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Maria-Isabel Yuseff Sepulveda

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Antigen processing and presentation by B Lymphocytes Immune synapse Cell polarity and membrane trafficking Cytoskeleton Dynamics Autoimmunity

BSc, Universidad de Concepción. Chile, 1998
PhD, Universidad de Chile. Chile, 2004

Associate Professor Full Time

P. Universidad Católica de Chile

Sciences

Santiago, Chile

2013 - A la fecha

Post Doctoral Fellow

Curie Institute

Paris, Francia

2006 - 2013
Post Doctoral Fellow

P. Universidad Católica de Chile

Santiago, Chile

2004 - 2006

1-Training of Students

• Thesis co-director conducing to the degree of PhD in Cellular and Molecular Biology and Neurosciences. Juan José Sáez, PhD program of Cellular and Molecular Biology and Neurosciences, Faculty of Sciences, Universidad de Chile. Thesis project entitled: “Exo70 regula la eficiente fusión de lisosomas en la sinapsis inmune”. 2014-2018.

• Thesis director conducing to the degree PhD in Cellular and Molecular Biology. Jorge Andres Ibañez Vega, PhD program of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. Thesis entitled: "Rol del proteosoma en la formacion y funcion de la sinapsis inmune en linfocitos B”. 2016-2019.

• Thesis director conducing to the degree PhD in Cellular and Molecular Biology. Danitza Natalia Fuentes Peña, PhD program of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. Thesis entitled: "Rol del receptor de KDEL en la formación y función de la Sinapsis inmune en Linfocitos B”. 2017-Present.

• Thesis director conducing to the degree PhD in Medical Sciences. Jonathan Alexander Lagos Orellana, PhD program of Medical Sciences, Faculty of Medicine, Pontificia Universidad Católica de Chile. Thesis entitled: "Regulación de la autofagia por señales inflamatorias y su impacto en la presentación de antígenos en linfocitos B”. 2018-Present.

• Thesis director conducing to the degree of Biochemist. Fernanda Estefanía Cabrera Reyes. Thesis entitled: "Caracterización de la proteína SNX5 durante la activación de linfocitos B". 2018 - Present.
• Thesis director conducing to the degree of Biochemist. Martina Alamo Rollandi. Thesis entitled: "Título “SNAP23 regula la extracción y presentación de antígeno promoviendo la secreción de lisosomas hacia la sinapsis inmune". 2016 - 2018.

• Thesis director conducing to the degree of Biologist. Christopher Rivas Needham. Thesis entitled: "Dinámica Nuclear en Linfocitos B". 2019 - Present.
• Thesis director conducing to the degree of Biologist. Felipe del Valle Batalla. Thesis entitled: "Rol del proteosoma y su relación con el centrosoma en la sinapsis immunológica de Linfocitos B". 2016.
• Thesis director conducing to the degree of Biologist. Juan Pablo Bozo Olea. Thesis entitled: "Caracterización del papel del complejo exocisto en la formación de la sinapsis inmunológica de linfocitos B". 2015.

2007-2013: Trained and supervised the research of two graduate student from Université Paris VII Diderot-Paris during their masters’ internship (M2) and PhD thesis .
1997: Teachers assistant in the course of Microbiology in the University of Lleida (INTERCAMPUS AL.E.97) as part of an exchange program (1997).
1995: Teachers assistant in courses of Organic Chemistry (1995) Department of Chemistry. University of Concepcion, Concepcion, Chile.

2-Courses:
-Graduate Course in Cell biology: Cytoskeleton and Cell Polarity. June 17-20th, 2014
-Summer School Cell biology Course: Processing and Presentation of Antigens by B cells. Jan 20th, 2014

3-Symposiums:
Symposium on Immune Regulation. “From Basic Science to Novel Immuno therapeutic Strategies”. Nov 7th, 2013. Facultad de Medicina Universidad de Chile. Invited Speaker.

Best Oral Presentation in Young Researchers in Life Sciences Meeting Paris, France.

INSTITUT CURIE DE PARIS

Francia, 2008

Awarded first prize for best oral presentation in Young Researchers in Life Sciences Meeting Paris, France.
Embo Global Investigator

European Union

Chile, 2019

Funding by Embo is given to early-career scientists based on their scientific merit, where researchers must demonstrate that they have successfully established themselves as independent researchers by presenting their projects and having published articles as a last/corresponding author. The enables scientists to establish collaborations with scientists from the Embo community and enhance training opportunities for myself and students from my group. Type


Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome Sanhueza, Sergio; Vidal, Mabel A.; Hernandez, Mauricio A.; Henriquez-Beltran, Mario E.; Cabrera, Camilo; Quiroga, Romina; Antilef, Barbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Figueroa, Marco Fraga; Nazal, Mauricio; Castro, Eritson; Lagos, Paola; Moreno, Alexa; Lastra, Jaime J.; Gajardo, Jorge; Garces, Pamela; Riffo, Benilde; Buchert, Jorge; Sanhueza, Rocio; Ormazaba, Valeska; Saldivia, Pablo; Vargas, Cristian; Nourdin, Guillermo; Koch, Elard; Zuniga, Felipe A.; Lamperti, Liliana; Bustos, Paula; Guzman-Gutierrez, Enrique; Tapia, Claudio A.; Ferrada, Luciano; Cerda, Gustavo; Woehlbier, Ute; Riquelme, Erick; Yuseff, Maria-Isabel; Ramirez, Braulio A. Munoz; Lombardi, Giovanna; De Gonzalo-Calvo, David; Salomon, Carlos; Verdugo, Ricardo A.; Quinones, Luis A.; Colombo, Alicia; Barria, Maria I.; Labarca, Gonzalo; Nova-Lamperti, Estefania Article ISI FRONTIERS IN MEDICINE (2023)
Medium-throughput image-based phenotypic siRNA screen to unveil the molecular basis of B cell polarization Obino, Dorian; Maurin, Mathieu; Dingli, Florent; Loew, Damarys; Lescure, Aurianne; Terriac, Emmanuel; Goudot, Christel; Malbec, Odile; Lankar, Danielle; Yuseff, Maria-Isabel; Lennon-Dumenil, Ana-Maria; Moreau, Helene D. Article ISI SCIENTIFIC DATA (2023)
Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells Lagos, Jonathan; Sagadiev, Sara; Diaz, Jheimmy; Bozo, Juan Pablo; Guzman, Fanny; Stefani, Caroline; Zanlungo, Silvana; Acharya, Mridu; Yuseff, Maria Isabel Article ISI CELLS (2022)
B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction Ulloa, Romina; Corrales, Oreste; Cabrera-Reyes, Fernanda; Jara-Wilde, Jorge; Saez, Juan Jose; Rivas, Christopher; Lagos, Jonathan; Haertel, Steffen; Quiroga, Clara; Yuseff, Maria-Isabel; Diaz-Munoz, Jheimmy Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells Cabrera Reyes, Fernanda; Parra-Ruiz, Claudia; Yuseff M.I.; Zanlungo S. Article Pubmed Front Cell Dev Biol. (2021)
Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells Cabrera-Reyes, Fernanda; Parra-Ruiz, Claudia; Yuseff, Maria Isabel; Zanlungo, Silvana Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity Prado, Carolina; Osorio-Barrios, Francisco; Falcón, Paulina.; Espinoza, Alexandra; Sáez, Juan José; Yuseff, Maria Isabel; Pacheco, Rodrigo Article JOURNAL OF NEUROINFLAMMATION (2021)
Ecm29-Dependent Proteasome Localization Regulates Cytoskeleton Remodeling at the Immune Synapse Ibanez-Vega, Jorge; Del Valle, Felipe; Saez, Juan Jose; Guzman, Fanny; Diaz, Jheimmy; Soza, Andrea; Yuseff, Maria Isabel Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover Tapia, Diego; Jimenez, Tomas; Zamora, Constanza; Espinoza, Javier; Rizzo, Riccardo; Gonzalez-Cardenas, Alexis; Fuentes, Danitza; Hernandez, Sergio; Cavieres, Viviana A.; Soza, Andrea; Guzman, Fanny; Arriagada, gloria; Isabel Yuseff, Maria; Mardones, Gonzalo A.; Burgos, Patricia, V; Luini, Alberto; Gonzalez, Alfonso; Cancino, Jorge Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells Ibanez-Vega, J; Batalla, FD; Saez, JJ; Soza, A; Yuseff, MI Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Studying Organelle Dynamics in B Cells During Immune Synapse Formation Ibanez-Vega, Jorge; Fuentes, Danitza; Lagos, Jonathan; Cancino, Jorge; Isabel Yuseff, Maria Article ISI SCOPUS JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells Jose Saez, Juan; Diaz, Jheimmy; Ibanez, Jorge; Pablo Bozo, Juan; Cabrera Reyes, Fernanda; Alamo, Martina; Gobert, Francois-Xavier; Obino, Dorian; Rosa Bono, Maria; Lennon-Dumenil, Ana-Maria; Yeaman, Charles; Yuseff, Maria-Isabel Article ISI SCOPUS JOURNAL OF CELL BIOLOGY (2019)
Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse Obino D.; Fetler L.; Soza A.; Malbec O.; Saez J.J.; Labarca M.; Oyanadel, C; Del Valle Batalla F.; Goles N.; Chikina A.; Lankar D.; Segovia-Miranda F.; Garcia C.; LÃ©ger T.; Gonzalez A.; EspÃ©li M.; Lennon-DumÃ©nil A.-M.; Yuseff M.-I. Article ISI SCOPUS CELL REPORTS (2018)
Tuning B cell responses to antigens by cell polarity and membrane trafficking del Valle Batalla F.; Lennon-Dumenil A.-M.; Yuseff M.-I. Article ISI SCOPUS MOLECULAR IMMUNOLOGY (2018)
Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes Obino, Dorian; Diaz, Jheimmy; Sáez, Juan José; Ibañez-Vega, Jorge; Sáez, Pablo J.; Alamo, Martina; Lankar, Danielle; Yuseff, Maria-Isabel (corresponding author) Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2017)
Actin nucleation at the centrosome controls lymphocyte polarity Obino D.; Farina, F; Malbec O.; Sáez P.J.; Maurin M.; Gaillard J.; Dingli F.; Loew D.; Gautreau A.; Yuseff M.-I.; Blanchoin L.; Théry M.; Lennon-Duménil A.-M. Article ISI SCOPUS Nature Communications (2016)
Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse Reversat, A; Yuseff, MI; Lankar D.; Malbec O.; Obino D.; Maurin M.; Penmatcha, NVG; Amoroso, A.; Sengmanivong, L; Gundersen, GG; Mellman, I; Darchen, F; Desnos, C; Pierobon, P; Lennon-Dumenil, AM Article ISI SCOPUS Molecular Biology of the Cell (2015)
How B cells capture, process and present antigens: a crucial role for cell polarity Yuseff, Maria-Isabel; Pierobon, Paolo; Reversat, Anne; Lennon-Dumenil, Ana-Maria Article ISI NATURE REVIEWS IMMUNOLOGY (2013)
Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation Yuseff, Maria-Isabel; Reversat, Anne; Lankar, Danielle; Diaz, Jheimmy; Fanget, Isabelle; Pierobon, Paolo; Randrian, Violaine; Larochette, Nathanael; Vascotto, Fulvia; Desdouets, Chantal; Jauffred, Bertrand; Bellaiche, Yohanns; Gasman, Stephane; Darchen, Francois; Desnos, Claire; Lennon-Dumenil, Ana-Maria Article ISI IMMUNITY (2011)
Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses 5. Yuseff MI, Lankar D, Lennon-Duménil AM Article ISI TRAFFIC (2009)
Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain Faure-Andre, G; Vargas, P.; Yuseff, MI; Heuze, M; Díaz, J; Lankar D.; Steri, V; Manry, J; Hugues, S; Vascotto, F; Boulanger, J; Raposo G.; Bono, MR.; Rosemblatt, M.; Piel M.; Lennon-Dumenil, AM Article ISI SCOPUS SCIENCE (2008)
A cytoplasmic PPPSP motif determines Megalin's phosphorylation and regulates receptor's recycling and surface expression Yuseff, MI; Farfan, P; Bu, GJ; Marzolo, MP Article ISI SCOPUS TRAFFIC (2007)
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes Cancino j.; Torrealba, C.; Soza A.; Yuseff, MI; Gravotta, D; Henklein, P; Rodriguez-Boulan, E; González A Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2007)
Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor Le Roux, Delphine; Lankar, Danielle; Yuseff, Maria-Isabel; Vascotto, Fulvia; Yokozeki, Takeaki; Faure-Andre, Gabrielle; Mougneau, Evelyne; Glaichenhaus, Nicolas; Manoury, Benedicte; Bonnerot, Christian; Lennon-Dumenil, Ana-Maria Article ISI MOLECULAR BIOLOGY OF THE CELL (2007)
Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains Marzolo, MP; Yuseff, MI; Retamal, C; Donoso M.; Ezquer, F; Farfan, P; Li, YH; Bu, GJ Article ISI SCOPUS TRAFFIC (2003)
Identification and characterization of GONST1, a Golgi-localized GDP-mannose transporter in Arabidopsis Baldwin, TC; Handford MG; Yuseff, MI; Orellana, A; Dupree, P Article ISI PLANT CELL (2001)
Cooper (III) Dithiocarbamate Complexes From Thiuram disulfides and Cooper (I) Halides 13. Luis Victoriano ; Hernán B. Cortes. M. Isabel S. Yuseff and Luis C. Fuentealba Article J Coord Chem (1996)


Studying MHC II Presentation of Immobilzed Antigen by B Lymphocytes 4. Yuseff MI and Lennon-Duménil, AM; Peter van Endert BookSection (2012)


Shaping the Immune Synapse by Centrosome-Associated Proteins=> Impact on B Cell Responses FONDECYT (284196) Proyecto 2018-2022 Director(a)
REGULATION OF IMMUNE SYNAPSES THROUGH CELL POLARITY=> IMPACT ON B CELL RESPONSES FONDECYT (1141182) Proyecto 2014-2018 Inv. Responsable


Lysosome motility and distribution: Relevance in health and disease OyarzÃºn J.E.; Lagos J.; VÃ¡zquez M.C.; Valls C.; De la Fuente C.; Yuseff M.I.; Alvarez A.R.; Zanlungo S. Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
B cells use conserved polarity cues to regulate their antigen processing and presentation functions Yuseff, MI; Lennon-Dumenil, AM Review ISI SCOPUS Frontiers in immunology (2015)

Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

Jheimmy Diaz

Investigador Adjunto

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Andrea Soza

Profesor Asociado

Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Oyanadel

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Viviana Cavieres

Postdoctoral Researcher

Medicina y Ciencias

Universidad San Sebastián

Santiago , Chile

GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Mario Rosemblatt

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

Michael Handford

Full Professor

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

alejandro amoroso

Profesor Asistente

Deoartamento de Ciencias Biológicas y Químicas

Universidad San Sebastián

santiago, Chile

Jorge Jara

Investigador Posdoctoral

ICBM, Facultad de Medicina

Universidad de Chile

Santiago, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

PATRICIO VARGAS

Profesor Titular

FISICA

USM

Valparaiso, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Diego Tapia

Asistente de Investigación

Universidad San Sebastián

Santiago, Chile

Ariel Orellana

Profesor Titular

Centro de Biotecnologia Vegetal

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Maria-Isabel Yuseff Sepulveda

Líneas de Investigación

Educación

BSc, Universidad de Concepción. Chile, 1998

PhD, Universidad de Chile. Chile, 2004

Experiencia Académica

Associate Professor Full Time

Experiencia Profesional

Post Doctoral Fellow

Post Doctoral Fellow

Formación de Capital Humano

Premios y Distinciones

Best Oral Presentation in Young Researchers in Life Sciences Meeting Paris, France.

Embo Global Investigator

Article (27)

BookSection (1)

Proyecto (2)

Shaping the Immune Synapse by Centrosome-Associated Proteins=> Impact on B Cell Responses

REGULATION OF IMMUNE SYNAPSES THROUGH CELL POLARITY=> IMPACT ON B CELL RESPONSES

Review (2)