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Fernando Eduardo Ezquer Romero

Full Professor

Universidad del Desarrollo

Santiago, Chile

Regenerative Medicine, Mesenchymal Stem Cells, Induced Pluripotent Stem Cells, Animal Models, Diabetes Mellitus, Alcoholism, Addictions

Cell Biology, Molecular Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2006
Molecular Biologist, Universidad Nacional de San Luis. Argentina, 2001

Associate Professor Full Time

Universidad del Desarrollo

Medicine

Santiago, Chile

2006 - 2020
Full Professor Full Time

Universidad del Desarrollo

Medicine

Santiago, Chile

2020 - A la fecha

Vice-Director Center for Regenerative Medicine Full Time

Universidad del Desarrollo

Santiago, Chile

2016 - A la fecha

Human Capital Training

Undergraduate Thesis

Karla Leal Villegas, Biotecnology, Faculty of Agricultural and Forestry Sciences, Universidad de la Frontera. Finished 2014 (Role: Director)
Scarlet Montecino Villalobos, Biochemist, Faculty of Sciences, Pontificia Universidad Catolica de Valparaiso. Finished 2015 (Role: Director)
Katheryne Gonzalez Bravo, Medical Technology, Universidad Pedro de Valdivia. Finished 2018 (Role: Director)
Diego Díaz Gomez, Biochemist, Faculty of Sciences, Pontifícia Universidad Católica de Valparaiso. Finished 2019 (Role: Director)
María Constanza Cárcamo Aguilera, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2020 (Role: Director)
Esteban Ariel Rodríguez Sanhueza, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2021 (Role: Director)
Carolina Ponce, Biotecnology, Faculty of Agricultural and Forestry Sciences, Universidad de la Frontera. Finished 2021 (Role: Director)

Master Thesis

Martina Redel Villaroel. Master in Neuroscience. Faculty of Medicine. Universidad de Chile. Finished 2021. (Role: Co-Director).

PhD Thesis

Andrea Tapia Bustos, PhD in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2020 (Role: Co-Director)
José Luis Ordoñes Belmar, PhD in Pharmaceutical Sciences, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Under developing (Role: Co-Director)
Alba Avila. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Under developiung (Role: Director).
Mauricio Quezada Diez. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Under developing (Role: Director).
Marta Catalina Zamorano Cataldo. PhD in Pharmacology. Faculty of Medicine. Universidad del Desarrollo. Under developing (Role: Co-Director).

Invention patents associated with Biopharmaceuticals

Ezquer M, Ezquer F. Pattent Application N°201502971 (5/10/2015). Biopharmacological composition that comprises components produced and / or secreted by mesenchymal stem cells (MSC) that allow to recover the tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regenerative capacity of the liver tissue is inhibited.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M. Pattent Application Nº 201700237 (27/01/2017). Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to deprivation, in a person with addiction.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M,. Pattent Application Nº PCT/CL2018/050063 (3/08/2018). Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction

Clinical Studies
Autores: Mizón C, Conget P, Ezquer F, Ezquer M. Administración intravenosa de células madre mesenquimáticas alogénicas contribuyen al tratamiento de pacientes con diabetes mellitus tipo 1. Clínica Alemana de Santiago (2015-2018).


Gut Microbiota-Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats Diaz-Ubilla, Macarena; Figueroa-Valdes, Aliosha I.; Tobar, Hugo E.; Quintanilla, Maria Elena.; Diaz, Eugenio; Morales, Paola.; Berrios-Cárcamo Pablo; Santapau, Daniela; Gallardo, Javiera; De Gregorio, Cristian; et al. Article ISI SCOPUS Journal of Extracellular Vesicles (2025)
No evidence for exosome treatment in reducing alcohol relapse - a failed confirmatory multi-center study Meinhardt, MW; Habelt, B; Skorodumov, I; Schwarz, C; Bernhardt, N; Winter, C; Hardar, R; Müller, CP; Israel, Y; Ezquer, F; et al. Article ISI SCOPUS Addiction Neuroscience (2025)
Paw Skin as a Translational Model for Investigating Fibrotic and Inflammatory Wound Healing Defects in Recessive Dystrophic Epidermolysis Bullosa De Gregorio, C; Ramos-Gonzalez, G; Morales-Catalán, B; Ezquer, F; Ezquer, M Article ISI SCOPUS International Journal of Molecular Sciences (2025)
Therapeutic Effects of Intranasal Administration of Mesenchymal Stem Cell-Derived Secretome in Rats Exposed to Chronic Unpredictable Mild Stress Avila, A; Riveros, ME; Adasme, S; Guevara, C; Del Rio, R; Ortiz, FC; Leibold, N; Ezquer, F Article ISI SCOPUS Pharmaceutics (2025)
A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment Schuh, Christina M. A. P.; Ezquer, Fernando; Mamani, Sigde; Campodonico, Paola R.; Carcamo, Constanza; Martinez-Gomez, Fabian; Aburto, Isabel; Ezquer, Marcelo; Morales, Bernardo; Olivares, Belen Article ISI SCOPUS International Journal of Pharmaceutics (2024)
Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence Quezada, Mauricio; Ponce, Carolina; Berrios-Cárcamo Pablo; Santapau, Daniela; Gallardo, Javiera; De Gregorio, Cristian; Quintanilla, Maria Elena.; Morales, Paola.; Ezquer, Marcelo; Herrera-Marschitz, Mario; et al. Article ISI SCOPUS CNS Neuroscience and Therapeutics (2024)
Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats Quintanilla, ME; Santapau, D; Díaz, E; Martinez, IV; Medina, N; Landskron, G; Dominguez, A; Morales, P; Ramírez, D; Hermoso, M; et al. Article ISI SCOPUS Scientific Reports (2024)
Morphine self-administration is inhibited by the antioxidant N-acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration Quintanilla, Maria Elena.; Morales, Paola.; Santapau, Daniela; Gallardo, Javiera; Rebolledo, Rocio; Riveras, Gabriel; Acuna, Tirso; Herrera-Marschitz, Mario; Israel, Yedy; Ezquer, Fernando Article ISI SCOPUS PLOS ONE (2024)
The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model Cuadra, B; Silva, V; Huang, YL; Díaz, Y; Rivas, C; Molina, C; Simon, V; Bono, MR; Morales, B; Rosemblatt, M; et al. Article ISI SCOPUS International Journal of Molecular Sciences (2024)
Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice Berrios-Cárcamo Pablo; Nunez, Sarah; Castaneda, Justine; Gallardo, Javiera; Bono, Maria Rosa; Ezquer, Fernando Article ISI SCOPUS International Journal of Molecular Sciences (2024)
Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use Quintanilla, Maria Elena.; Morales, Paola.; Santapau, Daniela; avila, Alba; Ponce, Carolina; Berrios-Cárcamo Pablo; Olivares, Belen; Gallardo, Javiera; Ezquer, Marcelo; Herrera-Marschitz, Mario; et al. Article ISI SCOPUS International Journal of Molecular Sciences (2023)
Spheroids derived from the stromal vascular fraction of adipose tissue self-organize in complex adipose organoids and secrete leptin Robledo, F; González-Hodar, L; Tapia, P; Figueroa, AM; Ezquer, F; Cortés, V Article ISI SCOPUS Stem Cell Research and Therapy (2023)
A dual mechanism fully blocks ethanol relapse: Role of vagal innervation Quintanilla, ME., Ezquer, F., Morales, P., Santapau, D., Ezquer, M., Herrera-Marschitz, M., Israel, Y. Article ADDICTION BIOLOGY (2022)
A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player. Ezquer, F., Quintanilla, ME., Morales, P., Santapau, D., Munita, JM,, Moya-Flores, F., Ezquer, M., Herrera-Marschitz, M., Israel, Y. Article DRUG AND ALCOHOL DEPENDENCE (2022)
A Novel Morphine Drinking Model of Opioid Dependence in Rats Berrios-Cárcamo Pablo; Quezada, Mauricio; Santapau, Daniela; Morales, Paola.; Olivares, Belen; Ponce, Carolina; avila, Alba; De Gregorio, Cristian; Ezquer, Marcelo; Quintanilla, Maria Elena.; et al. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
A Novel Morphine Drinking Model of Opioid Dependence in Rats. Berríos-Cárcamo, P., Quezada, M., Santapau, D., Morales, P., Olivares, B., Ponce, C., Ávila, A., De Gregorio, C., Ezquer, M., Quintanilla, ME., Herrera-Marschitz, M., Israel, Y., Ezquer, F. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression Article Antioxidants (2022)
Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence Elena Quintanilla, Maria; Quezada, Mauricio; Morales, Paola.; Berrios-Cárcamo Pablo; Santapau, Daniela; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy; Ezquer, Fernando Article ISI Translational Psychiatry (2022)
Improving cell recovery: Freezing and Thawing optimization of induced pluripotent stem cells Uhrig, M., Ezquer, F., Ezquer, M. Article CELLS (2022)
New perspectives to improve mesenchymal stem cell therapies for drud-induced liver injury Ezquer, F., Huang, YL., Ezquer, M. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury Ezquer, Fernando; Huang, Ya-Lin; Ezquer, Marcelo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer's disease Mugnaini, M., Polania, D., Diaz, Y., Ezquer, M., Ezquer, F., Deacon, RMJ., Cogram, P., Kropff, E. Article Scientific Reports (2022)
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease Mugnaini, Matias; Polania, Diana; Diaz, Yannina; Ezquer, Marcelo; Ezquer, Fernando; Deacon, Robert M. J.; Cogram, Patricia; Kropff, Emilio Article ISI Scientific Reports (2022)
Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats Article FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)
Innate gut microbiota predisposes to high alcohol consumption Article ISI ADDICTION BIOLOGY (2021)
Neonatal Mesenchymal Stem Cell Treatment Improves Myelination Impaired by Global Perinatal Asphyxia in Rats Tapia-Bustos, A., Lespay-Rebolledo, C., Vio, V., Pérez-Loboz, R., Casanova-Ortiz, E., Ezquer, F., Herrera-Marschitz, M., Morales, P. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Sustained energy déficit following perinatal asphyxia: A shift towards the fructose-2,6-bisphospahte (TIGAR)-dependent pentose phosphate pathway and postnatal development Article Antioxidants (2021)
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3) Figueroa V.A.; Jara, O; Oliva C.A. Article ISI SCOPUS Frontiers in Physiology (2020)
Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells CÃ¡ceres-Verschae A.; Durán, E; Vera, T Article SCOPUS SCIENTIFIC REPORTS (2020)
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice Contador, David; Campero, Mario Article ISI STEM CELL RESEARCH & THERAPY (2020)
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia Farfan, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzon, Estephania; Alvarado, Raul; Contreras, Norton; Israel, Yedy Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection Olivares, Belen; Israel, Yedy Article ISI FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules Elena Quintanilla, Maria; Israel, Yedy Article ISI ANTIOXIDANTS (2020)
Sensory neuron cultures derived from adult db/db mice as a simplified model to study type-2 diabetes-associated axonal regeneration defects Article DISEASE MODELS & MECHANISMS (2020)
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats Article ISI SCOPUS ADDICTION BIOLOGY (2019)
Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation Quintanilla, ME Article ISI SCOPUS ADDICTION BIOLOGY (2019)
Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options Quintanilla, ME Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2019)
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma Rosenberger, Leonie; Lillo-Vera, Fernando; Pedraza, Paulina L.; Ignacia Ortuzar, Maria; Figueroa-Valdes, Aliosha I.; Cuenca, Jimena Article ISI SCOPUS Scientific Reports (2019)
Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus Contador D. Article ISI SCOPUS BIOLOGY OPEN (2018)
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine Israel, Yedy Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2018)
Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Quintanilla, ME Article SCOPUS Addiction Biology (2018)
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking Elena Quintanilla, Mara; Santapau, Daniela; Israel, Yedy Article ISI SCOPUS Scientific Reports (2018)
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Monica Kurte, G.; Schuh, Christina M. A. P.; Khoury, Maroun Article ISI SCOPUS Frontiers in Physiology (2018)
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line Rivera-Meza, Mario; Quintanilla, Mar?a E. Article ISI SCOPUS FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2017)
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy Ezquer, F; Bahamonde, J; Huang, Y; Ezquer, M Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2017)
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats Israel, Y; Ezquer, F; Quintanilla, ME; Morales, P; Ezquer, M; Herrera-Marschitz M Article ISI ALCOHOL AND ALCOHOLISM (2017)
Preconditioning of Adipose Tissue-derived Mesenchymal Stem Cells with Deferoxamine Increases the Production of Pro-angiogenic, Neuroprotective and Anti-inflammatory Factors=> Potential Application in the Treatment of Diabetic Neuropathy Oses, Carolina; Olivares, Belén; Ezquer, Marcelo; Acosta, Cristian; Bosch, Paul; Donoso, Macarena; Léniz, Patricio; Ezquer, Fernando Article PLoS One (2017)
Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors=> Potential application in the treatment of diabetic neuropathy Oses, Carolina; Olivares, Belen; Ezquer, Marcelo; Acosta, Cristian; Bosch, Paul; Donoso, Macarena; Léniz, Patricio; Ezquer, Fernando Article PLOS ONE (2017)
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule Losinno A.D.; Sorrivas V.; Ezquer, M; Ezquer, F; López, LA; Morales, A. Article ISI SCOPUS CELL AND TISSUE RESEARCH (2016)
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice Ezquer, M; Urzua, C; Montecino, S; Leal, K; Conget, P; Ezquer, Fernando Article ISI SCOPUS STEM CELL RESEARCH & THERAPY (2016)
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease Ezquer, F; Bruna F.; Calligaris, S; Conget, P; Ezquer, M Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2016)
Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Conget, Paulette Article ISI WORLD JOURNAL OF STEM CELLS (2015)
Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells Contador D.; Ezquer, F; Espinosa,M; Arango-Rodriguez, M; Puebla, C; Sobrevia, L; Conget, P Article ISI SCOPUS Experimental Biology and Medicine (2015)
Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice Campero, M; Ezquer, M; Ezquer, F Article ISI EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY DIABETES (2015)
Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus Ezquer, F; Giraud-Billoud, M; Carpio, D; Cabezas, F; Conget, P; Ezquer, M Article ISI SCOPUS BioMed Research International (2015)
MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy Ezquer, Marcelo E; Ezquer, Fernando E; Arango-Rodriguez, Martha L.; Conget, Paulette A Article ISI SCIELO SCOPUS Biological Research (2012)
The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment Ezquer, F; Ezquer, M; Contador D.; Ricca M.; Simon, V; Conget, P Article ISI SCOPUS Stem Cells (2012)
Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene Encina, G; Ezquer, F; Conget, P; Israel, Y Article ISI SCIELO SCOPUS Biological Research (2011)
Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome Ezquer, M; Ezquer, F; Ricca M.; Allers, C; Conget, P Article ISI SCOPUS Journal of Hepatology (2011)
The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells Ezquer, F; Ezquer, M; Simon, V; Conget, P Article ISI SCOPUS PLOS ONE (2011)
Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice Ezquer, F; Ezquer, M; Simon, V; Pardo, F; Yáñez, A; Carpio, D; Conget, P Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2009)
Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type I diabetic mice Ezquer FE; Ezquer ME; Parrau DB; Carpio, D Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2008)
Hereditary hemochromatosis: An opportunity for gene therapy Ezquer F; nunez mt; Rojas A.; Asenjo, J.; Israel Y Article Biological Research (2006)
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis Ezquer, F; Israel, Y Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2005)
Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains Yuseff, MI; Retamal, C; Donoso, M.; Ezquer, F; Farfan, P; Li, YH; Bu, GJ Article ISI SCOPUS TRAFFIC (2003)


Stem cells for the treatment of patients with type 1 diabetes mellitus Ezquer, F; Ezquer, M; Conget, P BookWhole SCOPUS Type 1 Diabetes: Causes, Treatment and Potential Complications (2014)


Biopharmacological composition comprising components produced and / or secreted by mesenchymal stem cells (MSC) that allow the recovery of tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regeneration capacity of liver tissue is inhibited Patent patent pending
Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to withdrawal, in a person with addiction Quintanilla, ME Patent patent pending
Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction Quintanilla, ME Patent Patent pending


Mesenchymal stem cell-derived secretome: A multitarget intervention to reduce long-term disabilities induced by in utero opioid exposure Ezquer, Fernando Proyecto (2024)
Pharmacologically induced NAD+ replacement reverses mitochondrial dysfunction and rescues from the long-term metabolic deficits induced by perinatal asphyxia (PA) in brain tissue: nucleotide salvage pathway and sentinel proteins as therapeutic targets Mario Herrea-Marschitz; Ezquer, Fernando Proyecto (2023)
Development of Novel Therapeutic Alternatives for Alcohol-Use Disorders: A Multidisciplinary Approach Ezquer, Eduardo Fernando Proyecto (2021)
Acute on chronic liver failure: reversion by systemic administration of 3D spheroids-derived mesenchymal stem cells Bono, MR; Carpio J.D. Proyecto (2020)
Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration Ezquer, Eduardo Fernando; Ezquer ME; Quintanilla, ME Proyecto (2020)
MESENCHYMAL STEM CELLS-SECRETOME PROVIDES PROTECTION IN NEONATAL HYPOXIA-REOXYGENATION. MECHANISMS AND TRANSLATIONAL STUDIES FONDECYT (1190562) Proyecto 2019-2023 Coinvestigador(a)
THE OXIDATIVE STRESS-NEUROINFLAMMATION SYNERGY=> ROLE IN THE PERPETUATION OF ALCOHOL INTAKE AND THERAPEUTIC AVENUES FONDECYT (1180042) Proyecto 2018-2021 Coinvestigador(a)
INTERNATIONAL RESEARCH NETWORK FOR THE DEVELOPMENT OF INDUCED PLURIPOTENT STEM CELL TECHNOLOGY PCI (REDES15006) Proyecto 2017-2018 Coinvestigador(a)
TREATING THE WHOLE NOT THE HOLE=> ADMINISTRATION OF ACELLULAR DERIVATIVE FROM MESENCHYMAL STEM CELLS SUBJECTED TO A PRECONDITIONING STIMULUS REVERTS DIABETIC NEUROPATHY AND PREVENTS DIABETIC FOOT ULCERS FONDECYT (1170712) Proyecto 2017-2020 Inv. Responsable
EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS, IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY FONDECYT (1150589) Proyecto 2015-2018 Coinvestigador(a)
Evaluación del potencial cardioprotector de productos derivados de células madre mesenquimáticas sobre la cardiotoxicidad inducida por doxorrubicina. Proyecto Corfo L1. Perfil de I+D Aplicada (13IDL1-25738) Proyecto 2014-2014 Coinvestigador(a)
DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS MODIFY THE NATURAL EVOLUTION OF RETINAL DAMAGE IN DIABETIC MICE FONDECYT (1130470) Proyecto 2013-2016 Inv. Responsable
PRODUCTO DERIVADO DE CELULAS TRONCALES MESENQUIMATICAS FAVORECE REGENERACION DEL HIGADO EN INDIVIDUOS CON ESTEATOSIS SOMETIDOS A UNA CIRUGIA DE RESECCION HEPATICA FONDEF (CA13/10088) Proyecto 2013-2015 Subdirector(a)
Estudio clínico fase II=> Administración intravenosa de células madre mesenquimáticas para tratar pacientes con Diabetes Mellitus Tipo 1 Corporación Chileno-Alemana de Beneficencia Proyecto 2012-2015 Coinvestigador(a)
THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS? FONDECYT (1120133) Proyecto 2012-2015 Coinvestigador(a)
Mecanismos celulares responsables de la prevención del daño renal tras la administración sistémica de células troncales mesenquimáticas a ratones con diabetes mellitus severa Universidad del Desarrollo (Concurso interno, VRA) Proyecto 2009-2010 Inv. Principal
Cerveza y Salud ACECHI Proyecto 2008-2009 Investigador(a)
IDENTIFICATION OF CELLULAR AND MOLECULAR MECHANISMS BEHIND BETA-PANCREATIC ISLETS REGENERATION INDUCED BY MULTIPOTENT MESENCHYMAL STROMAL CELLS ADMINISTRATION INTO TYPE 1 DIABETIC MICE. FONDECYT (11085033) Proyecto 2008-2011 Inv. Responsable
Instituto Milenio de Dinámica Celular y Biotecnología Iniciativa Científica Milenio Proyecto 2007-2011 Coinvestigador(a)
Medicina Regenerativa para diabetes y sus complicaciones Programa Bicentenario de Ciencia y Tecnología (PBCT) Proyecto 2006-2009 Coinvestigador(a)
IDENTIFICACION DE EPITOPES INMUNODOMINANTES INVOLUCRADOS EN LA RESPUESTA INMUNE CELULAR CONTRA HANTAVIRUS ANDES Y CARACTERIZACION DE LOS LINFOCITOS T RESPONSABLES=> BASE PARA EL DESARROLLO DE UNA VACUNA. FONDECYT (1050667) Proyecto 2005-2008 Personal técnico y/o de apoyo
Mecanismos genéticos de aversion al etanol=> Modelos celulares y moleculares FONDECYT (1040555) Proyecto 2004-2006 Coinvestigador(a)


Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options Quintanilla, ME Review ISI SCOPUS GENE THERAPY (2019)
Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity Review ISI SCOPUS CELL ADHESION & MIGRATION (2017)
Carbon monoxide: A new player in the redox regulation of connexin hemichannels Leon-Paravic, CG; Ezquer, M; Ezquer, F; Del Rio, R; Pupo, A; González, C Review ISI SCOPUS IUBMB Life (2015)
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears Ezquer, F; Gutierrez, J; Ezquer, M; Caglevic, C; Salgado, HC; Calligaris, SD Review ISI SCOPUS Stem Cell Research and Therapy (2015)
Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy? Ezquer, F; Ezquer, M; Arango-Rodriguez, M; Conget, P Review ISI ACTA OPHTHALMOLOGICA (2014)

Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

Alejandro Yañez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Jaime Villegas

Profesor Asociado

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

José Valdés

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

Cristhian Urzúa

Director

Oftalmologia

Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas. Universidad de Chile

Santiago, Chile

María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Flavia Bruna

Universidad del Desarrollo

Santiago, Chile

Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

David Contador

Universidad del Desarrollo

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Cristian De Gregorio

Postdoctoral fellow

medicine

Universidad del Desarrollo

Lo Barnechea, Chile

Fabián Martínez

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Monica Kurte

Investigador

Ninguna

Santiago, Chile

Glauben Landskron

Assistant Professor

Departamento de Tecnología Médica

Universidad de Chile

Santiago, Chile

Aliosha Figueroa

Asistente de Investigación Senior

Centro de Medicina Intervencional de Precisión y Terapia Celular Avanzada (IMPACT)

Santiago, Chile

Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

Christina Schuh

Associate Professor

Centre for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Javiera Gallardo

Profesor Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Ortúzar

Gerente de producto

Nalca Biotech SpA

Puerto Varas, Chile

Karla Leal

Profesor Investigador

Universidad Autónoma de Chile

Temuco, Chile

Andrea Tapia

Profesor adjunto

Facultad de Farmacia

Universidad de Valparaíso

valparaiso, Chile

Mauricio Quezada

Investigador Posdoctoral

Centro Investigación e Innovación Biomédica (CIIB)

Universidad de Los Andes

Las Condes, Santiago de Chile, Chile

Fernando Eduardo Ezquer Romero

Líneas de Investigación

Educación

Cell Biology, Molecular Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2006

Molecular Biologist, Universidad Nacional de San Luis. Argentina, 2001

Experiencia Académica

Associate Professor Full Time

Full Professor Full Time

Experiencia Profesional

Vice-Director Center for Regenerative Medicine Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (66)

BookWhole (1)

Patent (3)

Proyecto (22)

MESENCHYMAL STEM CELLS-SECRETOME PROVIDES PROTECTION IN NEONATAL HYPOXIA-REOXYGENATION. MECHANISMS AND TRANSLATIONAL STUDIES

THE OXIDATIVE STRESS-NEUROINFLAMMATION SYNERGY=> ROLE IN THE PERPETUATION OF ALCOHOL INTAKE AND THERAPEUTIC AVENUES

INTERNATIONAL RESEARCH NETWORK FOR THE DEVELOPMENT OF INDUCED PLURIPOTENT STEM CELL TECHNOLOGY

TREATING THE WHOLE NOT THE HOLE=> ADMINISTRATION OF ACELLULAR DERIVATIVE FROM MESENCHYMAL STEM CELLS SUBJECTED TO A PRECONDITIONING STIMULUS REVERTS DIABETIC NEUROPATHY AND PREVENTS DIABETIC FOOT ULCERS

EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS, IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY

Evaluación del potencial cardioprotector de productos derivados de células madre mesenquimáticas sobre la cardiotoxicidad inducida por doxorrubicina.

DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS MODIFY THE NATURAL EVOLUTION OF RETINAL DAMAGE IN DIABETIC MICE

PRODUCTO DERIVADO DE CELULAS TRONCALES MESENQUIMATICAS FAVORECE REGENERACION DEL HIGADO EN INDIVIDUOS CON ESTEATOSIS SOMETIDOS A UNA CIRUGIA DE RESECCION HEPATICA

Estudio clínico fase II=> Administración intravenosa de células madre mesenquimáticas para tratar pacientes con Diabetes Mellitus Tipo 1

THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS?

Mecanismos celulares responsables de la prevención del daño renal tras la administración sistémica de células troncales mesenquimáticas a ratones con diabetes mellitus severa

Cerveza y Salud

IDENTIFICATION OF CELLULAR AND MOLECULAR MECHANISMS BEHIND BETA-PANCREATIC ISLETS REGENERATION INDUCED BY MULTIPOTENT MESENCHYMAL STROMAL CELLS ADMINISTRATION INTO TYPE 1 DIABETIC MICE.

Instituto Milenio de Dinámica Celular y Biotecnología

Medicina Regenerativa para diabetes y sus complicaciones

IDENTIFICACION DE EPITOPES INMUNODOMINANTES INVOLUCRADOS EN LA RESPUESTA INMUNE CELULAR CONTRA HANTAVIRUS ANDES Y CARACTERIZACION DE LOS LINFOCITOS T RESPONSABLES=> BASE PARA EL DESARROLLO DE UNA VACUNA.

Mecanismos genéticos de aversion al etanol=> Modelos celulares y moleculares

Review (5)