Man

Martín Alejandro Montecino Leonard

Director

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Líneas de Investigación


Regulation of gene transcription; Epigenetic control of expression; Regulation of cell differentiation

Educación

  •  Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1989
  •  Biomedical Sciences, University of Massachusetts. Estados Unidos, 1996
  •  Biochemistry, Universidad de Concepción. Chile, 1991

Experiencia Académica

  •   Assistant Professor Full Time

    University of Concepcion

    Biological Sciences

    Concepcion, Chile

    1996 - 1997

  •   Associate Professor Full Time

    University of Concepcion

    Biological Sciences

    Concepcion, Chile

    1997 - 2004

  •   Professor Full Time

    University of Concepcion

    Biological Sciences

    Concepcion, Chile

    2004 - 2009

  •   Professor and Director of Institute of Biomedical Sciences Full Time

    Andres Bello University

    Biological Sciences

    Santiago, Chile

    2009 - A la fecha

Formación de Capital Humano


Direction of Post-doctoral fellows:

“Function and evolution of the Runx2-VDR interaction in vertebrate osteoblasts”. (2006-2008).
Dr. Sylvain Marcellini
“Regulación transcripcional de genes en cancer gastrointestinal”. (2007-2009).
Dr. Fernando Cruzat
“Regulación transcripcional de genes en cancer gastrointestinal”. (2008-2010).
Dra. Berta Henríquez
“Modelamiento In Silico de la diferenciación mesenquimal hacia los fenotipos óseo, muscular y adiposo”. (2011-2014).
Dr. Rodrigo Assar
“Análisis bioinformático de la respuesta transcripcional global durante la diferenciación celular”. (terminated 2015).
Dr. Felipe Veloso
“Regulación transcripcional del gen Runx2/p57 mediado por los niveles de glucosa durante el proceso de diferenciación ósea”. (Terminated in 2017).
Dr. Gino Nardocci
“Control de la expresión de Ezh1 y Ezh2 durante la maduración neuronal”. (Terminated in 2017).
Dra. Laura Guajardo
“Contribucion de las demetilasas de histona utx y jmjd3 a la mantencion del potencial de expresion de genes del linaje neuronal-hpocampal”. (Terminated in 2017).
Dra. Karen Jaramillo
“Complejo Polycomb Ezh1: genes blancos y mecanismos de control epigenético durante la maduración de neuronas hipocampales”. (Terminated in 2017).
Dr. Mauricio Saéz
“La proteína Rlf como regulador epigenético del proceso de adaptación de Orestias Ascotanensis”. (Terminado 2018, co-dirigida por Miguel Allende y Martín Montecino).
Nombre: Dra. Raquel Marina
“Higher order chromatin organization”. FONDAP 15090007 (Ongoing).
Nombre: Ingrid Araya
“Non-coding RNAs and adaptation of altiplanic fishes to environmental stress”. FONDAP 15090007 (Ongoing).
Nombre: Rodrigo Maldonado
“Control epigenético de la plasticidad hipocampal”. FONDAP 15090007 (Ongoing).
Nombre: Yennifer Arancibia

Doctoral thesis direction:

“Análisis del mecanismo de remodelamiento nucleosomal asociado con la expresión temporal de genes de histonas alfa durante la embriogénesis temprana del erizo de mar Tetrapygus niger”.(Finished).
Ricardo Medina Díaz
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Rol de factores inductores de transcripción basal en la reorganización nucleosomal de la región promotora proximal en el gen osteocalcina”. (Finished).
José Gutierrez
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Regulación de la transcripción del gen de osteocalcina en células osteoblásticas: Rol de la organización nucleosomal del promotor y de cofactores regulatorios generales”. (Finished).
José Sierra
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Modulación de la transactivación del gen de osteocalcina inducida por vitamina D mediante la fosforilación del receptor nuclear de 1alfa,25-dihidroxivitamina D3”. (Finished).
Roberto Paredes
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Participación de complejos remodeladores de cromatina SWI/SNF en la activación transcripcional del gen de osteocalcina: mecanismo de reclutamiento de estos complejos a la región promotora”. (Finished).
Alejandro Villagra
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Mecanismo de estimulación transcripcional del gen de osteocalcina por vitamina D3: reclutamiento de complejos coactivadores p160/p300/pCAF y/o DRIP en osteoblastos”. (Finished).
Loreto Carvallo
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Determinación de secuencias reguladoras dentro del promotor del factor de transcripción Runx2/Cbfa1”. (Finished).
Fernando Cruzat
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Resolución de la estructura terciaria de los dominios de transactivación y señalización a la matriz nuclear del factor de transcripción Cbfa1: Interacciones proteína-proteína que modulan la función de Cbfa1 en la diferenciación osteoblástica”. (Finished).
Carola Bruna
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Asociación del receptor de 1alfa,25-dihidroxivitamina D3 a dominios subnucleares: rol de la fosforilación y de la interacción con proteínas correguladoras”. (Finished).
Gloria Arriagada
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Mecanismos epigenéticos involucrados en la regulñación transcripcional del gen RUNX2: Rol de las modificaciones covalentes de las histonas H3 y H4 en el promotor P1”. (Finished).
Berta Henríquez
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción

“Estudio de la regulación transcripcional del promotor del gen REG-1alfa mediante la vía de señalización Wnt canónica en células de cáncer gástrico”. (Finished).
Soraya Bravo
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Mecanismo de regulacion transcripcional de genes que codifican para receptores/canales nociceptivos del dolor TRPV1 y P2X3: Rol de Runx1”. (Finished, co-directed with Brigitte van Zundert).
Giorgia Ugarte
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Caracterización del promotor del gen RIC-8B humano: Estudio de elementos de regulación tejido-específicos”. (Finished).
Rodrigo Grandy
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Rol de la proteína de andamiaje PSD-95 en la regulación de la arquitectura dendrítica: patrones epigenéticos involucrados en el control de su expresión durante el desarrollo”. (Finished, co-directed with Brigitte van Zundert).
Fernando Bustos
Program: Doctorado en Ciencias Biológicas, Universidad de Concepción.

“Regulación epigenética del gen Runx2 en células óseas: Identificación de proteínas involucradas en la metilación y demetilación de las histonas H3 y H4 en el promotor P1”. (Ongoing).
Adriana Rojas
Program: Doctorado en Ciencias mención Biología Celular y Neurociencias, Universidad de Chile.

“Estudio de los complejos de represión y/o silenciamiento transcripcional presentes en los promotores de genes linaje-específicos”. (Ongoing).
Hugo Sepúlveda
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Asociación del receptor de vitamina D a la matriz nuclear: dominio de interacción y modulación por fosforilación”. (Ongoing).
Cinthya Ruíz-Tagle
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Mecanismos de regulación transcripcional mediados por el receptor de vitamina D: Rol de la sumoilación de los coactivadores SRCs y DRIP205 en células osteoblásticas”. (Ongoing).
Paola Merino
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Determinantes moleculares asociadas a la actividad transcripcional de genes del programa de diferenciación osteoblástica”. (Ongoing).
Rodrigo Aguilar
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Contribución del patrón de modificaciones epigenéticas en el mecanismo de control transcripcional mediado por Vitamina D3 en osteoblastos”. (Ongoing).
Daniel Moena
Program: Doctorado en Biociencias Moleculares, Universidad Andrés Bello.

“Rol del factor de transcripción C/EBPß1 en terapia celular ósea”. (Ongoing).
Margarita Carrasco
Program: Doctorado en Biotecnología, Universidad Andrés Bello.

-Master thesis direction:

“Evaluación de la participación del receptor clásico VDR en las acciones no genómicas de 1alfa,25 (OH)2D3 en células osteoblásticas ROS 17/2.8 y ROS24/1”. (Finished).
Soraya Bravo
Program: Magister en Ciencias mención Bioquímica, Universidad de Concepción

“Evaluación in vitro de las interacciones entre el receptor de vitamina D3 y los coactivadores SRC-1 y DRIP205: Ro del la fosforilación”. (Finished).
Cinthya Ruíz-Tagle
Program: Magister en Ciencias mención Bioquímica y Bioinformática, Universidad de Concepción

“Mecanismos epigenéticos que regulan la expresión de genes durante la diferenciación ósea”. (Finished).
Hugo Sepúlveda
Program: Magister en Ciencias mención Bioquímica y Bioinformática, Universidad de Concepción



 

Article (115)

Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells
Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts
Switches in histone modifications epigenetically control vitamin D3-dependent transcriptional upregulation of the CYP24A1 gene in osteoblastic cells
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors
Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts.
Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans
Wnt/β-catenin signaling enhances transcription of the CX43 gene in murine Sertoli cells.
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2.
Identification of a novel lncRNA that promotes osteoblast differentiation
Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia.
A functional IL1RL1 gene variant regulates steroid-induced sST2 expression.
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Epigenetic signatures at the RUNX2-P1 and SP7 gene promoters control osteogenic lineage commitment of umbilical cord-derived mesenchymal stem cells.
Functional Analysis of All Salmonid Genomes (FAASG)=> an international initiative supporting future salmonid research, conservation and aquaculture.
Global gene expression analysis provides insight into local adaptation to geotermal streams in tadpoles of the Andean toad Rhinella spinulosa (Anura, Bufonidae)
Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase.
Tet-mediated DNA demethylation is required for SWI/SNF-dependent chromatin remodeling and histone modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment.
Essential role of HDAC6 in the regulation of PD-L1 in melanoma
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus.
The chromatin modifying complex CoREST/LSD1 negatively regulates Notch pathway during cerebral cortex development.
Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B
Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells
Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a
A Functional N-terminal Domain in C/EBP beta-LAP* is Required for Interacting with SWI/SNF and to Repress Ric-8B Gene Transcription in Osteoblasts
Symbolic Extensions Applied to Multiscale Structure of Genomes
Enhanced CRAd Activity Using Enhancer Motifs Driven by a Nucleosome Positioning Sequence
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons
Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene
Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBP ss factors
Epigenetic Control of Cell Cycle-Dependent Histone Gene Expression Is a Principal Component of the Abbreviated Pluripotent Cell Cycle
Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility
Reusing and composing models of cell fate regulation of human bone precursor cells
Ric-8: Different cellular roles for a heterotrimeric G-protein GEF
Runx1 and C/EBP ss transcription factors directly up-regulate P2X3 gene transcription
C/EBP beta Binds the P1 Promoter of the Runx2 Gene and Up-Regulates Runx2 Transcription in Osteoblastic Cells
The Ric-8B Gene Is Highly Expressed in Proliferating Preosteoblastic Cells and Downregulated during Osteoblast Differentiation in a SWI/SNF- and C/EBP beta-Mediated Manner
Wnt/beta-Catenin Signaling Enhances Cyclooxygenase-2 (COX2) Transcriptional Activity in Gastric Cancer Cells
1 alpha,25-Dihydroxy Vitamin D-3 Induces Nuclear Matrix Association of the 1 alpha,25-Dihydroxy Vitamin D-3 Receptor in Osteoblasts Independently of Its Ability to Bind DNA
Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and Chromatin Remodeling in Nuclear Microenvironments
Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1
Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblasto]genesis
Mitotic bookmarking of genes: a novel dimension to epigenetic control
Pbx1 Represses Osteoblastogenesis by Blocking Hoxa10-Mediated Recruitment of Chromatin Remodeling Factors
Recruitment and subnuclear distribution of the regulatory machinery during 1 alpha,25-dihydroxy vitamin D-3-mediated transcriptional upregulation in osteoblasts
Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer
Altered Chromatin Modifications in AML1/RUNX1 Breakpoint Regions Involved in (8;21) Translocation
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway
Co-stimulation of the Bone-related Runx2 P1 Promoter in Mesenchymal Cells by SP1 and ETS Transcription Factors at Polymorphic Purine-rich DNA Sequences (Y-repeats)
Molecular Switches Involving Homeodomain Proteins, HOXA10 and RUNX2 Regulate Osteoblastogenesis
Organization, Integration, and Assembly of Genetic and Epigenetic Regulatory Machinery in Nuclear Micro environments Implications for Biological Control in Cancer
Subnuclear Targeting of the Runx3 Tumor Suppressor and Its Epigenetic Association With Mitotic Chromosomes
SWI/SNF-Independent Nuclease Hypersensitivity and an Increased Level of Histone Acetylation at the P1 Promoter Accompany Active Transcription of the Bone Master Gene Runx2
Transcription-factor-mediated epigenetic control of cell fate and lineage commitment
1 alpha,25-dihydroxy vitamin D-3-Enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1 alpha,25-dihydroxy vitamin D-3 Receptor-SRC-1 coactivator complex
Chromatin immunoprecipitation assays: Application of chip-on-chip for defining dynamic transcriptional mechanisms in bone cells
G alpha q negatively regulates the Wnt-beta-catenin pathway and dorsal embryonic Xenopus laevis development
Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
In situ nuclear organization of regulatory machinery
Phenotypic transcription factors epigenetically mediate cell growth control
The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes
Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery
xRic-8 is a GEF for Gs alpha and participates in maintaining meiotic arrest in Xenopus laevis oocytes
An architectural perspective of vitamin D responsiveness
Chromatin remodeling by SWI/SNF results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter
Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand-binding domain
Crystallization and preliminary X-ray analysis of a domain in the Runx2 transcription factor that interacts with the 1 alpha, 25 dihydroxy vitamin D3 receptor
HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes
Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence
Organization of transcriptional regulatory machinery in nuclear microenvironments: Implications for biological control and cancer
Phosphorylation at serine 208 of the 1 alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators
The 1 alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene
Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes
Chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene require CCAAT/enhancer-binding protein beta-dependent recruitment of SWI/SNF activity
Plasma membrane destination of the classical Xenopus laevis progesterone receptor accelerates progesterone-induced oocyte maturation
The classic receptor for 1 alpha,25-dihydroxy vitamin D3 is required for non-genomic actions of 1 alpha,25-dihydroxy vitamin D3 in osteosarcoma cells
A g beta gamma stimulated adenylyl cyclase is involved in Xenopus laevis oocyte maturation
Bone-specific transcription factor Runx2 interacts with the 1 alpha,25-dihydroxyvitamin D-3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells
Dlx3 transcriptional regulation of osteoblast differentiation: Temporal recruitment of Msx2 Dlx3 an Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
Mutation of the highly conserved Arg(165) and Glu(168) residues of human Gs alpha disrupts the alpha D-alpha E loop and enhances basal GDP/GTP exchange rate
Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals
The Runx2 transcription factor plays a key role in the 1 alpha,25-dihydroxy vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells
The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain
Conservative segregation of maternally inherited CS histone variants in larval stages of sea urchin development
Human brain synembryn interacts with Gs alpha and Gq alpha and is translocated to the plasma membrane in response to isoproterenol and carbachol
Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer
Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D-3 receptor but not p300 intrinsic histone acetyltransferase activity
Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions
Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histories H3 and H4
CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
Historic acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.
Interaction of the 1 alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling
Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts
Remodeling of sperm chromatin after fertilization involves nucleosomes formed by sperm histones H2A and H2B and two CS histone variants
Cytoplasm of sea urchin unfertilized eggs contains a nucleosome remodeling activity
Developmentally-regulated interaction of a transcription factor complex containing CDP/cut with the early histone H3 gene promoter of the sea urchin Tetrapygus niger is associated with changes in chromatin structure and gene expression
Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site
Intranuclear trafficking of transcription factors: implications for biological control
Nuclear matrix proteins as cancer markers
Nuclear structure-gene expression interrelationships: Implications for aberrant gene expression in cancer
Phosphorylation protects sperm-specific histones H1 and H2B from proteolysis after fertilization
Subnuclear organization and trafficking of regulatory proteins: Implications for biological control and cancer
Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo
Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization
Nuclear structure/gene expression interrelationships
Phosphorylation-mediated control of chromatin organization and transcriptional activity of the tissue-specific osteocalcin gene
Poly(ADP-ribosylation) protects maternally derived histones from proteolysis after fertilization
Identification of a cysteine protease responsible for degradation of sperm histones during male pronucleus remodeling in sea urchins
Decreased heterogeneity of CS histone variants after hydrolysis of the ADP-ribose moiety
Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells

Abstract (1)

Inhibition of progesterone-induced Xenopus oocyte maturation by synembryn

BookWhole (1)

Control of the human pluripotent cell cycle

ConferencePaper (3)

Modeling cell decisions in bone formation
Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex
Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: Implications for biological control in cancer

Proyecto (16)

Epigenetic silencing of the osteogenic master regulator Runx2-p57 in pluripotent cells
“C/EBPbeta-mediated control of transcription during osteoblast differentiation”
“Molecular Mechanisms Regulating Nociceptor Expression”
“Center for Genome Regulation”
“Reactivation of dendritic arbor development and plasticity in developing and adult brain=> role of NMDA receptors, CAMKII and PSD95”
“Characterization of Ric-8, a novel non-receptor G-protein regulator”
“Mechanisms that control transcriptional responsiveness to 1a,25-dihydroxy vitamin D3 in osteoblasts”
Leyes de la Física II
“Consorcio de Tecnológica e Innovación para la Salud CTI-Salud”
“Estudios Avanzados en Señalización Celular y Regulación Génica”
“Acción no genómica del receptor de progesterona. El ovocito de Xenopus laevis como sistema de estudio"
“Mecanismo de reclutamiento de complejos que remodelan cromatina y regulan la transcripción de un gen específico de células óseas”
“Bone cell structure and gene expression”
POSICIONAMIENTO NUCLEOSOMAL ESPECIFICO Y DISPOSICION ESPACIAL DEL PROMOTOR DE OSTEOCALCINA=> ROL EN LA TRANSCRIPCION BASAL Y ESTIMULADA POR VITAMIVA D3
”Chromatin structure in expression of osteocalcin gene”
MECANISMOS MOLECULARES INVOLUCRADOS EN EL REMODELAMIENTO NUCLEOSOMAL DEL GEN OSTEOCALCINA ASOCIADO CON LA ACTIVACION TRANSCRIPCIONAL=> ROL DE LOS FACTORES DE TRANSCRIPCION.

Review (19)

Multiple levels of epigenetic control for bone biology and pathology
Bookmarking Target Genes in Mitosis: A Shared Epigenetic Trait of Phenotypic Transcription Factors and Oncogenes?
The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease
The Architectural Organization of Human Stem Cell Cycle Regulatory Machinery
An architectural genetic and epigenetic perspective
Bookmarking the Genome: Maintenance of Epigenetic Information
Architectural Epigenetics: Mitotic Retention of Mammalian Transcriptional Regulatory Information
Nuclear microenvironments in biological control and cancer
An architectural perspective of cell-cycle control at the G1/S phase cell-cycle transition
Networks and hubs for the transcriptional control of osteoblastogenesis
Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer
The dynamic organization of gene-regulatory machinery in nuclear microenvironments
Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control
Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation
Regulatory controls for osteoblast growth and differentiation: Role of Runx/Cbfa/AML factors
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
Chromatin remodeling during sea urchin early development: molecular determinants for pronuclei formation and transcriptional activation
Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair
Nuclear microenvironments support physiological control of gene expression
127
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

13
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

13
Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

9
Gloria Arriagada

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

7
Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

7
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

6
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

3
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

3
Violeta Morin

Associate Research

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Marta Cecilia Bunster

DIRECTORA

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

3
Gino Nardocci

Investigador

Universidad de Los Andes

Santiago, Chile

3
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

3
Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile

3
Alejandro Maass

Director

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

3
Soraya Bravo

Independiente

Independiente

Concepción, Chile

2
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

2
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Philippe Pihán

Posdoctorado

Fisiología

Universidad de Chile

Santiago, Chile

2
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

2
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Carola Bruna

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS

Concepción, Chile

2
Dante Travisany

Scientist

CMM

Universidad de Chile

Santiago, Chile

2
José Martínez

Associate professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Matias Hepp

Profesor asistente - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

1
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Marcela Stuardo

Asistente de Investigación

Biología Molecular

Universidad de Concepción

Concepción, Chile

1
Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Carlos Oliva

Profesor Asistente

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Klaus Puschel

Full Professor

Family Medicine

FACULTAD MEDICINA PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Milka Martinez

Profesor

Instituto Profesional Virginio Gomez

Concepcion, Chile

1
Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ariel Orellana

Profesor Titular

Centro de Biotecnologia Vegetal

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Felipe Zuñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Claudia Muñoz

Investigadora

Biotecnología

Instituto de Investigaciones Agropecuarias INIA-La Platina

Santiago, Chile

1
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

1
Juan Maass

Asistan Professor

universidad de chile

Santiago, Chile

1
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

1
Eduardo Pérez

Profesor Investigador

Centro de Genética y Genómica, Facultad de Medicina Clínica Alemana

Universidad del Desarrollo

Santiago, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Veronica Cambiazo

Associate Professor

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

1
Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Angelica Reyes

Profesor Asociado

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Alex Di Genova

Assistant professor

Engineering sciences

Universidad de O'Higgins

Rancagua, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

1
Maximiliano Bendek

ninguno

ninguna

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Nicole Farfán

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

1
Alejandra Bustos

Profesor Asociado

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Mabel Vidal

Estudiante de doctorado

Ciencias de la Computación

Universidad de Concepción

Concepcion, Chile

1
Fredy Diaz

ASISTENTE

CIENCIAS BÁSICAS

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

Concepción, Chile

1
jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Eleodoro Riveras

Investigador postdoctoral

Instituto de Biologia Integrativa, Ibio

Santiago, Chile