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Natalia Isabel Diaz Valdivia

Postdoctoral Fellow

Universidad de Barcelona

Barcelona , España

Líneas de Investigación


Educación

  •  Biochemistry /Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007
  •  Biochemistry / Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2010
  •  Biochemistry / Bioquímica , UNIVERSIDAD DE CHILE. Chile, 2016

Experiencia Profesional

  •   Undergraduate Thesis Student / Tesista de Pregrado Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    2008 - 2010

  •   Research Assistant / Asistente de Laboratorio Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    2010 - 2011

  •   Graduate Student, PhD Thesis / Tesista de Doctorado Full Time

    Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

    Santiago, Chile

    2011 - 2016

  •   Postdoctoral Fellow / Investigador Postdoctoral Full Time

    Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile.

    Santiago, Chile

    2016 - 2018

  •   Postdoctoral Fellow / Investigador Postdoctoral Full Time

    Universidad de Barcelona

    Barcelona , España

    2018 - A la fecha

  •   International PhD Student Fellow Full Time

    Linus Pauling Institute, Oregon State University.

    Corvallis, Oregon , Estados Unidos

    2014 - 2015

Premios y Distinciones

  •   Best Poster Prize

    Biochemical Journal and Advanced Center for Chronic Diseases (ACCDiS)

    Chile, 2016

    Best Poster Prize presented in the ACCDiS Cancer Spring Symposium 2016, 7-9 September 2016, Olmué, Chile given by the Biochemical Journal.


 

Article (21)

Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress
Stromal Markers of Activated Tumor Associated Fibroblasts Predict Poor Survival and Are Associated With Necrosis in Non-Small Cell Lung Cancer
Biomimetic Quantum dot labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis in vivo.
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress
Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses.
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis.
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.
Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells
CAVEOLIN-1 IN CELL MIGRATION AND METASTASIS
Molecular insights to a novel Caveolin-1-Rab5-Rac-1 signaling pathway important for metastatic cancer cell migration and invasion
Rab5 is required in metastatic cancer cells for Caveolin-1- enhanced Rac1 activation, migration and invasion
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription.
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells
Helicobacter pylori–Induced Loss of Survivin and Gastric Cell Viability Is Attributable to Secreted Bacterial Gamma-Glutamyl Transpeptidase Activity
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells

Abstract (1)

Sub-cytotoxic doses of anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells

Proyecto (8)

Phosphatases and exosomes in caveolin-1-mediated metastasis.
Centro de Estudios Avanzados de Enfermedades Crónicas (ACCDIS)
The Thy-1 receptors alphavbeta3 integrin and Syndecan-4 on astrocytes control mitochondrial location as well as ATP release and thereby contribute to the neurotoxic effects of reactive astrocytes
caveolin-1 dependent migration of metastasis of cancer cells requires Tyr14 phosphorylation sequestration of p85a and activation Rab5-Rac1 pathway which are inhibited by the expression of E-cadherin
CENTER FOR ADVANCED STUDIES OF CRONIC DISEASES
Pro-Inflammatory Stimuli Increase Alphavbeta3 Integrin Expression In Astrocytes, Which Upon Engagement Of Neuronal Thy-1 Triggers Bidirectional-Signaling Events Required For Astrocyte Migration And Axonal Retraction. 
Supression of tumor growth by caveolin-1 involved inhibition of unfolded protein response
CENTRO DE ESTUDIOS MOLECULARES DE LA CELULA (CEMC)
8
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

5
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ana Rojas

Asistente de Investigación

Universidad Autónoma de Chile

Santiago, Chile

2
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Manuel Valenzuela

Académico Investigador

VRA

Universidad Central de Chile

santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cesar Oyarce Diaz

Posdtoc

MMB

UMCG

Groningen, Holanda

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Ricardo Huilcamán

Investigador

Universidad de Chile

Santiago, Chile