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Rodrigo Andrés Pacheco Rivera

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Líneas de Investigación


NEUROIMMUNOLGY: neurotransmitters-mediated regulation of T-cell response; T-cell response in inflammatory bowel diseases; T-cell response involved in Parkinson's disease and multiple sclerosis; T-cells in the gut-brain axis in neuroinflammation.

Educación

  •  IMMUNOLOGY, Universidad de Barcelona. España, 2006
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001
  •  Bachelor in Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Experiencia Académica

  •   Associate Investigator Full Time

    Fundación Ciencia & Vida

    Santiago, Chile

    2009 - A la fecha

  •   POSTDOCTORAL Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2006 - 2008

  •   FULL PROFESSOR Full Time

    UNIVERSIDAD ANDRES BELLO

    FACULTAD DE CIENCIAS BIOLOGICAS

    SANTIAGO, Chile

    2014 - 2019

  •   Profesor Investigador Part Time

    Universidad San Sebastián

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Associate Investigator Full Time

    Fundación Ciencia & Vida

    Santiago, Chile

    2009 - A la fecha

  •   Profesor titular Full Time

    Universidad Andrés Bello

    Santiago, Chile

    2014 - 2019

  •   Profesor Investigador Part Time

    Universidad San Sebastián

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


ADVISOR OF POSTOCTORAL TRAINING, THESES AND RESEARCH UNITS

1. Postdoctoral training.

Hugo Gonzalez: "Generation of tolerogenic dendritic cells by transduction with lentivirus". January 2014 – December 2014.

Carolina Prado: "Development of an antigen-specific immunosuppressive cell-therapy for the treatment of Rheumatoid Arthritis". May 2013 – May 2016.

Francisco Contreras: "Targeting dopamine receptor D3 expressed in CD4+ T-cells as a cell-based therapy for Parkinson’s disease". February 2015 – February 2017.

María Gabriela Colmenares: "Role of dopamine receptor D5 signalling in septic shock". September 2017 – December 2017.

Pía Vidal: "Analysing the epigenetic and transcriptional control of pathogenic phenotypes of CD4+ T-cells associated to inflammatory bowel diseases". July 2018 – July 2019.

Daniela Elgueta: “Generation of regulatory CD4+ T cells with chimeric-antigen-receptors specific to nitrated-alpha-synuclein as a therapy to Parkinson’s disease”. September 2018 – March 2020.

Sebastián Gutierrez: “Insights on the oligomerization mechanisms of GPCR heteromers involved in the migration of CD4+ T-cells towards the intestinal mucosa”. January 2020 – present.

José Manuel Jiménez: "Deciphering the epigenetic control of transcriptional networks controlling pathogenic phenotypes of CD4+ T-cells associated to gut inflammation". March 2020 – present.

2. PhD theses.

Carolina Prado: PhD student from the program of Doctorate of Biotechnology of Universidad Andrés Bello. Thesis entitled " Role of dopamine receptor D5 expressed in immune cells in the development of Multiple Sclerosis". Finished at April 2013.

Hugo Gonzalez: PhD student from the program of Doctorate of Molecular Biosciences of Universidad Andrés Bello. Thesis entitled "Role of dopamine receptors expressed on T-cells in the onset and progression of Parkinson's disease". Finished at December 2013.

Francisco Contreras: PhD student from the program of Doctorate of Biotechnology of Universidad Andrés Bello. Thesis entitled "Role of dopamine receptor D3 in the regulation of CD4+ T-cell function and differentiation". Finished at January 2015.

Andro Montoya: PhD student from the program of Doctorate of Science (mention Molecular and Cellular Biology and Neurosciences) of the Universidad de Chile. Thesis entitled "Regulation of the neuroinflammatory process associated to Parkinson's disease by the dopamine receptor D3 expressed on glial cells". Finished at June 2018.

Daniela Elgueta: PhD student from the program of Doctorate of of Biotechnology of Universidad Andrés Bello. Thesis entitled "Evaluation of the therapeutic potential of targeting dopamine receptor D3 in a mouse model of chronic neurodegeneration". Started at March 2014 and currently ongoing. Finished at January 2019.

Javier Campos: PhD student from the program of Doctorate of of Biotechnology of Universidad Andrés Bello. Thesis entitled "Analysing the involvement of CD4+ T-cells in the gut-brain axis communication associated to Parkinson's disease". Started at March 2017 and currently ongoing. Expected to be finished at March 2021.

Coral Pardo: PhD student from the program of Doctorate of of Biotechnology of Universidad Andrés Bello. Thesis entitled "Evaluar la respuesta del Factor Transcripcional ArcA y el sensor quinasa ArcB de Salmonella Typhimurium a las condiciones encontradas dentro de células del sistema inmune innato y su papel en la evasión de la respuesta adaptativa del hospedero". Started at November 2016 and currently ongoing. Finished at April 2020.

Sebastián Contreras: PhD student from the program of Doctorate of of Biotechnology of Universidad Andrés Bello. “Búsqueda de genes reguladores maestros de la diferenciación linfocitaria en la enfermedad inflamatoria intestinal: una aproximación desde las herramientas computacionales". Started at June 2018 and currently ongoing. Expected to be finished at June 2021.

Zulmary Manjarres: PhD student from the program of Doctorate of Biological Science, mention in Fisiological Science of the Pontificia Universidad Católica de Chile. “Deciphering the role of the adaptive immunity in the microbiota-brain axis associated to Parkinson’s disease". Started at May 2020 and currently ongoing. Expected to be finished at March 2023.

3. MSc theses.

Francisco Osorio: MSc student of Universidad de Chile. Thesis entitled "Determination of the role of dopamine receptor D5 in the inflammatory function of CD4+ T-cells". Started at March 2014 and currently ongoing. Finished at October 2016.

Nicole Rivera: MSc student performing thesis to obtain the title of Master on Biochemist (M.Sc.) by the Universidad Andrés Bello. Title of thesis: "Analysing the interphase of heteromers formed by chemokine receptors and dopamine receptors". Finished at October 2018.

Ornella Chovar: MSc student performing thesis to obtain the title of Master on Science (M.Sc.) by the Universidad de Chile. Title of thesis: "Role of dopamine receptor D3 in the cytotoxic response mediated by CD8+ T-cells". Finished at March 2019.

Paola Tiozzo: MSc student performing thesis to obtain the title of Master on Biochemist (M.Sc.) by the Universidad Andrés Bello. Title of thesis: "Role of dopamine receptor D2 signalling in T-cells in the development of inflammatory colitis ". Started at March 2018 and expected to be finished at March 2019.

Gabriel Kruger: MSc student performing thesis to obtain the title of Master on Life Science (M.Sc.) by the Universidad Andrés Bello. Title of thesis: "Rol del sistema de dos componentes ArcAB en la supervivencia de Salmonella Typhimurium en la evasión de la respuesta inmune del hospedero". Finished at December 2019.

4. Undergraduated students performing theses.

Pablo Díaz: Undergraduated student performing thesis to obtain the title of Biochemist (BSc) by the Universidad de Santiago de Chile. Thesis entitled ”Role of dopamine in the modulation of signaling pathways triggered by inflammatory stimuli in dendritic cells". Finished at May 2010.

Dafne Franz: Undergraduated student performing thesis to obtain the title of Engineer in Molecular Biotechnology (BSc) by the Universidad de Chile. Title of thesis: Modulation of phosphorylation of MAPKs ERK1/2 by the stimulation of dopamine receptors D3 and D5 expressed on T-cells. Finished at July 2012.

Glenda Fuentealba: Undergraduated student performing thesis to obtain the title of Biotechnologist (BSc) by the Universidad de la Frontera. Title of thesis: Role of dopamine receptor D3 expressed on CD8+ T-cells in the induction of cytotoxic response. Finished at January 2013.

Catalina Valeria: Undergraduated student performing thesis to obtain the title of Biotechnologist (BSc) by the Universidad de la Frontera. Title of thesis: Role of dopamine receptor D3 expressed on CD8+ T-cells in the immune response against melanoma. Finished at May 2014.

Francisco Osorio: Undergraduated student performing thesis to obtain the title of Engineer in Molecular Biotechnology (BSc) by the Universidad de Chile. Title of thesis: "Role of dopamine receptor D5 expressed on CD4+ T-cells in the development and progression of experimental autoimmune encephalomyelitis". Finished at December 2014.

5. Research Units.

Fernando Sierra: Student of Medical Technology from Universidad San Sebastián. Research Unit entitled "Determination of intracellular calcium mobilization triggered by dopamine receptors stimulation in dendritic cells". Started at January 2010 and finished at February 2010.

Rafaela Erices: PhD student from the program of Doctorate of Biotechnology of Universidad Andrés Bello. Research Unit entitled "Modulation of dendritic cells function by factors secreted by melanoma cells". Started at March 2010 and finished at August 2010.

Andro Montoya: Engineer in Molecular Biotechnology, Universidad de Chile. Research Unit entitled "Role of dopamine receptors expressed on T cells in the immune response against tumours". Started at September 2010 and finished at March 2011.

Avisag Jara: Student of Bachelor in Biochemistry of Universidad San Sebastián. Research Unit entitled "Improving the screening analysis of knockout and transgenic mice". Started at November 2011 and finished at February 2012.

Valentina Castillo: Student of Engineer in Molecular Biotechnology, Universidad de Chile. Research Unit entitled "Role of dopamine receptor D5 expressed on CD8+ T-cells in the Experimental Autoimmune Encephalomyelitis". April 2012 - June 2012.

Javiera Álvarez: Student of Bachelor in Biochemistry of Universidad San Sebastián. Research Unit entitled "Role of dopamine receptors expressed in CD4+ T-cells in the development of autoimmunity". Started at December 2012 and finished at February 2013.

Alexandra García: Student of Bachelor in Biochemistry of Universidad de Chile. Research Unit entitled "Role of the neurotransmitter dopamine in the regulation of immunity". Started at December 2012 and finished at February 2013.

Francisco Osorio: Student of Engineer in Molecular Biotechnology, Universidad de Chile. Research Unit entitled "Analysis of the inflammatory cell populations infiltrated into the central nervous system during Experimental Autoimmune Encephalomyelitis". March 2013 - August 2013.

Juan José Saez: Engineer in Molecular Biotechnology, Universidad de Chile. Research Unit entitled "Evaluation of induction of tolerogenic dendritic cells with drugs affecting epigenetics modifications". September 2013 - January 2014.

Nicole Rivera: Student of Bachelor in Biochemistry of Universidad Andrés Bello. Research Unit entitled "Analysing the cross-antagonism of dopamine receptors expressed in dendritic cells". Started at September 2015 and expected to be finished at December 2015.

Camila Gudenschwager: Student of Engineer in Molecular Biotechnology (BSc) by the Universidad de Chile. Research Unit entitled "Analysing the role of dopamine receptor D5 expressed in the hematopoietic compartment in the regulation of sepsis". Started at March 2015 and finished at October 2015.

Vania Macias: Student of Bachelor in Biochemistry (BSc) by the Pontificia Universidad Católica de Chile. Research Unit entitled "Analysing the functional interaction between dopamine receptor D5 and C-C chemokine receptor 9 in the migration of CD4+ T-cells". Started at March 2016 and expected to be finished at August 2016.

Michelle Salazar: Engineer in Biotechnology, Universidad de Chile. Research Unit entitled "Evaluation of role of gut-microbiota in the protective effect of lack of dopamine receptor D3 in inflammatory colitis induced by dextran sodium sulfate". March 2017 - April 2017.

Paola Tiozzo: Student of Bachelor in Biochemistry of Universidad Andrés Bello. Research Unit entitled "Evaluating the role of dopamine receptor D2 signalling in T-cells in the development of inflammatory colitis". Started at September 2017 - February 2018.

Max Perilstein: Student of Bachelor in Biology from Washington & Jefferson College. Research Unit entitled "Evaluating the functional cross-talk between dopaminergic drugs and antagonists of chemokine receptors in T-cells”. June 2018 – August 2018.


Difusión y Transferencia


2012-present. Our laboratory received school students every year, which came to our institution to see how we do research. Every year in november-december, the students that have been interested in our research are invited to perform a short research unit for two weeks to better understand our research.

2012-2013. Hugo González, a PhD student of the Laboratory of Neuroimmunology participated in Bus Conciencia, a bus bearing a laboratory inside which aims to visit different schools to show and teach school students how scientists perform science.

2013. Andro Montoya, a PhD student of the Laboratory of Neuroimmunology gave two interviews: one in radio Universidad de Chile in the program "quiero ser científico" driven by Hortensia Morales (outreach director, Facultad de Ciencias of Universidad de Chile), and the other one in the television (program "camuflados" ArTV channel). In both interviews, he explained to the society how is the life of scientists and how a research laboratory works.

2014. An interview of Dr. Rodrigo Pacheco about the role of cannabinoids in the physiopathology of Parkinson's disease was published in a local non-scientific journal for general public: Revista CÁÑAMO vol.88, pp.44, August 2014.

2015. An interview of Dr. Rodrigo Pacheco about his experience performing research was published in the web page of redbionova. http://www.redbionova.com/perfiles/rodrigo-pacheco-yo-creo-que-en-chile-hay-cientificos-muy-buenos-y-que-logran-sacar-adelante-preguntas-muy-interesantes/

2016-2017. A capsule about Dr. Rodrigo Pacheco talking to the general society was shown in the television (many times during may-jury 2017) explaining what is his research looking for and why is so important biomedical research for our society.

2018. A report about the reserach performed in the Laboratory of Neuroimmunology was published in a TV program (Exploradores), which is also available in internet.

2018-present. Ciencia Joven program. Every year, head of research laboratories visited schools to advice primary school students in their scientific project. Afterward students visited reserachers at the laboratories to learn about the reserach conducted in each laboratory. In a separate sesion, school teachers visited researchers to get advice about how to teach science in the school.

2018. Interview in a national circulation newspaper "Las últimas noticias". The head of the laboratory of Neuroimmunology had an interview about his opinion in a biomedical research in Parkinson's disease conducted by a national reserach team.

2018. A report about the reserach performed in the Laboratory of Neuroimmunology was published in a national circulation newspaper (Las últimas noticias), which is also available in internet.

2018. Interview in a radio program "La invención del futuro" (Radio Pauta). The head of the laboratory of Neuroimmunology had an interview about an award received from Michael J Fox Foundation to perform biomedical research in Parkinson's disease.

2018. The web site RedBionova published a report about an award received by the Laboratory of Neuroimmunology of the Fundación Ciencia & Vida from the Michael J Fox Foundation to perform biomedical research in Parkinson's disease.

2018-2019. Undegraduate students of Biochemistry and Biotechnology from Universidad Austral visited research laboratories at Fundación Ciencia & Vida to learn about the research conduced in each area.

2020. EL GRAN IMPOSTOR, así engaña al cuerpo el coronavirus. Rodrigo Pacheco interview in LA TERCERA. 25 May 2020. https://www.latercera.com/que-pasa/noticia/el-gran-impostor-asi-engana-al-cuerpo-el-coronavirus/SZC3PYDZPBESZMUUVXO6KNKZNU/

2020. Vacunas contra el sarampión y tuberculosis podrían protegerte contra el coronavirus. Rodrigo Pacheco interview in LA TERCERA. 25 May 2020. https://www.latercera.com/que-pasa/noticia/vacunas-contra-el-sarampion-y-tuberculosis-podrian-protegerte-frente-al-coronavirus/YM6GG4326JHC7J35C5ZNNXVFJQ/

2020. El debate que surgirá cuando esté lista la vacuna contra el coronavirus: ¿quién primero?. Rodrigo Pacheco interview in LA TERCERA. 20 May 2020. https://www.latercera.com/que-pasa/noticia/el-debate-que-surgira-cuando-este-lista-una-vacuna-contra-el-coronavirus-quien-primero/IXO3DYUH6FBKVG4CPOTYKTCW7A/

2020. Radio agricultura. Dos vacunas se acercan a ser el antídoto contra el coronavirus. 28 May 2020. https://www.radioagricultura.cl/internacional/2020/05/28/dos-vacunas-se-acercan-a-ser-el-antidoto-contra-el-coronavirus.html

2020. Reportaje chilevisión Pandemia y hacinamiento. Fundación Ciencia y Vida. Rodrigo Pacheco. 2 June 2020. https://www.youtube.com/watch?v=shIjK6H49I8&feature=youtu.be

2020. No es solo una enfermedad respiratoria: Covid-19 también genera accidentes cerebrovasculares y en personas jóvenes. Rodrigo Pacheco interview in LA TERCERA. 17 June 2020. https://www.latercera.com/que-pasa/noticia/no-es-solo-una-enfermedad-respiratoria-covid-19-tambien-genera-accidentes-cerebrovasculares-y-en-personas-jovenes/EVYXGP4X5NHSVGHIIW3UIWWEZU/

2020. Featured Scientists. Los Recomendados por Rodrigo Pacheco. LA TERCERA 19 June 2020. https://s3-fotos-campanas.s3.amazonaws.com/NewsletterQuePasa/20201906/20201906.html

2020. Utilización de vacunas antiguas como tratamiento para coronavirus. Reportaje TVN noticiero central. 25 June 2020. https://www.youtube.com/watch?v=xF0FNhaHRJs&feature=youtu.be

2020. Covid-19 e inmunidad: evidencia en torno a uno de los mayores debates, explicada por un inmunólogo. Entrevista online 1 july 200 . https://www.kiltronoticias.com/post/covid-19-coronavirus-inmunidad-cuanto-tiempo-dura

2020. Científicos crean terapia contra el Parkinson interviniendo el sistema inmune. Reportaje en Las Últimas Noticias publicado el 31 de Octubre de 2020. https://www.lun.com/Pages/NewsDetail.aspx?dt=2020-10-31&SupplementId=0&BodyID=0&PaginaId=2&r=w


Premios y Distinciones

  •   Best qualifications of students graduated on 1999

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1999

    Best qualifications of bachelor in biochemistry. Students graduated on 1999.

  •   Scolarship for PhD studies

    MINISTERIO DE PLANIFICACION Y COOPERACION

    Chile, 2001

    Scholarship for studies of PhD outside of Chile. 2001-2003

  •   Scholarship for PhD studies

    Universidad de Barcelona

    España, 2003

    Scholarship for studies of PhD. 2003-2006.

  •   Postdoctoral scholarship from CONICYT

    CONICYT

    Chile, 2007

    Scholarship for postdoctoral training. FONDECYT 3070018.

  •   Featured publication in Journal of Immunology

    Journal of Immunology

    Estados Unidos, 2013

    Publication "Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during Parkinson's disease" featured in journal of immunology in the issue where it was published. The journal just features the 10% most relevant publications.

  •   Postdoctoral Scolarship

    Pontificia Universidad Católica de Chile

    Chile, 2008

    Scholarship for incorporation of Postdoctorates to the academy awarded by Vicerrectoría Adjunta de Investigación y Doctorado (VRAID) of the Pontificia Universidad Católica de Chile.

  •   100 young leaders

    El Mercurio

    Chile, 2009

    Awarded by "El Mercurio" in recognition as one of the 100 most professionally successful young persons in Chile 2009.

  •   Travel Grant

    American Association of Immunologists

    Estados Unidos, 2013

    AAI Travel Grant for the 15th ICI. Recognizing Scientists of Distinction?at Every Career Stage.

  •   Cover image in Journal of Neuroimmunology

    Journal of Neuroimmunology

    Holanda, 2009

    Journal of Neuroimmunology invited us to share one of the figures of our review article as the cover of Vol.216, issue 1-2, 2009

  •   Travel Grant

    American Association of Immunologists

    Estados Unidos, 2015

    AAI Travel Grant for the 5th ECI. Recognizing Scientists of Distinction?at Every Career Stage.

  •   Cover image in Journal of Neuroimmune Pharmacology

    Journal of Neuroimmune Pharmacology - Springer Nature

    Suiza, 2015

    Journal of Neuroimmune Pharmacology invited us to share one of the figure from our review as the cover image of Vol.10 issue 4, 2015.

  •   Daniel Hevia, Patricio Araos, Carolina Prado, Eugenia Fuentes Luppichini, Macarena Rojas, Rodrigo Alzamora, Flavia Cifuentes-Araneda, Alexis A. Gonzalez, Cristian A. Amador, Rodrigo Pacheco, Luis Michea.

    American Heart Association

    Estados Unidos, 2018

    Publication (Hevia et al., 2018) entitled: “Myeloid CD11c+ Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II plus High-Salt Diet” Featured in the editorial comments of HYPERTENSION.

  •   Rodrigo Pacheco

    American Association of Immunologists

    Estados Unidos, 2018

    AAI Travel Grant to attend the 5th ECI in Amsterdam. Recognizing Scientists of Distinction?at Every Career Stage.

  •   COVER IMAGE

    Springer Nature

    Suiza, 2020

    Cover image in Journal of Neuroimmune Pharmacology Vol.15, Issue 1, 2020.


 

Article (50)

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation
Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation
The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia
Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation
Dopamine Receptor D3 Expression Is Altered in CD4(+) T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
IRE1α activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T cell Priming
STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease.
T-cell-driven inflammation as a mediator of the gut-brain axis involved in Parkinson’s disease
Targeting the Dopaminergic System in Autoimmunity
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells
Dopaminergic stimulation of Myeloid antigen-Presenting cells attenuates signal Transducer and activator of Transcription 3-activation Favouring the Development of experimental autoimmune encephalomyelitis
IRE1 alpha Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming
Myeloid CD11c(+) Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet
Myeloid CD11c+ Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II plus High-Salt Diet
Smoking promotes exacerbated inflammatory features in dendritic cells of Chilean rheumatoid arthritis patients
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis
Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8(+) T-cells favoring anti-tumor immunity
Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease
Targeting dopamine receptor D3 signalling in inflammation
Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity
Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory
Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T-cell activation and dendritic cell maturation
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs
Dopamine receptors D3 and D5 regulate CD4(+) T-cell activation and differentiation by modulating ERK activation and cAMP production
Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+T-cells
Dopamine receptor D3 deficiency results in chronic depression and anxiety
The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model
Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease
Modulation of T-cell Mediated Immunity by Dopamine Receptor D5
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity
Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4(+) T cells
Emerging evidence for the role of neurotransmitters in the modulation of T cell responses to cognate ligands
Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells
Immunological Dysfunction in HIV-1-Infected Individuals by Impairment of Adenosine Deaminase-Induced Co-Stimulation of T-Cell Activation
Host Immunity during Respiratory Syncytial Virus pathogenesis.
Response to Drs. Straub and Jessop
Emergence of neurotransmitters as immune modulators
Enzymatic and extra-enzymatic role of adenosine deaminase 1 in T cell-dendritic cell contacts and in alterations of the immune function
Immune complex-induced enhancement of bacterial antigen presentation requires Fcγ Receptor III expression on dendritic cells.
Glutamate released by dendritic cells as a novel modulator of T-cell activation.
CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse
Role of CD26-adenosine deaminase interaction in the T cell-mediated immunity
Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation
Hemocyanin of the molluskan concholepas concholepas exhibits an unusual heterodecameric array of subunits.

Abstract (1)

Special Issue: Abstracts of the Annual Congress of the British Society for Immunology, 5-8 December 2011, Liverpool, UK

BookSection (1)

Cells, molecules and mechanisms involved in the neuro-immune interaction

ConferencePaper (20)

Dopaminergic regulation of T-cell-driven inflammation involved in Parkinson’s disease
Dopamine-driven inflammation in Parkinson's disease.
Dopamine-driven inflammation involved in Parkinson’s disease
Dopaminergic regulation of immunity in the gut and the brain
Dopaminergic regulation of T-cell-driven inflammation
Rol del sistema inmune en la enfermedad de Parkinson: el motor del proceso neurodegenerativo
Dopamine-driven inflammation in the gut and the brain
Regulación dopaminérgica de la respuesta de células T CD4+ involucrada en la enfermedad de Parkinson
Dopaminergic regulation of CD4+ T cell response associated to inflammatory and neurodegenerative disorders
Dopaminergic regulation of CD4+ T cell response in neurodegenerative disorders
T-cell mediated regulation of neuroinflammation involved in neurodegenerative diseases
The dopaminergic regulation of CD4+ T-cell response associated to inflammatory and neurodegenerative disorders.
The dopaminergic regulation of T-cell mediated immunity and its involvement in inflammatory disorders
Dopaminergic regulation of T-cell mediated immunity involved in Parkinson’s disease and Multiple Sclerosis
Dopaminergic regulation of T-cell mediated response involved in Multiple Sclerosis and Parkinson's disease
Involvement of dopamine receptor D3 mediated regulation of CD4+ T-cells function in the development of Parkinson's disease
Regulación dopaminérgica de la respuesta inmune
Papel de la dopamina en la regulación de la respuesta inmunitaria
Role of dopamine on the regulation of the immune response
Impact of the Immunology in the human health

ConferencePoster (27)

Dopamine receptor D5 shapes the adult T cell repertoire
Dopamine receptor D5 signaling regulates lymphopoiesis.
The inhibition of dopamine receptor D3 signalling in CD4+ T-cells exerts a therapeutic effect attenuating Parkinson's disease development in a mouse model
The inhibition of dopamine receptor D3 signalling in CD4+ T-cells exerts a therapeutic effect attenuating Parkinson's disease in a mouse model
Dopamine receptor 3 (D3R) promotes the generation of cytotoxic CD8+ T cell responses and antitumor protection
Dopamine receptor D3 plays a dual role in B-cells favoring antigen-presenting cell function and stimulating the suppressive activity of regulatory B-cells in autoimmunity
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation.
GSK-J4 A SELECTIVE INHIBITOR OF THE H3K27 DEMETHYLASE JMJD3/UTX LIMITS ACUTE COLITIS BY DE NOVO SYNTHESIS OF RETINOIC ACID IN DENDRITIC CELLS
The ablation of dendritic cells prevented hypertension, the induction of renal sodium transporters and enhances natriuresis in mice treated with angiotensin II and high salt diet
Dopamine receptor D3 signaling exerts a dual role in CD4+ T-cells-mediated immunity by impairing Tregs suppressive activity and favoring Th1 responses
Dopamine Receptor type 5 knockout mice (D5RKO) show memory impairments but normal affective behavior
Dopamine receptors D3 and D5 regulate CD4 +T-cell activation and differentiation by modulating ERK activation and cAMP production
The selective jumonji H3K27 demethylase inhibitor GSK-J4 limits inflammation through dendritic cell modulation
Ablation of Dendritic Cells Prevents Hypertension in Mice Infused with Angiotensin II plus High Salt Diet
Células Dendríticas son necesarias para el desarrollo de hipertensión y daño de tejidos en respuesta a Angiotensina II y dieta rica en sal.
Dopamine receptor D5 expressed on effector CD4+ T-lymphocytes favors the pathogenic immune response associated to Experimental Autoimmune Encephalomyelitis
Involvement of dopamine receptor D5 in the inflammatory reflex associated to sepsis
Role of Dendritic Cells in Angiotensin II-Induced Hypertension, Inflammation and Tissue Damage
Stimulation of dopamine receptor D3 expressed in glial cells contributes to neuroinflammation involved in Parkinson's disease
Caveolin-1 is required for LPS-induced dendritic cell maturation
Dopamine receptor D3 expressed on CD4+ T-cells favours neurodegeneration of dopaminergic neurons during Parkinson's disease.
Dopamine receptor D5 expressed on CD4+ T-cells differentially regulates the development of autoimmunity
Dopamine regulates the induction of Cytotoxic T-Lymphocyte by stimulation of dopamine receptor D3 expressed on CD8+ T-cells and on dendritic cells.
Expression of dopamine receptor D3 on CD4+ T-cells favors Th1-mediated immunity.
Role of DCs in Angiotensin II-induced hypertension, inflammation and tissue damage.
Stimulation of dopamine receptors D3 and D5 expressed on CD4+ T-cells regulates cellular activation and differentiation by mechanisms involving modulation of ERKs-activation and cAMP production
INHIBITION OF DOPAMINE RECEPTOR D3 SIGNALING IN DENDRITIC CELLS INCREASES ANTIGEN CROSS-PRESENTATION TO CD8+ T-CELLS FAVORING ANTI-TUMOR IMMUNITY

Editorial (1)

Editorial: Peripheral Immunity in Parkinson's Disease: Emerging Role and Novel Target for Therapeutics

Patent (1)

ATTENUATION OF NEURODEGENERATION ASSOCIATED TO PARKINSON'S DISEASE BY INHIBITION OF DOPAMINE D3 RECEPTOR ON CD4+ T CELLS

Proyecto (39)

Insights on the oligomerization mechanisms of GPCR heteromers involved in the migration of CD4+ T-cells towards the intestinal mucosa
Development of chimeric proteins as a vaccine strategy for preventing the first infection and the infection recurrence by Clostridium difficile
Development of chimeric proteins as a vaccine strategy for preventing the first infection and the infection recurrence by Clostridium difficile
Evaluating the therapeutic potential of the systemic antagonism of dopamine receptor D3 in the development of neuroinflammation and neurodegeneration in mice overexpressing alpha-synuclein
Evaluating the therapeutic potential of the systemic antagonism of dopamine receptor D3 in the development of neuroinflammation and neurodegeneration in mice overexpressing alpha-synuclein
Apoyo de financiamiento basal para centros de investigación de excelencia
Apoyo de Financiamiento Basal para Centros de Investigación de Excelencia
Generation of regulatory CD4+ T cells with chimeric-antigen-receptors specific to nitrated-alpha-synuclein as a therapy to Parkinson’s disease
Generation of regulatory CD4+ T cells with chimeric-antigen-receptors specific to nitrated-alpha-synuclein as a therapy to Parkinson’s disease
Role of heteromers formed by C-C chemokine receptor 9 and the dopamine receptor D5 in the gut-homing of CD4+ T-cells in inflammatory bowel diseases
Role of heteromers formed by C-C chemokine receptor 9 and the dopamine receptor D5 in the gut-homing of CD4+ T-cells in inflammatory bowel diseases
Targeting heteromers formed by G-protein coupled receptors involved in the gut-homing of T-cells in inflammatory bowel diseases
Identification and characterization of non-cognate partners of the Salmonella Typhimurium ArcAB two-component system in response to hydrogen peroxide and hypochlorous acid
Involvement of dopamine receptor D3 in the regulation of suppressive activity of regulatory T cells in the context of inflammatory bowel diseases
Involvement of dopamine receptor D3 in the regulation of suppressive activity of regulatory T cells in the context of inflammatory bowel diseases
Participation of TRPM7 in the generation of endothelial dysfunction characteristics, enhanced inflammatory response, and multiple organ failure during endotoxemia
Targeting heteromers formed by the chemokine receptor CCR9 and the dopamine receptor D5 expressed in CD4+ T-cells in inflammatory colitis
The role of the insula in anxiety and in anxiety-related disorders in the rat
INHIBITION OF DOPAMINE RECEPTOR D3 EXPRESSED IN CD4+ T-CELLS AS TREATMENT FOR PARKINSON’S DISEASE
TARGETING DOPAMINE RECEPTOR D3 EXPRESSED IN CD4+ T-CELLS AS TREATMENT FOR PARKINSON’S DISEASE
Interferon-gamma-induced activation of a regulatory T cell subset specialized in the suppression of experimental autoimmune encephalomyelitis and multiple sclerosis
INTERFERON-GAMMA-INDUCED ACTIVATION OF A REGULATORY T CELL SUBSET SPECIALIZED IN THESUPPRESSION OF EXPERIMENTAL AUTOINMMUNE ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS
INTERPLAY BETWEEN STRESS HORMONES AND BRAIN MONOAMINES IN CORTEX MODULATES THE REACTION TO EMOTIONALLY AROUSING EXPERIENCES
Interplay between stress hormones and brain monoamines modulates the reaction to emotionally arousing experiences
ROLE OF DOPAMINE RECEPTORS EXPRESSED ON CD4 T-CELLS AND ON DENDRITIC CELLS IN THE DEVELOPMENT OF AUTOIMMUNE RESPONSE AND IN CELLULAR MECHANISMS INVOLVED IN THE PHYSIOPATHOLOGY OF MULTIPLE SCLEROSIS
Role of dopamine receptors expressed on CD4+ T-cells and on dendritic cells in the development of autoimmune response and in cellular mechanisms involved in the physiopathology of multiple sclerosis
Mechanisms of action of IFN-gamma on regulatory T cells in the EAE model and in Múltiple Sclerosis patients. A possible immunomodulatory therapy for the treatment of progressive Multiple Sclerosis
Utilización de vectores lentivirales para el desarrollo de una terapia génica para la artritis reumatoidea
Utilización de vectores lentivirales para el desarrollo de una terapia génica para la artritis reumatoidea
Papel de los receptores de dopamina expresados en células T CD4+ y en células dendríticas en el desarrollo de autoinmunidad
Role of dopamine receptors expressed in CD4 + T-cells and dendritic cells in the development of autoimmunity
Basal Financing for Science and Technology Centers of Excellence
Papel de los receptores de dopamina en la función de las células dendríticas y su implicancia en autoinmunidad
Role of dopamine receptors in the function of dendritic cells and their involvement in autoimmunity
ROLE OF DOPAMINE RECEPTORS ON T-CELL MEDIATED IMMUNITY
Role of dopamine receptors on the T-cell mediated immunity
Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia
PAPEL DE LA VIDA MEDIA DE INTERACCION TCR/PMHC EN LA ACTIVACION DE CELULAS T DE MEMORIA.
Role of half-life of TCR/pMHC interaction on the activation of memory T cells

Review (6)

Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders
Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases
The dopaminergic system in autoimmune diseases
Role of dopamine in the physiology of T-cells and dendritic cells
Role of glutamate on T-cell mediated immunity
119
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

14
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

8
Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

8
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

6
Valentina Ugalde

Asistente de Investigación

Laboratorio de Neuroinmunología

Fundación Ciencia & Vida

Santiago, Chile

4
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

3
Andro Montoya

Docente de Laboratorio de Biología Celular

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

3
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

2
Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

2
Pia Vidal

assistant professor

Universidad Católica de la Santisima Concepción

Concepcion, Chile

2
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

2
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

2
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

2
Cesar Oyarce Diaz

Posdtoc

MMB

UMCG

Groningen, Holanda

2
Cristián Amador

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Patricio Araos

Postdoctoral Researcher

Fisiología

Universidad Autónoma de Chile

Santiago, Chile

1
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Evelyn Pardo

Investigadora Independiente

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

SANTIAGO , Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

1
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

1
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Luz Vásquez

Profesor Asociado

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

1
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
Jocelyn Neira

Especialista Profesional

Universidad Andrés Bello

Santiago, Chile

1
Sarah Nuñez

Académico Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Coral Pardo

Investigador postdoctoral

Universidad Andrés Bello

Santiago, Chile

1
Natalia Diaz

Postdoctoral Fellow

Biofísica y Bioingeniería

Universidad de Barcelona

Barcelona , España

1
Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

1
Reinaldo Uribe

Instructor Adjunto

Neurología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabian Montecino

Asistente de investigación

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Juan Castro

Post-Doctorante

Universidad Católica del Norte

Antofagasta, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
CLAUDIA CARCAMO

Profesor Asistente

neurology

PONTIFICIA UNIVERSIDADA CATÓLICA DE CHILE. DEPARTAMENTO DE NEUROLOGÍA

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile