Man

MARIO ALEX GALINDO DIAZ

Profesor Asociado

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Análisis transcriptómico (RNAm y miRNAs) y proteómico en cáncer pediátrico Mecanismos celulares y moleculares en progresión tumoral y metástasis en osteosarcoma Genotipificación y análisis personalizado de perfiles farmacogenéticos

Educación

  •  Biología Celular y Molecular, UNIVERSIDAD DE CHILE. Chile, 1998
  •  Biólogo, UNIVERSIDAD DE TALCA. Chile, 1990

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1994 - A la fecha

  •   Postdoctorado Full Time

    University of Massachussets

    Medical School

    Worcester, MA, Estados Unidos

    2001 - 2004

Experiencia Profesional

  •   Profesor Asociado Full Time

    Universidad de Chile

    Santiago, Chile

    1994 - A la fecha

  •   Director Programa de Biología Celular y Molecular, ICBM Full Time

    Universidad de Chile

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


FORMADOS
Postdoctorado:
Nelson Varela. (2015) Post-doctoral training. Assistant Professor. Escuela de Tecnología Médica, Facultad de Medicina, Universidad de Chile.

Doctorado:
Carla Álvarez. (2020) PhD Program. Doctorado en Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.
Hector Araya. (2018) PhD Program. Doctorado en Bioquímica, Facultad de Química y Farmacia, Universidad de Chile.
Sofía Jerez. (2017) PhD Program. Doctorado en Biotecnología. Universidad Nacional Andrés Bello.
Francisco Villanueva. (2015) PhD Program. Doctorado en Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.
Nelson Varela. (2010) Ph.D. in Biomedical Science. Faculty of medicine, University of Chile.
Denise Riquelme. (2009) Co-tutorship. Ph.D. in Biomedical Science. Faculty of medicine, University of Chile.

Magister:
Andres Stevenson. (2014) Master Program. Magister mención Morfología, Facultad de Medicina, Universidad de Chile.
Oscar Vega. (2012) Master in Cell Biology. Faculty of medicine, University of Chile.
Inga San Martin. (2009). Master of Dental Science, Faculty of Dentistry, University of Chile.

Pre-grado:
Alonso Lastra. (2017) Licenciatura en Biología, Facultad de Ciencias, Universidad de Chile.
Andrea Rojas. (2016) Licenciatura en Biotecnologia, Facultad de Ciencias, Universidad de Chile.
Pedro Briceño. (2016) Licenciatura en Biología, Facultad de Ciencias, Universidad de Chile.
Carolina Farfan. (2014) Tecnología Médica, Facultad de Medicina, Universidad de Chile.
José Zamorano. (2015) Tecnología Médica, Facultad de Medicina, Universidad de Chile.
Ismael Maldonado. (2009) Co-tutorship. Veterinary Medicine, Faculty of Veterinary Science, University of Chile.
Hector Araya. (2008) Biochemistry, Faculty of Chemical Sciences, University of Santiago Chile.
Karina Villegas. (2008) Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.



 

Article (38)

RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis

Álvarez, Carla; Abdalla, Henrique; Sulliman, Salwa; Wu, Yu-Chiao; Huang, Ren-Yeong; Galindo, Mario; Vernal, Rolando

Article ISI
FRONTIERS IN IMMUNOLOGY  (2021)

Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis

Álvarez, Carla; Suliman, Salwa; Almarhoumi, Rawan; Vega, Maria Elena; Monasterio, Gustavo; Galindo, Mario; Vernal, Rolando; Kantarci, Alpdogan

Article ISI
Scientific Reports  (2020)

Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro

Hevia, Daniel; Galindo, Mario

Article ISI SCOPUS
JOURNAL OF IMMUNOLOGY RESEARCH  (2019)

Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells

Pritzker, K; Heras, FL

Article ISI SCOPUS
GENE  (2019)

Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis

Jerez, Sofía; Hevia, Daniel; Irarrázaval, Carlos E.; Thaler, Roman; van Wijnen, Andre J.; Galindo, Mario

Article ISI SCOPUS
GENE  (2019)

Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway

Toro, Luis; Alzamora, Rodrigo; Barrientos, Victor; Villanueva, Francisco; Galindo, Mario; Heras, Facundo Las; moena, daniel; Lazcano, Andrea; Michea, Luis

Article ISI SCOPUS
JOURNAL OF BONE AND MINERAL RESEARCH  (2019)

The cancer-related transcription factor RUNX2 modulates expression and secretion of the matricellular protein osteopontin in osteosarcoma cells to promote adhesion to endothelial pulmonary cells and lung metastasis

Villanueva, F

Article ISI
JOURNAL OF CELLULAR PHYSIOLOGY  (2019)

Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients

Salduz, A; Okuno, MN; Herrick, JL; Okuno, SH; van Wijnen, AJ; Yaszemski, MJ; Maran, A

Article ISI SCOPUS
GENE  (2018)

Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients.

Bravo, Dalibel; Salduz, Ahmet; Shogren, Kristen L; Okuno, Madison N; Herrick, James L; Okuno, Scott H; Galindo, Mario; van Wijnen, Andre J; Yaszemski, Michael J; Maran, Avudaiappan

Article
Gene  (2018)

Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2

Jerez S.; Briceño P.F.; Thaler R.; Riester S.M.; Rodríguez J.P.; Moreno, R.D.; Charbonneau M.; Dubois C.M.; Galindo M.A.

Article ISI SCOPUS
Journal of Cellular Biochemistry  (2018)

Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2.

Araya, Héctor F; Sepulveda, Hugo; Lizama, Carlos O; Vega, Oscar A; Jerez, Sofia; Briceño, Pedro F; Thaler, Roman; Riester, Scott M; Antonelli, Marcelo; Salazar-Onfray, Flavio; Rodríguez, Juan Pablo; Moreno, Ricardo D; Montecino, Martin; Charbonneau, Martine; Dubois, Claire M; Stein, Gary S; van Wijnen, Andre J; Galindo, Mario A

Article
Journal of cellular biochemistry  (2018)

SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes

Salgado, Ginessa; Escobar, David; Galindo, Mario; Morin, Violeta; Castro, Ariel F.; Pincheira, Roxana;

Article ISI SCOPUS
Molecular Oncology  (2018)

Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation

Khani F.; Kruijthof-de Julio M.; Gordon J.A.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2017)

Hypoxia-related microRNA-210 is a diagnostic marker for discriminating osteoblastoma and osteosarcoma

Torres-Mora J.; Thaler R.R.; Zwartbol R.; Briaire-de Bruijn I.H.; Folpe A.L.; Inwards C.Y.; Rose P.S.; Shives T.C.; Sim F.H.; Cleven A.G.H.; et al.

Article ISI SCOPUS
JOURNAL OF ORTHOPAEDIC RESEARCH  (2017)

Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells

Mamo T.; Mladek A.C.; Shogren K.L.; Gustafson C.; Sarkaria J.N.

Article ISI SCOPUS
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2017)

Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals Secretion of Proteins Related to Tumor Progression

Jerez, S; Araya, H; Thaler, R; Charlesworth, MC; López-Solís, R; Kalergis, AM; Céspedes, PF; Dudakovic, A; Stein, GS; van Wijnen, AJ; Galindo, M.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2017)

Wnt/-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types

Araya H.F.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2017)

Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells

Ling, L; Helledie, T; Samsonraj, RM; Titmarsh, DM; Chua, RJ; Dreesen, O; Dombrowski, C; Rider, DA; Galindo, M; Lee I.; et al.

Article ISI SCOPUS
GENE  (2016)

Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells

Varela, N; Aranguiz, A; Lizama C.; Sepulveda, H; Antonelli M.; Thaler R.; Montecino, M.; Stein, GS; van Wijnen, AJ; Galindo, M

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2016)

Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end

Maturana, JL; Niechi, I; Silva, E.; Huerta, H.; Cataldo, R; Härtel, S; Barros, LF; Galindo, M

Article ISI SCOPUS
Gene  (2015)

MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma

van der Deen, M; Taipaleenmaki, H; Zhang, Y.; Teplyuk, NM; Gupta A.; Cinghu, S; Shogren, K; Maran, A; Yaszemski, MJ; Ling, L; et al.

Article ISI SCOPUS
Journal of Biological Chemistry  (2013)

The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

Lucero, CMJ; Vega, OA; Osorio, MM; Antonelli M.; Stein, GS; van Wijnen, AJ

Article ISI SCOPUS
Journal of Cellular Physiology  (2013)

Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility

van der Deen, M; Akech J.; Lapointe, D; Gupta, S; Montecino M.A.; Galindo, M

Article ISI SCOPUS
Journal of Biological Chemistry  (2012)

CK2 functionally interacts with AKT/PKB to promote the beta-catenin-dependent expression of survivin and enhance cell survival

Ponce, DP; Yefi, R; Cabello, P; Maturana, JL; Niechi, I; Silva, E.; Galindo, M; Antonelli M.; Marcelain, K; Armisen, R

Article ISI SCOPUS
Molecular and Cellular Biochemistry  (2011)

Phosphorylation of AKT/PKB by CK2 Is Necessary for the AKT-Dependent Up-Regulation of beta-Catenin Transcriptional Activity

Ponce, DP; Maturana, JL; Cabello, P; Yefi, R; Niechi, I; Silva, E.; Armisen, R; Galindo, M; Antonelli M.

Article ISI SCOPUS
Journal of Cellular Physiology  (2011)

Analysis of Toxoplasma gondii surface antigen 2 gene (SAG2). Relevance of genotype I in clinical toxoplasmosis

Sabaj V; Galindo, M; Silva D.; Sandoval, L.

Article ISI SCOPUS
Molecular Biology Reports  (2010)

Impaired Cell Cycle Regulation of the Osteoblast-Related Heterodimeric Transcription Factor Runx2-Cbf beta in Osteosarcoma Cells

San Martin, IA; Varela, N; Gaete, M; Villegas, K.; Osorio, M; Antonelli M.; Mancilla, EE; Pereira, BP; Nathan, SS; Lian, JB; et al.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2009)

Runx2, p53, and pRB Status as Diagnostic Parameters for Deregulation of Osteoblast Growth and Differentiation in a New Pre-Chemotherapeutic Osteosarcoma Cell Line (OS1)

Pereira, BP; Zhou, YF; Gupta A.; Leong, DT; Aung, KZ; Ling, L; Pho, RWH; Galindo, M; Salto-Tellez, M; Stein, GS; et al.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2009)

The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts

Teplyuk, NM; Zhang, Y.; Lou Y.; Hawse, JR; Hassan, MQ; Teplyuk, VI; Pratap, J; Galindo, M; Stein, JL; Stein, GS; et al.

Article ISI SCOPUS
MOLECULAR ENDOCRINOLOGY  (2009)

Echinococcus granulosus: Cellular territories and morphological regions in mature protoscoleces

Galindo, M; Schadebrodt, G; Galanti N.

Article ISI SCOPUS
EXPERIMENTAL PARASITOLOGY  (2008)

Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

Galindo, M; Pratap, J; Lapointe, D; Javed, A

Article SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2008)

Chromosomal size conservation through the cell cycle supports karyotype stability in Trypanosoma cruzi

Galindo, M; Sabaj V; Espinoza I; Toro, GC; Bua, J.; Grenet, J; Lopez-Solis, R; Ruiz, AM; Galanti N.

Article ISI SCOPUS
FEBS LETTERS  (2007)

Developmental expression pattern of histone H4 gene associated to DNA synthesis in the endoparasitic platyhelminth Mesocestoides corti

Espinoza I; Gomez, CR; Galindo, M; Galanti N.

Article ISI SCOPUS
GENE  (2007)

L-type calcium channels in growth plate chondrocytes participate in endochondral ossification

Mancilla, EE; Galindo, M; Fertilio, B; Herrera M.Á.; Salas K; Gatica H.; Goecke, A

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2007)

Early post-larval development of the endoparasitic platyhelminth Mesocestoides corti: Trypsin provokes reversible tegumental damage leading to serum-induced cell proliferation and growth

Espinoza I; Galindo, M; Bizarro, CV; Ferreira, HB; Zaha, A; Galanti N.

Article ISI SCOPUS
JOURNAL OF CELLULAR PHYSIOLOGY  (2005)

Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones

Galindo, M; Varela, N; Espinoza I; Toro, GC; Hellman, U; Wernstedt, C; Galanti N.

Article ISI SCOPUS
FEBS LETTERS  (2004)

Regionalization of DNA and protein synthesis in developing stages of the parasitic platyhelminth Echinococcus granulosus

Galindo, M; Paredes, R; Marchant, C; Mino, V; Galanti N.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2003)

Echinococcus granulosus protoscolex formation in natural infections

Galindo, M; Gonzalez, M.J.; Galanti N.

Article ISI SCIELO
BIOLOGICAL RESEARCH  (2002)

Abstract (1)

Sall2 transcription factor: A novel regulator of G1-S cyclins.

Hermosilla, VE; Escobar, DE; Hepp, MI; Riffo, EN; Salgado G.; Morin, V; Galindo, M; Castro, AF

Abstract ISI
CANCER RESEARCH  (2018)

Correction (1)

RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis (vol 12, 664756, 2021)

Álvarez, Carla; Galindo, Mario; Vernal, Rolando

Correction ISI
FRONTIERS IN IMMUNOLOGY  (2022)

Proyecto (6)

Genotipificación y análisis personalizado de perfiles farmacogenéticos para optimizar la terapia antidepresiva, prevenir los efectos adversos y aumentar la eficacia de los tratamientos de salud mental.

Galindo, Mario; Sabaj, Valeria; Araya, Lisette; Testa, Daniel; Reyes, Eugenio; Godoi, Elias; Poblete, Diana

Proyecto
 (2025)

Exploring deleterious outcomes of fungal colonization of the placenta by Pneumocystis for the mother-fetus binomia

Galindo, Mario

Proyecto
 (2024)

ROLE OF PERIODONTO-PATHOGENIC BACTERIAL SEROTYPES IN PROMOTING THE ALVEOLAR BONE RESORPTION DURING PERIODONTITIS THROUGH AN IMBALANCE OF TH1/TH 17 VERSUS TREG IMMUNE RESPONSES

FONDECYT (1140904)

Proyecto
2014-2018
Coinvestigador(a)

Funtional analysis of Runx2 transcription factor and Runx2-target genes involves in cell adhession and lung metastasis in osteosarcoma

FONDECYT (1130931)

Proyecto
2013-2016
Inv. Principal

Millennium Institute on Immunology and Immunotherapy

Ministerio de Economía, Fomento y Turismo (P09/016-F)

Proyecto
2011-2020
Inv. Principal

La vía wnt canónica modula la expresión y función del factor de trascripción Runx2 en el ciclo celular de osteosarcoma, afectando parámetros de progresión tumoral y metástasis

FONDECYT (1095234)

Proyecto
2009-2012
Inv. Principal

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Remigio López

Profesor Asociado

Biología Celular y Molecular

UNIVERSIDAD DE CHILE, FAC. MEDICINA, ICBM (BIOQUÍMICA Y BIOLOGÍA MOLECULAR)

Santiago, Chile

1
Milena Villarroel

JEFE CENTRO DE RESPONSABILIDAD

PEDIATRIA

HOSPITAL LUIS CALVO MACKENNA

Santiago, Chile

2
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
RODOLFO PAREDES

Medical Education and Clinical Simulation Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

1
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

1
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

6
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

3
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

3
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Roxana Pincheira

Full Professor

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

2
Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

3
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Flavio Salazar

Profesor Titular

Oncología Básico Clínica

Universidad de Chile

SANTIAGO, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

5
JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Matias Hepp

Profesor asociado - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile

1
Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

3
Ignacio Niechi

Profesor Adjunto

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile

1
Juan Rodriguez

Instructor Adjunto

Medicina Interna

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

1
Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

1
Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

1
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

5
Hector Araya

1
Felipe Falcón

Médico Cirujano

Pediatría

Hospital Clínico San Borja Arriarán

Santiago, Chile

1
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

1
Marcia Gaete

3
Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

1
Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

2
Claudia Lucero

Profesor-Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Camila Fuentes

Investigador Postdoctoral

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Daniel Moena

Docente

Química y Medio Ambiente

Universidad Técnica Federico Santa María

Concepción, Chile

1
Carolina Rojas

Docente

Universidad de Los Andes

Santiago, Chile

40
MARIO GALINDO

Profesor Asociado

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile