Man

Flavio Rigoberto Carrion Arriagada

Director Científico, Programa de Inmunología Traslacional. Director Doctorado en Ciencias e Innovación en Medicina. ICIM, Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Estudios Mecanismos immunomoduladores de las Células Madre mesenquimales; Estudio Mecanismos Enfermedades Proinflamatorias y Autoinmunes. Estudio y Diagnóstico Inmunodeficiencias Primarias.

Educación

  •  Doctor en Ciencias Biológicas, UNIVERSIDAD DE ALCALA DE HENARES. España, 1996
  •  Magíster en Administración y Gestión en Salud, UNIVERSIDAD DE LOS ANDES. Chile, 2006
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 1988

Experiencia Académica

  •   Investigador/Docente Full Time

    UNIVERSIDAD DEL DESARROLLO

    Medicina

    Santiago, Chile

    2016 - 2020

  •   Investigador/Docente Full Time

    Universidad de los Andes

    Medicina

    Santiago, Chile

    1997 - 2016

  •   Director Full Time

    Universidad del Alba

    Ciencias de la Salud

    Santiago, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Director Científico, Programa de Inmunología Traslacional. ICIM, Facultad de Medicina Full Time

    Universidad del Desarrollo

    Santiago, Chile

    2016 - 2020

  •   Investigador Full Time

    Universidad de los Andes

    Santiago, Chile

    1997 - 2016

Formación de Capital Humano


Como parte del desarrollo de mis líneas de investigación y diferentes proyectos (Fondecyt, Corfo, otros) he tenido la oportunidad de estar implicado en la formación de alumnos de pre y postgrado los cuales detallo a continuación.

Dirección de Tesis de Post-Grado
6 PhD (3 en curso)
2 Magíster

Dirección de Tesis de Pre-Grado
Bioquímica (9)
Tecnología Médica (12)
Quimico Farmaceutico (1)
Médico Veterinario (1)
Biotecnología (2)
Odontología (3)


Difusión y Transferencia


Como investigador en el área de las células madres mesenquimales y de patologías inmunológicas participo activamente en congresos relacionados así como en seminarios, workshop etc..
Pertenezco además a la Sociedad Chilena de Inmunología y al grupo de Inmunodeficiencias.
Participo también activamente en el programa explora anualmente difundiendo la ciencia a diversos colegios de enseñanza media.



 

Article (89)

Extracellular Vesicle Transmission of Chemoresistance to Ovarian Cancer Cells Is Associated with Hypoxia-Induced Expression of Glycolytic Pathway Proteins, and Prediction of Epithelial Ovarian Cancer Disease Recurrence
Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review
Mesenchymal stem cells derived from human inflamed dental pulp exhibit impaired immunomodulatory capacity in vitro
Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue
Mucosal Vaccination with Lactococcus lactis-Secreting Surface Immunological Protein Induces Humoral and Cellular Immune Protection against Group B Streptococcus in a Murine Model
Surface Immunogenic Protein of Streptococcus Group B is an Agonist of Toll-Like Receptors 2 and 4 and a Potential Immune Adjuvant
Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE
Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.
Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells
Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF-7 breast cancer cells
Curcumin and paclitaxel induce cell death in breast cancer cell lines
IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis
TGF beta 3 secretion by three-dimensional cultures of human dental apical papilla mesenchymal stem cells
Differential TLR Activation of Murine Mesenchymal Stem Cells Generates Distinct Immunomodulatory effects in EAE
Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE.
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.
Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model
[Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy].
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis
Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy
Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy [Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología]
Long-Term results of the intracoronary transplantation of Autologous Bone Marrow Cells in Patients with Dilated Cardiomyopathy of Diverse Etiology
Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering
TGFβ3 secretion by three-dimensional cultures of human dental apical papilla mesenchymal stem cells.
El Transplante intracoronario de células mononucleares de médula ósea se asocia a mejoría de la función ventrícular izquierda, en pacientes con cardiopatía Dilatada de diferente etiología
EL TRASPLANTE INTRACORONARIO DE CÉLULAS MONONUCLEARES DE MÉDULA ÓSEA SE ASOCIA A MEJORÍA�A LA FUNCIÓN VENTRICULAR IZQUIERDA, EN PACIENTES CON CARDIOPATÍA�A DILATADA DE DIFERENTE ETIOLOGÍA=> PROYECTO INNOVA CHILE N° 205-4350
Expresión de citoquinas Th17 y su correlación con periodontopatógenos y el área periodontal inflamada en pacientes con periodontitis crónica
Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study
Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study
Isolation and Characterization of Mesenchymal Stem Cells from Human Dental Pulp and Follicle
Isolation and characterization of mesenchymal stem cells from pulp and human dental follicle
Mesenchymal stem cells generate a CD4(+)CD25(+) Foxp3(+) regulatory T cell population during the differentiation process of Th1 and Th17 cells
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
Morphological effects of mesenchymal stem cells and pulsed ultrasound on condylar growth in rats. A pilot study
Morphological effects of mesenchymal stem cells and pulsed ultrasound on condylar growth in rats: a pilot study
Th17 cytokines expression and its correlation with periodontopathogens and periodontal inflammed surface area (PISA) in patients with chronic periodontitis
Evaluation of Mesenchymal Stem Cell proliferation using different low intensity pulsed ultrasound intensities.
Haploidentical stem cell transplantation for children with high-risk leukemia
Haploidentical stem cell transplantation for children with high-risk leukemia in Chile
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction.
Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
Mesenchymal Stem Cell treatment for autoinnmune diseases: a critical review
Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway
Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway
Asociación entre periodontitis crónica, interleuquina -6 (IL-6) e índice de masa corporal (IMC) en embarazadas
Asociación entre periodontitis crónica, interleuquina -6 (IL-6) e índice de masa corporal (IMC) en embarazadas
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
Mesenchymal Stem Cells for the treatment of Systemic Lupus Erythematosus Is the cure for Connective Tissue Diseases within Connective Tissue?
Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4(+) T cell activation
Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation
Proliferación de Células Madres Mesenquimales Obtenidas de Tejido Gingival Humano sobre una Matriz de Quitosano: estudio in vitro
Autologous Mesenchymal Stem Cell Treatment Increased T Regulatory Cells with no Effect on Disease Activity in Two SLE patients
Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
Culture and Characterization of Mesenchymal Stem Cells From Human Gingival Tissue
Culture and Characterization of Mesenchymal Stem Cells from Human Gingival Tissue
Calpain inhibitors prevent heat-induced but not physiological apoptosis in rat puberal testis
Impaired Immune Response in Severe Human Lower Tract Respiratory Infection by Respiratory Syncytial Virus
Molecular characterization of hospital-acquired adenovirus infantile respiratory infection in Chile using species-specific PCR assays
Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease
Presencia de ADN bacteriano en el tejido valvular de pacientes con cardiopatía reumática crónica
Establishment of a pediatric HSCT program in a public hospital in Chile
Establishment of a pediatric HSCT program in a public hospital in Chile.
Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: A pilot study.
[Clinical findings and immunologic variability in 9 patients with DiGeorge syndrome].
Clinical findings and immunologic variability in 9 patients with DiGeorge syndrome
Hyper-IgM syndrome in members of two unrelated Chilean families: molecular and mutation analysis
[Study of polymorphism of Fc gamma IIa receptors in Chilean patients with systemic lupus erythematosus].
[X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder neoplasm: clinical case].
Selective depletion of CD8+V2+ T cells in human peripheral blood from rheumatic heart disease patients
Selective depletion of V beta 2+CD8+ T cells in peripheral blood from rheumatic heart disease patients
X-linked hyper-IGM syndrome associated to sclerosing cholangitis and gallbladder cancer
Relationship between response to interferon-alpha and function of peripheral blood mononuclear cells in chronic hepatitis C patients
Relationship between response to interferon-alpha and function of peripheral blood mononuclear cells in chronic hepatitis C patients.
Restriction in the usage of variable beta regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients
Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: long term follow up of patients with subclinical disease
A genetic and molecular perspective for present time clinical immunology
[Effects of bromocriptine in patients with active rheumatoid arthritis].
Altered pattern of cytokine production by peripheral blood CD2+ cells from B chronic lymphocytic leukemia patients.
Bromocriptine induces immunological changes related to disease parameters in rheumatoid arthritis.
Morphological variants of leukemic cells in B chronic lymphocytic leukemia are associated with different T cell and NK cell abnormalities.
Thymostimulin increases natural cytotoxic activity in patients with breast cancer
Thymostimulin increases natural cytotoxic activity in patients with breast cancer.
Anticardiolipin Antibodies in Acute Rheumatic Fever
Differential TLR Activation of Murine Mesenchymal Stem Cells Generates Distinct Immunomodulatory effects in EAE
EL TRASPLANTE INTRACORONARIO DE CÉLULAS MONONUCLEARES DE MÉDULA ÓSEA SE ASOCIA A MEJORÍAA LA FUNCIÓN VENTRICULAR IZQUIERDA, EN PACIENTES CON CARDIOPATÍAA DILATADA DE DIFERENTE ETIOLOGÍA: PROYECTO INNOVA CHILE N° 205-4350
Overexpression of Glutamate Decarboxylase In Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties And Increases GABA And Nitric Oxide Levels

Abstract (7)

TRANSPLANTATION OF AUTOLOGOUS BONE MARROW CELLS, IMPROVE THE EJECTION FRACTION IN PATIENTS WITH DILATED CARDIOMYOPATHY OF DIVERSE ETIOLOGY
Immunomodulatory properties of MSCs on Th17 cells: the role of cell-contact and IL-6
Intracoronary bone marrow derived CD34+cells improve left ventricular function in patients with severe dilated cardiopathy
PROINFLAMMATORY PHENOTYPE AND DECREASED EXPRESSION OF DUAL TH17/TREG CD4+CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
ALTERNATIVE DONORS FOR HIGH RISK HEMATOLOGICAL MALIGNANCY IN ETHNIC MINORITIES: EXPERIENCE WITH HAPLOIDENTICAL TRANSPLANTS
Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two SLE patients
A 14 year old girl with a severe pseudomonas sepsis and very low number of CD19+cells.

Proyecto (13)

UNDERSTANDING HOST RESPONSE TO ANDV INFECTION, IMMUNOLOGICAL AND TRANSCRIPTOMICS APPROACH
Desarrollo de un test de diagnóstico temprano de Isquemia Cardíaca Silente no invasivo y de bajo costo basado en la detección de hipoxia tisular
Desarrollo de una nueva metodología para aumentar la eficiencia inmunosupresora de las células madre mesenquimales para su uso clínico.
The protective role of Nuclear Factor of Activated T-cells 5 (NFAT5) during renal ischemia/reperfusion is dependent of inducible nitric oxide synthase (iNOS)=> participation of AQP-1
GABA=> ROLE IN T HELPER DIFFERENTIATION AND MESENCHYMAL STEM CELL-MEDIATED IMMUNOSUPPRESSION IN VITRO AND IN AN EXPERIMENTAL MODEL OF AUTOIMMUNITY.
Investigación y desarrollo de una nueva metodología para aumentar la eficiencia inmunosupresora de las células madre mesenquimales para su uso clínico.
TOLL-LIKE RECEPTOR MEDIATES THE IMMUNOSUPPRESSIVE TO PROINFLAMMATORY SWITCH IN MESENCHYMAL STEM CELLS=> IN VITRO AND IN VIVO EVALUATION IN AUTOIMMUNE MODELS OF MULTIPLE SCLEROSIS AND RHEUMATOID ARTHRITIS.
Desarrollo piloto de células madre mesenquimales de origen placentario con aplicación clínica para insuficiencia cardiaca
Efecto de las Células Madres Mesenquimales sobre la Plasticidad de los Linfocitos Treg/Th17.
Toll-like Receptor Mediates the Immunosuppressive to Proinflammatory Switch in Mesenchymal Stem Cells=> In vitro and in vivo Evaluation in an Experimental Autoimmune Encephalomyelitis Model.
Desarrollo e implementación de una nueva terapia para el tratamiento de pacientes con infarto agudo al miocardio=> Cultivo e infusión de células madres autólogas
INFECCION POR VIRUS RESPIRATORIO SINCICIAL=> ESTUDIO DE POLIMORFISMOS DE LOS GENES IL-4. IL-8. SP-A Y SP-D RELACIONADAS A ENFERMEDAD GRAVE POR VRS EN POBLACION CHILENA SUSCEPTIBLE.
SUPERANTIGENOS EN LA FIEBRE REUMATICA=> ANALISIS DEL USO DE GENES DE LA REGION VARIABLE DEL RECEPTOR - T (TCR) Y TRANSCRIPCION DE CITOQUINAS EN PACIENTES CON ENFERMEDAD ACTIVA

Review (2)

Stem cells for the treatment of cardiovascular diseases. An update
Calpain Inhibitors Prevent p38 MAPK Activation and Germ Cell Apoptosis After Heat Stress in Pubertal Rat Testes
56
Flavio Carrion

Director Científico, Programa de Inmunología Traslacional. Director Doctorado en Ciencias e Innovación en Medicina. ICIM, Facultad de Medicina

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

20
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

7
Maroun Khoury

A/Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

7
Patricia Luz

Profesor asistente

Universidad de los Andes

Santiago , Chile

6
Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

4
Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

4
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

4
antonio quintero

Profesor Asistente

Periodoncia e Implantología Oral

Universidad de los Andes

Santiago, Chile

3
Carolina Nazzal

Profesor Asociado

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

3
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
RICARDO MANZO

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO SALUD PUBLICA DE CHILE

SANTIAGO, Chile

3
Claudia Paris

Médico

Pediatria

Hospital Luis Calvo Mackenna

Santiago, Chile

2
Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

2
Diego Díaz

Jefe (s)

ANDID

Instituto de Salud Pública de Chile

Santiago, Chile

2
Fabio Valdes

Staff

Cirugia

Instituto Nacional del Cancer

Santiago, Chile

2
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Valeria Ramirez

Profesor asistente

Universidad de Los Andes

Santiago, Chile

2
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Gustavo Monckeberg

Profesor - investigador

Medicina interna

Universidad de Los Andes

Santiago, Chile

1
Claudio Cappelli

Technical Laboratory Manager

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Ricardo Larrea

Médico Jefe

Enfermedades Cardiovasculares

Clinica Dávila

Santiago, Chile

1
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

1
Rafael Contreras

PhD student

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

1
Sergio Mella

Profesor Asociado

Medicina Interna

Universidad de Concepción

Concepción, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Patricia Fuenzalida

Lab Manager

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Caroline Weinstein

profesor titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Julio Berrios

Académico Full-time

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Rodrigo Somoza

Senior Research Associate

Biology

Case Western Reserve University

Cleveland, Estados Unidos

1
natalia quiñones

profesor ajdunto

UNIVERSIDAD DE VALPARAISO

Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fernando Verdugo

Residente

Cardiologia

Clinica Las Condes

Santiago, Chile

1
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

1
CLAUDIA JARA

Asistente de Investigación

Universidad Austral de Chile

valdivia, Chile

1
Fernando Lanas

Profesor titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile