Man

German Ebensperger Darrouy

PROFESOR ASISTENTE

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Líneas de Investigación


HIPOXIA FETAL Y NEONATAL (PERINATAL); FISIOLOGIA Y MEDICINA DE GRANDES ALTITUDES; FISIOPATOLOGIA VASCULAR; INFLAMACIÓN VASCULAR; CIRCULACIÓN PULMONAR; CANALES IONICOS; FUNCION Y REACTIVIDAD VASCULAR; FUNCION CARDIOPULMONAR; FETAL PROGRAMMING

Educación

  •  Ciencias Biomedicas, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Bioquimico, UNIVERSIDAD DE CHILE. Chile, 2001

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    SANTIAGO, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Ayudante de Investigacion Full Time

    Laboratorio Dr. Roberto Reyes

    Santiago, Chile

    2002 - 2007

  •   Asistente de Investigacion Full Time

    Laboratorio Dr. Anibal Llanos

    Santiago, Chile

    2007 - 2012


 

Article (62)

Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates
Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.
Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs
Melatonin modulates the expression of pulmonary prostanoids
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions.
Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs.
Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs.
Plasmatic Concentrations of ADMA and Homocystein in Llama () and Regulation of Arginase Type II=> An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia.
Plasmatic Concentrations of ADMA and Homocystein in Llama () and Regulation of Arginase Type II=> An Animal Resistent to the Development of Pulmonary Hypertension Induced by Hypoxia.
Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia.
Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia.
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
2-aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive hewborn lambs with partial gestation at high altitude.
2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano.
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano.
Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep
Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep.
Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs
Role of the RhoA/Rock pathway in high-altitude associated neonatal pulmonary hypertension in lambs.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep.
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures.
Pharmacological approaches in either intermittent or permanent hypoxia=> A tale of two exposures.
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs.
The placental pursuit for an adequate oxidant balance between the mother and the fetus.
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia.
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs.
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude.
The Hypoxic Placenta
The hypoxic placenta.
Counterpoint: high altitude is not for the birds!
COUNTERPOINT: HIGH ALTITUDE IS NOT FOR THE BIRDS!
Fetal and postnatal pulmonary circulation in the Alto Andino
Fetal and postnatal pulmonary circulation in the Alto Andino.
Last word on point:counterpoint: high altitude is/is not for the birds!
Role of the alpha-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species
Role of the alpha-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species.
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level.
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano.
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep.
Evolving in thin air - Lessons from the llama fetus in the altiplano
Evolving in thin air - Lessons from the llama fetus in the altiplano
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
Fetal brain hypometabolism during prolonged hypoxaemia in the llama
Fetal brain hypometabolism during prolonged hypoxaemia in the llama
Analysis of molecular epidemiology of Chilean Salmonella enterica serotype enteritidis isolates by pulsed-field gel electrophoresis and bacteriophage typing
Analysis of molecular epidemiology of Chilean Salmonella enterica serotype enteritidis isolates by pulsed-field gel electrophoresis and bacteriophage typing.
Epidemiología molecular de un brote de infecciones por Streptococcus pyogenes en una unidad de quemados
Molecular epidemiology of a Streptococcus pyogenes related nosocomial outbreak in a burn unit

Abstract (16)

TREATMENT WITH CINACIGUAT IMPROVED THE VASOACTIVE PROPERTIES OF LAMB SMALL PULMONARY ARTERIES
SEA LEVEL POSTNATAL EXPOSURE MODIFIES THE PULMONARY ARTERIAL PRESSURE, REACTIVITY AND REMODELING IN NEONATAL LAMBS BORN IN HIGHLANDS
Hemin Treatment Increases cGMP Role in the Regulation of Pulmonary Artery Tone in Newborn Lambs from the Andean Altiplano
FETAL AND NEONATAL PULMONARY CIRCULATION IN THE ALTO ANDINO
Hemin Increases Pulmonary HO Protein Expression and Pulmonary CO Production in Newborn Lambs from the Andean Altiplano
Persistent pulmonary hypertension of the newborn even following transient exposure of the pregnancy to high altitude
Brain hypometabolism after 24h of hypoxemia in the llama fetus
Carbon monoxide (CO): A key vasodilator in the pulmonary circulation in the llama neonate
Cardiovascular responses to acute hypoxemia in low altitude(LA)and high altitude (HA) fetal sheep (FS)
Hemoxygenase expression in lung tissue from high and low altitude newborn lambs
Regional changes of NaKATPase activity in the brain of the hypoxemic llama fetus
Nakatpase, temperature and ion channels in the fetal llama brain submitted to hypoxia.
Role of nitric oxide in the pulmonary circulation in high- and low-altitude newborn lambs.
Chronic hypoxia decreases the soluble guanylate cyclase in the neonatal lung of lowland species.
Chronic hypoxia modifies the cardiovascular function and the arterial contractility in the neonatal sheep
Lambs born at high altitude have a blunted pituitary-adrenal axis response to acute hypoxia.

Letter (1)

Last Word on Point:Counterpoint: High altitude is/is not for the birds!

Proyecto (10)

TO BE BORN HIGH AND FLAT (ANDEAN ALTIPLANO)=> HEALING VASCULAR FUNCTION AND PULMONARY ARTERIAL HYPERTENSION BY A COMBINED TREATMENT IN NEONATAL LAMBS
AFTER YEARS OF "NO"TREATMENT, WE SEEK FOR YES TREATMENTS=> SOLUBLE AND PARTICULATE GUANYLYL CYCLASES COULD SAY YES TO TREAT PULMONARY ARTERIAL HYPERTENSION OF THE NEWBORN.
HEME OXYGENASE INDUCTION BY HEMIN REDUCES LUNG INFLAMMATION, OXIDATIVE STRESS, PULMONARY VASCULAR PROLIFERATION AND PULMONARY ARTERIAL HYPERTENSION IN CHRONICALLY HYPOXIC NEONATES IN THE ANDEAN ALTIPLANO
Blockade of store operated channels and ryanodine receptors as a strategy to treat the neonatal pulmonary hypertension induced by chronic hypoxia
DEL MAL GAS AL BUEN GAS. TRATAMIENTO DE LA HIPERTENSION ARTERIAL PULMONAR DEL RECIEN NACIDO CON MOLECULAS DADORAS DE MONOXIDO DE CARBONO E INDUCTORAS DE LA HEM-OXIGENASA-1.
Hemoxigenasa, monóxido de carbono y canales iónicos en la regulación de la circulación y remodelamiento pulmonar de recién nacidos de tierras bajas y altas
El origen fetal de la hiperreactividad vascular pulmonar y de la hipertensión pulmonar postnatal
Effects of chronic hypoxia on fetal cardiovascular and endocrine functions in the sheep
Hipometabolismo cerebral acoplado a menor expresión de canales iónicos con la hipoxia prolongada como estrategia adaptativa en un modelo tolerante a la hipoxia
Adaptaciones fisiológicas y moleculares de la circulación pulmonar a la hipoxia en el recién nacido de llama, resultado de una historia de exposición a las grandes altitudes en el altiplano andino

Review (3)

Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures
The placental pursuit for an adequate oxidant balance between the mother and the fetus
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude
45
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

34
Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

21
Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

18
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

11
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

7
Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

5
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Marcela Diaz

Directora de Departamento

Promocion de la Salud de la Mujer y el recién Nacido

Universidad de Chile/Facultad de Medicina

Santiago, Chile

3
Alejandro Gonzalez

investigador Postdoctoral

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

3
ISMAEL HERNANDEZ

TECNOLOGO MEDICO

FISIOPATOLOGIA

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

SANTIAGO, Chile

1
Gloria Calaf

Directora Laboratorio Biología del cáncer

Universidad de Tarapacá

Arica, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

1
Daniela Parrau

Profesor asistente

Morfofunción

Universidad Diego Portales

Santiago, Chile

1
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

1
Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

1
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Jorge Fernandez

JEFE SUBDEPTO

BIOMEDICO NACIONAL Y DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

santiago, Chile

1
Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile