Man

Mario Rosemblatt Silber

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

Líneas de Investigación


Immunology, Immune Regulation and T Cell Plasticity

Educación

  •  Biochemistry, Wayne State University. Estados Unidos, 1973
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1966

Experiencia Académica

  •   Full Professor Part Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    1983 - A la fecha

  •   Full Professor Other

    Universidad Andres Bello

    Biological Sciences

    Santiago, Chile

    2000 - A la fecha

  •   Research Fellow in Medicine Full Time

    HARVARD UNIVERSITY

    Massachusetts General Hospital

    Cambridge, Estados Unidos

    1973 - 1976

  •   Researcher Full Time

    Boston Biomedical Research Institute

    Boston, Estados Unidos

    1977 - 1983

  •   Profesor Part Time

    _Universidad San Sebastian

    Medicina y Ciencias

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Investigator Full Time

    Research Fellow in Medicine

    Boston, Estados Unidos

    1973 - 1976

  •   Professor Part Time

    Universidad de Chile

    Santiago, Chile

    1983 - A la fecha

  •   Professor Other

    Iniversidad Andres Bello

    Santiago, Chile

    2001 - A la fecha

  •   Executive Director - Researcher Other

    Fundacion Ciencia & Vida

    Santiago, Chile

    1997 - A la fecha

  •   Deputy Director Full Time

    Millennium Institute for Fundamental and Applied Biology

    Chile

    2000 - 2010

  •   Scientific Advisor Full Time

    Grupo Bios S. A.

    Chile

    1996 - 2008

  •   President Part Time

    Chilean Society for Cell Biology

    Chile

    2002 - 2004

  •   Profesor Part Time

    Universidad San Sebastian

    Santiago, Chile

    2020 - A la fecha

Formación de Capital Humano


ADVISOR TO GRADUATE STUDENTS

• Cristian Doñas (2017). Regulación Epigenética de la Autoinmunidad. University Andrés Bello
• Karen Navarrete (2016). Caracterización Morfo-funcional de leucocitos fagocíticos en Salmón Atlántico Universidad Andrés Bello
• Gabriela Tejón (2015). Balance entre Toleracia e Inmunidad. Homing y conversion de linfocitos T reguladores a Th17
• Macarena Fritz (2013). Modulación de la diferenciación de linfocitos T reguladores y Helper mediante drogas epigenéticas. Universidad Andrés Bello
• Solange Rubio (2013) Identificación de linfocitos B en pez cebra. University Andres Bello
• Paulina Ruiz (2013). Interacciones entre los mecanismos de tolerancia central y periférica en la respuesta inmune alogénica. University of Chile
• Macarena Fritz (2013). Modulación de la diferenciación de linfocitos T reguladores y T helper 17 mediante drogas epigenéticas. University Andres Bello
• Nicole Halcartegaray (2012), Identificación, aislación y caracterización de subpoblaciones linfoides en Salmo salar mediante anticuerpos monoclonales. Univ Andres Bello
• Alejandra Gleisner (2012) Papel de los receptores slam en el desarrollo del lupus. University of Chile
• Paz Reyes (2011) El desarrollo del Lupus Eritematoso Sistémico es influenciado por alteraciones en el microambiente. University Andres Bello
• Carolina Alarcón (2010) Inducción de tolerancia periférica en trasplantes alogénicos. University Andres Bello
• Leidy Lagos (2011) Estudio del sistema inmune de salmo salar
• Jaime De Calisto (2010). Modulación del fenotipo y función de las células dendríticas de ratón por el ácido all-trans retinoico. University of Chile
• Daniela Sauma (2009). Microenvironmental influence on the polarization of T cell by dendritic cells. University of Chile
• Raúl Elgueta (2008). Mechanisms regulating T cell homing. University of Chile
• Jennifer Alfaro (2008). The biology of dendritic cells in the Lupus. University of Chile
• Pablo Vargas (2007). Role of cellular proteases in the biology of dendritic cells. University of Chile
• Lilian Reyes (2006). Expression of MHC class II molecules on HEVs induced after B cell adhesion. University of Chile
• Claudio Cortés (2004). Differential regulation of MHC class II expression by different isoforms of CIITA. University of Chile
• Rodrigo Mora (2001). The role of dendritic cells in the establishment of the homing potential of lymphocytes. University of Chile
• Laura Salas-Cortez (2001). The SRY protein: Expression during the normal and abnormal development of the gonad. Université de Paris
• Rodrigo Naves (1999). Regulation of the expression of MHC class II proteins. University of Chile
• Ana María Lennon (1994). Identification d'un nouveau facteur impliqué dans la transduction du signal de l'interféron gamma Université de Paris
• Andrea Castro (1990). Adhesion receptors in the interactions between lymphocytes and stromal cells from murine spleen. University of Chile (M.Sc.)
• Gonzalo Pérez (1988). Immunological studies of the surface membrane from skeletal muscle transverse T-tubules. University of Chile (M.Sc.)

SUPERVISION OF MEDICAL STUDENTS (IMMUNOLOGY CURRICULUM)

• Dr. Nicole Jadue Andriola. University of Chile 2006
• Dr. Patricia Roessler Vergara. University of Chile 2006
• Dr. Alfonso Loosli. University of Chile 2006
• Dr. Ana María Gallardo. University of Chile 2006
• Dr. Jefferson Hidalgo Villalva. University of Chile 2006
• Dr. Daniela Greppi Quezada. University of Chile2005
• Dr. Patricio Jara Véliz University of Chile 2005
• Dr. Matsumi Grau. University of Chile2005
• Dr. Alfonso Moraga. University of Chile2005
• Dr. Rodrigo Ovalle Fernández. University of Chile 2005
• Dr. Paula Duarte. University of Chile 2004
• Dr. Lorena Jiusan Linzmayer. University of Chile2004
• Dr. Laura Orellana Ríos. University of Chile 2004
• Dr. Pablo Raby. University of Chile 2004
• Dr. Marisol Loreto Ayala Concha. University of Chile 2001
• Dr. Andrea Alejandra Meyer Kother. University of Chile 2001

ADVISOR OF UNDERGRADUATE STUDENTS

• Pablo Cifuentes. (2012). Bioquímica. Universidad Andrés Bello
• Macarena Carrasco (2013). Biotecnología. Universidad Andrés Bello
• Felipe Vilches (2011). Molecular Biotechnology - University of Chile
• Pablo Espejo (2010). Molecular Biotechnology - University of Chile
• Alejandra Gleissner (2007). Molecular Biotechnology - University of Chile
• Jocelyn Neira (2007). Biochemistry - University of Chile
• Gonzalo Ureta (2006). Molecular Biotechnology - University of Chile
• Paula Michea. Molecular Biotechnology - University of Chile 2006
• Fernando Sepúlveda. Biochemistry - University of Chile 2005
• Karina Pino. Molecular Biotechnology - University of Chile 2005
• Fabiola Osorio. Molecular Biotechnology - University of Chile 2004
• Daniela Sauma. Biochemistry - University of Chile 2003
• Pablo Vargas. Molecular Biotechnology - University of Chile 2003
• Paula Escobar. Biochemistry - University of Chile 2002
• Gisella Puga. Biochemistry - University of Chile 1998
• Alejandra Loyola. Biochemistry - University of Chile 1996
• Laura Salas. Biochemistry - University of Chile 1995
• Rodrigo Naves. B.Sc. - University of Chile 1993
• Ana-María Lennon. B.Sc. - University of Chile 1992
• Daniel Rojo. Biochemistry - University of Chile 1991
• Pamela Zamudio. Molecular Pharmacy - University of Chile 1987
• Aurora Flores. Biochemistry - University of Chile 1986


Difusión y Transferencia


Dissemination

• Workshops on Genetic Engineering for Opinion Leaders (2004-2015). Fundación Ciencia & Vida
• Immunology Workshop for general public (2016) Puerto de Ideas Festival. Antofagasta, Chile
• Scientific Advisor for several Explora Projects, such as "Xentinelas Xelulares" videogame and "Ursi y Magnogeek" TV series
• Conferences and workshops on immunology for high school teachers and students

PATENTS

1696-2006
29.06.2006
Vacuna contra el síndrome rickettsial del salmón que comprende 1 fragmento de ADN que codifica para la transglicosidasa lítica de membrana B (MLTB) de Piscirikettsia salmonis, procedimiento de preparación, ADN que la codifica y método de detección de anticuerpos contra MLTB.
P. Valenzuela, L. Burzio y M. Rosemblatt

023-2006
05.01.2006
Método para la obtención de anticuerpos policlonales o monoclonales que comprende la inmunización de un mamífero roedor con células dendríticas isogénicas precargadas in Vitro con al menos un antígeno de interés; y anticuerpos obtenidos mediante este método.
M. Rosemblatt, M.R. Bono, P. Vargas

1652-2005
30.06.2005
Composición para vacuna que comprende una combinación de al menos dos proteínas de Aeromonas salmonicida seleccionadas entre HSP60, HSP70, OMPA y FSTB, o las regiones inmunogénicas de estas; usos, vacuna recombinante que contiene la composición; y procedimiento de preparación de dicha vacuna contra la furunculosis.
V. Wilhelm, A. Miquel, L. Burzio, M. Rosemblatt, P. Valenzuela, F. Santana
Nº Registro 46002 / 06.10.2009

1409-2003
09.07.2003
Composición compuesta por proteínas seleccionadas de MLTB-1, MLTB-2, TBPB-1 de Piscirickettsia salmonis; vacuna recombinante y su uso para prevenir o proteger la infección por Piscirickettsia salmonis.
P. Valenzuela, L. Burzio, M. Rosemblatt y V. Wilhelm
Nº Registro 46114 / 25.11.2009

1408-2003
09.07.2003
Composición que comprende HSP60, HSP70, y FIgG de Piscirickettsia salmonis; vacuna recombinante que comprende la composición anterior; y uso de la vacuna para prevenir o proteger la infección por P. salmonis.
P. Valenzuela, L. Burzio, M. Rosemblatt y V. Wilhelm
Nº Registro 46540 / 01.06.2010

1049-2003
26.05.2003
Vacuna contra el síndrome rickettsial del salmón basada en un fragmento de ADN que codifica para la proteína de unión a transferrina de Piscirickettsia salmonis (TBPB) o una región inmunogénica de ésta; vacuna polipeptídica con TBPB; procedimiento de preparación; ADN que codifica TBPB y sus usos.
P. Valenzuela, L. Burzio y M. Rosemblatt
Nº Registro 46172 / 15.01.2010

1048-2003
26.05.2003
Vacuna para el síndrome rickettsial del salmón que comprende 1 fragmento de ADN que codifica para la transglicosidasa lítica soluble (SLT70) de Piscirickettsia salmonis; procedimiento de preparación; ADN que codifica SLT70; vacuna recombinante que comprende SLT70; usos; y método de detección de anticuerpos contra SLT70.
P. Valenzuela, L. Burzio y M. Rosemblatt

1047-2003
26.05.2003
Secuencia de ADN que codifica una proteína del factor de virulencia (VacB) de Piscirickettsia salmonis; vacuna de ADN y proteica que comprende VacB; método de detección de anticuerpos contra VacB; proceso de preparación de la vacuna y usos contra P. salmonis.
P. Valenzuela, L. Burzio y M. Rosemblatt

3113/2001
20.12.2001
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 16 (HSP16) de Piscirickettsia salmonis para generar respuesta inmune contra Piscirickettsia salmonis.
P. Valenzuela, L. Burzio y M. Rosemblatt
Nº Registro 46059 / 10.11.2009

3112/2001
20.12.2001
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 60 (HSP60) de Piscirickettsia salmonis, insertado en un vector PUK21-A2 para expresar la proteína y generar respuesta inmune contra Piscirickettsia salmonis en vertebrados.
P. Valenzuela, L. Burzio y M. Rosemblatt
Nº Registro 46227 / 30.12.2009

3111/2001
20.12.2001
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 10 (HSP10) de Piscirickettsia salmonis para generar respuesta inmune contra Piscirickettsia salmonis.
P. Valenzuela, L. Burzio y M. Rosemblatt
Nº Registro 46115 / 25.11.2009

3110/2001
20.12.2001
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 70 (HSP70) de Piscirickettsia salmonis, insertado en un vector PUK21-A2 para expresar la proteína y generar respuesta inmune contra Pisciriketssia salmonis en vertebrados.
P. Valenzuela, L. Burzio y M. Rosemblatt
Nº Registro 46351 / 26.03.2010


Premios y Distinciones

  •   Prize to The Best CD-ROM

    Health Care and Telemedicine

    España, 2012

    Prize to The Best CD-ROM “La Patrulla Celular” Videomed: International Competition on Medical Movies, Health Care and Telemedicine. Badajoz, Spain

  •   Basic Science Mentee/Mentor Award

    The Transplantation Society, USA

    Estados Unidos, 2010

    Basic Science Mentee/Mentor Award. The Transplantation Society, USA

  •   Award of Science Merit

    Universidad Andres Bello

    Chile, 2008

    Premio al Mérito Universidad Andrés Bello. Mención Ciencias

  •   Academic Excellence Award

    UNIVERSIDAD DE CHILE

    Chile, 2008

    Premio a la Excelencia Académica Facultad de Ciencias Universidad de Chile

  •   Best Interactive Video

    VI Festival de Cine Médico y Científico

    Argentina, 2007

    Best Interactive Video: DVD “La Patrulla Celular” VI Festival de Cine Médico y Científico. Córdoba, Argentina

  •   Best PhD Thesis

    Chilean Society for Cell Biology

    Chile, 2009

    Award to Raul Elgueta, PhD student of Dr. Rosemblatt

  •   Young Scientist Award

    NATIONAL INSTITUTES OF HEALTH (NIH)

    Estados Unidos, 1980

    Calcium Binding Proteins and Muscle Physiology


 

Article (131)

P2X7 Receptor at the Crossroads of T Cell Fate
Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice
In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo
Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
Adoptive transfer of autoinmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
Combined effect of retinoic acid and Rapamycin determine the generation, activity and homing potential of induced human regulatory T cell
Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
Purinergic Signaling as a Regulator of Th17 Cell Plasticity
Purinergic Signaling as a Regulator of Th17 Cell Plasticity.
Retinoic Acid as a Modulator of T Cell Immunity
Retinoic Acid as a Modulator of T Cell Immunity.
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance
Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance.
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression
CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression.
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells.
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
Differential Modulation of Homing Receptors in Polyclonal Human Treg Generated Ex Vivo.
Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities
Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities
Development of a recombinant vaccine against ISA virus based on synthetic genes
Epithelial control of the human pDC response to extracellular bacteria
Epithelial control of the human pDC response to extracellular bacteria
Identification of B lymphocytes in zebrafish
Isolation and identification of lymphoid subpopulations from Salmo salar
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour.
Transplant tolerance: new insights and strategies for long-term allograft acceptance.
Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
Trichostatin A promotes the generation and suppressive functions of regulatory T cells.
Allogeneic inducible regulatory T cells allow the generation of mixed chimerism via nonmyeloablative conditioning in mice models
CD40L-A costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)
CD40L-A costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)
Notch signalling regulates cytokine production by CD8+ and CD4+ T cells.
Notch Signalling Regulates Cytokine Production by CD8+and CD4+T Cells
T-cell homing to the gut mucosa: general concepts and methodological considerations.
Delivery of Alloantigens via Apoptotic Cells Generates Dendritic Cells With an immature Tolerogenic Phenotype
Delivery of Alloantigens via Apoptotic Cells Generates Dendritic Cells With an immature Tolerogenic Phenotype
Differential Regulation of Notch Ligands in Dendritic Cells upon Interaction with T Helper Cells
Differential Regulation of Notch Ligands in Dendritic Cells upon Interaction with T Helper Cells
For "The Perfect Antagonists" the winners are: MyoIC and MyoIE, for their role in "Actin shaping for vesicle exocytosis at the immune synapse."
MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells
MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells
Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation
Retinoic Acid Generates Regulatory T Cells in Experimental Transplantation
T-cell homing to the gut mucosa: General concepts and methodological considerations
Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4(+)CD25(+) regulatory T cell proliferation
Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4(+)CD25(+) regulatory T cell proliferation
Dendritic Cells and B Cells Cooperate in the Generation of CD4(+)CD25(+)FOXP3(+) Allogeneic T Cells
Dendritic Cells and B Cells Cooperate in the Generation of CD4(+)CD25(+)FOXP3(+) Allogeneic T Cells
Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and Fc gamma R Intervals within the Nba2 Autoimmune Susceptibility Locus
Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus.
Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of Anti-MHC Antibodies and T Cell Mediated Alloreactivity.
Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation
Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation.
Transforming Growth Factor-beta and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors
Transforming Growth Factor-beta and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors
Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells
Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells
Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses
Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses.
Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain
Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
Generation of dendritic cells with regulatory properties
Generation of dendritic cells with regulatory properties.
A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins
A vaccine against the salmonid pathogen Piscirickettsia salmonis based on recombinant proteins.
Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
Lymphoid B cells induce NF-kappa B activation in high endothelial cells from human tonsils
Lymphoid B cells induce NF-kappa B activation in high endothelial cells from human tonsils
Hantavirus Gc glycoprotein: evidence for a class II fusion protein
Hantavirus Gc glycoprotein: evidence for a class II fusion protein.
Human and rodent humoral immune responses to Andes virus structural proteins
Human and rodent humoral immune responses to Andes virus structural proteins
Production and immune response of recombinant Hsp60 and Hsp70 from the salmon pathogen Piscirickettsia salmonis
Production and immune response of recombinant Hsp60 and Hsp70 from the salmon pathogen Piscirickettsia salmonis.
Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells
Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells
Isolation and expression of the genes coding for the membrane bound transglycosylase B (MltB) and the transferrin binding protein B (TbpB) of the salmon pathogen Piscirickettsia salmonis
Isolation and expression of the genes coding for the membrane bound transglycosylase B (MltB) and the transferrin binding protein B (TbpB) of the salmon pathogen Piscirickettsia salmonis.
Cloning and expression of the coding regions of the heat shock proteins HSP10 and HSP16 from Piscirickettsia salmonis
Cloning and expression of the coding regions of the heat shock roteins HSP10 and HSP16 from Piscirickettsia salmonis
Cloning and expression of the coding regions of the heat shock roteins HSP10 and HSP16 from Piscirickettsia salmonis
Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
Cyclosporine preconditions dendritic cells during differentiation and reduces IL-2 and IL-12 production following activation: A potential tolerogenic effect
Cyclosporine preconditions dendritic cells during differentiation and reduces IL-2 and IL-12 production following activation: a potential tolerogenic effect.
Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis
Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells.
Adhesion of B cell lines to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation
Adhesion of B cell lines to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation
Adhesion of B cell lines to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation(1)
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation
Low-dose prednisone accounts for a transient reduction on CD4(+) and CD8(+) T cells in renal transplant patients under triple therapy
Low-dose prednisone accounts for a transient reduction on CD4(+) and CD8(+) T cells in renal transplant patients under triple therapy
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator
MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator
CD4 and CD8 cytokine-producing T cells are transiently reduced following cyclosporine intake: Maximal inhibition occurs at 2 hours coincidental with drug C-max
CD4 and CD8 cytokine-producing T cells are transiently reduced following cyclosporine intake: Maximal inhibition occurs at 2 hours coincidental with drug C-max
Expression of the human SRY protein during development in normal male gonadal and sex-reversed tissues
Expression of the human SRY protein during development in normal male gonadal and sex-reversed tissues
The bacteriophage ? DNA packaging enzyme: Identification of four structural domains of the gpNu1 subunit using limited proteolysis
The bacteriophage lambda DNA packaging enzyme: Identification of four structural domains of the gpNul subunit using limited proteolysis
The bacteriophage lambda DNA packaging enzyme: Identification of four structural domains of the gpNul subunit using limited proteolysis
The Bacteriophage lambdaDNA packaging enzyme: Identification of four structural domains of the gpNu1 subunit using limited proteolysis
SRY protein is expressed in ovotestis and streak gonads from human sex-reversal
SRY protein is expressed in ovotestis and streak gonads from human sex-reversal
CIITA B-cell-specific promoter suppression in MHC class II-silenced cell hybrids.
Expression and function of integrins on hematopoietic progenitor cells.
Lymphocyte adhesion to endothelium derived from human lymphoid tissue.
Coexpression of two fibronectin receptors, VLA-4 and VLA-5, by immature human erythroblastic precursor cells.
Alzheimer's disease: microtubule-associated proteins 2 (MAP 2) are not components of paired helical filaments.
Immunological and biochemical properties of transverse tubule membranes isolated from rabbit skeletal muscle.
Highly purified sarcoplasmic reticulum vesicles are devoid of Ca2+-independent (basal) ATPase activity
The essential role of chemokines in the selective regulation of lymphocyte homing.

Abstract (11)

RAPAMYCIN AND RETINOIC ACID DOWNREGULATE THE METHYLATION OF FOXP3 AFTER RESTIMULATION IN HUMAN TREG DERIVED FROM NAIVE T CELLS.
Differential Modulation of Homing Receptors in Polyclonal Human Treg Generated Ex Vivo.
Development of a recombinant vaccine against ISA virus based on synthetic genes
Identification of B lymphocytes in zebrafish
Isolation and identification of lymphoid subpopulations from Salmo salar
Allogeneic inducible regulatory T cells allow the generation of mixed chimerism via nonmyeloablative conditioning in mice models
For "The Perfect Antagonists" the winners are: MyoIC and MyoIE, for their role in "Actin shaping for vesicle exocytosis at the immune synapse."
Transference of Phagosomes in an Allogeneic Immunisation Protocol Down Regulates the Production of Anti-MHC Antibodies and T Cell Mediated Alloreactivity.
Cyclosporine reduces IL-2 and IL-12 production by dendritic cells: A potential tolerogenic effect
Cyclosporine reduces IL-2 and IL-12 production by dendritic cells: Implications in organ transplantation.
Lymphocyte adhesion induces MHC class II, ICAM-1 and VCAM-1 expression on human endothelial cells.

BookSection (11)

Desarrollo de inmunoterapia celular para el tratamiento del cáncer
Piscirickettsia salmonis: Un enfoque genómico para un problema de la salmonicultura
Ontogenia y Diferenciación de Células T y B
Receptores de Adhesión, “Homing” y Activación de Linfocitos
Nuevas alianzas en la comunidad Biotecnológica Chilena
Adhesion of erythroid cells to fibronectin and identification of receptors for extracellular matrix proteins
Monoclonal antibodies as probes of triad structure and exitation-contraction coupling in skeletal muscle.
Hibridomas y Anticuerpos Monoclonales
Molecular mechanism of calcium release from sarcoplasmic reticulum in vitro. Current status and prospects
Approaches to the synthesis of an antibody combining site
Restricted clonal responses: A tool in understanding antibody specificity

Comentario (1)

XVI Reunión Anual de la Sociedad de Biología Celular de Chile

ComunicacionBreve (1)

CHILE INVITA A CHILE: INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA ORGANIZA ORIGINAL ENCUENTRO DE ESTUDIANTES

ConferenceProceedingWhole (27)

International Symposium on T Cell Regulation and of the Adaptive Immune response
Manipulating Lymphocyte Re-Programming and Function
Conference on Hard Science and Serendipity
Exploring the Salmonids Immune System
Lymphocytes and Dendritic Cells. Exploring Their Rational Usage
Return of Skill and Human Capital
The Experience with Science Innovators
Harvesting on the Natural Mechanisms of the Immune System for a better Transplant
Mechanisms of Immune Tolerance
Coordinated Regulation of Immune Cell Traffic
The relation between Biotechnology and the Productive Sector in Chile
The Role of Lymphocytes in Autoimmunity
Academic research and product development in Chile. A case study
Biotechnology at Fundación Ciencia para la Vida
Mechanisms of T cell homing to mucosal tissue
Regulación celular y molecular del tráfico linfocitario
Dendritic cells as regulators of Lymphocyte Homing
New paradigms on T cell migration
Peyer's patches-derived dendritic cells preferentially induce the mucosa-specific homing integrin a4b7 on murine TCR transgenic T cells
The role of resident dendritic cells in the establishment of tissue-specific homing on T cells
Adhesion receptors and lymphocyte homing
Adhesion molecules in lymphocyte traffic and differentiation
Cell Adhesion in the Immune Response
Functional rol of Integrines VLA-4 and VLA-5 in the adhesion of human erythroblastic precursors to microenvironment components
Monoclonal antibodies as probes of triad structure and excitation-contraction coupling in skeletal muscle
Monoclonal antibodies against the T-tubule modulate Ca2+ release by a triad fraction
Amino acid sequences of rabbit anti-Pneumoccocal antibodies hypervariable regions and their relation to immunoglobulin structure and function

Patent (12)

Vacuna contra el síndrome rickettsial del salmón que comprende 1 fragmento de ADN que codifica para la transglicosidasa lítica de membrana B (MLTB) de Piscirikettsia salmonis, procedimiento de preparación, ADN que la codifica y método de detección de anticuerpos contra MLTB.
Composición que comprende HSP60, HSP70, y FIgG de Piscirickettsia salmonis; vacuna recombinante que comprende la composición anterior; y uso de la vacuna para prevenir o proteger la infección por P. salmonis.
Vacuna contra el síndrome rickettsial del salmón basada en un fragmento de ADN que codifica para la proteína de unión a transferrina de Piscirickettsia salmonis (TBPB) o una región inmunogénica de ésta; vacuna polipeptídica con TBPB; procedimiento de preparación; ADN que codifica TBPB y sus usos.
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 70 (HSP70) de Piscirickettsia salmonis, insertado en un vector PUK21-A2 para expresar la proteína y generar respuesta inmune contra Pisciriketssia salmonis en vertebrados.
Composición compuesta por proteínas seleccionadas de MLTB-1, MLTB-2, TBPB-1 de Piscirickettsia salmonis; vacuna recombinante y su uso para prevenir o proteger la infección por Piscirickettsia salmonis.
Composición para vacuna que comprende una combinación de al menos dos proteínas de Aeromonas salmonicida seleccionadas entre HSP60, HSP70, OMPA y FSTB, o las regiones inmunogénicas de estas; usos, vacuna recombinante que contiene la composición; y procedimiento de preparación de dicha vacuna contra la furunculosis.
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 10 (HSP10) de Piscirickettsia salmonis para generar respuesta inmune contra Piscirickettsia salmonis.
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 16 (HSP16) de Piscirickettsia salmonis para generar respuesta inmune contra Piscirickettsia salmonis.
Vacuna de ADN que comprende un fragmento de ADN que codifica para la proteína de estrés térmico 60 (HSP60) de Piscirickettsia salmonis, insertado en un vector PUK21-A2 para expresar la proteína y generar respuesta inmune contra Piscirickettsia salmonis en vertebrados.
Método para la obtención de anticuerpos policlonales o monoclonales que comprende la inmunización de un mamífero roedor con células dendríticas isogénicas precargadas in Vitro con al menos un antígeno de interés; y anticuerpos obtenidos mediante este método.
Secuencia de ADN que codifica una proteína del factor de virulencia (VacB) de Piscirickettsia salmonis; vacuna de ADN y proteica que comprende VacB; método de detección de anticuerpos contra VacB; proceso de preparación de la vacuna y usos contra P. salmonis.
Vacuna para el síndrome rickettsial del salmón que comprende 1 fragmento de ADN que codifica para la transglicosidasa lítica soluble (SLT70) de Piscirickettsia salmonis; procedimiento de preparación; ADN que codifica SLT70; vacuna recombinante que comprende SLT70; usos; y método de detección de anticuerpos contra SLT70.

Proyecto (34)

LEUKOCYTE TRAFFICKING AS A DETERMINANT OF AUTOIMMUNITY
GENERATION OF HUMAN REGULATORY T CELLS ABLE TO INHIBIT SPECIFICALLY THE ALLOGENEIC IMMUNE RESPONSE TO THE DIRECT AND INDIRECT PRESENTATION PATHWAYS.
TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA) FAVOURS TUMOUR GROWTH BY MODULATING INVASIVE, FIBROTIC AND IMMUNE RESPONSES IN HUMAN BREAST CANCER
Generación de un método inmunológico para el sexaje de semen de toro
Reprogramming of Regulatory T cells in Gut Immunity
REPROGRAMMING OF REGULATORY T CELLS IN GUT IMMUNITY
ROLE OF DENDRITIC CELLS IN THE DEVELOPMENT OF LUPUS
Desarrollo de un metodo inmunologico mejorado para el sexage de semen de ganado vacuno
Fundacion Ciencia & Vida
Proyecto basal PFB-16 (AFB 170004)
UTILIZACION DE MECANISMOS COMBINADOS DE TOLERANCIA CENTRAL Y PERIFERICA PARA INDUCIR TOLERANCIA A TRASPLANTES
MODULACION DEL HOMING EN EL SISTEMA INMUNE.
MICROAMBIENTE LINFOIDE Y POLARIZACION DE LA RESPUESTA INMUNE.
MODULACION DEL HOMING EN EL SISTEMA INMUNE.
Modulación del Homing en el sistema inmune
UTILIZACION DE MECANISMOS FISIOLOGICOS PARA INDUCIR TOLERANCIA EN TRASPLANTE DE ORGANOS.
MECANISMOS QUE REGULAN LA EXPRESION DE RECEPTORES DE HOMING EN LINFOCITOS T.
Mecanismos que regulan la expresión de receptores de Homing en linfocitos T
PAPEL FUNCIONAL DE LAS MOLECULAS DE HISTOCOMPATIBILIDAD DE CLASE II INDUCIDAS POR LA ADHESION DE LOS LINFOCITOS B A CELULAS ENDOTELIALES
INDUCCION DE LAS MOLECULAS DE HISTOCOMPATIBILIDAD DE CLASE II POR LA ADHESION LINFOCITARIA
REGULACION DE LOS GENES DE CLASE II DEL COMPLEJO MAYOR DE HISTOCOMPATIBILIDAD
MICROAMBIENTE LINFOIDE Y DIFERENCIACION LINFOCITARIA
Microambiente linfoide y diferenciación linfocitaria
Mecanismos genéticos que regulan la expresión del sexo masculino en mamíferos
VIAS DE INDUCCION DE MOLECULAS IMPLICITAS EN LA RESPUESTA INMUNE POR CITOQUINAS
INTERACCIONES CELULARES QUE REGULAN EL DESARROLLO LINFOCITARIO EN ORGANOS LINFOIDES SECUNDARIOS
Interacciones celulares que regulan el desarrollo linfocitario en órganos linfoides secundarios
Identificación de las secuencias blanco del DNA controladas por la proteína SRY determinante del sexo.
REGULACION DE LA EXPRESION DE LOS ANTIGENOS DE HISTOCOMPATIBILIDAD DE CLASE-II POR EL INTERFERON GAMA
ANALISIS DE LAS BASES MOLECULARES DE LA ADHESION CELULAR Y SU RELACION CON LA DIFERENCIACION ERITROBLASTICA Y LINFOCITARIA
ANALISIS DEL MECANISMO DE ACOPLAMIENTO EXCITANCION - CONTRACCION EN MUSCULO ESTRIADO MEDIANTE ANTICUERPOS MONOCLONALES.
Development of monoclonal antibody technology for the diagnostic and treatment of bone marrow transplant patients
TECNICAS BASICAS PARA TRANSPLANTE DE MEDULA OSEA HUMANA=> PRESERVACION Y DESCONTAMINACION POR MEDIO DE ANTICUERPOS MONOCLONALES.
Use of monoclonal antibodies as probes of membrane function

Review (3)

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
The essential role of chemokines in the selective regulation of lymphocyte homing
Functional consequences of immune cell adhesion to endothelial cells
137
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

46
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

25
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

10
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

8
Yessia Hidalgo

Flow Facility manager

Consorcio Regenero S.A.

Santiago, Chile

7
Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

6
Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

5
Paulina Ruiz

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

5
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

5
Sarah Nuñez

Investigador Postdoctoral

Laboratorio de Inmunología Celular y Molecular

Fundación Ciencia & Vida

Santiago, Chile

4
Jaime De Calisto

Director Docente

Escuela de Biotecnología

Universidad Mayor

Santiago, Chile

3
LILIAN REYES

Director de Escuela de Bioquímica

Universidad San Sebastián

Santiago, Chile

3
Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

2
Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

2
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

2
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

2
Jocelyn Neira

Especialista Profesional

Universidad Andrés Bello

Santiago, Chile

2
Sebastian Valenzuela

Director de Area Veterinaria

Area Veterinaria

Fundación Ciencia para la Vida

Santiago, Chile

2
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

2
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

2
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

2
Rodrigo Naves

Associate Professor

Program of Immunology

Universidad de Chile

Santiago, Chile

2
Evelyn Menares

investigador postdoctoral

programa disciplinario de inmunología

Universidad de Chile

santiago, Chile

2
Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

2
Andrés Ramirez

Flow Cytometry Facility Manager

Consorcio Regenero

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Esteban Engel

Principal Investigator

Neuroscience

Princeton University

Princeton, Estados Unidos

1
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Camila Covián

Investigador

Genética molecular y microbiología

Pontificia Universidad Católica

Santiago, Chile

1
Leidy Lagos

Senior Researcher

Department of Animal and Aquacultural Sciences

Norwegian University of Life Sciences

Ås, Noruega

1
Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
PATRICIO VARGAS

Profesor Titular

FISICA

USM

Valparaiso, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Eugenio Ramírez

INSTITUTO DE SALUD PÚBLICA DE CHILE

Santiago, Chile

1
Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
pamela araya

JEFE DE SECCIÓN

BIOMEDICO

INSTITUTO DE SALUD PUBLICA DE CHILE

SANTIAGO, Chile