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HUGO ARNALDO GONZALEZ VELOZO

Postdoctoral Fellow

University of California San Francisco

San Francisco, Chile

Líneas de Investigación


Cancer Biology, Metastasis, tumor-immune crosstalk, Bioinformatics, Cancer System Biology.

Educación

  •  Tecnologia Medica, UNIVERSIDAD DE TALCA. Chile, 2005
  •  Tecnologo Medico, UNIVERSIDAD DE TALCA. Chile, 2005
  •  Molecular Biology, UNIVERSIDAD ANDRES BELLO. Chile, 2013

Experiencia Académica

  •   PhD Candidate and Professor Full Time

    UNIVERSIDAD ANDRES BELLO

    Biological Sciences

    Santiago, Chile

    2008 - 2010

  •   PhD Candidate Full Time

    FUNDACION CIENCIA PARA LA VIDA

    Santiago, Chile

    2009 - 2014

  •   POSTDOCTORAL FELLOW Full Time

    UNIVERSITY OF CALIFORNIA SAN FRANCISCO

    SAN FRANCISCO, Estados Unidos

    2015 - A la fecha

Experiencia Profesional

  •   Postdoctoral Fellow Full Time

    University of California San Francisco

    San Francisco, Estados Unidos

    2015 - A la fecha

  •   PhD candidate and postdoctoral researcher Full Time

    Fundacion Ciencia y Vida

    Santiago, Chile

    2009 - 2014

  •   Professor Full Time

    Universidad Andres Bello

    Santiago, Chile

    2008 - 2010

Formación de Capital Humano


MENTORING AND TEACHING EXPERIENCE
Mentoring (Alumni)

• Master program mentor for Merel van Gogh, University of Utrecht, Netherlands. Current appointment: PhD candidate at University of Zurich.

• Master program Mentor for Tamara Verbeek, University of Utrecht, Netherlands. Current appointment: PhD student at University of Utrecht.

• Mentor for Wenbin Mei, Peking University, China (intern). Current appointment: PhD candidate at Rockefeller University.

• Mentor for Isabella Robles, University of California Berkeley (intern). Current appointment: Stanford University.

• Mentor for Sandhya Kalavacherla, Massachusetts Institute of Technology (MIT) (intern). Current appointment: University of California San Diego.

• Mentor for Stephen Georgiou, University of California Berkeley (intern). Current appointment: University of California San Francisco.

• Mentor for Ankitha Nanjaraj, University of California San Francisco (Research Associated). Current appointment: Sangamo Therapeutics Inc.


Difusión y Transferencia


Collaborations with biopharmaceutical companies in the USA.

• Company: 3T BIOSCIENCES INC.
Location: South San Francisco, CA, USA.
Dates of collaboration: (12/2020-12/2021).
Role: Scientific advisor in developing new ex-vivo systems for testing next-generation T cell therapies against solid cancers.

• Company: SENTI BIOSCIENCES, INC.
Location: South San Francisco, CA, USA.
Dates of collaboration: (08/2021-Present).
Role: Scientific advisor and collaborator in developing next-generation NK cell therapies for carcinomas.


Premios y Distinciones

  •   BECA DE POSTDOCTORADO EN EL EXTRANJERO BECAS CHILE

    CONICYT

    Chile, 2015

    Scholarship to perform postdoctoral training in an international institution.

  •   BECA DE DOCTORADO EN CHILE

    CONICYT

    Chile, 2010

    Scholarship for Ph.D. studies in Chile.

  •   BECAS DE TÉRMINO DE TESIS DOCTORAL

    CONICYT

    Chile, 2012

    Scholarship to fund the completion of doctoral dissertation.

  •   Summa Cum Laude Distinction for doctoral dissertation.

    UNIVERSIDAD ANDRES BELLO

    Chile, 2013

    Doctoral dissertation evaluated with the highest distinction.


 

Article (17)

Cellular architecture of human brain metastases
Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer
STAT3 Activation in combination with NF-KappaB inhibition induces tolerogenic dendritic cells with High therapeutic potential to attenuate collagen-induced arthritis
Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis
Innate and acquired immune surveillance in the postdissemination phase of metastasis
Roles of the immune system in cancer: from tumor initiation to metastatic progression
GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis
ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression
Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity
Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory
Dopamine receptors D3 and D5 regulate CD4(+) T-cell activation and differentiation by modulating ERK activation and cAMP production
Dopamine receptor D3 deficiency results in chronic depression and anxiety
Neuroprotective effect of the monoacylglycerol lipase inhibitor JZL184 in the chronic MPTP mouse model
Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

Abstract (2)

Dopamine receptor D5 expressed on dendritic cells promotes CD4+T-cell-mediated autoinununity
Stimulation of dopamine receptor D3 expressed on CD4(+) T-cells favours Th1 immunity

Proyecto (4)

Role of dopamine receptors expressed on CD4+ T-cell and on dendritic cells in the development of autoimmune response and in cellular mechanisms involved in the physiopathology of multiple sclerosis
Proyecto de inicio a la investigación para estudiantes de doctorado=> "Papel de los receptores de dopamina expresados en células T CD4+ en el desarrollo de la enfermedad de Parkinson".
Role of dopamine receptors on the T-cell mediated immunity
Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia

Review (1)

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases
19
HUGO GONZALEZ

Postdoctoral Fellow

Anatomy Department

University of California San Francisco

San Francisco, Chile

7
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

6
Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

6
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

3
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

2
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

2
Valentina Ugalde

Asistente de Investigación

Laboratorio de Neuroinmunología

Fundación Ciencia & Vida

Santiago, Chile

1
Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

1
Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

1
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

1
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile