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Margarita Calvo Bascuñan

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


My research interest in neuropathic pain is complementary to my clinical work. I study both animal models and patients employing a variety of techniques ranging from transgenic mouse models to human psychophysical studies and genetics.

Educación

  •  Neuroscience, KINGS COLLEGE LONDON. Reino Unido, 2010
  •  Pain Management, KINGS COLLEGE LONDON. Reino Unido, 2009
  •  Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
  •  Peripheral Nervous system, UNIVERSITA DEGLI STUDI DI MILANO. Italia, 2020

Experiencia Académica

  •   Postdoctoral fellow Full Time

    KINGS COLLEGE LONDON

    Biomedical school

    london-oxford, Reino Unido

    2010 - 2013

  •   Profesor Visitante Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Cs Biologicas

    santiago, Chile

    2013 - 2014

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Cs Biologicas

    santiago, Chile

    2014 - A la fecha

  •   Profesor Visitante Full Time

    UNIVERSITY OF OXFORD

    NDCN

    Oxford, Reino Unido

    2013 - 2014

Experiencia Profesional

  •   Postdoctoral fellow Full Time

    Kings College London

    london, Reino Unido

    2010 - 2013

  •   Honorary contract- Clinical researcher Full Time

    Kings College London hospitals

    London, Reino Unido

    2010 - A la fecha

  •   Honorary contract- Clinical researcher Other

    Chelsea and Westminster Hospital-Imperial College

    London, Reino Unido

    2010 - 2013

  •   Visitant Professor Full Time

    Oxford University

    Oxford, Reino Unido

    2013 - A la fecha

  •   Visitant Professor Full Time

    Oxford University

    Oxford, Reino Unido

    2016 - 2016

  •   profesor visitante Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2013 - 2014

  •   Medico acreditado-Unidad del Dolor Other

    Red de salud UC Christus

    Santiago, Chile

    2014 - A la fecha

  •   Profesor Asistente Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2014 - 2019

  •   Early-Career Advisory Group (ECAG) member Other

    eLife

    Reino Unido

    2017 - A la fecha

  •   Management committee Other

    Neuropathic Pain Special Interest group (NeuPSIG)

    London, Reino Unido

    2018 - A la fecha

  •   IASP Councillor Other

    International Association for the study of pain

    Chile

    2020 - A la fecha

  •   Directora Other

    Inicitaiva Cinetífico Millennium Nucleus -ANID

    Chile

    2020 - A la fecha

Formación de Capital Humano


Dirección De Tesis De Pregrado
- Completa: Daniela Schmidt
- En ejecución. Marcelo Kim , Luna Olguin, Pilar Morales
- Inmersión en investigación de alumna universidad Los Andes 2014-2015 Sofia von Bischhoffshausen
- Investigación para pregrado verano/invierno :2014 Miguel Calderon,
2015 Renate Reisenegger/ Miguel Calderon,
2017 Sofía Guajardo
2018 Matias Torres Jesús Vega
2019 Daniella Pérez, Francisca Henríquez

Dirección De Tesis De Post-Grado (Solo Doctorado)
Rotación de primer año de doctorado de Néstor Corro 2015
En ejecución, Luis Martin Gonzalez
Paula Díaz
Macarena Tejos
Zulmary Manjarres


Difusión y Transferencia


Conferencias:
Nacionales
-2018: Sociedad de Neurociencias, Puerto Varas
-2016: XXXVIII Congreso Anual De La Sociedad De Farmacología De Chile. Castro, Chiloé

Internacionales
-2020 1st EB World Congress, London, UK
- 2019 7th International Congress on Neuropathic Pain (NeuPSIG 2019), London, UK
-2019 eLife Annual Meeting, London, UK
-2018 17th World Congress in Pain IASP. Boston, USA
-2017. Peripheral Nerve Society 2017, Sitges, Spain
-2017. Neuropathic pain Special interest Group IASP, NeuPSIG 2017, Gothenburg, Sweden
-2017 eLife Annual meeting, Boston, USA
-2016. 16th World Congress in Pain IASP. Yokohama, Japan
-2016. Euroconference in Pain, Taormina, Sicily, Italy
-2015. 5to International Congress NeuPSIG. Nice, France
-2015. EFIC IX Pain Congress, Vienna, Austria
-2015. World Congress in neurology, Santiago, Chile
-2015. Chilean Congress in Pain (ACHED). Santiago, Chile
-2014. Satellite symposium in painful neuropathies (NeuPSIG, IASP) Santiago, Chile
-2013. Peripheral Nerve Society Biennial Meeting, St Malo, France
-2012. Joint Italian and British Peripheral Nerve Societies meeting. London, UK
Posters en Congresos Internacionales
- 2016. 16th World Congress in Pain IASP. Yokohama, Japan
- 2015 5th NeuPSIG. Nice, France
- 2015. EFIC IX Pain Congress, Vienna, Austria
- 2014 15th World Congress in Pain IASP. Buenos Aires, Argentina
- 2013 4to Congreso Internacional NeuPSIG. Athens, Greece
- 2012 14th World Congress in Pain IASP. Milan, Italy
- 2010 13th World Congress in Pain IASP. Montreal, Canada
- 2009 Peripheral Nerve Society meeting. Würzburg , Germany
- 2008 12th World Congress in Pain IASP. Glasgow, UK
- 2007. Peripheral Nerve Society,meeting. Snowbird, Utah, USA

Participación En Otras Actividades Asociadas A Investigación.

Revisor de Publicaciones Internacionales (Journal, fecha)
eLife 2018, Glia 2017, Plos NTD 2017, Journal of molecular histology 2017, Neuroscience letters 2017, 2015, 2014, Journal of Pain 2015, Pain Research and Treatment 2015, Pain Medicine 2014, Journal of pain Research 2014 , Biological Research 2014-2018, Revista médica de Chile 2018

Revisor de Proyectos Nacionales
FONDEF 2015, 2019 2020, FONDECYT INICIO 2015, Becas Chile (doctorado extranjero) 2018-2020, Conicyt Doctorado Chile 2018-2020

Revisor de Proyectos Extranjeros
-Newton Prize 2019-2020 UK National Commission for UNESCO Team.
-The Netherlands Organisation for Scientific Research (NWO/ZonMw) 2016
-Italian Ministry of Health (MOH) Riserca Sanitaria 2014-2017

Rol en Sociedades Internacional
-Member of the eLife early careers advisory group 2017-2019
-Member of management committee Neuropathic Pain SIG IASP 2019-2020
-Elected council IASP 2020-2026


Premios y Distinciones

  •   Beca Presidente de la Republica

    Gobienro de Chile

    Chile, 2007

    Beca para estudiar el PhD.

  •   Beca Alban

    COMUNIDAD ECONOMICA EUROPEA

    Portugal, 2006

    Beca Alban para estudios de postgrado en la Comunidad Europea

  •   P.K Thomas Fellowship Award

    Peripheral Nerve Society

    Estados Unidos, 2009

    Mejor presentacion del congreso de PNS

  •   travel grant

    UNIVERSITY COLLEGE LONDON

    Reino Unido, 2010

    TRavel grant

  •   travel grant

    KINGS COLLEGE LONDON

    Chile, 2009

    travel grant

  •   travel grant

    IBRO

    Estados Unidos, 2010

    TRAVEL GRANT

  •   travel grant

    IASP

    Chile, 2010

    International Association for the study of pain travel grant

  •   travel grant

    IASP

    Chile, 2008

    International association for the study of pain travel grant

  •   Travel grant

    eLife

    Chile, 2017

    eLife is a non-profit organisation inspired by research funders and led by scientists. eLife was founded in 2011 by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust, who provide financial support and strategic guidance. They provide a few grants each year to early-stage researchers on eLife papers for funding towards presenting their work at a meeting of their choice.

  •   IASP councilor

    International Association for the study of pain

    Estados Unidos, 2020

    I am an elected councillor for the biggest International society in Pain (IASP). I have been working hard in special interest groups task and in managing the neuPSIG (one of the main SIG of IASP). This year I was selected as one in the " IASP Hall of Champions" (https://www.iasp-pain.org/Membership/Content.aspx?ItemNumber=6221) and then elected to be councillor for 6 years.

  •   Natural and exact sciences Millenium Nucleus

    FONDECYT

    Chile, 2020

    MiNuSPain, milenium nucleus for the study of pain. Adjudicado en concurso 2020 Directora


 

Article (12)

Metformin protects from oxaliplatin induced peripheral neuropathy in rats
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy
Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury
Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy
Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia
CXCL5 Mediates UVB Irradiation-Induced Pain
Following Nerve Injury Neuregulin-1 Drives Microglial Proliferation and Neuropathic Pain via the MEK/ERK Pathway
Specific involvement of atypical PKC zeta/PKM zeta in spinal persistent nociceptive processing following peripheral inflammation in rat
Neuregulin-ErbB Signaling Promotes Microglial Proliferation and Chemotaxis Contributing to Microgliosis and Pain after Peripheral Nerve Injury

BookSection (1)

Signals from injured neurons that modulate microglia

Proyecto (5)

A double-blind, randomized, cross-over, multi-centre, feasibility trial of pregabalin for the treatment of RDEB-associated neuropathic pain and itch
Investigating neurotrophins role in small fibre neuropathy in Recessive Dystrophic Epidermolysis Bullosa
SHAKER-TYPE-KV-CHANNELS AS MODULATORS OF HYPEREXCITABILITY; IMPACT ON NEUROPATHIC PAIN STATES.
Investigating a novel mechanism of hypersensitivity induced by exclusive damage to intraepidermal nerve fibres=> neuropathic pain in Epidermolysis Bullosa
Determining the frequency and pathophysiological mechanisms underlying neuropathic pain in epidermolysis bullosa and its potential as a novel mechanism of hypersensitivity induced by sole cutaneous nerve fibre damage

Review (3)

The Genetics of Neuropathic Pain from Model Organisms to Clinical Application
The mechanisms of microgliosis and pain following peripheral nerve injury
The role of the immune system in the generation of neuropathic pain
16
Margarita Calvo

Profesor Asociado

Fisiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Dinka Ivulic

Tesista

Universidad de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile