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Flavia Alejandra Bruna Tello

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


-Medicina regenerativa -Terapia con células madres mesenquimáticas -Lesiones precancerosas orales -Biomarcadores tumorales

Educación

  •  Bsc, Universidad Nacional de San Luis (UNSL). Argentina, 2007
  •  PhD, PROBIOL, Universidad Nacional de Cuyo. Argentina, 2016

Experiencia Académica

  •   Investigador Asociado Indefinido

    Universidad del Desarrollo

    Santiago, Chile

    2009 - Sin Información

  •   Docente ayudante de primera ad honorem Other

    Universidad Nacional de Cuyo, Mendoza, Argentina

    Facultad de Odontología

    Mendoza, Argentina

    2017 - A la fecha

  •   ASSISTANT RESEARCH Full Time

    IMBECU CCT-MENDOZA CONICET UNCUYO

    Mendoza Capital, Argentina

    2016 - A la fecha

Experiencia Profesional

  •   Project Manager

    Universidad del Desarrollo

    Santiago, Chile

    2014 - Sin Información

Premios y Distinciones

  •   Secon place-young investigator award 2019

    Albert Ludwings University of Freiburg

    Argentina, 2019

    Oral presentation of the work: Study of the influence of human renal adipose tissue on tumor progression in kidney cancer Echegaray MD, Romeo LR, Bruna FA, Carón RW, Pistone Creydt V Tumor stroma is one of the emerging topics of interest in cancer research. In the present work, we evaluated: 1)adiponectin, ADAMTS1 and perilipin expression in conditioned media (CMs) of human adipose tissue explants from normal (hRAN) and tumor (hRAT) kidney; 2) AdipoR1, ObR, adiponectin and perilipin expression in hRAN- and hRAT. We also evaluated changes in the expression of: 1) AdipoR1, ObR, CD44 and vimentin in tumor (786-O, ACHN, Caki-1) and non tumor (HK-2) renal epithelial cells; 2) pERK/ERK and pPI3K/PI3K changes in cell lines incubated by 2 and 24h with hRAN-, hRAT, or control-CMs. Human renal adipose tissues were obtained from patients with renal cell carcinoma (hRAT, n=10) and kidney donors (hRAN, n=11). The CMs of hRAN and hRAT were collected 24h post incubation. Protein expression was evaluated by IHQ and WB. The cell lines were treated with CMs by 24h. Statistical differences were evaluated by one-way ANOVA or t-test, with Tukey´s post hoc tests. We observed a lower perilipin expression in hRAT-CMs vs. hRAN-CMs; and we found that adiponectin, AdipoR1, and perilipin expression were significantly increased in hRAN vs. hRAT explants (p<0.01). Also, we observed a decrease in the expression of AdipoR1 in ACHN and Caki-1 and the increased expression of ObR and CD44, when these cells were incubated with hRAT-CMs compared to hRAN- and control-CMs (p<0.001). In addition, we observed an increase in the expression of vimentin in HK-2, when these cells were incubated with hRAT-CMs. Further, we found an increase in the expression of pERK and pPI3K in HK-2 and 786-O, when these cells were incubated with hRAT-CMs compared to hRAN- and control-CMs (p &lt;0.001). In conclusion, changes observed in the adipose microenvironment could be favoring tumor progression and therefore, the tumor stroma should be taken into consideration when dealing with a malignancy.


 

Article (16)

SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level
Evaluation of different total Leishmania amazonensis antigens for the development of a first-generation vaccine formulated with a Toll-like receptor-3 agonist to prevent cutaneous leishmaniasis
The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential
Effects of hypothyroidism on the mesenteric and omental adipose tissue in rats
High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats
Human renal adipose tissue from normal and tumor kidney: its influence on renal cell carcinoma
Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: a new biosafety insight
Human renal adipose tissue induces the invasion and progression of renal cell carcinoma
Omental adipose tissue is a more suitable source of canine Mesenchymal stem cells
The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma
The effect of biological heterogeneity on R-CHOP treatment outcome in diffuse large B-cell lymphoma across five international regions
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Protocol for qRT-PCR analysis from formalin fixed paraffin embedded tissue sections from diffuse large b-cell lymphoma: Validation of the six-gene predictor score
Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
Prospective International Cohort Study Demonstrates Inability of Interim PET to Predict Treatment Failure in Diffuse Large B-Cell Lymphoma
Participation of Opioid Peptides in Sucking-induced Oxytocin and Prolactin Secretions in Lactating Goats

Abstract (1)

MESENCHYMAL STEM CELLS CONTRIBUTE TO STRUCTURAL AND MORPHOLOGICAL RECUPERATION OF PROLAPSED ANTERIOR VAGINAL WALL: IN VITRO STUDY

BookSection (1)

"Multipotent Stromal Cells in a Tumor Microenvironment"

Letter (1)

Identification of a Patient Cohort with Relapsing Diffuse Large B-Cell Lymphoma with a Low International Prognostic Index in PET/CT Using a 2-Gene (LMO2/TNFRSF9) Scoring System
19
Flavia Bruna

Universidad del Desarrollo

Santiago, Chile

2
Anita Plaza

Investigador

Medicina

Universidad Austral de Chile

Valdivia, Chile

2
David Contador

Professor Instructor

School of Medicine

Universidad del Desarrollo

Santiago, Chile

2
Iris Espinoza

Associated Professor

Departament of Oral Patology and Medicine

Universidad de Chile

Santiago, Chile

1
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

1
Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile