Man

Soraya Elisa Gutierrez Gallegos

Profesor Titular

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

Líneas de Investigación


Ciclo celuar; cathepsin L; Cancer; 1. Molecular characterization of an adenilyl cyclase from Xenopus laevis. Function-Structure studies. ((Torrejon y cols. 1997, Torrejon y cols. 1998, Echeverria y cols. 2000).; 2. Screening of genes that participate during neural development by insertional mutagenesis using the gene-trap approach. Postdoctoral position with Dr Sigrid Reinsch.; 3. Function and localization of XtRIC-8 during Xenopus tropicalis embryogenesis; Translocaciones cromosomales; Estructura de cromatina; Regulacion transcripcional

Educación

  •  Cell and Molecular Biology, UNIVERSITY OF MASSACHUSETTS. Estados Unidos, 2003
  •  Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1994
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 1987

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2019 - A la fecha

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2007 - 2018

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Biológicas

    Concepción, Chile

    2003 - 2006

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Biológicas

    Concepción, Chile

    1991 - 2002

  •   Profesor Part Time

    UNIVERSIDAD ADVENTISTA DE CHILE

    Ingeniería y Negocios

    Chillán, Chile

    1991 - 1995

Experiencia Profesional

  •   Profesor Titular Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2019 - A la fecha

  •   Profesor Asociado Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2007 - 2018

  •   Profesor Asistente Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2003 - 2006

  •   Instructor Full Time

    Universidad de Concepcion

    Concepcion, Chile

    1991 - 2002

  •   Profesor Part Time

    Universidad Adventista de Chile

    Chillán, Chile

    1991 - 1995


 

Article (26)

Etoposide-induced DNA damage in a chromosomal breakpoint of RUNX1 gene is independent of RUNX1 expression
Identification of a novel long non-coding RNA within RUNX1 intron 5
Alternative RUNX1 Promoter Regulation by Wnt/beta-Catenin Signaling in Leukemia Cells and Human Hematopoietic Progenitors
Transcriptional Auto-Regulation of RUNX1 P1 Promoter
“Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells”
“Specificity protein 7 is not essential for tooth morphogenesis”
Cis-regulatory elements are harbored in Intron5 of the RUNX1 gene.
Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and Differentiation
Breakpoint Regions of ETO Gene Involved in (8;21) Leukemic Translocations Are Enriched in Acetylated Histone H3
Epigenetic changes: a common theme in acute myelogenous leukemogenesis.
Runx2 regulates the gene network associated with insulin signaling and energy homeostasis.
“Chondrocyte-specific regulatory activity of runx2 is essential for survival and skeletal development”
Altered chromatin modifications in AML1/RUNX1 breakpoint regions involved in (8;21) translocation.
Specific Residues of RUNX2 Are Obligatory for Formation of BMP2-Induced RUNX2-SMAD Complex to Promote Osteoblast Differentiation
Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal
Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: contributions of the DNA sequence
Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation
Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1
The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain
Conservative segregation of maternally inherited CS histone variants in larval stages of sea urchin development
Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D-3 receptor but not p300 intrinsic histone acetyltransferase activity
Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions
CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression
Interaction of the 1 alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling
Remodeling of sperm chromatin after fertilization involves nucleosomes formed by sperm histones H2A and H2B and two CS histone variants

Abstract (7)

Effect of a cathepsin L variant on colorectal cancer HCT116 cell proliferation
Identification of a putative promoter element in intron5 of the RUNX1 gene
SCL and RUNX1 regulate RUNX1 gene expression by association to RUNX1-P1 promoter
Effect of Cathepsin L variant gen silencing over proliferation, viability and organization of mitotic spindle in cell lines of colorectal cancer (Caco-2) and uterine cervical cancer (HeLa)
The breakpoint cluster regions of ETO gene involved in (8;21) leukemic translocations are enriched in acetylated histone H3
Epigenetic regulation of bone-phenotypic genes
Chromatin remodeling of the proximal rat osteocalcin promoter is dependent on vitamin D receptor binding at the distal promoter element

Proyecto (7)

Lox-1 Receptor Activation By Oxldl Is A Fundamental Molecular Switch Among Obesity, Pro-inflammatory Milieu And Colorectal Cancer Development And Progression.
IDENTIFICATION AND CHARACTERIZATION OF A NOVEL ANTISENSE RNA ENCODED IN INTRON5 OF THE RUNX1 GENE
DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES IN ADULT AND AGING INDIVIDUALS=> THE ROLE OF MATERNAL MELATONIN IN THE REGULATION OF FETAL TRANSCRIPTIONAL AND GENE PROMOTER ACTIVITY.
ROLE OF HISTONE ACETYLATION IN FORMATION OF LEUKEMIA CAUSING (8;21) TRANSLOCATION
CISTEIN-PROTEASA QUE PARTICIPA EN REMODELACION DEL PRONUCLEO MASCULINO POSTFECUNDACION=> CONSOLIDACION DE UN MODELO Y PERSPECTIVAS FUTURAS.
ROL DE LA ESTRUCTURA DE CROMATINA EN LA GENERACION DE TRANSLOCACIONES CROMOSOMICAS.
ROL DE LA ESTRUCTURA DE CROMATINA EN LA GENERACION DE TRANSLOCACIONES CROMOSOMICAS.

Review (2)

Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation
Nuclear microenvironments support physiological control of gene expression
29
Soraya Gutierrez

Profesor Titular

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

11
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
MARCELA HINOJOSA

Profesor Asistente

Tecnología Médica

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

3
Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

2
Marcela Stuardo

Asistente de Investigación

Biología Molecular

Universidad de Concepción

Concepción, Chile

2
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Nicolás Schnake

Colaborador Académico

Departamento de Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

2
Milka Martinez

Profesor

Instituto Profesional Virginio Gomez

Concepcion, Chile

1
Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Elena Uribe

Associate Professor

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Miguel Avila

Docente/Investigador

Universidad de las Américas

Santiago, Chile

1
Violeta Morin

Associate Research

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Gloria Arriagada

Profesor Asociado-Investigador Principal

Instituto de Ciencias Biomédicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Alejandra Bustos

Profesor Asociado

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Matías Medina

Docente

Ciencias

Universidad San Sebastián

Puerto Montt, Chile