Man

Ariel Castro

Associate Professor

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Líneas de Investigación


cancer biology; oncogenes and tumor supressors; signal transduction; Small GTPases/mTOR/AMPK signaling.

Educación

  •  Cell Biology, UNIVERSIDAD DE BUENOS AIRES. Argentina, 1994
  •  Biochemistry, Universidad de Buenos Aires. Argentina, 1988

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    INDIANA UNIVERSITY-PURDUE UNIVERSITY INDIANAPOLIS

    Indiana, Estados Unidos

    1998 - 2001

  •   Postdoctoral Fellow Full Time

    UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON

    texas, Estados Unidos

    1995 - 1998

  •   Assistant Scientist Full Time

    INDIANA UNIVERSITY-PURDUE UNIVERSITY INDIANAPOLIS

    Indianapolis, Estados Unidos

    2001 - 2004

  •   Assistant Research Professor Full Time

    INDIANA UNIVERSITY-PURDUE UNIVERSITY INDIANAPOLIS

    Indianapolis, Estados Unidos

    2004 - 2005

  •   Assitant Professor Full Time

    UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

    San Francisco, Estados Unidos

    2005 - 2010

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2010 - A la fecha

Experiencia Profesional

  •   Assistant Scientist Full Time

    Indiana University and Purdue University

    Indianapolis, Estados Unidos

    2001 - 2004

  •   Assistant Research Professor Full Time

    Indiana University and Purdue University

    Indianapolis, Estados Unidos

    2004 - 2005

  •   Assistant Professor, Adjunct Full Time

    University of California

    California, Estados Unidos

    2005 - 2010

Formación de Capital Humano


STUDENTS’ MENTORING (University of Concepcion)

Undergraduate students
Maria Fernanda Sanchez (co-mentor)
Marisol Estrella Armijo (mentor)
Javiera Ziehe (mentor)
Francisco Fuentes (mentor)
Mario Palma ( mentor)

Graduate Students
Nicole Valenzuela (co-mentor)


Premios y Distinciones

  •   Ariel Castro

    National Research Council of Argentina (CONICET)

    Argentina, 1989

    Initiation Research Fellowship

  •   Ariel Castro

    UNIVERSITY OF CALIFORNIA

    Estados Unidos, 2008

    Member Academic Senate Research Committee San Francisco

  •   Ariel Castro

    Department of Defense

    Estados Unidos, 2012

    Review Panel Invitation. Congressionally Directed Medical Research Program/ US Department of Defense


 

Article (33)

beta-catenin aggregation in models of ALS motor neurons: GSK3 beta inhibition effect and neuronal differentiation
CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress
Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data
A Trichostatin A (TSA)/Spl-mediated mechanism for the regulation of SALL2 tumor suppressor in Jurkat T cells
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
Developmental SALL2 transcription factor: a new player in cancer
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy
Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells
Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer
Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis
Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.
AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.
Measuring Ras-family GTP levels in vivo--running hot and cold.
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases.
Nucleotide triphosphatase activity of the N-terminal nucleotide-binding domains of the multidrug resistance proteins P-glycoprotein and MRP1.
Analyses of M-Ras/R-Ras3 signaling and biology.
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.
Expression and purification of the first nucleotide-binding domain and linker region of human multidrug resistance gene product: comparison of fusions to glutathione S-transferase, thioredoxin and maltose-binding protein.
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.
Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers.
Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl- currents.
Extracellular ATP and bradykinin increase cGMP in vascular endothelial cells via activation of PKC.
Characterization of a novel bisacridone and comparison with PSC 833 as a potent and poorly reversible modulator of P-glycoprotein.
Control of proximal tubule acidification by the endothelium of the peritubular capillaries.
Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein.
DIRECT VASCULAR EFFECTS IN THE RAT OF THE VEHICLES USED FOR THE INTRAVENOUS AND ORAL-ADMINISTRATION OF CYCLOSPORINE-A

Abstract (8)

NUAK1 regulates breast cancer cell bioenergetics
Sall2 transcription factor: A novel regulator of G1-S cyclins.
Nuclear NUAK1 function on cancer cell survival, independently of LKB1 and p53
Effect of a cathepsin L variant on colorectal cancer HCT116 cell proliferation
Effect of the small GTPase Rheb on the regulation of LKB1 kinase
The Sall2 transcription factor is involved in cellular stress responses
p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.
Rheb regulation of p27KIP promotes metabolic stress-induced autophagy in colon cancer cells

Proyecto (10)

MECHANISMS OF REGULATION OF CANCER CELL METABOLISM COUNTERACTING OXIDATIVE STRESS
MOLECULAR MECHANISMS OF CANCER CELL RESISTANCE TO METABOLIC STRESS=> THE ROLE OF NUAK1 SIGNALING
REGULATION AND FUNCTION OF THE SALL2 TRANSCRIPTION FACTOR DURING CELLULAR STRESS
212.037.017-1.0. Título=> Integrating signaling pathways, transcriptional regulation and cell behavior in the study of mechanisms of carcinogen
INTERRUPTED RHEB-TO-AMPK FEEDBACK SIGNALING WITH CYTOPLASMIC P27 RETENTION=> MECHANISMS AND BIOLOGICAL CONSEQUENCES.
Strengthening of international alliances for the implementation of a research unit to promote the realization of preclinical studies in the eight region of Chile
Regulation of the cell-cycle inhibitor p27Kip1 by aberrant Rheb GTPase activation
Alterations of TSC2/Rheb signaling in colorectal cancer
Functional Relevance of the Ras-related GTPase Rheb in Tuberous Sclerosis
Role of Rap and Estrogen in Lymphangioleiomyomatosis

Review (1)

Rheb signaling and tumorigenesis: mTORC1 and new horizons
27
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

15
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

6
Matias Hepp

Profesor asistente - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

3
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
PABLO PEREZ

Investigador Postdoctoral

Anatomía Patológica/Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
César Trigo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Francisco Aguayo

Profesor Asociado

Departamento de Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Sebastián Riquelme

Estudiante doctorado

Virología

Universidad de Chile

Santiago, Chile

1
José Gutiérrez

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Julio Tapia

Profesor Asociado

Oncologia Basico Clinica

Universidad de Chile

Santiago, Chile

1
Boris Rebolledo

Researcher

Center for Genetics and Genomics

Universidad del Desarrollo

Santiago, Chile

1
Viviana Hermosilla

Colaborador Docente

Departamento de Bioquímica y Biología Molecular

Universidad de Concepción

Concepción, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Elena Uribe

Associate Professor

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile