Man

Fabiola Beatriz Osorio Olivares

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Identification of Cellular Stress Responses as Key Regulators of Immunity Role of the Unfolded Protein Response in the coordination of the immune response Molecular Immunology, Biology of antigen presenting cells

Educación

  •  Bachelor in Sciences, Molecular Biotechnology, Universidad de Chile. Chile, 2004
  •  Molecular Biotechnology Engineer, Universidad de Chile. Chile, 2006
  •  PhD in Immunology and Molecular Pathology, University College London. Reino Unido, 2010

Experiencia Académica

  •   Associated Investigator Full Time

    Universidad de Chile

    Facultad de Medicina

    Santiago, Chile

    2014 - 2016

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2016 - 2020

  •   Postdoctoral researcher Full Time

    Inflammation Research Center - Flanders Institute of Biotechnology- Ghent University

    Ghent, Bélgica

    2011 - 2013

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Thesis student

    Universidad de Chile

    Santiago, Chile

    2004 - 2006

  •   PhD candidate

    University College London

    London, Reino Unido

    2006 - 2010

  •   Postodoctoral Fellow

    Ghent University

    Ghent, Bélgica

    2011 - 2013

  •   Associate Investigator Full Time

    Universidad de Chile

    Santiago, Chile

    2014 - 2016

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2016 - 2020

  •   Associate Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2020 - A la fecha

Formación de Capital Humano


• Master Co-supervisor, Master in de Biomedische Wetenschappen. Faculteit Geneeskunde en Gezondheidwetenschappen, Universiteit Gent : Elisabeth Gilis. Thesis entitled “Role of the unfolded protein response and ER stress in the activation of dendritic cells”. Director: Prof Dr Bart Lambrecht, Co-Director : Dra Fabiola Osorio. Academiejaar 2011-2012. Winter-Spring 2012. Ghent, Belgium.

• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Cristobal Javier Costoya Tolosa. Thesis entitled: Thesis entitled “Role of the endoplasmic reticulum stress in dendritic cell function under inflammatory contexts”. September 2014- March 2016.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Bernardita Medel. Thesis entitled: “Role of the unfolded protein response sensor IRE1a in cross-presentation of antigens by CD8a+ like DCs”. September 2015- September 2016
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Antonia Geisse. Thesis entitled: “Role of the unfolded protein response sensor IRE1a in the differentiation of dendritic cells”. July 2017- April 2019.
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Maria Francisca Gutierrez. Thesis entitled: "Determination of IRE1a activation in secretory and non-secretory organs immune cells from reporter mice for IRE1a RNase activity". October 2018 -Jan 2021
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Jose Ignacio Bernales. Thesis entitled: "Role of the IRE1a/XBP1 pathway in the regulation of the antigenic presentation machinery in activated dendritic cells". October 2018- Dec 2021
• Thesis director conducing to the degree of Molecular Biotechnology Engineer. Alonso Lira. Thesis entitled: ""Characterization of the constitutive activation of the IRE1a-XBP1 axis and its physiological role in cDC1 generated in vitro". March 2019- March 2021

• Thesis director conducing to the degree of Master in Biological Sciences. Cristobal Javier Costoya Tolosa. Thesis entitled: Role of the signalling axis IRE1a/XBP1s in dendritic cells during cancer immunotherapy in murine models”. August 2015- September 2017.
• Thesis director conducing to the degree of Master in Biological Sciences. Sandra Gaete. Thesis entitled: “Activation of the sensor of the unfolded protein response sensor IRE1a in intratumoral dendritic cells”. March 2017- March 2019
• Thesis director conducing to the degree of Master in Biological Sciences. Antonia Geisse Thesis entitled: “Regulation of conventional type 1 dendritic cell function in the intestinal tract through the activation of the IRE1a/XBP1s axis”. March 2019- Present.
• Thesis director conducing to the degree of Master in Biological Sciences. Maria Francisca Gutierrez. Thesis entitled: " Control of immunity by ATF6 signaling in dendritic cells". November 2020- Present
• Thesis director conducing to the degree of Master in Biological Sciences. Jose Ignacio Bernales. Thesis entitled: "Regulation of phago-lysosomal maturation by IRE1 in dendritic cells". November 2020- Present

• Thesis director conducing to the degree of PhD in Biotechnology. Bernardita Medel, PhD program in Biotechnology, Universidad Andres Bello. Thesis project entitled: “Regulation of dendritic cell activation by the unfolded protein response sensor IRE1a”. June 2017-Present
• Thesis director conducing to the degree of PhD in Cellular and Molecular Biology and Neurosciences. Felipe Flores, PhD program of Cellular and Molecular Biology and Neurosciences, Faculty of Sciences, Universidad de Chile. Thesis project entitled: “Regulation of antitumor immunity by the unfolded protein response sensor IRE1a”. 2017-Present
• Thesis director conducing to the degree of PhD in Biomedical Sciences. Jonathan Morales. PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile. Thesis project entitled: “Regulation of dendritic cell activation by the unfolded protein response sensor ATF6” July 2018-Present
• Thesis director conducing to the degree of PhD in Biomedical Sciences. Monica Guzman. PhD program in Biomedical Sciences. Faculty of Medicine, Universidad de Chile. Thesis project entitled: "control of antiviral immunity by the IRE1/XBP1 axis in dendritic cells". June 2021- Present.

• Postdoctoral Supervisor. Dr Paulina Garcia-Gonzalez. Postdoctoral Project entitled: “Regulation of Human Dendritic Cell Function by the Unfolded Protein Response Sensor IRE1a”. March 2018-Present. Funded by FONDECYT postdoctoral fellowships.


Difusión y Transferencia


2019 President of the Chilean Association of Immunologists (ASOCHIN)
2019 Member of the American Association of Immunologists (AAI)
2018 Member of the Chilean Society of Cell Biology SBCCh
2018 Organizer of the “II meeting of the Chilean Association of Immunology”, in conjunction with the XXIV Latinoamerican Association of
Microbiology ALAM . 13-16th November 2018, Santiago, Chile.
2018 Member of the Scientific Committee of Latin American Association of Immunology (ALAI) meeting 2018, held in Cancun, Mexico.
2018 Editor in Frontiers in Immunology journal for the Research Topic entitled: “Looking Beyond Pattern Recognition: Perturbations in Cellular
Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function”
2017 Scientific Reviewer of the scientific and technological research projects (PICT), Argentinean National Scientific and Technical Research Council
(CONICET)
2017 Organizer of the “I meeting of the Chilean Association of Immunology”. 28th April 2017, Valparaiso, Chile
2017 Member of the Academic Committee of the PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile
2016 Member of the Faculty Board of the PhD program in Biomedical Sciences, Faculty of Medicine, Universidad de Chile
2016 Guest Associate Editor in Antigen Presenting Cell Biology journal Frontiers in Immunology
2016 Member of the Chilean Society of Biology
2016 Director of the Chilean Association of Immunology ASOCHIN
2016 Member of the Chilean Association of Immunology ASOCHIN
2016 Founder member of the Chilean Association of Immunology ASOCHIN
2016 Organizer of the Symposium “Bright Present and Future of Cancer Immunotherapy”. Faculty of Medicine, University of Chile, Santiago, Chile.
15-16th December 2016.
2016 Organizer of the “I Immunology Week 2016”. Faculty of Medicine, University of Chile, Santiago, Chile. 20, 21-24,25th October 2016
2014 Organizer of II Symposium on Immune Regulation SIREG 2014. Faculty of Medicine, University of Chile, Santiago, Chile. October 2014.
2011 Member of the Federation of European Biochemical Societies, (FEBS)


Premios y Distinciones

  •   • Concurso Nacional de Apoyo al Retorno de Investigadores desde el extranjero

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2014

    Grant de 2 años para desarrollo de proyecto de investigación científica en el pais.

  •   Federation of European Biochemical Societies (FEBS) Long Term Fellowship

    Federation of European Biochemical Societies (FEBS)

    Bélgica, 2011

    Postdoctoral fellowship

  •   • Marie Curie Intra-European Fellowship for career development (IEF

    Marie Curie Actions, European Commission

    Chile, 2011

    Postdoctoral fellowship

  •   • University College London Graduate School Research Scholarship (GSRS) for M.Phil/PhD research

    UNIVERSITY COLLEGE LONDON

    Reino Unido, 2007

    PhD Scholarship

  •   • University College London Graduate School Research Scholarship (GSRS) for M.Phil/PhD research

    UNIVERSITY COLLEGE LONDON

    Reino Unido, 2007

    PhD Scholarship

  •   • Cancer Research UK scholarship for M.Phil/PhD research

    CANCER RESEARCH UK

    Chile, 2006

    PhD Scholarship

  •   • Best presentation in XIX annual meeting of Cellular Biology Society of Chile

    Sociedad de Biologia Celular de Chile

    Chile, 2005

    Best oral presentation

  •   • Best poster at Division of Infection & Immunity Postgraduate Colloquium

    UNIVERSITY COLLEGE LONDON

    Reino Unido, 2009

    Best poster award

  •   Howard Hughes Medical Institute International Research Scholar

    HOWARD HUGHES MEDICAL INSTITUTE

    Estados Unidos, 2017

    The Howard Hughes Medical Institute (HHMI) has teamed up with the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation to develop scientific talent around the world. Each researcher will receive a total of $650,000 over five years. The award is a big boon for scientists early in their careers, and offers the freedom to pursue new research directions and creative projects that could develop into top-notch scientific programs.

  •   Programa ECOS- CONICYT

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2019

    Proyecto de Investigacion asociativa por 3 años entre Chile y Francia (Dr Pablo Vargas, Institute Curie), en calidad de investigador responsable.

  •   FONDECYT Regular 1161212

    FONDECYT

    Chile, 2016

    Proyecto FONDECYT Regular en calidad de investigador responsable


 

Article (16)

The Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells
Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases
IRE1 alpha Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration
Isolation of Splenic Dendritic Cells Using Fluorescence-activated Cell Sorting
Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection
The unfolded-protein-response sensor IRE-1 alpha regulates the function of CD8 alpha(+) dendritic cells
An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma
Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
DC activated via dectin-1 convert Treg into IL-17 producers
Generation of dendritic cells with regulatory properties
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

Errata (1)

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma (vol 34, pg 527, 2011)

Review (7)

Crosstalk between RNA metabolism and cellular stress responses during zika virus replication
Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways
Role of dendritic cells in the induction of lymphocyte tolerance
Tumor cell lysates as immunogenic sources for cancer vaccine design
The UPR and lung disease
Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense
The essential role of chemokines in the selective regulation of lymphocyte homing
25
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

2
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

2
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

2
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

2
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Fermín González

Profesor Asociado

universidad de chile

Santiago, Chile

1
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Aarón Oyarzún

Estudiante de Posgrado

Faculty of Medicine

Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences

Santiago, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

1
Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

1
Felipe Falcón

Médico Cirujano

Pediatría

Hospital Clínico San Borja Arriarán

Santiago, Chile

1
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

1
Luis Alonso

Estudiante Postdoctoral

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago de Chile, Chile

1
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile