Mavvfoto.jpg_thumb90

Manuel Valenzuela Valderrama

Académico Investigador

Universidad Central de Chile

santiago, Chile

Líneas de Investigación


Helicobacter pylori-associated gastric cancer, Inflammation and oxidative stress, Translational control of the antiapoptotic protein Survivin, Photodynamic therapy.

Educación

  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Académico Investigador Full Time

    Universidad Central de Chile

    Facultad de Ciencias de la Salud

    Santiago, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Post-doctorado

    Universidad Católica de Lovaina

    Bélgica

    2011 - 2013

  •   Postdoctorado

    Universidad de Chile

    Chile

    2009 - 2011

  •   Investigador Fondap AccDis Part Time

    Universidad de Chile

    santiago, Chile

    2014 - A la fecha

  •   Academico Investigador

    Universidad Central de Chile

    Chile

    2016 - A la fecha

Formación de Capital Humano


2018-2020 Co-Director tesis post-grado estudiante de Doctorado en Bioquímica, Universidad de Chile: Esteban Palacios. "Papel de Nrf2 en la reactividad de astrocitos inducida por OMVs de Helicobacter pylori".

2018 Director tesis de pregrado estudiante de Tecnología Médica Universidad Central de Chile:

Alejandra Neculman (TM) :"Evaluación in vitro del efecto bactericida y citotóxico de Leptocarpina extraída desde Leptocarpha rivularis (Palo negro) sobre la viabilidad de Helicobacter pylori y células gástricas"
Cecilia Sandoval (TM): "Efecto antimicrobiano del compuesto fotosensible (Ir(F2ppy)2NOHpplPF6) contra Helicobacter pylori".

2017-2018. Director tesis de pregrado estudiantes de Tecnología Médica Universidad Central de Chile:
-Karina Álvarez “Papel de la ureasa de Helicobacter pylori en la inducción de HIF-1? en células gástricas humanas”
-Francisca Andrade “Estudio del efecto protector de Nrf2 frente a la citotoxicidad e inflamación inducidas por Helicobacter pylori en células gástricas”
-Claudio Vega “Estudio del efecto protector de Nrf2 frente a la citotoxicidad e inflamación inducidas por Helicobacter pylori en células gástricas”
-Jenny Hormazábal“Asociación del grado de susceptibilidad antibiótica con la expresión de factores de patogenicidad de
Klebsiella pneumoniae y evaluación de una terapia fotodinámica alternativa contra los bacilos Gram negativos Klebsiella pneumoniae y Helicobacter pylori”,
-Karla Alvarez “Asociación del grado de susceptibilidad antibiótica con la expresión de factores de patogenicidad deKlebsiella pneumoniae y evaluación de una terapia fotodinámica alternativa contra los bacilos Gram negativos Klebsiella pneumoniae y Helicobacter pylori”,


Difusión y Transferencia


Difusión:

2016
Diario El Lector de Linares http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=38556916&idT=700547&org=no&carp=universidadcentral&ve=0
Portal web Radio Polar http://www.radiopolar.com/noticia_125059.html
Portal web Revo http://revo30.com/especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-chile/
Diario Austral de Atacama http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=38545329&idT=700547&org=no&carp=universidadcentral&ve=0
Portal web Gigante de Atacama http://gigantedeatacama.cl/doctor-en-ciencias-biomedicas-una-alimentacion-sana-es-clave-para-prevenir-el-cancer-gastrico-en-chile/
Portal web Espacios FM http://espaciosfm.cl/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/
Portal Austral de Valdivia http://www.australvaldivia.cl/impresa/Sociedad/2016/10/13/423462/Especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-Chile/ciudad/
Portal El Acontecer http://www.elacontecer.cl/index.php/u-s/item/1106-cancer-gastrico
Portal web Es Noticia http://esnoticia.cl/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/
Portal web Belleza y Alma https://www.bellezayalma.com/una-alimentacion-sana-clave-prevenir-cancer-gastrico-chile/
Portal web Entorno Inteligente http://www.entornointeligente.com/articulo/9086302/Una-alimentacion-sana-es-clave-para-prevenir-el-cancer-gastrico-en-Chile-13102016
Portal web Soy Chile http://www.soychile.cl/Santiago/Sociedad/2016/10/13/423462/Especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-Chile.aspx
Portal web Reporte Chile https://reportechile.net/2016/10/especialista-entrega-las-claves-para-prevenir-el-cancer-gastrico-en-chile/
Portal web FM Dos http://www.fmdos.cl/noticias/atentos-estos-alimentos-ayudan-prevenir-cancer-gastrico/
Portal web Soy Chile TV https://www.youtube.com/watch?v=DCrcce7hqik
Portal Solución Web http://solucionweb.cl/2016/10/13/conoce-los-alimentos-que-pueden-ayudar-a-prevenir-el-cancer-gastrico/

2017
Diario La Prensa de Curicó http://www.litoralpress.cl/sitio/PDF3/litoralpresspdf.aspx?id=39581542&idT=700547&org=no&carp=universidadcentral&ve=0 


2018
-Canal Chilevisión, programa ‘CHV Noticias Central’ https://www.litoralpress.cl/deposito/videosm/7921373.mp4 
-Canal CNN Chile, programa ‘Mirada Central’ "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Portal Canal Chilevisión, programa ‘CHV Noticias Central’ https://www.litoralpress.cl/deposito/videosm/7921373.mp4 
-Portal Canal CNN Chile, programa ‘Mirada Central’ "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Canal CNN Chile, programa ‘Mirada Central’ (Repetición) "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Canal CNN Chile, programa ‘Mirada Central’ (Repetición) "Parte I: https://www.litoralpress.cl/deposito/videosm/7945158.mp4
-Parte II: https://www.litoralpress.cl/deposito/videosm/7941040.mp4 "
-Docente Evaluador en evento Expociencias Nacional (17-19 Noviembre)

Congresos:
1. Antibacterial and antitumorigenic effects of organic extracts from the Chilean medicinal plant leptocarpha rivularis gainst Helicobacter pylori and gastric cancer cells, respectively. A. Neculman; N. Carrasco N; I. Montenegro; J. Villena; M. Valenzuela. EHMSG XXXIst International Workshop on Helicobacter & Microbiota in Inflammation & Cancer. 12-14 Septiembre 2018, Kaunas, Lituania.
2. Urease virulence factor of Helicobacter pylori induces HIF-1? activity in gastric cells. Valenzuela M, Cerda P, Canales J, Bravo D and Quest AFG. European Helicobacter and Microbiota Study Group – EHMSG XXXth International Workshop on Helicobacter & Microbiota in Inflammation & Cancer. 7-9 Septiembre, Bordeaux, Francia.
3. HIF-1? activation following Helicobacter pylori infection reduces Cyclin D1 to promote cell cycle arrest in gastric cells. Canales J, Valenzuela M, Bravo D, Toledo H, Quest AFG. AccDis Cancer Spring Symposium, 7-9 de Septiembre 2016. Olmué, Chile.


Premios y Distinciones

  •   F.R.S.-FNRS-Télévie postdoctoral fellow

    KATHOLIEKE UNIVERSITEIT LEUVEN (KUL)

    Bélgica, 2011

    beca postdoctoral

  •   Becas Chile postdoctoral fellow

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2011

    Becas postdoctoral en el extranjero

  •   Collaborator Researcher

    FONDAP

    Chile, 2014

    Collaborator researcher Fondap ACCDis


 

Article (43)

Caveolin-1-mediated tumor suppression is linked to reduced HIF1α S-nitrosylation and transcriptional activity in hypoxia
Photodynamic treatment with cationic Ir(III) complexes induces a synergistic antimicrobial effect with imipenem over carbapenem-resistant Klebsiella pneumoniae
Synergistic effect of combined imipenem and photodynamic treatment with the cationic Ir(III) complexes to polypyridine ligand on carbapenemresistant Klebsiella pneumoniae
The 5’ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells
NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE(2) Signaling Axis
Photodynamic treatment for multidrug-resistant Gram-negative bacteria: Perspectives for the treatment of Klebsiella pneumoniae infections
The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1 alpha in Gastric Cells
Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells
Synthesis and Antiproliferative Activity of New Cyclodiprenyl Phenols against Select Cancer Cell Lines
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1 alpha to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1 alpha to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
Phosphorylation of Caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
The twisted survivin connection to angiogenesis
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
Characterization of the arginine decarboxylase gene (ORF HP0422) involved in acid tolerance in Helicobacter pylori
Characterization of the Arginine Decarboxylase Gene (ORF HP0422, speA) Involved in Acid Tolerance in Helicobacter pylori
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells
Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells
Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and involve the appearance of a senescent phenotype in human bladder cancer cells
Helicobacter pylori induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma glutamyl transpeptidase activity
Helicobacter pylori-Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity
Arginine 66 Residue of Fur is Required for the Regulatory Function of this Protein in the Acid Adaptation Mechanism of Helicobacter pylori
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells
Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells
Arginine 66 residue of Fur is required for the regulatory function of this protein in the acid adaptation mechanism of Helicobacter pylori
Helicobacter pylori exhibits a Fur-dependent acid tolerance response
Helicobacter pylori Exhibits a Fur-Dependent Acid Tolerance Response
Helicobacter pylori induced loss of the inhibitor of apoptosis protein survivin is linked to gastritis and death of human gastric cells
Helicobacter pylori-Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells
Overview on chemotaxis and acid resistance in Helicobacter pylori
Overview on chemotaxis and acid resistance in Helicobacter pylori
Resistencia antimicrobiana en Helicobacter pylori: aspectos clínicos y moleculares
Acid stress response in Helicobacter pylori
Acid stress response in Helicobacter pylori

Abstract (1)

The urease virulence factor of Helicobacter pylori is required to induce HIF-1alpha activity in gastric cells

Proyecto (4)

TRANSLATIONAL REGULATION OF THE ANTIAPOPTOTIC PROTEIN SURVIVIN BY CONTROL ELEMENTS IN THE 5' UNTRANSLATED REGION (5'UTR)
TRANSLATIONAL REGULATION OF THE ANTIAPOPTOTIC PROTEIN SURVIVIN BY CONTROL ELEMENTS IN THE 5' UNTRANSLATED REGION (5'UTR)
Role of pro-oxidants in the sensitivity of HL-60 leukemic cells exposed to chemotherapies under Nrf2 activation
FUNCION DE LA ARGININA DESCARBOXILASA DE HELICOBACTER PYLORI EN LA ADAPTACION DE LA BACTERIA AL PH ACIDO DEL ESTOMAGO=> UN MECANISMO DE ADAPTACION AL ESTRES ACIDO DESARROLLADO POR HELICOBACTER PYLORI?

Review (4)

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
The twisted survivin connection to angiogenesis
17
Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

6
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

2
Maritza Garrido

Bioquímico

Obstetricia y Ginecología

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Christian Palavecino

Profesor asistente

Universidad Central de Chile

Santiago, Chile

1
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Iván González

Profesor

Universidad Central de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alejandro Madrid

Academico Asociado

Química

Universidad de Playa ancha

Valparaíso, Chile

1
Enrique Werner

Académico

Ciencias Básicas

UNIVERSIDAD DEL BIO-BIO

Chillán, Chile

1
Patricio Godoy

Director

Facultad de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Nelson Caro

Director de Centro

Centro de Investigación Austral Biotech

Universidad Santo Tomás

Santiago, Chile

1
Paula Díaz

-

-

-, Chile

1
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Ricardo Huilcamán

Investigador

Universidad de Chile

Santiago, Chile