; Calderón C, Urzua; U, Munroe D.; Rosas, C; Lemus D., Díaz N; Wright, MC; Leyton, L; Tapia, JC; Quest, AFG Article Molecular Cancer (2014)
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription Jaime G Fernández, Diego A Rodríguez, Manuel Valenzuela, Claudia Calderon, Ulises Urzúa, David Munroe, Carlos Rosas, David Lemus, Natalia Díaz, Mathew C Wright, Lisette Leyton, Julio C Tapia, Andrew Fg Quest Article Molecular Cancer (2014)
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells Felipe, KB; Benites, J.; Glorieux C., Sid; B., Valenzuela; M., Kviecinski; MR, PedrosaA; RC, Valderrama; JA, Leveque; P, Gallez; B, Verrax J.; Calderon, PB Article Biochemical and Biophysical Research Communications (2013)
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and involve the appearance of a senescent phenotype in human bladder cancer cells Karina Bettega Felipe, Julio Benites, Ch. Glorieux, Brice Sid, Manuel Valenzuela, Maicon R. Kviecinski, Rozangela Curi Pedrosa, Jaime A. Valderrama, Philippe Levêque, Bernard Gallez, Julien Verrax, and Pedro Buc Calderon Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Helicobacter pylori induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma glutamyl transpeptidase activity Manuel Valenzuela, Denisse Bravo, Jimena Canales, Carlos Sanhueza, Natalia Diaz, Oscar Almarza, Héctor Toledo, Andrew F. G. Quest Article JOURNAL OF INFECTIOUS DISEASES (2013)
Helicobacter pylori-Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity Valenzuela,M.; Bravo D., Canales; J, Sanhueza C.; Díaz N, Almarza O.; Toledo, H; Quest, AFG Article JOURNAL OF INFECTIOUS DISEASES (2013)
Arginine 66 Residue of Fur is Required for the Regulatory Function of this Protein in the Acid Adaptation Mechanism of Helicobacter pylori Toledo, H; Villafaena C., Valenzuela; M., Lopez-Solis Article Helicobacter (2012)
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells Kviecinski M.R., Pedrosa R.C.; Felipe K.B., Farias M.S.; Glorieux C., Valenzuela; M., Sid; B., Benites; J., Valderrama; J.A., Verrax J.; Buc Calderon, P. Article Biochemical and Biophysical Research Communications (2012)
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells Kviecinski MR, Pedrosa RC, Felipe KB, Farias MS, Glorieux C, Valenzuela M, Sid B, Benites J, Valderrama JA, Verrax J, Buc Calderon P Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Arginine 66 residue of Fur is required for the regulatory function of this protein in the acid adaptation mechanism of Helicobacter pylori Héctor Toledo, Carlos Villafaena, Manuel Valenzuela and Remigio López-Solis Article HELICOBACTER (2011)
Helicobacter pylori exhibits a Fur-dependent acid tolerance response M Valenzuela, JP Albar, A Paradela and H Toledo Article HELICOBACTER (2011)
Helicobacter pylori Exhibits a Fur-Dependent Acid Tolerance Response Valenzuela,M.; Albar, JP; Paradela A., Toledo Article Helicobacter (2011)
Helicobacter pylori induced loss of the inhibitor of apoptosis protein survivin is linked to gastritis and death of human gastric cells Manuel Valenzuela, Guillermo Pérez-Pérez, Alejandro H. Corvalán, Gonzalo Carrasco, Hery Urra, Denisse Bravo, Héctor Toledo and Andrew F. G. Quest Article JOURNAL OF INFECTIOUS DISEASES (2010)
Helicobacter pylori-Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells Valenzuela,M.; Perez-Perez, G; Corvalan, AH; Carrasco, G; Urra, H; Bravo D., Toledo; H, Quest Article Journal of Infectious Diseases (2010)
Overview on chemotaxis and acid resistance in Helicobacter pylori Valenzuela,M.; Cerda O., Toledo Article Biological Research (2003)
Overview on chemotaxis and acid resistance in Helicobacter pylori Valenzuela M, Cerda O, Toledo H Article BIOLOGICAL RESEARCH (2003)
Resistencia antimicrobiana en Helicobacter pylori: aspectos clínicos y moleculares Vallejos C, Cerda O, Valenzuela M, Toledo H Article REVISTA MEDICA DE CHILE (2003)
Acid stress response in Helicobacter pylori Toledo H, Valenzuela M, Rivas A, Jerez C.A Article FEMS MICROBIOLOGY LETTERS (2002)
Acid stress response in Helicobacter pylori Toledo, H; Valenzuela,M.; Rivas, A; Jerez, CA Article FEMS MICROBIOLOGY LETTERS (2002)


The urease virulence factor of Helicobacter pylori is required to induce HIF-1alpha activity in gastric cells Valenzuela, M Abstract ISI HELICOBACTER (2017)


TRANSLATIONAL REGULATION OF THE ANTIAPOPTOTIC PROTEIN SURVIVIN BY CONTROL ELEMENTS IN THE 5' UNTRANSLATED REGION (5'UTR) Valenzuela M.. A Proyecto (2017)
TRANSLATIONAL REGULATION OF THE ANTIAPOPTOTIC PROTEIN SURVIVIN BY CONTROL ELEMENTS IN THE 5' UNTRANSLATED REGION (5'UTR) FONDECYT (1171615) Proyecto 2017-2020 Inv. Principal
Role of pro-oxidants in the sensitivity of HL-60 leukemic cells exposed to chemotherapies under Nrf2 activation FNRS, Belgium (F5/202) Proyecto 2011-2013 Investigador(a)
FUNCION DE LA ARGININA DESCARBOXILASA DE HELICOBACTER PYLORI EN LA ADAPTACION DE LA BACTERIA AL PH ACIDO DEL ESTOMAGO=> UN MECANISMO DE ADAPTACION AL ESTRES ACIDO DESARROLLADO POR HELICOBACTER PYLORI? FONDECYT (1085193) Proyecto 2008-2011 Postdoctorado


Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression Valderrama, MV Review ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2018)
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects Hoare, A; Valenzuela, MA. Review ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2018)
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis Valenzuela, MA.; Canales, J; Corvalan, AH; Quest, AFG Review ISI SCOPUS World Journal of Gastroenterology (2015)
The twisted survivin connection to angiogenesis Sanhueza C.; Wehinger, S; Bennett, JC; Valenzuela,M.; Owen, GI; Quest, AFG Review ISI SCOPUS Molecular Cancer (2015)