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Francisca Andrea Alcayaga Miranda

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Cell Therapy, stem cells, regenerative medicine, extracellular vesicles, exosomes, cancer, angiogenesis

Veterinaria, Universidad Autonoma de Barcelona. España, 2009
Medico Veterinario, Universidad Mayor. Chile, 2002

Profesor Instructor Full Time

Universidad de los Andes

Medicina

Santiago, Chile

2011 - A la fecha

Profesor Instructor Full Time

Universidad de los Andes

Chile

2011 - A la fecha
Investigador Senior Full Time

Cells for Cells

Santiago, Chile

2011 - A la fecha

DIRECCIÓN DE TESIS PRE- Y POST-GRADO
2013-2014: Antonella Rossati. Tesis. Veterinaria. Universidad de Viña del Mar. Director de Tesis.
2012-2014: Diego Seguel. Tesis. Ingeniería en Biotecnología. USACH. Co-Director de Tesis.
2020-2021: Nicolas Georges. Tesis. Ingeniería en Biotecnología. UTEM. Director de Tesis
2020-2021: Darío Donoso Meneses. Tesis. Bioquímica. Universidad de Chile. Director de Tesis

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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis Georges-Calderon, Nicolas; Tobar, Hugo E.; Cuenca, Jimena; Varela, Cristobal; Vernal, Rolando; Nardocci, Gino; Adasme-Vidal, Catalina; Kunze-Kullmer, Maximiliano; Hidalgo, Yessia Article ISI JOURNAL OF NANOBIOTECHNOLOGY (2025)
Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases Hevia, Daniel; Hidalgo, Yessia; Urquidi, Cinthya Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
CR5/CCL5 axis is linked to a poor outcome, and inhibition reduces metastasis in oral squamous cell carcinoma Maripillan, Jaime Article ISI JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)
Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles Article ISI PHARMACEUTICS (2023)
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome Silva, Johnatas Dutra; da Silva, Luisa Helena Andrade; Cruz, Fernanda Ferreira; Utreras, Yildy; Hidalgo, Yessia; Cadiz, Maria Ignacia; Limonchi, Rafael Tapia; Cuenca, Jimena Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Turning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor-associated macrophages re-education Donoso-Meneses, Dario; Tobar, Hugo E. Article ISI BIOENGINEERING TRANSLATIONAL MEDICINE (2023)
CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity Article ISI FRONTIERS IN ONCOLOGY (2022)
A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells Hidalgo, Yessia Article ISI FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)
Camouflage strategies for therapeutic exosomes evasion from phagocytosis Article ISI SCOPUS Journal of Advanced Research (2021)
Exosomes on the border of species and kingdom intercommunication Cuenca, Jimena Article ISI SCOPUS TRANSLATIONAL RESEARCH (2019)
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma Rosenberger, Leonie; Lillo-Vera, Fernando; Pedraza, Paulina L.; Ignacia Ortuzar, Maria; Figueroa-Valdes, Aliosha I.; Cuenca, Jimena Article ISI SCOPUS Scientific Reports (2019)
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial Matas, Jose; Orrego, Mario; Amenabar, Diego; Infante, Catalina; Tapia-Limonchi, Rafael; Ignacia Cadiz, Maria; Muse, Emilio; Espinoza, Francisco Article ISI SCOPUS STEM CELLS TRANSLATIONAL MEDICINE (2019)
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration Cuenca, Jimena; Le-Gatt, Alice; Castillo, Valentina; Belletti, Jose; Monica Kurte, G.; Schuh, Christina M. A. P.; Khoury, Maroun Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies Alcayaga-Miranda, Francisca Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2017)
Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]) Bartolucci, Jorge G; Verdugo, Fernando J; González, Paz L; Larrea, Ricardo E; Lopez, Valentina M; Brobeck, Matthew J; Patel, Amit N Article ISI SCOPUS Circulation Research (2017)
Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration. Alcayaga-Miranda, F; Varas-Godoy, M; Khoury, M Article Stem cells international (2016)
Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species Article ISI SCOPUS ONCOTARGET (2016)
The Immunosuppressive Signature of Menstrual Blood Mesenchymal Stem Cells Entails Opposite Effects on Experimental Arthritis and Graft Versus Host Diseases Luz-Crawford, P; Torres, MJ; Noel, D; Fernandez A., Toupet; K, Alcayaga-Miranda; F, Tejedor; G, Jorgensen; C, Illanes; SE, Figueroa FE; Djouad F, khoury M Article Stem Cells. (2016)
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells. Alcayaga-Miranda, Francisca; Cuenca, Jimena; Luz-Crawford, Patricia; Aguila-Díaz, Carolina; Fernandez, Ainoa; Figueroa, Fernando E; Khoury, Maroun Article Stem cell research & therapy (2015)
Chorion Mesenchymal Stem Cells Show Superior Differentiation, Immunosuppressive, and Angiogenic Potentials in Comparison With Haploidentical Maternal Placental Cells Gonzalez, PL; Carvajal C., Cuenca; J, Alcayaga-Miranda; F, Figueroa FE; Bartolucci J., Salazar-Aravena; L, khoury M Article Stem Cells Translational Medicine (2015)
Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis Alcayaga-Miranda, F; Cuenca, J; Martin A., CONTRERAS; L., Figueroa FE Article Stem Cell Research and Therapy (2015)
The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy. Khoury, Maroun; Alcayaga-Miranda, Francisca; Illanes, Sebastián E; Figueroa, Fernando E Article Frontiers in immunology (2014)
Minimal RB-responsive E1A promoter modification to attain potency, selectivity, and transgene-arming capacity in oncolytic adenoviruses. Rojas, Juan J; Guedan, Sonia; Searle, Peter F; Martinez-Quintanilla, Jordi; Gil-Hoyos, Raúl; Alcayaga-Miranda, Francisca; Cascallo, Manel; Alemany, Ramon Article Molecular therapy : the journal of the American Society of Gene Therapy (2010)
Osteosarcoma cells as carriers to allow antitumor activity of canine oncolytic adenovirus in the presence of neutralizing antibodies. Alcayaga-Miranda, F; Cascallo, M; Rojas, J J; Pastor, J; Alemany, R Article Cancer gene therapy (2010)

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CONDITIONAL IMMUNOSUPRESSIVE PROPERTY OF MENSTRUAL BLOOD-DERIVED STEM CELLS IN VITRO Luz-Crawford, P; Fernández A; Torres M.; Alcayaga, F; Salazar, L; Figueroa F.; Khoury, M Abstract ISI CYTOTHERAPY (2013)

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Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo Proyecto (2023)
Revealing the contribution of melanoma-derived circulating cell-free mitochondria in the formation of premetastatic niche in lymph nodes and their impact in the early development of metastasis Proyecto (2023)
Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT) Alcayaga, Francisca; Cuenca, Jimena; Luz C, Patricia; Wyneken, INGE URSULA Proyecto (2021)
Investigating the effect of MAVs-enriched mitochondrial transplantation on intracellular antiviral immunity and their restorative and immunomodulatory effects in a viral-induced acute lung injury model Jimena Cuenca M; Alcayaga, Francisca; Hidalgo, Yessia Proyecto (2021)
INVESTIGATING THE IMMUNOREGULATORY AND ANTI-RHEUMATOID ARTHRITIS ACTIVITIES OF SMALL EXTRACELLULAR VESICLES-SHUTTLED BIOACTIVE MICRORNA DERIVED FROM GLYCOLYTIC MESENCHYMAL STEM CELL Luz C, Patricia; Alcayaga, Francisca Proyecto (2021)
Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue FONDECYT (1190411) Proyecto 2019-2023 Inv. Responsable
Desarrollo y validación de un producto celular alogénico derivado de células madre estromales para su uso en síndrome de distrés respiratorio agudo FONDEF (IT16I10084) Proyecto 2017-2019 Investigador(a)
Exospand=> suplemento humano para expansión de células progenitoras hematopoyéticas Universidad de los Andes (PMI UAN1301-205) Proyecto 2015-2016 Director(a)
REGENERO The Chilean Stem Cell Consortium CORFO (13CTI – 21522) Proyecto 2013-2023 Investigador(a)
‘Evaluación del efecto anti- tumoral de las MSC-derivadas del fluido menstrual (MenSC) en un sistema de cocultivo’ . Fondo de Apoyo a la Investigación FAI modalidad iniciación 2013. Universidad de los Andes Proyecto 2013-2015 Director(a)
Investigando las propiedades inmunomodulatorias de una nueva población stem cell de fluido menstrual recientemente caracterizada y exploración de su aplicación potencial en enfermedades inflamatorias’ FONDEF (CA12i10349) Proyecto 2012-2014 Coinvestigador(a)
Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue Cuenca, Jimena Proyecto (0)