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Fernando Eduardo Ezquer Romero

Full Professor

Universidad del Desarrollo

Santiago, Chile

Regenerative Medicine; Mesenchymal Stem Cells; Animal Models; Alcoholism; Addictions; Neurological Diseases; Gut-Brain axis; Gut Microbiota

Cell Biology, Molecular Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2006
Molecular Biologist, Universidad Nacional de San Luis. Argentina, 2001

Associate Professor Full Time

Universidad del Desarrollo

Medicine

Santiago, Chile

2006 - 2020
Full Professor Full Time

Universidad del Desarrollo

Medicine

Santiago, Chile

2020 - A la fecha

Vice-Director Center for Regenerative Medicine Full Time

Universidad del Desarrollo

Santiago, Chile

2016 - A la fecha

Human Capital Training

Undergraduate Thesis

Karla Leal Villegas, Biotecnology, Faculty of Agricultural and Forestry Sciences, Universidad de la Frontera. Finished 2014 (Role: Director)
Scarlet Montecino Villalobos, Biochemist, Faculty of Sciences, Pontificia Universidad Catolica de Valparaiso. Finished 2015 (Role: Director)
Katheryne Gonzalez Bravo, Medical Technology, Universidad Pedro de Valdivia. Finished 2018 (Role: Director)
Diego Díaz Gomez, Biochemist, Faculty of Sciences, Pontifícia Universidad Católica de Valparaiso. Finished 2019 (Role: Director)
María Constanza Cárcamo Aguilera, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2020 (Role: Director)
Carolina Ponce, Biotecnology, Faculty of Agricultural and Forestry Sciences, Universidad de la Frontera. Finished 2021 (Role: Director)
Esteban Ariel Rodríguez Sanhueza, Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2022 (Role: Director)
Diego Manque Aguilera. Biochemist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2025 (Role: Director)
Pablo Herrera Mendoza. Pharmacist, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2026 (Role: Director)
Solange Gonzalez Huenchuguala, Biotecnologist, Universidad Mayor, 2026 (Role: Director).

Master Thesis

Martina Redel Villaroel. Master in Neuroscience. Faculty of Medicine. Universidad de Chile. Finished 2021. (Role: Co-Director).
Ingrid Rafaela Muñóz Allendes. Master in Biological Sciences, Faculty of Science, Universidad de Valparaiso, Finished 2026 (Role: Co-Director).

PhD Thesis

Andrea Tapia Bustos, PhD in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2020 (Role: Co-Director)
José Luis Ordoñes Belmar, PhD in Pharmaceutical Sciences, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Finished 2022 (Role: Co-Director)
Alba Avila. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Finished 2022 (Role: Director).
Mauricio Quezada Diez. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. Finished 2023 (Role: Director).
Marta Catalina Zamorano Cataldo. PhD in Pharmacology. Faculty of Medicine. Universidad del Desarrollo. Finished 2024 (Role: Co-Director).
Macarena Diaz Ubilla. PhD in Science and Innovation in Medicine, Faculty of Medicine Clínica Alemana-Universidad del Desarrollo. (Role: Director).

Invention patents associated with Biopharmaceuticals

Ezquer M, Ezquer F. Pattent Application N°201502971 (5/10/2015). Biopharmacological composition that comprises components produced and / or secreted by mesenchymal stem cells (MSC) that allow to recover the tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regenerative capacity of the liver tissue is inhibited.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M. Pattent Application Nº 201700237 (27/01/2017). Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to deprivation, in a person with addiction.

Ezquer F, Israel Y, Ezquer M, Quintanilla ME, Morales P, Herrera-Marschitz M. Pattent Application Nº PCT/CL2018/050063 (3/08/2018). Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction

Ezquer M, Ezquer F, De Gregorio C. Pattent Application 63/812,751 Receipt date 05/27/2025 “Combined Secretome Compositions and Uses Thereof.

Ezquer F, Ezquer M, Gallardo J, Ramirez D Patternt Application US 63/796,965 Receipt date 04/29/2025 “Recombinat Proteins for Use Against Substance Addiction”

Ezquer F, Ezquer M, Israel Y, Quintanilla ME, Morales P. Pattent Application PCT/US2025/042665 Filing Date 19/08/2025 “Cysteine-Bound Short-Chain Fatty Acid Derivatives for the Treatment od Addictions.

Clinical Studies
Autores: Mizón C, Conget P, Ezquer F, Ezquer M. Administración intravenosa de células madre mesenquimáticas alogénicas contribuyen al tratamiento de pacientes con diabetes mellitus tipo 1. Clínica Alemana de Santiago (2015-2018).


Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach Díaz-Urbina L; Almarza C; Davidson H; Cortés A; Lobos P; Karahanian E; Inzunza J; Ezquer F; Morales, P; Urra F; et al. Article PHARMACOLOGICAL RESEARCH (2026)
Modeling microbiota-mediated risk for alcohol use disorder: a preclinical study of fecal transplantation from ethanol-exposed mice Fornero, Luana; Wille-Bille, Aranza; Fabio, Maria Carolina; Penalver, Pedro; Marengo, Leonardo; Ezquer, Fernando; Pautassi, Ricardo Marcos Article ISI AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2026)
Gut Microbiota-Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats Diaz-Ubilla, Macarena; Figueroa-Valdes, Aliosha I.; Tobar, Hugo E.; Quintanilla, Maria Elena; Diaz, Eugenio; Morales, Paola; Berrios-Cárcamo Pablo; Santapau, Daniela; Gallardo, Javiera; De Gregorio, Cristian; et al. Article ISI SCOPUS Journal of Extracellular Vesicles (2025)
No evidence for exosome treatment in reducing alcohol relapse - a failed confirmatory multi-center study Meinhardt, MW; Habelt, B; Skorodumov, I; Schwarz C.; Bernhardt, N; Winter, C; Hardar, R; Müller, CP; Israel Y.; Ezquer F; et al. Article ISI SCOPUS Addiction Neuroscience (2025)
Paw Skin as a Translational Model for Investigating Fibrotic and Inflammatory Wound Healing Defects in Recessive Dystrophic Epidermolysis Bullosa De Gregorio C.; Ramos-Gonzalez, G; Morales-Catalán, B; Ezquer F; Ezquer M. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2025)
Therapeutic Effects of Intranasal Administration of Mesenchymal Stem Cell-Derived Secretome in Rats Exposed to Chronic Unpredictable Mild Stress Ãvila A.; Riveros M.E.; Adasme, S; Guevara C.; Del Rio R.; Ortiz F.C.; Leibold, N; Ezquer F Article ISI SCOPUS Pharmaceutics (2025)
A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment Schuh, Christina M. A. P.; Ezquer, Fernando; Mamani, Sigde; Campodonico, Paola R.; Carcamo, Constanza; Martinez-Gomez, Fabian; Aburto, Isabel; Ezquer, Marcelo; Morales, Bernardo; Olivares, Belen Article ISI SCOPUS International Journal of Pharmaceutics (2024)
Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence Quezada, Mauricio; Ponce, Carolina; Berrios-Cárcamo Pablo; Santapau, Daniela; Gallardo, Javiera; De Gregorio, Cristian; Quintanilla, Maria Elena; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz, Mario; et al. Article ISI SCOPUS CNS Neuroscience and Therapeutics (2024)
Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats Quintanilla M.E.; Santapau D.; Diaz E.; Martinez, IV; Medina N.; Landskron G.; Dominguez A.; Morales, P; Ramírez, D; Hermoso M.; et al. Article ISI SCOPUS Scientific Reports (2024)
Mesenchymal stem cells as a promising therapy for alcohol use disorder Gallardo, Javiera; Berrios-Cárcamo Pablo; EZQUER-ROMERO, EDUARDO FERNANDO Article ISI SCOPUS International Review of Neurobiology (2024)
Methadone directly impairs central nervous system cells in vitro Handy, Álex; Wyneken, Ursula Article ISI SCOPUS Scientific Reports (2024)
Mitochondrial dynamics and sex-specific responses in the developing rat hippocampus: Effect of perinatal asphyxia and mesenchymal stem cell Secretome treatment Zamorano-Cataldo M.; Urra, F. A.; Farfan-Troncoso N. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2024)
Morphine self-administration is inhibited by the antioxidant N-acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration Quintanilla, Maria Elena; Morales, Paola; Santapau, Daniela; Gallardo, Javiera; Rebolledo, Rocio; Riveras, Gabriel; Acuna, Tirso; Herrera-Marschitz, Mario; Israel, Yedy; Ezquer, Fernando Article ISI SCOPUS PloS one (2024)
Role of histaminergic regulation of astrocytes in alcohol use disorder Leibold, Nicole K. Article ISI SCOPUS Progress in Neuro-Psychopharmacology and Biological Psychiatry (2024)
The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model Cuadra, B; Silva, V; Huang Y.L.; Diaz Y.; Rivas C.; Molina C.; Simon V.; Bono MR; Morales B.; Rosemblatt M; et al. Article ISI SCOPUS International Journal of Molecular Sciences (2024)
Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice Berrios-Cárcamo Pablo; Nunez, Sarah; Castaneda, Justine; Gallardo, Javiera; Bono, Maria Rosa; Ezquer, Fernando Article ISI SCOPUS International Journal of Molecular Sciences (2024)
Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen Leniz, Patricio Article ISI SCOPUS Cells (2023)
Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use Quintanilla, Maria Elena; Morales, Paola; Santapau, Daniela; avila, Alba; Ponce, Carolina; Berrios-Cárcamo Pablo; Olivares, Belen; Gallardo, Javiera; Ezquer, Marcelo; Herrera-Marschitz, Mario; et al. Article ISI SCOPUS International Journal of Molecular Sciences (2023)
Spheroids derived from the stromal vascular fraction of adipose tissue self-organize in complex adipose organoids and secrete leptin Robledo F.; González-Hodar, L; Tapia P.; Figueroa A.M.; Ezquer F; Cortes V. Article ISI SCOPUS Stem Cell Research and Therapy (2023)
A dual mechanism fully blocks ethanol relapse: Role of vagal innervation Elena Quintanilla, Maria; Ezquer, Fernando; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy Article ISI SCOPUS Addiction Biology (2022)
A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player Article ISI SCOPUS Drug and Alcohol Dependence (2022)
A Novel Morphine Drinking Model of Opioid Dependence in Rats Berrios-Cárcamo Pablo; Quezada, Mauricio; Santapau, Daniela; Morales, Paola; Olivares, Belen; Ponce, Carolina; avila, Alba; De Gregorio, Cristian; Ezquer, Marcelo; Quintanilla, Maria Elena; et al. Article ISI SCOPUS International Journal of Molecular Sciences (2022)
Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression Article Antioxidants (2022)
Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence Elena Quintanilla, Maria; Quezada, Mauricio; Morales, Paola; Berrios-Cárcamo Pablo; Santapau, Daniela; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy; Ezquer, Fernando Article ISI SCOPUS Translational Psychiatry (2022)
Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease Garduno, B. Maximiliano; Bruno, Agostino; Kimbell, Allison; Wilkinson, Brent; Aburto, Pedro F.; Deacon, Robert; Altimiras, Francisco; Whitney Vanderklish, Peter; Zampieri, Guido; Angione, Claudio; et al. Article ISI SCOPUS Frontiers in Aging Neuroscience (2022)
Improving cell recovery: Freezing and Thawing optimization of induced pluripotent stem cells Uhrig, M., Ezquer, F., Ezquer, M. Article CELLS (2022)
Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease Oyarce-Pezoa, Sebastian; Fernanda Hernandez, Maria; Uhrig, Markus; Cornejo, Victor H.; Manque, Patricio A. Article ISI SCOPUS Cells (2022)
New perspectives to improve mesenchymal stem cell therapies for drud-induced liver injury Ezquer, F., Huang, YL., Ezquer, M. Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury Ezquer, Fernando; Huang, Ya-Lin; Ezquer, Marcelo Article ISI SCOPUS International Journal of Molecular Sciences (2022)
Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function Prieto, Catalina P.; Chacon, Carlos Article ISI SCOPUS Molecular Psychiatry (2022)
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease Mugnaini, Matias; Polania, Diana; Diaz, Yannina; Ezquer, Marcelo; Ezquer, Fernando; Deacon, Robert M. J.; Cogram, Patricia; Kropff, Emilio Article ISI SCOPUS Scientific Reports (2022)
Sustained Energy Deficit Following Perinatal Asphyxia: A Shift towards the Fructose-2,6-bisphosphatase (TIGAR)-Dependent Pentose Phosphate Pathway and Postnatal Development Perez-Lobos, Ronald; Farfan-Troncoso, Nancy; Zamorano-Cataldo, Marta; Redel-Villarroel, Martina Article ISI SCOPUS Antioxidants (2022)
Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats Article ISI SCOPUS FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)
Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation Israel Y.; Quintanilla M.E.; Ezquer F; Morales, P; Santapau D.; BerrÃƒÂos-CÃƒÂ¡rcamo P.; Ezquer M.; Olivares B.; Herrera-Marschitz M Article ISI SCOPUS Addiction Biology (2021)
Innate gut microbiota predisposes to high alcohol consumption Israel, Yedy Article ISI SCOPUS Addiction Biology (2021)
Neonatal Mesenchymal Stem Cell Treatment Improves Myelination Impaired by Global Perinatal Asphyxia in Rats Article ISI SCOPUS International Journal of Molecular Sciences (2021)
Sensory neuron cultures derived from adult db/db mice as a simplified model to study type-2 diabetes-associated axonal regeneration defects Article SCOPUS DMM Disease Models and Mechanisms (2021)
Sustained energy déficit following perinatal asphyxia: A shift towards the fructose-2,6-bisphospahte (TIGAR)-dependent pentose phosphate pathway and postnatal development Article Antioxidants (2021)
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3) Figueroa V.A.; Jara O.; Oliva C.A. Article ISI SCOPUS Frontiers in Physiology (2020)
Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells CÃ¡ceres-Verschae A.; DurÃ¡n E.; Vera T. Article SCOPUS Scientific Reports (2020)
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice Contador, David; Campero, Mario Article ISI SCOPUS Stem Cell Research and Therapy (2020)
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia Farfan, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzon, Estephania; Alvarado, Raul; Contreras, Norton; Israel, Yedy Article ISI SCOPUS International Journal of Molecular Sciences (2020)
N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection Olivares, Belen; Israel, Yedy Article ISI SCOPUS FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules Israel, Yedy Article ISI SCOPUS Antioxidants (2020)
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats Article ISI SCOPUS ADDICTION BIOLOGY (2019)
Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options Quintanilla M.E. Article ISI SCOPUS STEM CELL RESEARCH AND THERAPY (2019)
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma Rosenberger, Leonie; Lillo-Vera, Fernando; Pedraza, Paulina L.; Ignacia Ortuzar, Maria; Figueroa-Valdes, Aliosha I.; Cuenca, Jimena Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus Contador D. Article ISI SCOPUS BIOLOGY OPEN (2018)
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine Israel, Yedy Article ISI SCOPUS ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2018)
Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Quintanilla M.E. Article SCOPUS Addiction Biology (2018)
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking Elena Quintanilla, Mara; Santapau, Daniela; Israel, Yedy Article ISI SCOPUS SCIENTIFIC REPORTS (2018)
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Monica Kurte, G.; Schuh, Christina M. A. P.; Khoury, Maroun Article ISI SCOPUS Frontiers in physiology (2018)
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line Rivera-Meza, Mario; Quintanilla, Mar?a E. Article ISI SCOPUS FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2017)
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy Ezquer, F; Bahamonde, J; Huang, Y; Ezquer, M Article ISI SCOPUS STEM CELL RESEARCH AND THERAPY (2017)
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats Israel, Y; Ezquer, F; Quintanilla, ME; Morales, P; Ezquer, M; Herrera-Marschitz M Article ISI ALCOHOL AND ALCOHOLISM (2017)
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule Losinno A.D.; Sorrivas V.; Ezquer M.; Ezquer F; Lopez L.A.; Morales A Article ISI SCOPUS CELL AND TISSUE RESEARCH (2016)
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis Article ISI SCOPUS OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice Ezquer M.; Urzua C.; Montecino, S; Leal K.; Conget P.; Ezquer, Fernando Article ISI SCOPUS STEM CELL RESEARCH AND THERAPY (2016)
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease Ezquer F; Bruna F.; Calligaris, S; Conget P.; Ezquer M. Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2016)
Could cancer and infection be adverse effects of mesenchymal stromal cell therapy? Conget, Paulette Article ISI WORLD JOURNAL OF STEM CELLS (2015)
Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells Contador D.; Ezquer F; Espinosa,M; Arango-Rodriguez, M; Puebla C.; Sobrevia L.; Conget P. Article ISI SCOPUS Experimental Biology and Medicine (2015)
Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice Campero, M.; Ezquer M.; Ezquer F Article ISI EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY DIABETES (2015)
Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus Ezquer F; Giraud-Billoud, M; Carpio D.; Cabezas F.; Conget P.; Ezquer M. Article ISI SCOPUS BioMed Research International (2015)
MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy Ezquer, Marcelo E; Ezquer, Fernando E; Arango-Rodriguez, Martha L.; Conget, Paulette A Article ISI SCIELO SCOPUS Biological Research (2012)
The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment Ezquer F; Ezquer M.; Contador D.; Ricca M.; Simon V.; Conget P. Article ISI SCOPUS Stem Cells (2012)
Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene Encina G.; Ezquer F; Conget P.; Israel Y. Article ISI SCIELO SCOPUS Biological Research (2011)
Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome Ezquer M.; Ezquer F; Ricca M.; Allers, C; Conget P. Article ISI SCOPUS Journal of Hepatology (2011)
The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells Ezquer F; Ezquer M.; Simon V.; Conget P. Article ISI SCOPUS PLOS ONE (2011)
Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice Ezquer F; Ezquer M.; Simon V.; Pardo F.; Yanez A.; Carpio D.; Conget P. Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2009)
Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type I diabetic mice Ezquer FE; Ezquer M.E.; Parrau DB; Carpio D. Article ISI SCOPUS BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2008)
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis Ezquer F; Israel Y. Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2005)
Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains Yuseff M.I.; Retamal C.; Donoso M.; Ezquer F; Farfan, P; Li Y.H.; Bu, GJ Article ISI SCOPUS TRAFFIC (2003)


Stem cells for the treatment of patients with type 1 diabetes mellitus Ezquer F; Ezquer M.; Conget P. BookWhole SCOPUS Type 1 Diabetes: Causes, Treatment and Potential Complications (2014)


Biopharmacological composition comprising components produced and / or secreted by mesenchymal stem cells (MSC) that allow the recovery of tissue regenerative capacity, in a situation of hepatic steatosis or where the endogenous regeneration capacity of liver tissue is inhibited Patent patent pending
Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to withdrawal, in a person with addiction Quintanilla M.E. Patent patent pending
Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction Quintanilla M.E. Patent Patent pending


Mesenchymal stem cell-derived secretome: A multitarget intervention to reduce long-term disabilities induced by in utero opioid exposure Ezquer, Fernando Proyecto (2024)
Pharmacologically induced NAD+ replacement reverses mitochondrial dysfunction and rescues from the long-term metabolic deficits induced by perinatal asphyxia (PA) in brain tissue: nucleotide salvage pathway and sentinel proteins as therapeutic targets Mario Herrea-Marschitz; Ezquer, Fernando Proyecto (2023)
Development of Novel Therapeutic Alternatives for Alcohol-Use Disorders: A Multidisciplinary Approach Ezquer, Eduardo Fernando Proyecto (2021)
Acute on chronic liver failure: reversion by systemic administration of 3D spheroids-derived mesenchymal stem cells Bono MR; Carpio J.D. Proyecto (2020)
Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration Ezquer, Eduardo Fernando; Ezquer M.E.; Quintanilla M.E. Proyecto (2020)


Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options Quintanilla M.E. Review ISI SCOPUS GENE THERAPY (2019)
Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity Review ISI SCOPUS CELL ADHESION & MIGRATION (2017)
Carbon monoxide: A new player in the redox regulation of connexin hemichannels Leon-Paravic, CG; Ezquer M.; Ezquer F; Del Rio R.; Pupo A.; González, C. Review ISI SCOPUS IUBMB Life (2015)
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears Ezquer F; Gutierrez J.; Ezquer M.; Caglevic C.; Salgado, HC; Calligaris, SD Review ISI SCOPUS Stem Cell Research and Therapy (2015)
Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy? Ezquer F; Ezquer M.; Arango-Rodriguez, M; Conget P. Review ISI ACTA OPHTHALMOLOGICA (2014)

Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

Alejandro Yañez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

Jaime Villegas

Profesor Asociado

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

René Vidal

Profesor Asociado

Universidad Mayor

Santiago, Chile

Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

Elie Poulin

Profesor Titular

Ciencias Ecologicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

José Valdés

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

Cristhian Urzúa

Director

Oftalmologia

Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas. Universidad de Chile

Santiago, Chile

María Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Mario Rivera

Profesor Asociado

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Hugo Tobar

GLP Unit Manager

IMPACT

IMPACT Center, Universidad de los Andes

Santiago, Chile

Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Flavia Bruna

Universidad del Desarrollo

Santiago, Chile

Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

David Contador

Universidad del Desarrollo

Santiago, Chile

Valentina Parra

Profesora Asociada / Associate Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

MANUEL VARAS

Associated Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Víctor Cornejo

Profesor Asistente

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

Jose Munita

Profesor Asociado

Internal Medicine

FACULTAD DE MEDICINA CLINICA ALEMANA- UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

Jorge Toledo

Investigador

Centro de Investigacion Clinica Avanzada CICA

Universidad de Chile, Hospital Clinico Universidad de Chile

Santiago, Chile

Cristian De Gregorio

Postdoctoral fellow

medicine

Universidad del Desarrollo

Lo Barnechea, Chile

Carol San Martín

Profesora Asistente

Instituto de Nutrición y Tecnología de los Alimentos (INTA)

Universidad de Chile

Santiago, Chile

Fabián Martínez

Académico

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Bárbara Casas

Postdoctoral Fellow

Biología

Universidad de Chile

Santiago, Chile

CATALINA PRIETO

Investigadora senior

Biología

Universidad de Chile

Santiago, Chile

Monica Kurte

Investigador

Ninguna

Santiago, Chile

Glauben Landskron

Assistant Professor

Departamento de Tecnología Médica

Universidad de Chile

Santiago, Chile

Aliosha Figueroa

Asistente de Investigación Senior

Centro de Medicina Intervencional de Precisión y Terapia Celular Avanzada (IMPACT)

Santiago, Chile

Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

Christian Caglevic

Director Científico

Departamento de Investigación del Cáncer

Fundación Arturo Lopez Perez

Santiago, Chile

Francisco Altimiras

Associate Professor

Universidad de Las Américas

Santiago, Chile

J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

Christina Schuh

Associate Professor

Centre for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Javiera Gallardo

Profesor Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

Wileidy Gómez

Postdoctorado

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

Maria Ortúzar

Gerente de producto

Nalca Biotech SpA

Puerto Varas, Chile

Karla Leal

Profesor Investigador

Universidad Autónoma de Chile

Temuco, Chile

Andrea Tapia

Profesor adjunto

Facultad de Farmacia

Universidad de Valparaíso

valparaiso, Chile

Carlos Chacon

Asistente de Investigación

Impact

Universidad de Los Andes

Santiago, Chile

Pedro Fernández

Postdoctorado

INSTITUTO DE ECOLOGIA Y BIODIVERSIDAD

Nunoa, Chile

sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

Mauricio Quezada

Investigador Posdoctoral

Centro Investigación e Innovación Biomédica (CIIB)

Universidad de Los Andes

Las Condes, Santiago de Chile, Chile

Fernando Eduardo Ezquer Romero

Líneas de Investigación

Educación

Cell Biology, Molecular Biology and Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2006

Molecular Biologist, Universidad Nacional de San Luis. Argentina, 2001

Experiencia Académica

Associate Professor Full Time

Full Professor Full Time

Experiencia Profesional

Vice-Director Center for Regenerative Medicine Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (72)

BookWhole (1)

Patent (3)

Proyecto (5)

Review (5)