Man

Sebastian Bernales Odino

Founder

Merken Biotech

Santiago, Chile

Líneas de Investigación


Development in the area of Biopharmaceutical, development of new therapies to treat chronic diseases in patients have limited treatment options.

Educación

  •  Cell Biology, UNIVERSITY OF CALIFORNIA-SAN FRANCISCO. Estados Unidos, 2006
  •  Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1995
  •  Biochemistry, CATHOLIC UNIVERSITY OF AMERICA. Chile, 2000

Experiencia Académica

  •   Doctoral Student Full Time

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    Peter Walter

    San Francisco, CA, Estados Unidos

    2001 - 2006

  •   Postdoctoral Fellow Full Time

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    Marc Shuman

    San Francisco CA, Estados Unidos

    2007 - 2009

  •   Research Assistant Full Time

    Millennium Institute

    Santiago, Chile

    2001 - 2001

  •   HHMI research student Full Time

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    Santiago, Estados Unidos

    2000 - 2000

Experiencia Profesional

  •   Vice presidend of discovery biology Full Time

    Medivation inc.

    San Francisco, California, Estados Unidos

    2015 - 2016

  •   Founder Other

    Merken Biotech

    Santiago, Chile

    2016 - A la fecha

  •   Senior Director of research Full Time

    Medivation inc.

    San Francisco, California, Chile

    2013 - 2015

  •   Director of research Full Time

    Medivation Inc.

    San Francisco, CA, Estados Unidos

    2011 - 2013

  •   Associate Director of research Full Time

    Medivation Inc.

    San Francisco, CA, Chile

    2011 - 2011

  •   Consultant Full Time

    Medivation Inc.

    San Francisco, CA, Chile

    2007 - 2011

  •   Director of International Programs Other

    Fundacion Ciencia & Vida

    Santiago, Chile

    2007 - A la fecha

  •   Scientific Director Other

    EcoScience

    Santiago, Chile

    2007 - A la fecha

  •   CEO Full Time

    Praxis Biotech LLC

    San Francisco, California, Estados Unidos

    2016 - A la fecha

Formación de Capital Humano


Pregrado,
Jorge Cerda, Estudio de la respuesta a proteinas mal plegadas en la mitocondria (mtUPR)

Postgrado:
Sebastian Belmar, Estudio del Receptor huérfano tipo-receptor tirosina quinasa 2 (Ror2) como blanco farmacológico para la terapia de lesiones osteolíticas.
Gonzalo Ureta, Inhibicion selectiva de la translocacion de proteinas del reticulo endoplasmico como posible tratamiento contra el mieloma multiple.
Luz Delgado, Caracterización del efecto de latrepirdina en modelos de sobreexpresión de alfa-sinucleina.
Daniela Perez, Regulacion citosolica de UPR por Ak.
Marisol Morales, Transactivation of IRE1 and PERK by a small kinase inhibitor molecule.
Carolina Garri,Cell-based high-throughput screening for the discovery of small molecule modulators of the ATF6 branch of the unfolded protein response pathway.

Postdoctoral:
Jennifer Alfaro, Unfolded Protein Response, Drug Discovery for oncology
Ivan Alfaro, Drug Discovery for Neurodegenerative Diseases
Javier Guerrero,Drug discovery for Oncology
Eduardo Riquelme, Drug discovery for metabolic Diseases
Marcelo Chacon, Alzheimer's Disease
Mónica Rodrigo-Breni, Unfolded Protein Responce in disease
Alejandro Amoroso,Unfolded Protein Responce in disease
Erwin De la Fuente,The Unfolded Protein Response and Autophagy During Prostate Cancer Development.
Emma McCullagh,Unfolded Protein Response
Sebastian Belmar, ,Drug discovery for Oncology
Gonzalo Ureta, ,Drug discovery for Oncology
Luz Delgado ,Drug discovery for Oncology


Premios y Distinciones

  •   Premio a la Trayectoria Innovadora Anacleto Angelini

    Avonni

    Chile, 2020

    El Premio de Innovación Avonni es el reconocimiento honorífico más importante de Chile, que busca visibilizar los casos de éxito que están creando valor mediante la innovación en distintos rubros y categorías.


 

Article (28)

Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease
Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma
Small molecule cognitive enhancer reverses age-related memory decline in mice
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110 delta as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignanciess
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR
Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors
Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide.
Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain
Modulation of T-cell Mediated Immunity by Dopamine Receptor D5
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity
Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration.
Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism
Role of dopamine in the physiology of T-cells and dendritic cells.
The unfolded protein response during prostate cancer development.
ER-phagy: Selective autophagy of the endoplasmic reticulum
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
Eisosomes mark static sites of endocytosis
Intracellular Signaling by the Unfolded Protein Response
IRE1-Independent Gain Control of the Unfolded Protein Response
The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha

Patent (9)

Compositions containing repair cells and cationic dyes
Pellet composition containing repair cells
Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance
Sterol regulatory element-binding proteins (srebps) inhibitors
Compounds and treatment methods
Treatment methods
Methods and compositions for modulating IRE1, SRC, and ABL activity
Targeted therapeutics
Treatment methods using diarylthiohydantoin derivatives

Proyecto (9)

BETA-CARBOLINE MODULATORS OF CHAPERONE MEDIATED AUTOPHAGY
Beta-Carboline modulators of chaperone mediated autophagy
Deciphering the role of the unfolded protein response in disease
ROLE OF DOPAMINE RECEPTORS ON T-CELL MEDIATED IMMUNITY
Role Of Dopamine Receptors On T-Cell Mediated Immunity
AUTOFAGIA Y UPR DURANTE LA PROGRESION DEL CANCER
Autophagy & UPR during cancer progression
HIGADO GRASO NO ALCOHOLICO=> ESTUDIOS CLINICOS Y EXPERIMENTALES SOBRE EL ROL DE LOS ACIDOS BILIARES, LAS ADIPOQUINAS Y EL ESTRES DEL RETICULO ENDOPLASMICO
Non-alcoholic fatty liver: clinical and experimental studies about the role of bile acids, adipokines and ER stress

Review (3)

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration
Role of dopamine in the physiology of T-cells and dendritic cells
The unfolded protein response during prostate cancer development
41
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

8
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

6
SarvaJit Chakravarty

Manager

Praxis Biotech LLC

San Francisco, Estados Unidos

5
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

3
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

2
Marisol Morales

Líder de Programas Y Transferencia

Cetaqua Chile

Santiago, Chile

2
Luz Delgado

Investigador

Fundacion Ciencia para la vida

Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

1
Felipe Olivares

Profesional

CENTRO REGIONAL LA PLATINA (INIA - PLATINA)

INSTITUTO DE INVESTIGACIONES AGROPECUARIAS (INIA)

Santiago, Chile

1
Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile