Man

RICARDO DANIEL MORENO MAURO

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Líneas de Investigación


Mecanismo de acción de los disruptores endocrinos en la fisiología reproductiva Fecundación en mamíferos

Educación

  •  Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
  •  Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996
  •  Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1996

Formación de Capital Humano


1. Eva Ingrid Bustamante Barra "Laminina-1 estimula la adhesión, proliferación y sobrevida de las espermatogonias de rata. Estudio de la participación de integrina en estos eventos" Tesis para optar al grado deDoctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile, 2007

2. Ximena Bustamante-Marín Glucosa y Lactato controla la apoptosis de células germinales en cultivo Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Finalizada en Diciembre del 2009

3. Natalia Isabel Urzúa Vega Biological activity of phenolic compounds present in a native and endemic Chilean plant Tesis para optar al grado de Doctor en Ciencias de la Agricultura, otorgado por la Facultad de Agronomía e Ingeniería Forestal de la Pontificia Universidad Católica de Chile, 2012

4. Carlos Omar Lizama Valenzuela "Regulación por agentes tóxicos de las metaloproteasas ADAM9, 10 y 17 en el testículo de ratas prepúberes" tesis para optar al grado de Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad xenoestrógenos Católica de Chile, 2011

5. Raúl Lagos-Cabré "Los producen apoptosis en células germinales a través de un mecanismo dependiente de la ADAM17" Tesis para optar al grado de Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile, 2013

6. Jurriaan Brower-Visser "Insulin-like growth factor 2 promotes ovarian cancer growth and resistance to traditional chemotherapy" Tesis para optar al grado de Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile, 2014

7. Paulina Urriola Muñoz " ADAM17 participa en la apoptosis fisiológica e inducida por xenoestrógenos durante la espermatogénesis" Tesis para optar al grado de Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile, 2015

8. Jorge Luis Alejandro Torres Fuentes Participación de los hemicanales formados por pannexinas en la diferenciación de células germinales y la fisiología del espermatozoide Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Finalizada Octubre, 2015

9. Francisca Salas Pérez Evaluación del riesgo metabólico en la descendencia de madres obesas expuestas a disruptores endocrinos durante la gestación en un modelo murino Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Finalizada Diciembre 2016

10. María Verónica Aguirre Arias Participación de las metaloproteasas ADAM17 y ADAM10 y Especies Reactivas del Oxígeno en la apoptosis de células germinales en el testículo de rata diabética Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Finalizada Noviembre, 2016

11. Julio Arduino Buñay Noboa Regulación y función de microRNAs en las alteraciones del testículo de ratón inducidas por exposición a mezclas de ftalatos y alquifenoles. Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Noviembre, 2016.

12. Daniel Patiño García Una mezcla de disruptores endocrinos (ftalatos y alquilfenoles) altera la función gonadal en ratón hembra a través de un mecanismo dependiente de microARNs Doctor en Ciencias Biológicas con mención en Ciencias Fisiológicas. Pontificia Universidad Católica de Chile Finalizada Agosto, 2017.

13. Lina Correa Estrada "Efecto del fotoperiodo sobre la estacionalidad eproductiva en guanacos (Lama guanicoe) hembras" tesis para optar al grado de Doctor en Ciencias de la Agricultura, Pontificia Universidad Católica de Chile Diciembre 2019



 

Article (83)

GnRHa treatments of Atlantic Salmon broodstock suppresses effects of endocrine disruptors, benefitting offspring quality
Antigen retrieval by citrate solution improves western blot signal
Combined proteomic and miRNome analyses of mouse testis exposed to an endocrine disruptors chemicals mixture reveals altered toxicological pathways involved in male infertility
Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
Editor's Highlight: Differential Effects of Exposure to Single Versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes
Editor's Highlight=> Differential Effects of Exposure to Single Versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes.
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2
Reproductive Alterations in Chronically Exposed Female Mice to Environmentally Relevant Doses of a Mixture of Phthalates and Alkylphenols
Reproductive Alterations in Chronically Exposed Female Mice to Environmentally Relevant Doses of a Mixture of Phthalates and Alkylphenols.
The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands
Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction
Effects of ascorbic acid on spermatogenesis and sperm parameters in diabetic rats
Pannexin channels increase propidium iodide permeability in frozen-thawed dog spermatozoa.
Pannexin channels increase propidium iodide permeability in frozen?thawed dog spermatozoa
2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells.
Effects of Fatty Acids on Intracellular [Ca2+], Mitochondrial Uncoupling and Apoptosis in Rat Pachytene Spermatocytes and Round Spermatids
Effects of Fatty Acids on Intracellular [Ca2+], Mitochondrial Uncoupling and Apoptosis in Rat Pachytene Spermatocytes and Round Spermatids.
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells
Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa
A Mechanism of Male Germ Cell Apoptosis Induced by Bisphenol-A and Nonylphenol Involving ADAM17 and p38 MAPK Activation
Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability.
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability.
Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats
Differential effects of temperature on reactive oxygen/nitrogen species production in rat pachytene spermatocytes and round spermatids
Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes
Contribution of environmental pollutants to male infertily: a working model of germ cell apoptosis induced by plasticizers.
Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis
The hypoxic testicle: physiology and pathophysiology
Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model
Expression of BCL-2 family genes in germ cells undergoing apoptosis during the first wave of spermatogenesis in the rat
Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis
Protease activity involvement in the passage of mammalian sperm through the zona pellucida
The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis
Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice
Life-giving caspases: revealing new roles during mouse embryo preimplantation development
p73 participates in male germ cells apoptosis induced by etoposide
TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis
A molecular evaluation of germ cell death induced by etoposide in pubertal rat testes
Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis
Mitotic, but not rneiotic, oriented cell divisions in rat spermatogenesis
Relevance of caspase activity during apoptosis in pubertal rat spermatogenesis
Evaluation of cortical granules and viability of canine oocytes during long-term in vitro maturation
Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat
Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis
Caspase activation throughout the first wave of spermatogenesis in the rat
Comparative analysis of apoptotic pathways in rat, mouse, and hamster spermatozoa
Proacrosin/acrosin quantification as an indicator of acrosomal integrity in fresh and frozen dog spermatozoa
The mammalian acrosome as a secretory lysosome: New and old evidence
Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa
Differential expression of lysosomal associated membrane protein (LAMP-1) during mammalian spermiogenesis
Egg coats of the rock shrimp Rhynchocinetes typus: Ultrastructural characterization and their function during fertilization
Experimentally induced anhydrobiosis in the tardigrade Richtersius coronifer: Phenotypic factors affecting survival
Golgi apparatus dynamics during mouse oocyte in vitro maturation: Effect of the membrane trafficking inhibitor brefeldin A
Inhibition of mouse in vitro fertilization by an antibody against a unique 18-amino acid domain in the polysulfate-binding domain of proacrosin/acrosin
A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis
Differential effects of polysulphates between mouse and hamster during in vitro fertilization
Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis
Purification and biochemical characterization of a trypsin-like enzyme present in the sperm of the rock shrimp, Rhynchocinetes typus
Targeting and fusion proteins during mammalian spermiogenesis
A basic 18-amino acid peptide contains the polysulfate-binding domain responsible for activation of the boar proacrosin/acrosin system
Contractile apparatus of the normal and abortive cytokinetic cells during mouse male meiosis
Microtubule configurations and post-translational ?-tubulin modifications during mammalian spermatogenesis
SNAREs in mammalian sperm: Possible implications for fertilization
The Golgi Apparatus Segregates from the Lysosomal/Acrosomal Vesicle during Rhesus Spermiogenesis: Structural Alterations
Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryosj
Vesicular traffic and Golgi apparatus dynamics during mammalian spermatogenesis: Implications for acrosome architecture
Functional interactions between sulphated polysaccharides and proacrosin: Implications in sperm binding and digestion of zona pellucida
On-stage selection of single round spermatids using a vital, mitochondrion-specific fluorescent probe MitoTracker(TM) and high resolution differential interference contrast microscopy
Optimization strategies for production of mammalian embryos by nuclear transfer
Ubiquitin tag for sperm mitochondria
Developmental regulation of mouse brain monomeric acetylcholinesterase
Modulation of the molecular interactions between the zona pellucida and acrosome-reacted spermatozoa
The polysulphate binding domain of human proacrosin/acrosin is involved in both the enzyme activation and spermatozoa-zona pellucida interaction
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme
Early steps of sperm-egg interactions during mammalian fertilization
Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors
Tetrameric (G4) acetylcholinesterase: structure, localization, and physiological regulation
Mitosis of Schwann cells and demyelination are induced by the amyloid precursor protein and other protease inhibitors in the rat sciatic nerve
Monomeric amphiphilic forms of acetylcholinesterase appear early during brain development and may correspond to biosynthetic precursors of the amphiphilic G4 forms
Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases
Effect of Test-yolk upon human sperm acrosome reaction

Abstract (9)

ROLE OF PRENATAL EXPOSURE TO ENVIRONMENTAL POLLUTANTS AND MATERNAL OBESITY IN FETAL PROGRAMMING OF CHRONIC DISEASES IN MICE
Xenoestrogens, Bisphenol A (BPA) and 4-nonilphenol (NP), induce activity of ADAM17
Cross-reactivity of monoclonal antibodies against human acrosin to dog spermatozoa
Mitochondrial dynamics and cytoskeletal association in rat pachytene spermatocytes and round spermatids
Signs of death in espermatocytes of testis rat, glucose possible modulator
Caspases are executioners of apoptosis during the first wave of spermiogenesis in the rat
Differential expression of laminin isoforms during postnatal testis development
Differential expression and localization of endosomal and lysosomal proteins during mammalian spermiogenesis.
Membrane trafficking and maturation of mouse oocytes.

BookWhole (2)

Molecular basis of heat stress damage in mammalian testis
Spermatogenesis at the extreme: Oxidative stress as a converging mechanism of testicular damage due to pathological and environmental exposure

ConferencePaper (1)

Ultrastructural and functional characterization of sperm in the rock shrimp Rhynchocinetes Typus

Letter (1)

Rebuttal of a role for the epididymis in sperm quality control by phagocytosis of defective sperm - Reply

Proyecto (14)

A MIXTURE OF ENDOCRINE DISRUPTORS (PHTALATES AND ALKYLPHENOLS) IMPAIR GONADAL FUNCTION BY REGULATING MICRORNAS THAT CONTROL SEX STEROID HORMONE LEVELS
"UNSATURATED FATTY ACIDS REGULATE THEIR OWN SIGNALING PATHWAYS IN RAT SPERMATOGENIC CELLS=> ROLE OF MITOCHONDRIAL UNCOUPLING, INTRACELLULAR CA2+ AND PPAR ALFA"
INVOLVEMENT OF TACE/ADAM17 AND PANNEXIN HEMICHANNELS IN XENOESTROGENS INDUCED APOPTOSIS IN MAMMALIAN SPERMATOGENESIS
Compuestos derivados de fenilsufonaminas sustituidas, inhibidores de calpaínas, composiciones farmacéuticas, útiles en el tratamiento de enfermedades asociadas con actividad de calpaínas tales como infertilidad masculina, torsión testicular, varicocele, enfermedad de Alzheimer, Parkinson y SIDA”
Desarrollo de un extracto botánico contra células tumorales, a partir de plantas nativas chilenas.
Extractos fenólicos de recursos naturales (miel de abeja y plantas nativas) con propiedades quimioprotectoras en el testículo de mamífero.
Obtención de nuevos productos naturales bactericidas contra patógenos del agro y humanos a partir de plantas medicinales chilenas.
Modelo in vitro para estudiar el efecto de la prolongación del tiempo de exposición en radioterapia por modulación de intensidad (IMRT).
Millennium Nucleus in Developmental Biology
Acrosome Biogenesis as a Target for Contraception
Papel del cito-esqueleto de microtúbulos en la formación del acrosoma de mamíferos
Estudio de compuestos polisulfatados que afectan la tasa de activación de proacrosina
Study of the interactions between acrosin and zona pellucida as a tool to understand the inter and intra-specific fertilization
Ubiquitin Based Semen Quality Assay in Toxicology”. Colaborator

Review (4)

In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans
Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
Calpain Inhibitors Prevent p38 MAPK Activation and Germ Cell Apoptosis After Heat Stress in Pubertal Rat Testes
Control of membrane fusion during spermiogenesis and the acrosome reaction
93
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

6
jaime palomino

Investigador Asociado

Ciencias Fisiológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

2
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

2
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

2
RENAN ORELLANA

Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

2
Monica De los Reyes

Profesora Titular

Fom Prod Animal

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

1
Nelson Osses

Profesor Titular

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
CAROLINA FIGUEROA

Investigador Postdoctoral

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

1
Andrea Zepeda

Docente/Investigador

Universidad Autónoma de Chile

Temuco, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Nelson Varela

Académico

Oncología Básico-Clínico

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Martha Flórez

Profesional

Medicina

Instituto de Investigación Materno Infantil

Santiago, Chile

1
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Loni Berkowitz

Profesor Asistente - Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Ethel Velásquez

investigador

Departamento de Tecnologías Nucleares

Comisión Chilena de Energía Nuclear

Santiago, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
María Rodríguez

Profesora Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Flavio Carrion

Director Científico, Programa de Inmunología Traslacional. Director Doctorado en Ciencias e Innovación en Medicina. ICIM, Facultad de Medicina

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
José Pino

Director de Departamento

Medicina

Universidad de Atacama

Copiapó, Chile

1
Víctor Parraguez

Profesor Titular

Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Alejandro Amoroso

Profesor Asistente

Deoartamento de Ciencias Biológicas y Químicas

Universidad San Sebastián

santiago, Chile