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jaime eduardo villegas olavarria

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


Mitochondrial ncRNAs in normal and malignant cell proliferation; Diagnostics and therapy of cancer

Educación

  •  Ciencias Biológicas, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1988
  •  Ciencias, mención Biología Celular y Molecular, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Asistente Full Time

    Universidad Andrés Bello

    Ciencias de la Vida

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Investigador Senior Other

    Andes Biotechnologies SpA

    Santiago, Chile

    2011 - 2019

  •   Investigador Part Time

    Grupo BIOS

    Santiago, Chile

    2008 - 2019

Formación de Capital Humano


Tutor de una tesis doctoral, cinco tesis de magister, 10 tesis de pregrado, miembro comisión de 26 tesis de magíster, 18 tesis de doctorado, 8 tesis de pregrado.


Difusión y Transferencia


Taller de Ingeniería Genética para Líderes de Opinión. Taller teórico-practico de tres días de duración. (2004, 2005, 2006, 2007,2012, 2014, 2018)
Taller Bio-class: Acercando el mundo científico a la comunidad escolar. (Invitado)


Premios y Distinciones

  •   Distinción Académica: Premio Medalla “R. A. Phillipi

    UNIVERSIDAD AUSTRAL DE CHILE

    Chile, 1999

    Premio a la mejor tesis de pregrado, patrocinado por la Dirección de Investigación de la UNiversidad

  •   Premio Fundación científica Biovision

    Fundación Científica Biovision

    Francia, 2003

    Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial

  •   Premio “Emprendimiento Biotecnológico BIOTECH 2004

    Red AMSUD-Pasteur

    Uruguay, 2004

    Premio a la mejor investigación en biotecnología en el campo de terapias antitumorales, otorgada por el Instituto Pasteur, filial Uruguay

  •   Premio Fundación Científica Biovision

    Fundación Científica Biovision

    Francia, 2005

    Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial

  •   Premio Fundación Científica Biovision

    Fundación Científica Biovision

    Chile, 2007

    Premio en reconocimiento como uno de los científicos jóvenes más promisorio a nivel mundial

  •   Premio a la Investigación Científica Universitaria: Cura y Prevención del Cáncer

    Santander Universidades y el Mercurio

    Chile, 2013

    Premio a la mejor investigación en desarrollo de nuevas metodologías de diagnostico y tratamiento del cáncer


 

Article (23)

Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells
Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors
HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors
Cervical cancer, human papillomavirus and vaccines: assessment of the information retrieved from general knowledge websites in Chile
In vivo knockdown of antisense noncoding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization
Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model
Assessment of the Expression of Long Noncoding Mitochondrial RNAs (lncmtRNAs) during cervical cancer progression and cervical carcinoma
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors
The Urgent Need for New Therapeutical Approaches for Renal and Bladder Cancer: Mitochondrial Non-Coding RNAs as Efficient Targets
Down-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy
Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer
The Mitochondrial Antisense ncRNAs are Down-Regulated in Early Cervical Carcinoma
Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer
Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes
Nuclear localization of the mitochondrial ncRNAs in normal and cancer cells
Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells
Expression of a novel non-coding mitochondrial RNA in human proliferating cells
The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhyncus tshawytscha
A putative RNA editing from U to C in a mouse mitochondrial transcript
Localization of the 16S mitochondrial rRNA in the nucleus of mammalian spermatogenic cells
A novel chimeric mitochondrial RNA localized in the nucleus of mouse sperm

Abstract (6)

Mitochondrial non-coding RNAs as therapeutic target in cervical cancer
Non Coding Mitochondrial RNAs as Novel Teragnostic Molecular Tool in Cervix Cancer
The antisense non-coding mitochondrial RNA as a molecular therapeutic target for a murine model of melanoma
A single FISH procedure for the detection of tumor cells: Bladder cancer as model
Sense and antisense noncoding mitochrondrial RNA differentiate normal from tumor cells
Identification of a novel editing reaction in a mouse mitochondrial chimeric RNA

BookSection (5)

Long Noncoding Mitochondrial RNAs (LncmtRNAs) as Targets for Cancer Therapy
Targeting Non-Coding Mitochondrial RNAs (ncmtRNAs) in Gynecological and Urinary Malignancies: Universal Targets for the Development of an Efficient Therapy?
Long non-coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer.
Biosíntesis de pegamentos de organismos marinos.
Piscirickettsia salmonis: un enfoque genómico para un problema de la salmonicultura

BookWhole (1)

Long non coding mitochondrial RNAs as potential targets for diagnosis and therapy of bladder cancer

ConferencePaper (1)

Evaluation of antisense therapy in PDX models of advanced cervical cancer: Mitochondrial non-coding RNAs as target

ConferencePoster (26)

Antisense therapy against non-coding mitochondrial RNAs as potent therapy for prostate cancer
La interferencia del RNA mitocondrial no codificante largo (RNAmtnc-AS) como un nuevo tratamiento para el cáncer renal humano
The antisense long non-coding Mitochondrial RNA (AS-NCMTRNA) interference with andes-1537 as a novel treatment for renal carcinoma
Evaluation in vivo of the efficacy of an antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer
. Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer
Evaluation of the efficacy of antisense therapy in a patient derived xenograft model (PDX) of advanced cervical cancer
HPV-18 E2 protein induces partial immortalization of human keratinocytes followed by replicative senescence and modulation of the mitochondrial SncmtRNA and the ASncmtRNAs
Lactadherin and VE-cadherin Incorporated in to exosomes secreted postinterference of ASncmtRNA decrease tumorigenic property in breast cancer cell
Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model.
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors
Long non-coding mitochondrial RNAs as therapeutic targets in gynecological cancers.
. Exosomes released upon knockdown of the antisense non-coding mitochondrial RNAs modulate tumorigenic properties of the human breast cancer cell line MDA -mb-231
The antisense non-coding mitochondrial RNAs as therapeutic targets in cervical and ovarian cancer
Knockdown of the mitochondrial antisense ncRNAs abolishes murine melanoma tumor growth and metastasis
Knockdown of the mitochondrial antisense ncRNAs induces complete inhibition of murine melanoma tumor growth and metastasis
La interferencia del RNA mitocondrial no codificante antisentido (RNAmtnc-AS) suprime el crecimiento tumoral y aumenta la sobrevida en modelos ortotópicos de cáncer renal subcutáneo y ortotópico
Targeted inhibition of ASnc mtRNA promote apoptosis and inhibit tumorigenic properties in genitourinary cancer in vitro and in vivo.
The Antisense long non-coding mitochondrial RNA (AS-ncmtRNA) interference as a novel treatment for Renal carcinoma
Evaluation of the expression of a family of non-coding mitochondrial RNAs through the progression of cervical cancer: a novel tool for diagnosis
Non-coding mitochondrial RNAs (ncmtRNAs) as therapeutic target of cervical cancer
Evaluation of a diagnostic method for cervical cancer: Non-coding mitochondrial RNAs as markers
Gene therapy against bladder cancer: A new strategy to fight the urothelial carcinoma
Targeting non-coding mitochondrial RNA induces cell death of primary cultures of cervical cancer
Targeting the antisense non-coding mitocondrial RNA (AsncmtRNA) inhibits neoplastic characteristic of human bladder cell lines
Non-coding mitochondrial RNAs as novel theragnostic molecular tool in cervix cancer
Renal cell carcinoma: evaluation of the mitochondrial non-coding RNAs as potential targets for therapy

Editorial (1)

Different cancers, same target?

Proyecto (12)

Evaluación de una nueva terapia para el cáncer de próstata resistente a castración
Validación de terapia antisentido para cáncer cervicouterino in vivo
Preclinical animal studies required for the treatment of human cancer using oligonucleotides
Developing a targeted therapy against cervical cancer
Development of a prototype diagnostic kit for the detection and monitoring of bladder cancer from urine samples.
Evaluation of a novel antisense mitochondrial RNA as an element of early cáncer diagnosis
DEVELOPMENT OF A HIGHLY EFFICIENT SYSTEM FOR IDENTIFICATION OF NEOPLASTIC CELLS IN BLADDER CANCER PATIENTS, BASED ON THE DIFFERENTIAL EXPRESSION OF A NOVEL FAMILY OF MITOCHONDRIAL RNAs.
Development of new products for the diagnosis and therapy of cancer
Development of new tools for the detection of viral pathogens in plants and their use in certified virus-free plants
Use of antisense oligonucleotides against a family of human mitochondrial chimeric RNAs=> potential use in diagnosis and therapy of cancer
Human chimeric mitochondrial RNA=> Role in cell proliferation and apoptosis
Translocation of mitochondrial RNAs to the nucleus of spermatogenetic cells
58
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

20
Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

17
jaime villegas

Investigador Senior

Andes Biotechnologies

Fundación Ciencia para la Vida

Santiago, Chile

14
Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

13
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

4
Alexis Rivas

Investigador Postdoctoral

Instituto de Neurociencias Biomédicas

Universidad de Chile

Santiago, Chile

4
Eduardo Landerer

ENCARGADO POSTGRADO UROLOGÍA HFB

UROLOGÍA

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

4
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

4
Vincenzo Borgna

Investigador

Inmuno-Oncología

FUNDACION CIENCIA VIDA

Santiago, Chile

4
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Ronny Martinez

Académico Investigador

UNIVERSIDAD DE LA SERENA

La Serena, Chile

2
Reynaldo Gomez

Jefe del Servicio de Urología

Departmento de urología

Hospital del Trabajador

Santiago, Chile

2
LAURA VELARDE

Uróloga

Departmento de urología

Hospital del Trabajador

Santiago, Chile

2
Maximiliano Bendek

ninguno

ninguna

Santiago, Chile

2
Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

1
Ana Meneses

Académico

Universidad Diego Portales

Santiago, Chile

1
Erwin Krauskopf

Profesor Asociado

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

1
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

1
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

1
Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

1
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Cancino

Assistant Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

1
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

1
Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

1
Nicole Farfán

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
pamela araya

JEFE DE SECCIÓN

BIOMEDICO

INSTITUTO DE SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Enrique Werner

Académico

Ciencias Básicas

UNIVERSIDAD DEL BIO-BIO

Chillán, Chile

1
Franko Restovic

Manager

Bioeconomy

Fundación Fraunhofer Chile Research

Santiago, Chile