Man

Eduardo Marcelo Ezquer

Director/Full Professor

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

Líneas de Investigación


regenerative medicine; mesencymal stem cells and liver regenerations; development of therapeutic alternatives through the use of stem cells for the treatment of epidermolysis bullosa and diabetes; stem cells in vitro preconditioning

Educación

  •  PhD in Biology, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo. Argentina, 2006
  •  Molecular Biologist, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis. Argentina, 2000

Experiencia Académica

  •   Associate Professor Full Time

    Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo

    Santiago, Chile

    2006 - 2020

  •   Full Profesor Full Time

    Universidad del Desarrollo

    Facultad de Medicina

    Santiago, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Researcher Full Time

    Centro de Medicina Regenerativa, Facultad de Medicina, Universidad del Desarrollo

    Santiago, Chile

    2006 - 2015

  •   Director/researcher Full Time

    Centro de Medicina Regenerativa, Facultad de Medicina, Universidad del Desarrollo

    Santiago, Chile

    2015 - A la fecha

Formación de Capital Humano


supervision of postdoctoral students

Dra. Paola Murgas, Programa de Mejoramiento Institucional (PMI), (2016-2017).
Dr. Maximiliano Giraud-Billoud, Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt) Beca Postdoctoral 3140024 (2013-2015).
Dra. Javiera Bahamondes, Fondo de Fomento y Desarrollo Científico y Tecnológico (FondeF) (2013-2015).
Dr. Cristian De Gregorio, Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt) Beca Postdoctoral 2020

supervision of master's students

Fabián Cabezas, Facultad de Ciencias Biológicas, Escuela de Ingeniería en Biotecnología. Universidad Andrés Bello. (2012-2013).
Michell Gatica, Facultad de Ciencias Biológicas, Escuela de Ingeniería en Biotecnología. Universidad Andrés Bello. (2013-2014)
Victoria Arredondo, Facultad de Ciencias Biológicas, Escuela de Ingeniería en Biotecnología, Universidad Andrés Bello. (2014-2015)

supervision of doctoral PhD students
Lic. Ya-Lin Huang, Programa de Doctorado en Biología (PROBIOL), de la Universidad Nacional de Cuyo, Argentina desde 2015 (Director).
Lic. Flavia Bruna, Programa de Doctorado en Biología (PROBIOL), de la Universidad Nacional de Cuyo, Argentina 2013-2016. (Co-Director).
Farmacéutica Belén Olivares, Programa de Doctorado en Biología (PROBIOL), de la Universidad Nacional de Cuyo, Argentina 2018-. (Co-Director)
Bioquímico Eduardo Durán, Doctorado en Ciencias e Innovación en Medicina, ICIM-UDD, Chile 2017 (Co-Director)

supervision of undergraduate students

Valeria Labra, Biotecnóloga, Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, 2016. (Tutor).
Tatiana Diaz, Tecnología Médica con Mención en Morfofisiopatología y Citodiagnóstico. Universidad Pedro de Valdivia, 2017. (Tutor)
Gisselle Haydeé Gaby Peñaloza, Tecnología Médica con Mención en Morfofisiopatología y Citodiagnóstico. Universidad Pedro de Valdivia, 2017. (Tutor)


Difusión y Transferencia


patent application
Ezquer F., Israel Y., Ezquer M., Quintanilla M., Morales P., Herrera M. PCT N° CL2018 050063 (2018) Composición Farmacéutica para el tratamiento de la adicción a sustacias psicoactivas y/o para la prevención de las recaídas a dicha adicción

Ezquer F., Israel Y., Ezquer M., Quintanilla M., Morales P., Herrera M. N° 201700237 (2016) Composición inyectable o intranasal que comprende células madre mesenquimaticas (MSCs) sin estimular o precondicionadas, medios de cultivo derivados de MSCsprecondicionadas o exosomas derivados de su cultivo, y excipientes; y su uso para reducir consumo de drogas o bloquear recaída por privación, en una persona con adicción.

Ezquer M, Ezquer F. Solicitud de Patente N°201502971 (05/10/15) Composición biofarmacológica que comprende productos y/o derivados secretados por células troncales mesenquimáles (MSC) que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática o donde la capacidad de regeneración endógena se encuentra inhibida.

Diffusión

organizing committee “IPS 2017: Pluripotent Stem Cells and Gene Editing Symposium: From Bench Success to Clinical Promises”. Universidad de los Andes (CH), Universidad del Desarrollo (CH) y Universidad de Cambridge (GB), marzo 2017.



 

Article (45)

Innate gut microbiota predisposes to high alcohol consumption
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3)
Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats
Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation
Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.
Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options
Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma
Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus.
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats=> Inhibition by N-Acetylcysteine
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration
Acquisition maintenance and relapse-like alcohol drinking lesson from the UChB rat line
Administration of multipotent mesenchymal stromal cells restores liver regeneration and improves liver function in obese mice with hepatic steatosis after partial hepatectomy
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol and Alcoholisms
Preconditioning of adipose tissue-derived mesenchymal stem cellswith deferroxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors=> potential application in the treatment of diabetic neuropathy
Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: increasing transplanted cell resistance and increasing tissue receptivity
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis
Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus
Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?
Nerve Excitability and Structural Changes in Myelinated Axons from Diabetic Mice
Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus
Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats
Mesenchymal stem cell therapy in type 1 diabetes mellitus and its main complications: From experimental findings to clinical practice
Reversion by Vitamin E Treatment of the Oxidative Damage but Not of the Advancement in Reproductive Senescence Produced by Neonatal Hypoxia or Hypoxia-Ischemia in Female Rats
Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phase of diabetic cardiomiopathy
MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment
Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome
The Antidiabetic Effect of MSCs Is Not Impaired by Insulin Prophylaxis and Is Not Improved by a Second Dose of Cells
Endovenous Administration of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells Prevents Renal Failure in Diabetic Mice
PItuitary changes involved in prolactin secretion induced by mifepristone and naloxone during late pregnancy
Advancement of reproductive senescence and changes in the early expression of estrogen, progesterone and mu-opioid receptors induced lay neonatal hypoxia in the female rat
Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type I diabetic mice
Acute sublethal global hypoxia induces transient increase of GAP-43 immunoreactivuty in the striatum of neonatal rats
Hypothyroidism prolongs corpus luteum function in the pregnant rat
Inflammatory responses of the substantia nigra after acute hypoxia in neonatal rats
Bovine pars tuberalis secretions release growth hormone from rat pars distalis of pituitary gland
c-fos and tyrosine hydroxylase expression after an excitotoxic lesion on the nigrostriatal system: a study on the effects of hypoxia used as a preconditioning stimulu

BookWhole (1)

Stem cells for the treatment of patients with type 1 diabetes mellitus

Proyecto (16)

Acute on chronic liver failure: reversion by systemic administration of 3D spheroids-derived mesenchymal stem cells
Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration
Evaluación del efecto terapéutico de la administración endovenosa de células troncales mesenquimáticas, sobre la recuperación de la función cognitiva, en ratas sometidas al consumo crónico de alcohol.
International Research Network for the development of induced pluripotent stem cell technology
Treating the whole not the hole=> administration of acellular derivative from mesenchymal stem cells subjected to a preconditioning stimulus reverts diabetic neuropathy and prevents diabetic foot ulcers
Modelamiento matematico en medicina=> desarrollo de un algoritmo matematico capaz de predecir cual es el mejor fármaco biológico para el tratamiento de la neuropatía diabética
EVALUATION OF THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELL -ACELULAR DERIVATE- ON DRUG INDUCED STEATOSIS, IN A MODEL OF NORMAL AND IMPAIRED LIVER REGENERATION CAPACITY
Evaluación del potencial cardioprotector de productos derivados de células madre mesenquimáticas sobre la cardiotoxicidad inducida por doxorrubicina
Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy?
DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS MODIFY THE NATURAL EVOLUTION OF RETINAL DAMAGE IN DIABETIC MICE
EFECTO DE LAS CELULAS MADRE MESENQUIMATICAS SOBRE LA ESTRUCTURA Y FUNCION TUBULAR EN ESTADIOS TEMPRANOS DE LA NEFROPATIA DIABETICA
Producto derivado de células troncales mesenquimáticas favorece regeneración del hígado en individuos con esteatosis sometidos a una cirugía de resección hepática
Estudio clínico fase II=> Administración intravenosa de células madre mesenquimáticas para tratar pacientes con Diabetes Mellitus Tipo 1.
THE ETIOLOGY OF DIABETES AND/OR THE STAGE OF DIABETIC NEPHROPATHY MODIFY THE RENOPROTECTIVE EFFECT OF DONOR MULTIPOTENT MESENCHYMAL STROMAL CELLS?
CHARACTERIZATION OF THE MECHANISMS ASSOCIATED TO THERAPEUTIC EFFECTS OBSERVED SFTER MESENCHYMAL STEM CELL ADMINISTRATION INTO MICE WITH THE HEPATIC MANIFESTATION OF METABOLIC SYNDROME.
Medicina Regenerativa para diabetes y sus complicaciones

Review (4)

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options
Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears
Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy?
46
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

23
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

5
Paulette Conget

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

4
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

3
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
J Daniel Carpio

Director Ejecutivo-Profesor Asociado

Unidad Microscopía Electrónica

Universidad Austral de Chile

Valdivia, Chile

2
Micaela Ricca

Subdirección Área Veterinaria

Área Veterinaria

Fundación Ciencia & Vida

Santiago, Chile

2
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

2
Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

2
Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

2
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
David Contador

Universidad del Desarrollo

Santiago, Chile

1
vania figueroa

Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Aníbal Vargas

Investigador postdoctoral

Universidad de O'Higgins

Rancagua, Chile

1
Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

1
Cristhian Urzúa

Director

Oftalmologia

Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas. Universidad de Chile

Santiago, Chile

1
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

1
Flavia Bruna

Universidad del Desarrollo

Santiago, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile