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Gloria Monserrat Calaf Sarrat

Directora Laboratorio Biología del cáncer

Universidad de Tarapacá

Arica, Chile

Líneas de Investigación


Biología del cáncer; Carcinogénesis mamaria; Resistencia a drogas quimiterapéuticas

Educación

  •  Biology and Chemistry, UNIVERSIDAD DE CHILE. Chile, 1961
  •  Biological sciences, MICHIGAN STATE UNIVERSITY. Estados Unidos, 1968
  •  Biological sciences, MICHIGAN STATE UNIVERSITY. Estados Unidos, 1975

Experiencia Académica

  •   Teaching and Research Assistant Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    1962 - 1963

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Antofagasta, Chile

    1963 - 1974

  •   Research and Teaching Assistant Full Time

    MICHIGAN STATE UNIVERSITY

    East Lansing, Michigan, Estados Unidos

    1970 - 1974

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1977 - 1978

  •   Full Professor Full Time

    UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACION

    Santiago, Chile

    1981 - 1989

  •   Visiting Professor Full Time

    UNIVERSITY OF WISCONSIN-MADISON

    Madison, Wisconsin, Estados Unidos

    1985 - 1985

  •   Visiting Professor Full Time

    Universite du Paris XII. Henri Mondor Hospital

    Cretei, Francia

    1987 - 1989

  •   Associate Research Scientist Full Time

    Michigan Cancer Foundation

    Detroit, Michigan, Estados Unidos

    1989 - 1990

  •   Associate Research Scientist Full Time

    Fox Chase Cancer Center

    Philadelphia, Pennsylvania, Chile

    1990 - 1992

  •   Assistant Member Full Time

    Fox Chase Cancer Center

    Philadelphia, Pennsylvania, Chile

    1992 - 1996

  •   Associate Research Scientist Full Time

    COLUMBIA UNIVERSITY

    Center for Radiological Research

    New York, NY, Chile

    1997 - 2003

  •   Adjunct Professor Full Time

    UNIVERSIDAD DE TARAPACA

    Science

    Arica, Chile

    1998 - 2003

  •   Visiting Professor Full Time

    UNIVERSIDAD DE CHILE

    Center for Radiological Research for the Man in the Desert

    Arica, Chile

    2003 - 2003

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Science

    Arica, Chile

    2004 - 2005

  •   Adjunct Research Scientist Full Time

    COLUMBIA UNIVERSITY

    Center for Radiological Research

    New York, NY, Estados Unidos

    2004 - 2013

  •   Full Professor Full Time

    UNIVERSIDAD DE TARAPACA

    Institute for Advanced Research

    Arica, Chile

    2006 - A la fecha

Premios y Distinciones

  •   Best presentation

    Spandidos Publications

    Grecia, 2005

    10th World Congress on Advances in Oncology, and 8th International Symposium on Molecular Medicine. Crete Maris Hotel. Hersonissos, Crete, Greece: “A critical approach to the malignant transformation of human breast epithelial cells with physical and chemical carcinogens”. October 15, 2005

  •   Best Professor and Researcher

    UNIVERSIDAD DE TARAPACA

    Chile, 2009

    Instituto de Alta Investigación. Arica, Chile. October 23

  •   National Award Terra Woman

    Terra Woman

    Chile, 2009

    Category: Science. September 20

  •   Best Professor and Researcher

    UNIVERSIDAD DE TARAPACA

    Chile, 2012

    Institute for Advanced Research. Arica, Chile. April 20

  •   Recognition Award

    UNIVERSIDAD DE TARAPACA

    Chile, 2012

    Recognition Award for grant FONDECYT 2012. April 20

  •   Best Professor and Researcher

    UNIVERSIDAD DE TARAPACA

    Chile, 2012

    October 23

  •   Career Award

    UNIVERSIDAD DE TARAPACA

    Chile, 2012

    Best Professor and Researcher, Career Award among other 4. Arica, Chile. October 23

  •   Chairperson and organizer of XX International Charles Heidelberger Symposium on Cancer Research

    UNIVERSIDAD DE TARAPACA

    Chile, 2014

    Chairperson and organizer of “20th International Charles Heidelberger Symposium on Cancer Research”. October 8–11

  •   Nominated Emeritus AACR

    American Association for Cancer Research (AACR)

    Estados Unidos, 2015

    Nominated Emeritus Member of American Association for Cancer Research: April

  •   Appointed as expert

    World Health Organization (IARC)

    Francia, 2015

    Appointed as expert by “World Health Organization, International Agency for Cancer Research (IARC)” to take part in Monograph # 112 in “Monographs on the evaluation of carcinogenic risks to humans– ‘Some organophosphate insecticides”. From July 2014 to March 2015.Meeting: March 1-13, 2016

  •   Appointed as expert

    World Health Organization (IARC)

    Chile, 2016

    Experta seleccionada por Organización Mundial de la Salud, World Health Organization, International Agency for Cancer Research (IARC) para participar en la elaboración de Monography # 117 Monographs on the evaluation of carcinogenic risks to humans,– ‘Pentachlorophenol and Some Related Compounds’. Desde Marzo a Octubre 2016. Reunión: Octubre 1-13, 2016

  •   Lead Guest Editor

    Hindawi

    Estados Unidos, 2016

    Appointed as Lead Guest Editor for Journal: Oxidative Medicine and Cellular Longevity (4.5 impact factor): November, 2016. Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer Lead Guest Editor: Gloria M. Calaf Guest Editors: Consolato M. Sergi, Angeles Juarranz, Debasish Roy, Francisco A. Gonzalez Submission Deadline: Friday, 25 August 2017 Publication Date: January 2018


 

Article (125)

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude
Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing alpha-particle radiation
Apoptotic effect of noscapine in breast cancer cell lines
Carcinogenicity of pentachlorophenol and some related compounds
Curcumin and epithelial-mesenchymal transition in breast cancer cells transformed by low doses of radiation and estrogen
Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP + -linked-polyhydroxybenzoates
Effect of curcumin and paclitaxel on breast carcinogenesis
Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines
Ras protein expression as a marker for breast cancer
Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs
Antitumor activity of pamidronate in breast cancer cells transformed by low doses of alpha-particles and estrogen in vitro
Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate
Molecular aspects of breast cancer resistance to drugs (Review)
Mutation of beta-catenin in a radiation and estrogen breast cancer model
Ultraviolet light exposure, skin cancer risk and vitamin D production
Allelic loss at chromosome 11q13 alters FGF3 gene expression in a human breast cancer progression model
Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis
Skin cancer risk affected by ultraviolet solar irradiance in Arica, Chile
Vimentin and Notch as biomarkers for breast cancer progression
Differential expression of cell adhesion molecules in an ionizing radiation-induced breast cancer model system
Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice
Radiation-induced non-targeted response in vivo: role of the TGF beta-TGFBR1-COX-2 signalling pathway
Blueberry Extracts Protect Testis from Hypobaric Hypoxia Induced Oxidative Stress in Rats
Effect of curcumin on irradiated and estrogen-transformed human breast cell lines
Malignant Transformation of Rat Kidney Induced by Environmental Substances and Estrogen
Melatonin Protects the Heart, Lungs and Kidneys from Oxidative Stress under Intermittent Hypobaric Hypoxia in Rats
Prediction of skin cancer occurrence by ultraviolet solar index
Synergistic effect of malathion and estrogen on mammary gland carcinogenesis
The Stemness Phenotype Model
Catechol estrogens as biomarkers for mammary gland cancer
Deleterious MnSOD signals lead to abnormal breast cell proliferation by radiation and estrogen exposure
Metastatic suppressor CD44 is related with oxidative stress in breast cancer cell lines
Prevalence of human papillomavirus university young women
Protective role of curcumin in oxidative stress of breast cells
TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells
Transforming growth factor-beta-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway
Ultraviolet light exposure influences skin cancer in association with latitude
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis
Oxidative Stress in Rat Testis and Epididymis Under Intermittent Hypobaric Hypoxia: Protective Role of Ascorbate Supplementation
P504S expressing circulating prostate cells as a marker for prostate cancer
Phosphoproteomic profiling of arsenite-treated human small airway epithelial cells
Profiling of cell cycle genes of breast cells exposed to etodolac
Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes
Presence of prostate cells in bone marrow biopsies as a sign of micrometastasis in cancer patients
Ultraviolet light exposure and skin cancer in the city of Arica, Chile
BigH3 protein expression as a marker for breast cancer
Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells
Cell adhesion proteins altered by 17 beta estradiol and parathion in breast epithelial cells
Gene expression profiling of breast cells induced by X-rays and heavy ions
Neoplastic transformation of human small airway epithelial cells induced by arsenic
Patterns of recurrence and survival in breast cancer
Rat lung cancer induced by malathion and estrogen
Cell proliferation and tumor formation induced by eserine, an acetylcholinesterase inhibitor, in rat mammary gland
Gene and protein expressions induced by 17 beta-estradiol and parathion in cultured breast epithelial cells
Gene expression signature of parathion-transformed human breast epithelial cells
Human drug metabolism genes in parathion and estrogen-treated breast cells
PAC1 is a direct transcription target of E2F-1 in apoptotic signaling
Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression
Growth factor biomarkers associated with estrogen- and radiation-induced breast cancer progression
Susceptibility of human breast epithelial cells in vitro to hormones and drugs
Beta catenin is associated with breast cancer progression in vitro
Differential gene expression of sulindac-treated human breast epithelial cells
Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells
Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation
Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene
Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity
Ionizing radiation induces alterations in cellular proliferation and c-myc, c-jun and c-fos protein expression in breast epithelial cells
Allelic imbalance at 11p15.5-15.4 correlated withc-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells
Critical role of oxidative stress in estrogen-induced carcinogenesis
Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Organophosphorous pesticides in breast cancer progression
Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell
The pesticide malathion induces alterations in actin cytoskeleton and in cell adhesion of cultured breast carcinoma cells
A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression
Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high let radiation
Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation
Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells
Retinol, oncoproteins, and free radicals in a radiation and estrogen-induced breast cancer model
Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model
Tumor suppressor genes, cellular invasion, and degradative proteases are modulated by short chain fatty acids in an in vitro invasive human colorectal cancer cell model
Establishment of a radiation- and estrogen-induced breast cancer model
Morphological phenotypes in neoplastic progression of benz(alpha)pyrene-treated breast epithelial cells
Morphological phenotypes in neoplastic progression of human breast epithelial cells
What is the alpha/beta ratio for prostate cancer cells?
Neoplastic progression of breast epithelial cells - a molecular analysis
Cathepsins D, B, and L in transformed human breast epithelial cells
ACTIVATION OF C-MYC, C-NEU AND INT-2 ONCOGENES IN THE TRANSFORMATION OF THE HUMAN BREAST EPITHELIAL-CELL LINE MCF-10F TREATED WITH CHEMICAL CARCINOGENS IN-VITRO
C-HA-RAS ENHANCES THE NEOPLASTIC TRANSFORMATION OF HUMAN BREAST EPITHELIAL-CELLS TREATED WITH CHEMICAL CARCINOGENS
Cathepsins D, B and L in Breast Carcinoma and in Transformed Human Breast Epithelial Cells (HBEC)
GENOME SCANNING USING ENDOGENOUS LTR-LIKE ELEMENTS FOR RAPID DNA-FINGERPRINTING OF BREAST-CANCER AND TRANSFORMED HUMAN BREAST EPITHELIAL-CELLS
INFLUENCE OF LOBULAR DEVELOPMENT ON BREAST EPITHELIAL-CELL PROLIFERATION AND STEROID-HORMONE RECEPTOR CONTENT
ROLE OF P53 IN MCF-10F CELL IMMORTALIZATION AND CHEMICALLY-INDUCED NEOPLASTIC TRANSFORMATION
Allele loss and point mutation in codons 12 and 61 of the c-Ha-ras oncogene in carcinogen-transformed human breast epithelial cells
Hormone receptors and cathepsin D levels in human breast epithelial cells transformed by chemical carcinogens and c-Ha-ras transfection
A critical approach to the malignant transformation of human breast epithelial cells with chemical carcinogens
Critical Steps in Breast Carcinogenesis
Transformation of human breast epithelial cells by chemical carcinogens
New cell lines of human breast cancer origin
DNA-Synthesis Under the Effect of a Placental Protein in Mammary Gland in Culture
Influence of age and gland topography on cell kinetics of normal human breast tissue
Laboratory models of hormone-dependent cancer
Stimulation of breast cancer cellsin vitro by the environmental estrogen enterolactone and the phytoestrogen equol
EFFECT OF ESERINE TREATMENT ON DNA-SYNTHESIS OF RAT SUBMANDIBULAR-GLAND
EFFECTS OF INSULIN AND HUMAN GROWTH-HORMONE ON DNA-SYNTHESIS IN TISSUE-CULTURE OF BENIGN BREAST-LESIONS
Effects of peptides and steroid hormones on cell kinetic parameters of normal human breast tissue in organ culture
Influence of hormones on DNA synthesis of breast tumors in culture
TAMOXIFEN ACTION ON CELL-PROLIFERATION OF BREAST-TUMORS IN CULTURE
The mammary gland as model of study in cell proliferation
[Steroid hormone receptors in breast cancer]
DNA-synthesis under the effect of a placental protein in mammary-gland in culture
Age-related variations in growth-kinetics of primary human-breast cell-cultures
Effect of estrogen on the length of s phase of human-breast tissue in organ-culture
Effects of hormones on growth fraction of human-breast tissue in organ-culture
Hormonal response of human-breast tissue in organ-culture
The influence of age on DNA labeling index of human-breast epithelium
Effects of human placental-lactogen, prolactin and progesterone on DNA-synthesis in organ-culture of benign breast-tumors
DIRECT ACTION OF HORMONES ON GROWTH OF BENIGN HUMAN-BREAST TUMORS
EFFECTS OF ESTROGEN IN DNA-SYNTHESIS OF HUMAN-BREAST TISSUE IN ORGAN-CULTURE
Effect of human, bovine and ovine prolactin on DNA synthesis by organ cultures of benign human breast tumours
EFFECTS OF ESTRADIOL 17 BETA-(E) AND HUMAN PLACENTAL-LACTOGEN (HPL) ON DNA-SYNTHESIS IN ORGAN-CULTURE OF BENIGN HUMAN-BREAST TUMORS
Autoimmune factors associated with anaemia in acute Haemobartonella and Eperythrozoon infections of rodents

Abstract (5)

Metastatic gene signature in breast carcinogenesis
Targeting multiple genes in breast carcinogenesis
In vivo and in vitro models for breast carcinogenesis
Oxidative stress and genomic instability in breast tumorigenesis
LIPID PEROXIDATION IN TESTIS AND EPIDIDYMIS UNDER INTERMITTENT HYPOBARIC HYPOXIA: PROTECTIVE ROLE OF ASCORBIC ACID

BookSection (3)

Carcinogénesis inducida por radiación
Role of Ras Oncogene in Human Breast Cancer: An Experimental Approach
Hormones and proliferative activity in breast tissue

BookWhole (2)

Curcumin, Oxidative Stress, and Breast Cancer
La función de las hormonas en la tumorigénesis mamaria en lauchas, ratas y seres humanos

Errata (1)

Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation (vol 31, pg 314, 2010)

Review (4)

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
Male reproductive system and antioxidants in oxidative stress induced by hypobaric hypoxia
Factors that influence the incidence of breast cancer in Arica, Chile (Review)
140
Gloria Calaf

Directora Laboratorio Biología del cáncer

Universidad de Tarapacá

Arica, Chile

9
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

7
Andrea Zepeda

Docente/Investigador

Universidad Autónoma de Chile

Temuco, Chile

3
MARIA MONTALVO

ACADEMICa

DE TECNOLOGIA MEDICA

UNIVERSIDAD DE TARAPACA

ARICA, Chile

2
Eduardo Parra

ACADÉMICO - ESCUELA DE MEDICINA

MEDICINA

UNIVERSIDAD DE TARAPACA

Arica, Chile

2
marcela gallardo

Particular

Partcular

arica, Chile

1
Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

1
CAROLINA FIGUEROA

Investigador Postdoctoral

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

1
Marcela Diaz

Directora de Departamento

Promocion de la Salud de la Mujer y el recién Nacido

Universidad de Chile/Facultad de Medicina

Santiago, Chile

1
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

1
Susana Alfaro

Encargada de contenidos y soporte metodológico

Universidad de Tarapacá

Arica, Chile

1
José Jara

Assistant Professor

Research Institute of Dental Sciences

Universidad de Chile

Santiago, Chile

1
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Elías Figueroa

Associate Professor.

Department of Biological and Chemical Sciences

Catholic University of Temuco

Temuco, Chile

1
Alex Berg

Director Ejecutivo UDT

Universidad de Concepción

Coronel, Chile

1
PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

1
Sebastián Fuentes

Estudiante postgrado

Farmacología

Universidad de Chile

Santiago, Chile

1
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

1
JORGE FUENTEALBA

Chairman

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Cynthia Fuentealba

Médico Urólogo

Urología

Hospital DIPRECA

Santiago, Chile

1
Leonardo Sáenz

Profesor Asociado

Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile