Man

Víctor Roberto Reyes Catalán

Profesor Asociado

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

Líneas de Investigación


Fisiopatología Vascular; Hipoxia perinatal; HIPOXIA FETAL Y NEONATAL (PERINATAL); FISIOLOGÍA Y MEDICINA DE GRANDES ALTITUDES; Patogenia del virus respiratorio sincicial; Patogenia del asma bronquial; Función y Reactividad vascular; Función Cardiopulmonar; HIPOXIA PERINATAL Y CIRCULACIÓN PULMONAR; HIPOXIA PERINATAL Y SISTEMA NERVIOSO CENTRAL; CANALES IÓNICOS

Educación

  •  Ciencias Biológicas, Université de Nice - Sophia Antipolis. Francia, 1999
  •  Bioquímico, UNIVERSIDAD DE CONCEPCION. Chile, 1987
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1994

Experiencia Académica

  •   Asistente de Investigación Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina / Facultad de Ciencias Biológicas

    Santiago, Chile

    1987 - 1989

  •   Asistente de Investigación Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    1990 - 1994

  •   Asistente de Investigación Other

    Ruhr-Universität

    Institut für Physiologische Chemie

    Bochum, Alemania

    1993 - 1993

  •   Asistente de Investigación - PhDc Other

    Université de Nice - Sophia Antipolis

    Institut de Pharmacologie Moléculaire et Céllulaire (IPMC)

    Sophia Antipolis, Francia

    1995 - 1999

  •   Investigador asociado Other

    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

    Sophia Antipolis, Chile

    1999 - 1999

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2000 - 2008

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2009 - A la fecha

Experiencia Profesional

  •   Asistente de Investigación Full Time

    Universidad Católica de Chile

    Santiago, Chile

    1987 - 1989

  •   Asistente de Investigación Full Time

    Universidad de Chile

    Santiago, Chile

    1990 - 1994

  •   Estadía de Investigación Full Time

    Ruhr-Universitat

    Bochum, Alemania

    1993 - 1993

  •   Asistente de Investigación - Estadía de formación doctoral Full Time

    Institut de Pharmacologie Moléculaire et Céllulaire

    Sophia - Antipolis, Francia

    1995 - 1999

  •   Investigador Asociado Full Time

    Institut de Pharmacologie Moléculaire et Céllulaire

    Sophia Antipolis, Francia

    1999 - 1999

  •   Profesor asistente Full Time

    Universidad de Chile

    Santiago, Chile

    2000 - 2008

  •   Profesor Asociado Full Time

    universidad de Chile/Facultad de Medicina/Instituto de Ciencias Biomédicas

    Santiago, Chile

    2009 - A la fecha

  •   Profesor Part Time

    Universidad Andrés Bello/Departamento de Ciencias Químicas

    Santiago, Chile

    2000 - 2000

  •   Profesor Part Time

    Universidad Andrés Bello / Facultad de Medicina

    Santiago, Chile

    2007 - 2007


 

Article (68)

Cinaciguat (Bay-582667) modifies the cardiopulmonary and systemic circulations in chronically hypoxic and pulmonary hypertensive neonatal lambs in the Alto Andino
Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function
The action of 2-aminoethyldiphenyl borinate on the pulmonary arterial hypertension and remodeling of high-altitude hypoxemic lambs
Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates
Enhanced vasoconstriction mediated by α1-adrenergic mechanisms in small femoral arteries in newborn llama and sheep gestated at low altitude and high altitude
Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia
Cardiovascular function programming by hypoxia at high altitude. Lambs as a translational model of pulmonary arterial hypertension of the neonate
Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates
Melatonin long‐lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates
Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama
Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama
Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia
Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep
Melatonin modulates the expression of pulmonary prostanoids
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions
Circulation in neonatal llamas and sheep: A tale of two species
Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs
Revisiting the role of TRP, Orai and ASIC channels in the pulmonary arterial response to hypoxia
Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia.
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland llamas
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano
Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep
Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs
The placental pursuit for an adequate oxidant balance between the mother and the fetus
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude
COUNTERPOINT: HIGH ALTITUDE IS NOT FOR THE BIRDS!
Counterpoint: high altitude is not for the birds!
Fetal and postnatal pulmonary circulation in the Alto Andino
Fetal and postnatal pulmonary circulation in the Alto Andino
Last word on point:counterpoint: high altitude is/is not for the birds!
Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species
Role of the alpha-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species
Long term exposure to high altitude chronic hypoxia during gestation induces neonatal pulmonary hipertension at sea level
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano.
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep.
Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes
Evolving in thin air - Lessons from the llama fetus in the altiplano
Evolving in thin air--lessons from the llama fetus in the altiplano.
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep.
Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat.
Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear.
The fetal llama versus the fetal sheep: different strategies to withstand hypoxia.
Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves.
Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system.
IP(3) receptors, IP(3) transients, and nucleus-associated Ca(2+) signals in cultured skeletal muscle.
TREK-1 is a heat-activated background K(+) channel.
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.
Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.
Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney.
TASK, a human background K+ channel to sense external pH variations near physiological pH.
The structure, function and distribution of the mouse TWIK-1 K+ channel.
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.
Functional muscarinic receptors in cultured skeletal muscle.
Rusticyanin: initial studies on the regulation of its synthesis and gene isolation

Abstract (1)

FETAL AND NEONATAL PULMONARY CIRCULATION IN THE ALTO ANDINO

BookSection (2)

Fetal Llama Adaptation to Altitude in the Andean Altiplano
Fetal Llama Adaptation to Altitude in the Andean Altiplano. Chapter 5 In: Hypoxic Respiratory Failure in the Newborn – From Origins to Clinical Management.

Letter (1)

Last Word on Point:Counterpoint: High altitude is/is not for the birds!

Proyecto (21)

Targeting the Orai1 channel against pulmonary vascular overconstriction and cardiopulmonary remodeling in ovine models with neonatal pulmonary hypertension induced by chronic hypoxia.
Reprogramming cardiovascular health after intrauterine hypoxia: epigenetics, antioxidants and endogenous gasotransmitters
The action of 2-APB in the pulmonary circulation of newborn sheep and llama with perinatal hypoxia
Biochemical characterization of the control mechanisms of pulmonary vascular tone and remodeling in lambs with perinatal hypoxia treated with 2-APB
Caracterización bioquímica de los mecanismos de control del tono y remodelamiento vascular pulmonar en corderos con hipoxia perinatal tratados con 2-APB.
TO BE BORN HIGH AND FLAT (ANDEAN ALTIPLANO)=> HEALING VASCULAR FUNCTION AND PULMONARY ARTERIAL HYPERTENSION BY A COMBINED TREATMENT IN NEONATAL LAMBS
AFTER YEARS OF "NO"TREATMENT, WE SEEK FOR YES TREATMENTS=> SOLUBLE AND PARTICULATE GUANYLYL CYCLASES COULD SAY YES TO TREAT PULMONARY ARTERIAL HYPERTENSION OF THE NEWBORN.
HEME OXYGENASE INDUCTION BY HEMIN REDUCES LUNG INFLAMMATION, OXIDATIVE STRESS, PULMONARY VASCULAR PROLIFERATION AND PULMONARY ARTERIAL HYPERTENSION IN CHRONICALLY HYPOXIC NEONATES IN THE ANDEAN ALTIPLANO
BLOCKADE OF STORE OPERATED CHANNELS AND RYANODINE RECEPTORS AS A STRATEGY TO TREAT THE NEONATAL PULMONARY HYPERTENSION INDUCED BY CHRONIC HYPOXIA
MELATONIN THERAPY FOR PREVENTING/TREATING PULMONARY HYPERTENSION IN THE HIGH ALTITUDE NEONATE UNDER OXIDATIVE STRESS=> A NEW LIGHT FOR THE NIGHT HORMONE.
DEL MAL GAS AL BUEN GAS. TRATAMIENTO DE LA HIPERTENSION ARTERIAL PULMONAR DEL RECIEN NACIDO CON MOLECULAS DADORAS DE MONOXIDO DE CARBONO E INDUCTORAS DE LA HEM-OXIGENASA-1.
HEMOXIGENASA, MONOXIDO DE CARBONO Y CANALES IONICOS EN LA REGULACION DE LA CIRCULACION Y REMODELAMIENTO PULMONAR DEL RECIEN NACIDO DE TIERRAS BAJAS Y ALTAS
EL ORIGEN FETAL DE LA HIPERREACTIVIDAD VASCULAR PULMONAR Y DE LA HIPERTENSION PULMONAR POSTNATAL.
HIPOMETABOLISMO CEREBRAL ACOPLADO A MENOR EXPRESION DE CANALES IONICOS CON LA HIPOXIA PROLONGADA COMO ESTRATEGIA ADAPTATIVA EN UN MODELO TOLERANTE A LA HIPOXIA.
HIPOMETABOLISMO CEREBRAL ACOPLADO A MENOR EXPRESION DE CANALES IONICOS CON LA HIPOXIA PROLONGADA COMO ESTRATEGIA ADAPTATIVA EN UN MODELO TOLERANTE A LA HIPOXIA.
ADAPTACIONES FISIOLOGICAS Y MOLECULARES DE LA CIRCULACION PULMONAR A LA HIPOXIA EN EL RECIEN NACIDO DE LLAMA. RESULTADO DE UNA HISTORIA DE EXPOSICION A LAS GRANDES ALTITUDES EN EL ALTIPLANO ANDINO
Caracterización farmacológica de receptores adrenérgicos en recién nacidos de llama y de oveja, una aproximación a las bases moleculares de la adaptación a la hipoxia crónica
Caracterización farmacológica de receptores adrenérgicos y de endotelinas en vasos arteriales de feto de llama y de oveja
METABOLISMO DE FOSFOINOSITIDOS EN MUSCULO ESQUELETICO EN CULTIVO. EFECTOS DEL POTENCIAL DE MEMBRANA
METABOLISMO DE FOSFOINOSITIDOS EN MUSCULO ESQUELETICO EN CULTIVO=> EFECTO DEL POTENCIAL DE MEMBRANAS
EFECTOS DEL ACEITE DE PESCADO EN SUJETOS NORMALES, EN CARDIOPATAS CORONARIOS Y EN MODELOS ANIMALES.

Review (4)

Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures
The placental pursuit for an adequate oxidant balance between the mother and the fetus
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude
46
Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

23
Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

21
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

13
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

8
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

5
Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

4
Alejandro Gonzalez

investigador Postdoctoral

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

4
Marcela Diaz

Directora de Departamento

Promocion de la Salud de la Mujer y el recién Nacido

Universidad de Chile/Facultad de Medicina

Santiago, Chile

3
ISMAEL HERNANDEZ

TECNOLOGO MEDICO

FISIOPATOLOGIA

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

SANTIAGO, Chile

2
Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

1
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudio Garcia

Associate Professor

Departamento de Ingenieria Mecanica

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Jorge Farias

Full Professor

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

1
Daniela Parrau

Profesor asistente

Morfofunción

Universidad Diego Portales

Santiago, Chile