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MARIO ALEX GALINDO DIAZ

Profesor Asociado

Universidad de Chile

Santiago, Chile

Análisis transcriptómico (RNAm y miRNAs) y proteómico en cáncer pediátrico Mecanismos celulares y moleculares en progresión tumoral y metástasis en osteosarcoma Genotipificación y análisis personalizado de perfiles farmacogenéticos

Biología Celular y Molecular, UNIVERSIDAD DE CHILE. Chile, 1998
Biólogo, UNIVERSIDAD DE TALCA. Chile, 1990

Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1994 - A la fecha
Postdoctorado Full Time

University of Massachussets

Medical School

Worcester, MA, Estados Unidos

2001 - 2004

Profesor Asociado Full Time

Universidad de Chile

Santiago, Chile

1994 - A la fecha
Director Programa de Biología Celular y Molecular, ICBM Full Time

Universidad de Chile

Santiago, Chile

2019 - A la fecha

FORMADOS
Postdoctorado:
Nelson Varela. (2015) Post-doctoral training. Assistant Professor. Escuela de Tecnología Médica, Facultad de Medicina, Universidad de Chile.

Doctorado:
Carla Álvarez. (2020) PhD Program. Doctorado en Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.
Hector Araya. (2018) PhD Program. Doctorado en Bioquímica, Facultad de Química y Farmacia, Universidad de Chile.
Sofía Jerez. (2017) PhD Program. Doctorado en Biotecnología. Universidad Nacional Andrés Bello.
Francisco Villanueva. (2015) PhD Program. Doctorado en Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.
Nelson Varela. (2010) Ph.D. in Biomedical Science. Faculty of medicine, University of Chile.
Denise Riquelme. (2009) Co-tutorship. Ph.D. in Biomedical Science. Faculty of medicine, University of Chile.

Magister:
Andres Stevenson. (2014) Master Program. Magister mención Morfología, Facultad de Medicina, Universidad de Chile.
Oscar Vega. (2012) Master in Cell Biology. Faculty of medicine, University of Chile.
Inga San Martin. (2009). Master of Dental Science, Faculty of Dentistry, University of Chile.

Pre-grado:
Alonso Lastra. (2017) Licenciatura en Biología, Facultad de Ciencias, Universidad de Chile.
Andrea Rojas. (2016) Licenciatura en Biotecnologia, Facultad de Ciencias, Universidad de Chile.
Pedro Briceño. (2016) Licenciatura en Biología, Facultad de Ciencias, Universidad de Chile.
Carolina Farfan. (2014) Tecnología Médica, Facultad de Medicina, Universidad de Chile.
José Zamorano. (2015) Tecnología Médica, Facultad de Medicina, Universidad de Chile.
Ismael Maldonado. (2009) Co-tutorship. Veterinary Medicine, Faculty of Veterinary Science, University of Chile.
Hector Araya. (2008) Biochemistry, Faculty of Chemical Sciences, University of Santiago Chile.
Karina Villegas. (2008) Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.


RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis Alvarez, Carla; Abdalla, Henrique; Sulliman, Salwa; Wu, Yu-Chiao; Huang, Ren-Yeong; Galindo, Mario; Vernal, Rolando Article ISI FRONTIERS IN IMMUNOLOGY (2021)
Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis Alvarez, Carla; Suliman, Salwa; Almarhoumi, Rawan; Vega, Maria Elena; Monasterio, Gustavo; Galindo, Mario; Vernal, Rolando; Kantarci, Alpdogan Article ISI SCIENTIFIC REPORTS (2020)
Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro Hevia, Daniel; Galindo, Mario Article ISI SCOPUS JOURNAL OF IMMUNOLOGY RESEARCH (2019)
Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells Pritzker, K; Heras, FL Article ISI SCOPUS GENE (2019)
Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis Jerez, Sofía; Hevia, Daniel; Irarrázaval, Carlos E.; Thaler, Roman; van Wijnen, Andre J.; Galindo, Mario Article ISI SCOPUS GENE (2019)
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway Toro, Luis; Alzamora, Rodrigo; Barrientos, Victor; Villanueva, Francisco; Galindo, Mario; Heras, Facundo Las; moena, daniel; Lazcano, Andrea; Michea, Luis Article ISI SCOPUS JOURNAL OF BONE AND MINERAL RESEARCH (2019)
The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis Villanueva, F Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients Salduz, A; Okuno, MN; Herrick, JL; Okuno, SH; van Wijnen, AJ; Yaszemski, MJ; Maran, A Article ISI SCOPUS GENE (2018)
Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients. Bravo, Dalibel; Salduz, Ahmet; Shogren, Kristen L; Okuno, Madison N; Herrick, James L; Okuno, Scott H; Galindo, Mario; van Wijnen, Andre J; Yaszemski, Michael J; Maran, Avudaiappan Article Gene (2018)
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2 Jerez S.; BriceÃ±o P.F.; Thaler R.; Riester S.M.; RodrÃguez J.P.; Moreno, R.D.; Charbonneau M.; Dubois C.M.; Galindo M.A. Article ISI SCOPUS Journal of Cellular Biochemistry (2018)
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2. Araya, Héctor F; Sepulveda, Hugo; Lizama, Carlos O; Vega, Oscar A; Jerez, Sofia; Briceño, Pedro F; Thaler, Roman; Riester, Scott M; Antonelli, Marcelo; Salazar-Onfray, Flavio; Rodríguez, Juan Pablo; Moreno, Ricardo D; Montecino, Martin; Charbonneau, Martine; Dubois, Claire M; Stein, Gary S; van Wijnen, Andre J; Galindo, Mario A Article Journal of cellular biochemistry (2018)
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes Salgado, Ginessa; Escobar, David; Galindo, Mario; Morin, Violeta; Castro, Ariel F.; Pincheira, Roxana; Article ISI SCOPUS Molecular Oncology (2018)
Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation Khani F.; Kruijthof-de Julio M.; Gordon J.A. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Hypoxia-related microRNA-210 is a diagnostic marker for discriminating osteoblastoma and osteosarcoma Torres-Mora J.; Thaler R.R.; Zwartbol R.; Briaire-de Bruijn I.H.; Folpe A.L.; Inwards C.Y.; Rose P.S.; Shives T.C.; Sim F.H.; Cleven A.G.H.; Oliveira A.M.; Cleton-Jansen A.-M.; Bovée J.V.M.G. Article ISI SCOPUS JOURNAL OF ORTHOPAEDIC RESEARCH (2017)
Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells Mamo T.; Mladek A.C.; Shogren K.L.; Gustafson C.; Sarkaria J.N. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression Jerez, S; Araya, H; Thaler, R; Charlesworth, MC; López-Solís, R; Kalergis, AM; Céspedes, PF; Dudakovic, A; Stein, GS; van Wijnen, AJ; Galindo, M. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Wnt/-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types Araya H.F. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells Ling, L; Helledie, T; Samsonraj, RM; Titmarsh, DM; Chua, RJ; Dreesen, O; Dombrowski, C; Rider, DA; Galindo, M; Lee I.; Hong, WJ; Hui, JH; Nurcombe, V; van Wijnen, AJ; Cool, SM Article ISI SCOPUS GENE (2016)
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells Varela, N; Aranguiz, A; Lizama C.; Sepulveda, H; Antonelli M.; Thaler R.; Montecino, M.; Stein, GS; van Wijnen, AJ; Galindo, M Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end Maturana, JL; Niechi, I; Silva, E.; Huerta, H.; Cataldo, R; Hartel, S; Barros, LF; Galindo, M Article ISI SCOPUS Gene (2015)
MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma van der Deen, M; Taipaleenmaki, H; Zhang, Y.; Teplyuk, NM; Gupta A.; Cinghu, S; Shogren, K; Maran, A; Yaszemski, MJ; Ling, L; Cool, SM; Leong, DT; Dierkes, C; Zustin, J; Salto-Tellez, M; Ito, Y; Bae, SC; Zielenska, M; Squire, JA; Lian, JB; Stein, JL; Zambetti, GP; Jones, SN; Galindo, M; Hesse E.; Stein, GS; van Wijnen, AJ Article ISI SCOPUS Journal of Biological Chemistry (2013)
The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines Lucero, CMJ; Vega, OA; Osorio, MM; Antonelli M.; Stein, GS; van Wijnen, AJ Article ISI SCOPUS Journal of Cellular Physiology (2013)
Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility van der Deen, M; Akech J.; Lapointe, D; Gupta, S; Montecino M.A.; Galindo, M Article ISI SCOPUS Journal of Biological Chemistry (2012)
CK2 functionally interacts with AKT/PKB to promote the beta-catenin-dependent expression of survivin and enhance cell survival Ponce, DP; Yefi, R; Cabello, P; Maturana, JL; Niechi, I; Silva, E.; Galindo, M; Antonelli M.; Marcelain, K; Armisen, R Article ISI SCOPUS Molecular and Cellular Biochemistry (2011)
Phosphorylation of AKT/PKB by CK2 Is Necessary for the AKT-Dependent Up-Regulation of beta-Catenin Transcriptional Activity Ponce, DP; Maturana, JL; Cabello, P; Yefi, R; Niechi, I; Silva, E.; Armisen, R; Galindo, M; Antonelli M. Article ISI SCOPUS Journal of Cellular Physiology (2011)
Analysis of Toxoplasma gondii surface antigen 2 gene (SAG2). Relevance of genotype I in clinical toxoplasmosis Sabaj V; Galindo, M; Silva D.; Sandoval L. Article ISI SCOPUS Molecular Biology Reports (2010)
Impaired Cell Cycle Regulation of the Osteoblast-Related Heterodimeric Transcription Factor Runx2-Cbf beta in Osteosarcoma Cells San Martin, IA; Varela, N; Gaete, M; Villegas, K.; Osorio, M; Antonelli M.; Mancilla, EE; Pereira, BP; Nathan, SS; Lian, JB; Stein, JL; Stein, GS; van Wijnen, AJ; Galindo, M Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Runx2, p53, and pRB Status as Diagnostic Parameters for Deregulation of Osteoblast Growth and Differentiation in a New Pre-Chemotherapeutic Osteosarcoma Cell Line (OS1) Pereira, BP; Zhou, YF; Gupta A.; Leong, DT; Aung, KZ; Ling, L; Pho, RWH; Galindo, M; Salto-Tellez, M; Stein, GS; Cool, SM; van Wijnen, AJ; Nathan, SS Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts Teplyuk, NM; Zhang, Y.; Lou Y.; Hawse, JR; Hassan, MQ; Teplyuk, VI; Pratap, J; Galindo, M; Stein, JL; Stein, GS; Lian, JB; van Wijnen, AJ Article ISI SCOPUS MOLECULAR ENDOCRINOLOGY (2009)
Echinococcus granulosus: Cellular territories and morphological regions in mature protoscoleces Galindo, M; Schadebrodt, G; Galanti N. Article ISI SCOPUS EXPERIMENTAL PARASITOLOGY (2008)
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors Galindo, M; Pratap, J; Lapointe, D; Javed, A Article SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Chromosomal size conservation through the cell cycle supports karyotype stability in Trypanosoma cruzi Galindo, M; Sabaj V; Espinoza, I; Toro, GC; Bua, J.; Grenet, J; Lopez-Solis, R; Ruiz, AM; Galanti N. Article ISI SCOPUS FEBS LETTERS (2007)
Developmental expression pattern of histone H4 gene associated to DNA synthesis in the endoparasitic platyhelminth Mesocestoides corti Espinoza, I; Gomez, CR; Galindo, M; Galanti N. Article ISI SCOPUS GENE (2007)
L-type calcium channels in growth plate chondrocytes participate in endochondral ossification Mancilla, EE; Galindo, M; Fertilio, B; Herrera M.Á.; Salas K; Gatica H.; Goecke, A Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Early post-larval development of the endoparasitic platyhelminth Mesocestoides corti: Trypsin provokes reversible tegumental damage leading to serum-induced cell proliferation and growth Espinoza, I; Galindo, M; Bizarro, CV; Ferreira, HB; Zaha, A; Galanti N. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones Galindo, M; Varela, N; Espinoza, I; Toro, GC; Hellman, U; Wernstedt, C; Galanti N. Article ISI SCOPUS FEBS LETTERS (2004)
Regionalization of DNA and protein synthesis in developing stages of the parasitic platyhelminth Echinococcus granulosus Galindo, M; Paredes, R.; Marchant, C; Mino, V; Galanti N. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2003)
Echinococcus granulosus protoscolex formation in natural infections Galindo, M; Gonzalez, MJ; Galanti N. Article ISI SCIELO BIOLOGICAL RESEARCH (2002)


Sall2 transcription factor: A novel regulator of G1-S cyclins. Hermosilla, VE; Escobar, DE; Hepp, MI; Riffo, EN; Salgado G.; Morin, V; Galindo, M; Castro, AF Abstract ISI CANCER RESEARCH (2018)


RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis (vol 12, 664756, 2021) Alvarez, Carla; Galindo, Mario; Vernal, Rolando Correction ISI FRONTIERS IN IMMUNOLOGY (2022)


Genotipificación y análisis personalizado de perfiles farmacogenéticos para optimizar la terapia antidepresiva, prevenir los efectos adversos y aumentar la eficacia de los tratamientos de salud mental. Galindo, Mario; Sabaj, Valeria; Araya, Lisette; Testa, Daniel; Reyes, Eugenio; Godoi, Elias; Poblete, Diana Proyecto (2025)
Exploring deleterious outcomes of fungal colonization of the placenta by Pneumocystis for the mother-fetus binomia Galindo, Mario Proyecto (2024)
ROLE OF PERIODONTO-PATHOGENIC BACTERIAL SEROTYPES IN PROMOTING THE ALVEOLAR BONE RESORPTION DURING PERIODONTITIS THROUGH AN IMBALANCE OF TH1/TH 17 VERSUS TREG IMMUNE RESPONSES FONDECYT (1140904) Proyecto 2014-2018 Coinvestigador(a)
Funtional analysis of Runx2 transcription factor and Runx2-target genes involves in cell adhession and lung metastasis in osteosarcoma FONDECYT (1130931) Proyecto 2013-2016 Inv. Principal
Millennium Institute on Immunology and Immunotherapy Ministerio de Economía, Fomento y Turismo (P09/016-F) Proyecto 2011-2020 Inv. Principal
La vía wnt canónica modula la expresión y función del factor de trascripción Runx2 en el ciclo celular de osteosarcoma, afectando parámetros de progresión tumoral y metástasis FONDECYT (1095234) Proyecto 2009-2012 Inv. Principal

MARIO GALINDO

Profesor Asociado

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Hector Araya

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Flavio Salazar

Profesor Titular

Oncología Básico Clínica

Universidad de Chile

SANTIAGO, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Ignacio Niechi

Profesor Adjunto

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Matias Hepp

Profesor asociado - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

Full Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Juan Rodriguez

Instructor Adjunto

Medicina Interna

Pontificia Universidad Catolica de Chile

Santiago, Chile

Remigio López

Profesor Asociado

Biología Celular y Molecular

UNIVERSIDAD DE CHILE, FAC. MEDICINA, ICBM (BIOQUÍMICA Y BIOLOGÍA MOLECULAR)

Santiago, Chile

Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Marcia Gaete

Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

Daniel Moena

Docente

Química y Medio Ambiente

Universidad Técnica Federico Santa María

Concepción, Chile

Carolina Rojas

Docente

Universidad de Los Andes

Santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Milena Villarroel

JEFE CENTRO DE RESPONSABILIDAD

PEDIATRIA

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

RODOLFO PAREDES

Medical Education and Clinical Simulation Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

MARIO ALEX GALINDO DIAZ

Líneas de Investigación

Educación

Biología Celular y Molecular, UNIVERSIDAD DE CHILE. Chile, 1998

Biólogo, UNIVERSIDAD DE TALCA. Chile, 1990

Experiencia Académica

Profesor Asociado Full Time

Postdoctorado Full Time

Experiencia Profesional

Profesor Asociado Full Time

Director Programa de Biología Celular y Molecular, ICBM Full Time

Formación de Capital Humano

Article (38)

Abstract (1)

Correction (1)

Proyecto (6)

ROLE OF PERIODONTO-PATHOGENIC BACTERIAL SEROTYPES IN PROMOTING THE ALVEOLAR BONE RESORPTION DURING PERIODONTITIS THROUGH AN IMBALANCE OF TH1/TH 17 VERSUS TREG IMMUNE RESPONSES

Funtional analysis of Runx2 transcription factor and Runx2-target genes involves in cell adhession and lung metastasis in osteosarcoma

Millennium Institute on Immunology and Immunotherapy

La vía wnt canónica modula la expresión y función del factor de trascripción Runx2 en el ciclo celular de osteosarcoma, afectando parámetros de progresión tumoral y metástasis