Man

Fernando Eduardo Ezquer Romero

Full Professor

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Regenerative Medicine, Mesenchymal Stem Cells, Induced Pluripotent Stem Cells, Animal Models, Diabetes Mellitus, Alcoholism, Addictions

Educación

  •  Cell Biology, Molecular Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Molecular Biologist, Universidad Nacional de San Luis. Argentina, 2001

Experiencia Académica

  •   Associate Professor Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    2006 - 2020

  •   Full Professor Full Time

    Universidad del Desarrollo

    Medicine

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Vice-Director Center for Regenerative Medicine Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2016 - A la fecha

Formación de Capital Humano


Human Capital Training

Undergraduate Thesis

Karla Leal Villegas, Biotecnology, Faculty of Agricultural and Forestry Sciences, Universidad de la Frontera. Finished 2014 (Role: Director)
Scarlet Montecino Villalobos, Biochemist, Faculty of Sciences, Pontificia Universidad Catolica de Valparaiso. Finished 2015 (Role: Director)
Katheryne Gonzalez Bravo, Medical Technology, Universidad Pedro de Valdivia. Finished 2018 (Role: Director)
Diego Díaz Gomez, Biochemist, Faculty of Sciences, Pontifícia Universidad Católica de Valparaiso. Finished 2019 (Role: Director)
María Constanza Cárcamo Aguilera, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2020 (Role: Director)
Esteban Ariel Rodríguez Sanhueza, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Under developing (Role: Director).

Master Thesis

Martina Redel Villaroel. Master in Neuroscience. Faculty of Medicine. Universidad de Chile. Under developing. (Role: Co-Director).

PhD Thesis

Andrea Tapia Bustos, PhD in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finioshed 2020 (Role: Co-Director)
José Luis Ordoñes Belmar, PhD in Pharmaceutical Sciences, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Under developing (Role: Co-Director)
Alba Avila. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Under developiung (Role: Director).
Mauricio Quezada Diez. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Under developiung (Role: Director).
Marta Catalina Zamorano Cataldo. PhD in Pharmacology. Faculty of Medicine. Universidad del Desarrollo. Under developing (Role: Co-Director).


Difusión y Transferencia


Invention patents associated with Biopharmaceuticals

Ezquer M, Ezquer F. Pattent Application N°201502971 (5/10/2015). Biopharmacological composition that comprises components produced and / or secreted by mesenchymal stem cells (MSC) that allow to recover the tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regenerative capacity of the liver tissue is inhibited.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M. Pattent Application Nº 201700237 (27/01/2017). Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to deprivation, in a person with addiction.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M,. Pattent Application Nº PCT/CL2018/050063 (3/08/2018). Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction

Clinical Studies
Autores: Mizón C, Conget P, Ezquer F, Ezquer M. Administración intravenosa de células madre mesenquimáticas alogénicas contribuyen al tratamiento de pacientes con diabetes mellitus tipo 1. Clínica Alemana de Santiago (2015-2018).



 

Article (41)

Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats
Innate gut microbiota predisposes to high alcohol consumption
Neonatal Mesenchymal Stem Cell Treatment Improves Myelination Impaired by Global Perinatal Asphyxia in Rats
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3)
Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules
Sensory neuron cultures derived from adult db/db mice as a simplified model to study type-2 diabetes-associated axonal regeneration defects
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats
Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation
Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma
Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine
Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats
Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors=> Potential application in the treatment of diabetic neuropathy
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?
Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells
Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice
Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus
MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment
Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene
Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome
The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells
Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice
Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type I diabetic mice
Hereditary hemochromatosis: An opportunity for gene therapy
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis
Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains

BookWhole (1)

Stem cells for the treatment of patients with type 1 diabetes mellitus

Patent (3)

Biopharmacological composition comprising components produced and / or secreted by mesenchymal stem cells (MSC) that allow the recovery of tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regeneration capacity of liver tissue is inhibited
Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to withdrawal, in a person with addiction
Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction

Proyecto (12)

Acute on chronic liver failure: reversion by systemic administration of 3D spheroids-derived mesenchymal stem cells
Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration
MESENCHYMAL STEM CELLS-SECRETOME PROVIDES PROTECTION IN NEONATAL HYPOXIA-REOXYGENATION. MECHANISMS AND TRANSLATIONAL STUDIES
THE OXIDATIVE STRESS-NEUROINFLAMMATION SYNERGY=> ROLE IN THE PERPETUATION OF ALCOHOL INTAKE AND THERAPEUTIC AVENUES
INTERNATIONAL RESEARCH NETWORK FOR THE DEVELOPMENT OF INDUCED PLURIPOTENT STEM CELL TECHNOLOGY
Treating the whole not the hole: Administration of acellular derivative from mesenchymal stem cells subjected to a preconditioning stimulus reverts diabetic neuropathy and prevents diabetic foot ulcers
TREATING THE WHOLE NOT THE HOLE=> ADMINISTRATION OF ACELLULAR DERIVATIVE FROM MESENCHYMAL STEM CELLS SUBJECTED TO A PRECONDITIONING STIMULUS REVERTS DIABETIC NEUROPATHY AND PREVENTS DIABETIC FOOT ULCERS
EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS, IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY
DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS MODIFY THE NATURAL EVOLUTION OF RETINAL DAMAGE IN DIABETIC MICE
THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS?
IDENTIFICATION OF CELLULAR AND MOLECULAR MECHANISMS BEHIND BETA-PANCREATIC ISLETS REGENERATION INDUCED BY MULTIPOTENT MESENCHYMAL STROMAL CELLS ADMINISTRATION INTO TYPE 1 DIABETIC MICE.
IDENTIFICACION DE EPITOPES INMUNODOMINANTES INVOLUCRADOS EN LA RESPUESTA INMUNE CELULAR CONTRA HANTAVIRUS ANDES Y CARACTERIZACION DE LOS LINFOCITOS T RESPONSABLES=> BASE PARA EL DESARROLLO DE UNA VACUNA.

Review (5)

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options
Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity
Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears
Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy?
51
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

24
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

11
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

6
Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

4
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

3
Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

3
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

3
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

2
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

2
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

2
Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

2
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

2
David Contador

Universidad del Desarrollo

Santiago, Chile

2
Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

2
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

2
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

2
Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Maroun Khoury

A/Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

1
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Aliosha Figueroa

Asistente de Investigación

Consorcio Regenero S.A.

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
vania figueroa

Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

1
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Cristhian Urzúa

Director

Oftalmologia

Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas. Universidad de Chile

Santiago, Chile

1
Aníbal Vargas

Investigador postdoctoral

Universidad de O'Higgins

Rancagua, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Flavia Bruna

Universidad del Desarrollo

Santiago, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

1
Victor Aliaga

Investigador Asociado

Universidad de Chile

Santiago, Chile

1
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

1
Cristian De Gregorio

Postdoctoral fellow

medicine

Universidad del Desarrollo

Lo Barnechea, Chile

1
Vinicius Maracaja

Profesor Asistente

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile