Emilio.jpg_thumb90

Emilio Augusto HERRERA VIDELA

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Developmental Physiology, Cardiovascular function, DOHaD, Hypoxia, Oxidative Stress, High-Altitude, Pulmonary Hypertension, Vascular Function, Endothelial Function, Antioxidant treatment.

Educación

  •  Biomedical Sciences, Physiopathologist, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Veterinarian, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1999
  •  PostDoctorate, UNIVERSITY OF CAMBRIDGE. Reino Unido, 2010

Experiencia Académica

  •   Research Associate Full Time

    UNIVERSITY OF CAMBRIDGE

    Cambridge, Reino Unido

    2007 - 2010

  •   Large Animal Welfare - Veterinarian in charge of animal facility and procedures Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1999 - 2007

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2010 - 2015

  •   Assistant Professor Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2007 - 2010

  •   Demonstrator and Examiner Other

    UNIVERSITY OF CAMBRIDGE

    Physiology, Development & Neurosciences

    Cambridge, Reino Unido

    2008 - 2010

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2015 - A la fecha

  •   Post-doctoral Full Time

    UNIVERSITY OF CAMBRIDGE

    Physiology, Development & Nueroscience

    Cambridge, Reino Unido

    2007 - 2010

Experiencia Profesional

  •   Veterinarian responsible for large animal care and welfare Full Time

    Universidad de Chile

    Santiago, Chile

    1999 - 2007

  •   Assistant Professor Part Time

    Universidad de Chile

    Santiago, Chile

    2007 - 2010

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - 2015

  •   Director, Vascular Function and Reactivity Laboratory, ICBM Other

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha

  •   President, Bioethical Committee for Use of Research Animals Other

    Faculty of Medicine, Universidad de Chile

    Santiago, Chile

    2014 - 2019

  •   Board Scribe Other

    Fetal and Neonatal Physiological Society

    Chile

    2013 - A la fecha

  •   Sud-Director Postgraduate Comission Other

    Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile

    Santiago, Chile

    2014 - 2018

  •   Associate Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2015 - A la fecha

  •   Bioethical Committee member Other

    FONDECYT

    Chile

    2017 - A la fecha

  •   President Other

    Institutional Animal Care and Use Committee (IACUC)/VID/Universidad de Chile

    Chile

    2014 - A la fecha

  •   Adviser (member of the Graduate Council) Other

    Graduate School, Faculty of Medicine, University of Chile

    Chile

    2015 - 2019

  •   Secretario Ejecutivo Other

    Universidad de Chile, International Center for Andean Studies (INCAS)

    Santiago, Chile

    2017 - A la fecha

Formación de Capital Humano


MEMBERSHIP

Since 2006- Permanent Academic staff for Physiopathology at the Faculty of Medicine, University of Chile.
Since 2010- Member of the International Center for Andean Studies (INCAS-Putre), University of Chile.
Since 2010- Member of The Physiological Society.
Since 2010- Member of the Centre for Trophoblast Research (CTR), University of Cambridge, UK.
Since 2010- Member of the Fondazione Giorgio Pardi (FGPricerca), Italy.
Since 2012- Member of the Academic Staff for the PhD in Biomedical Sciences Program; and for the MPhil on Physiopathology.
Since 2013- Member of the Academic Staff for the MPhil on Morphology; and on Physiology; Faculty of Medicine, University of Chile.
Since 2014- Deputy Director of Graduate students in the Biomedical Sciences Institute (ICBM), Faculty of Medicine, University of Chile.
Since 2014- Member (Fellow) of the Pulmonary Vascular Research Institute (PVRI).
Since 2015- Member of the Chilean Board for the Developmental Origins of Health and Disease (DOHaD) Society (Iberoamerican Chapter).
Since 2015- Member of the Academic nucleus for the MPhil on Pathophysiology, Faculty of Medicine, University of Chile.
Since 2016- Member of the Academic Staff for the MPhil on Veterinary Sciences, University of Chile.

GRADUATE THESIS TUTORING (Since 2014)

1. N-acetilcisteína como tratamiento para gestaciones con restricción de crecimiento fetal (RCF): efectos en la función vascular umbílico-placentaria. PhD in Pharmacology, Universidad de Chile. Student: Alejandro Candia Henríquez. Under development.

2. Efecto de sildenafil como tratamiento vasodilatador y antirremodelante para la hipertensión arterial neonatal en ovejas (Ovis aries) sometidas a hipoxia crónica. MSc in Pathophysiology, Universidad de Chile. Student: Valentina Nicole Lepe Vásquez. Under development.

3. Efecto de melatonina, hemina y sildenafil como terapia vasodilatadora, antioxidante y antiremodelante vascular en arterias cerebrales medias de corderos gestados en hipoxia crónica. MSc in Pathophysiology, Universidad de Chile. Student: Antonio Acuña Pineda. Under development.

4. Efecto de melatonina y hemina como tratamiento antioxidante y antirremodelante para la hipertensión pulmonar en neonatos de oveja gestados en hipoxia crónica. PhD in Pharmacology, Universidad de Chile. Student: Alejandro Gonzalez-Candia. August 2019, score: 7,0/7,0.

5. Comportamiento mecánico de arterias de corderos gestados y nacidos en gran altitud geográfica: Caracterización experimental y simulación numérica. PhD in Mechanical Engineering, Universidad de Santiago de Chile. Student: Eugenio Rivera. Under development.

6. Caracterización cardiopulmonar de la transición feto-neonatal en ovejas (Ovis aries) de tierras bajas y del altiplano andino. MSc in Veterinary Sciences, Universidad de Chile. Student: René Alegría. July 2018, score: 7,0/7,0.

7. Marcadores de estrés oxidativo, capacidad antioxidante y estructura pulmonar en ratas expuestas a hipoxia intermitente. MSc in Pathophysiology, Universidad de Chile. Student: Jorge Rodriguez. August 2018, score: 5,8/7,0.
.
8. Hipoxia hipobárica intermitente: efectos agudos y crónicos en la función y estructura cardiovascular. MSc in Pathophysiology, Universidad de Chile. Student: Miguel Aguilar. May 2018 score: 7.0/7,0.

9. Efecto de la administración postnatal de melatonina sobre la función y estructura cardíaca en neonatos de oveja gestados y nacidos en hipoxia crónica. MSc in Pathophysiology, Universidad de Chile. Student: René Cantariño P. March 2017, score: 6,8/7,0.

10. Respuesta pulmonar neonatal de prostaglandinas vasodilatadoras a melatonina en corderos crónicamente hipóxicos por altura. MSc in Biotechnology, Universidad Andrés Bello. Student: Esteban Figueroa B. May 2016, score: 6,5/7,0.

11. Efecto de melatonina pre- y pos- natal sobre prostanoides vasoconstrictores en pulmón de neonatos de oveja gestados en hipoxia crónica. MSc in Biotechnology, Universidad Andrés Bello. Student: Cristian Villanueva B. May 2016, score: 6,9/7,0.

12. Efecto de melatonina como terapia antioxidante y antiremodelante vascular en neonatos con hipertensión pulmonar gestados en hipoxia crónica. MSc in Morphology, Universidad de Chile. Student: Cristián Astorga M. November 2015, score 6,4/7,0.

13. Efecto de melatonina pre-natal sobre la función vascular pulmonar de neonatos crónicamente hipóxicos. MSc in Physiology, Universidad de Chile. Student: Marcelino Véliz L. August 2015, score 6,9/7,0.

14. Rol antioxidante de melatonina en el desbalance oxidativo presente en la hipertensión pulmonar del neonato de oveja crónicamente hipóxico. MSc in Pathophysiology, Universidad de Chile. Student: Flavio Torres G. March 2014, score 7,0/7,0.

UNDER-GRADUATE THESIS TUTORING (Since 2014)

1. Efecto cardiopulmonar y seguridad farmacéutica de una triterapia compuesta por melatonina, hemina y sildenafil, como tratamiento para la hipertensión pulmonar neonatal en un modelo de ovejas gestadas y nacidas en hipoxia crónica. Student: Cristopher Gonzalez C. January 2020, score 7,0/7,0.

2. Estudio de los efectos anti remodelantes y antioxidantes de hemina y melatonina en recién nacidos de ovinos hipertensos pulmonares. Tesis para optar al título de Matrona. Midwifery. Students: Alejandra Fernández Navarrete, Constanza Higueras Arce. December 2018, score: 6,7/7,0.

3. Características biométricas en cobayos adultos nacidas RCIU y normales. Midwifery. Student: Alejandro Candia. December 2016, score: 6,5/7,0.

4. Características biométricas y doppler en cobayas que cursan gestaciones normales y con oclusión progresiva de arterias uterinas. Midwifery. Students: Constanza Meza V, Fernanda Villegas A. December 2015, score 6,7/7,0.

5. Caracterización de la función vascular de un modelo de restricción de crecimiento intra-uterino por oclusión progresiva de las arterias uterinas en cobayas. Veterinary Medicine. Student: René Alegría V. March 2015, score 7,0/7,0.

6. Función cardiopulmonar a nivel de mar en neonatos de oveja hipertensos pulmonares nacidos en la hipoxia crónica del Altiplano Andino. Veterinary Medicine. Student: Caroll Aburto S. August 2014, score 6,5/7,0.

RESEARCH UNITS AND SHORT STAYS TUTORING

-Since 2014 to date: Research stays for medical obstetrics sub-speciality of materno-fetal medicine (Medical specialization, University of Chile): Drs. Carolina Silva, Daniel Martin, Claudia Campanella, Ana Luisa Pérez, María Paz Marín, Daniela Luna.

-Since 2012 to date: Tutor for International Federation of Medical Students’ Associations (IFMSA): Carolina Vespucio (Universidade Sao Francisco, Brazil), Marie-Siri Solbakken (University of Oslo, Norway), Eulalia Rovira (Universidad de Barcelona, Spain), Konstantinos Melas (National and Kapodistrian University of Athens, Greece); Elisenda Feixes Prats (2015; Universidad de Lleida, Spain); Vojte Weiss (2015; Charles University, Czech Republic); Michal Latocha (2015; Medical University of Warsaw, Poland); Raluca Bievel (2016; Carol Davila University of Medicine and Pharmacy, Romania); Sarah Zipse (2016; Medical School Georg-August-University, Germany), Katalina Chuprine (2017; Universidad de Costa Rica, Costa Rica). .

-Since 2011 Tutoring of undergraduate students Research Units (Unidades de Investigacion y Ayudante Alumnos): Roberto Macchiavello, Sofia Palacios, Valentina Reyes, Daniela Zapata, Catalina Valdés, Fabián Vásquez, Ximena Salas, Valentina Mancilla, Alejandro Candia, Simon Aguilar, Pamela Arias, Ignacio Canquil, Tomás Grez, Ignacio Jiménez, Matías Oñate, Benjamín Cabrera, Cristóbal Pérez-Luco, Diego Villavicencio D, Victor Monreal, José Correa, Jose Widoycovich, Joaquín Jiménez, Carlos Guzmán.

-Since 2011 Tutoring Graduate Students in Research stays: Dr. Flavio Torres (MSc); Mr. Marcelino Veliz (MSc); Dr Javier Tapia (MSc); Dr René Cantariño (MSc); Dr Miguel Aguilar (MSc), Antonio Acuña (MSc), Valentina Lepe (MSc), )Cristian Campos (PhD); Alejandro Gonzalez (PhD).

-2008-2010: Co-Tutoring Graduate students in Physiology, Development & Neurosciences, University of Cambridge, UK. Students: Lindsey Berends (PhD), Kirsty Brain (PhD), Ciara Lusby (PhD), Misha Verkerk (MD), Dr Raghu Adya (MD-PhD), Andrew Kane(MD-PhD), Jeremy Hansell (PhD).


Difusión y Transferencia


TALKS & CONFERENCES as invited speaker (Last 10 years)

1. Regulación de los estándares bioéticos para la investigación en animales. Taller de Bienestar Animal en la Reunión Conjunta de las Sociedades Chilenas de Biología, Ecología, Evolución y Botánica. Valdivia, Chile. Marzo 2020. Conferencista invitado.

2. Análisis y discusión “Sugerencias para mejorar la regulación chilena de manipulación de vertebrados terrestres en poblaciones naturales en el contexto de investigaciones científicas”. IV Encuentro nacional de CICUAs. Valdivia, Chile. Enero 2020. Conferencista invitado.

3. Regulación de los estándares bioéticos para la investigación en animales. Conversatorio de Bienestar Animal en el X Congreso Chileno de Herpetología. Los Angeles, Chile. Enero 2020. Conferencista invitado.

4. Experimental models to assess fetal cardiovascular programming by hypoxia. Journal Club BCNatal, Fetal Medicine Research Center. Universitat de Barcelona. 21 de octubre 2019. Conferencista invitado.

5. Roles del estrés oxidativo y la hemoxigenasa en la respuesta pulmonar a la hipoxia. Simposio Internacional DECIPHER "Hipoxia y Pulmón". 16 de octubre 2019. Conferencista invitado.

6. Programación de la función cardiovascular por hipoxia y estrés oxidativo perinatal. 3er seminario del Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile. 27 de junio 2019. Conferencista invitado.

7. Adaptaciones cardiopulmonares en llamas recién nacidas del altiplano Andino: traslación a neonatos de tierras bajas. Primeras Jornadas de Investigación Multidisciplinaria Hospital Clínico Universidad de Chile. 13 de diciembre, 2018. Conferencista invitado.

8. Directrices de CONICYT respecto al uso de modelos animales con fines científicos. II Taller Cuidado y Uso de Animales de Experimentación y Aspectos Bioéticos. 4 de diciembre, Universidad Austral de Chile, Valdivia. Conferencista y experto invitado.

9. Pulmonary Hypertension of the Neonate due to chronic hypoxia: in need of antioxidant, vasodilator and antiremodeling agents. En: Simposio Blancos terapéuticos en modelos de hipoxia y estrés oxidativo cardiovascular: papel de la suplementación con antioxidantes. XL Congreso Anual SOFARCHI, Noviembre 2018. Conferencista invitado.

10. Directrices de CONICYT respecto a la utilización animal con fines científicos. En: I Jornada de difusión del CICUAL UCM: “Comités Institucionales de uso y cuidado de animales de laboratorio: ¿Dónde estamos y hacia dónde vamos?”. Experto en mesa redonda “Desafíos para la comunidad científica en el trabajo con animales de laboratorio”. 5 de octubre, Universidad Católica del Maule, Talca. Conferencista y experto invitado.

11. Orientaciones para la investigación en animales. Jornada de Actualización en etica de la investigación científica. Actividad organizada por el Comité Asesor de Bioética (CAB) para Fondecyt. 23 de mayo, 2018, Santiago, Chile. Expositor y organizador.

12. Animal models for studying cardiopulmonary effects of hypobaric hypoxia. Atacama-Leh Meeting 2018. March 6, 2018. San Pedro de Atacama, Chile. Expositor y organizador.

13. Regulación de la investigación en animales. XIII Taller de Bioética de Fondecyt - Avances y desafíos en ética de la investigación científica. 10 enero, 2018, Santiago, Chile. Expositor y organizador.

14. The Annual Sawyer Lecture: Physiological responses to chronic hypoxia: teachings from the Andean altiplano. Bates College, Maines, USA. March 28, 2017. Invited Speaker.

15. Symposium: Molecular targets for the treatment of pulmonary vascular disease. “Targeting oxidative stress in the treatment of pulmonary arterial hypertension of the neonate”. (XXXI Reunión anual de la Sociedad Chilena de Ciencias Fisiológicas). Huilo-Huilo, Chile, September 6-9, 2016. Invited Speaker.

16. Symposium: Hypoxic stress during pregnancy. “Perinatal hypoxia and oxidative stress: mechanisms and potential new therapies”. (PHYSOC 2016). Dublin, Ireland, July 28-30, 2016. Invited Speaker.

17. Seminario capítulo Iberoamericano de la Sociedad DOHaD 2016. ”Cardiovascular programming by fetal hypoxia”. Santiago, Chile, June 29-30, 2016. Invited Speaker.

18. Symposium: Pharmacological approaches for pathophysiological conditions associated with hypoxia and oxidative stress. “Perinatal hypoxia and oxidative stress: mechanisms and potential new therapies”. (XI Reunión anual de la Sociedad Chilena de Neurociencia, XXX Reunión anual de la Sociedad Chilena de Ciencias Fisiológicas y la XXXVII Congreso anual de la Sociedad de Farmacología de Chile). Enjoy-Coquimbo, September 25, 2015. Invited Speaker..

18. Seminario capítulo Iberoamericano de la Sociedad DOHaD. ”Pulmonary hypertension programming by chronic hypoxia during development”. Santiago, Chile, May 29-30, 2015. Invited Speaker.

19. I Reunión Investigación e Innovación en Salud Vascular - III Jornada de Estudio en Hipertensión del Embarazo. Universidad del Bio-Bio. “Use of melatonin for perinatal complications: studies on high-altitud pregnancies”. Chillán, Chile, April 28-30, 2015. Invited Speaker.

20. X Taller de Bioética de FONDECYT – Regulación del Uso y Cuidado de Animales de Investigación. “Realidad de los Comités de Cuidado y Uso Animal en Chile (Truth about the Institutional Animal Care and Use Committees in Chile”. Conicyt, Santiago, Chile, December 17, 2014. Invited Speaker.

21. Workshop on Pathomechanisms of High Altitude Pulmonary Hypertension and Genetic Basis of Adaption to High Altitude Hypoxia. “Comparative cardiovascular physiology in high- and low-altitude species”. ECCPS Building, Giessen (Alemania), November 24 – 26, 2014. Invited Speaker.

22. V Simposio Regional de Hipertension Pulmonar – Bayer. “Pulmonary Hypertension & High-Altitude”. Hotel Sheraton, Santiago, Chile, Octubre 2013. Invited Speaker - Round Table.

23. 40th Annual Meeting of the Fetal and Neonatal Physiological Society (FNPS), Gran Hotel Colonos del Sur, Puerto Varas, Chile. Septiembre 2013. Opening Lecture - Chairman.

24. II Jornada de Estudio en Hipertensión del Embarazo-I Jornada de Investigación Clínico-Básica en Patologías del Embarazo. Universidad del Bio-Bio. “Melatonina mejora la función vascular perinatal en gestaciones afectadas por hipoxia (Melatonin improves perinatal vascular function in hypoxic gestations)”. Chillán, Chile, April 2013. Invited Speaker.

25. I Jornada de Investigación de la Escuela de Medicina, Universidad de Valparaiso, San Felipe. “Enseñanzas de la naturaleza acerca de la hipertensión pulmonar neonatal (Nature teachings about pulmonary hypertension of the neonate)”. Opening Lecture. San Felipe, Chile, March 2013. Invited Speaker.

26. Simposio DOHaD, Pontificia Universidad Católica de Chile. “Origen fetal de alteraciones cardiovasculares: una fábula altiplánica (Fetal origin of cardiovascular alterations: a altiplanic fable)”. Santiago, Chile, September 2012. Invited Speaker.

27. Simposio de Programación de Enfermedades de Adulto, Segunda Jornada de Investigación de la Facultad de Medicina, Universidad Austral de Chile. “Origen fetal de alteraciones cardiovasculares: una historia desde las alturas andinas....(Fetal origin of cardiovascular alterations: a story from the andean highlands...)”. UACH, Valdivia, Chile, Mayo 2012. Invited Speaker.

28. Rosie Maternity Seminars, Addenbrooks Hospital, Cambridge, UK. “Antioxidants increase umbilical blood flow and protect against fetal growth restriction”. Cambridge, Reino Unido, April 2010. Invited Speaker.

29. PDN Postdoc Symposium (Physiology, Development & Neuroscience). “Antioxidants increase umbilical blood flow”. University of Cambridge, Cambridge, Reino Unido, March 2010. Invited Speaker.

INTERVIEWS & MEDIA (Broadcast, last 10 years)

1. Entrevista acerca del desarrollo y pruebas de un ventilador mecánico para enfrentar la pandemia COVID-19. Cooperativa Radio, 28 mayo 2020. https://cooperativa.cl/noticias/sociedad/salud/coronavirus/exitosa-prueba-en-oveja-de-reconversion-de-equipos-para-ventilacion-en/2020-05-28/234209.html

2. Entrevista de Periodistas fact-cheking (AFP Factual): “¿El uso de mascarillas provoca todos estos problemas respiratorios?”, 20 de mayo 2020. https://factual.afp.com/las-mascarillas-quirurgicas-no-provocan-que-el-usuario-respire-su-propio-co2-segun-expertos

3. Entrevista de Periodistas fact-cheking (AFP Factual): “Uso de mascarillas no provoca falta de oxígeno”, 5 de mayo 2020. https://factual.afp.com/usar-mascarillas-no-provoca-falta-de-oxigeno

4. Entrevista Diario La Segunda (especiales): “Ciencia aplicada para cambiar el mundo: Efectos cardiovasculares en altura”, 31 de diciembre 2019. https://digital.lasegunda.com/2019/12/31/A/DS3O39QP

5. Entrevista El Mostrador: “Cientificos chilenos investigan efectos cardiovasculares por exposición prolongada a altura”, 19 de diciembre 2019. https://www.elmostrador.cl/cultura/2019/12/19/chilenos-investigan-efectos-cardiovasculares-por-exposicion-prolongada-a-la-altura/

6. Entrevista en Radio Duna (Programa Aire Fresco), 17 de diciembre 2019. Investigadores sobre los efectos cardiovasculares en exposición prolongada en altura: “Nuestra sospecha es que esto puede inducir enfermedades crónicas”. https://www.duna.cl/programa/aire-fresco/2019/12/17/investigadores-sobre-los-efectos-cardiovasculares-en-exposicion-prolongada-en-altura-nuestra-sospecha-es-que-esto-puede-inducir-enfermedades-cronicas/

7. Entrevista Diario La Cuarta: “Mascotas en zona cero: cómo afectan las lacrimógenas al regalón”, 09 de diciembre 2019. https://www.lacuarta.com/cronica/noticia/mascotas-zona-cero-afectan-las-lacrimogenas-al-regalon/436404/

8. Presentación del Libro “Etica Animal: Fundamentos Empiricos, Teoricos y Dimension Practica”, 5 de diciembre 2019. https://www.udd.cl/eventos/medicina-lanzamiento-del-libro-etica-animal-fundamentos-empiricos-teoricos-y-dimension-practica/

9. Entrevista Diario Las Ultimas Noticias: “Qué le pasa al cuerpo cuando se expone a la falta de oxígeno por períodos intermitentes”, 20 de noviembre 2019. http://www.lun.com/Pages/NewsDetail.aspx?dt=2019-11-20&PaginaId=6&bodyid=0

10. Entrevista canal nacional 24 horas. Experto y Premio Nobel de Medicina: "Se podría disminuir la progresión del cáncer". 10 de octubre 2019. https://www.24horas.cl/videos/entrevistas24/experto-y-premio-nobel-de-medicina-se-podria-disminuir-la-progresion-del-cancer--3646104, https://www.youtube.com/watch?v=YNmTkwtu4g0

11. Radio Universidad de Chile: Entrevista – conversación en el Programa Creando Conocimiento, 22 de abril 2019. https://radio.uchile.cl/programas/creando-conocimiento/522584/

12. Comentario - Entrevista en el Mercurio (Vida, Ciencia y Tecnología) 12 de abril 2019: El espacio acelera los cambios en el cuerpo y retrasa el envejecimiento celular.

13. Entrevista en Radio Duna (Programa Aire Fresco), 21 de agosto 2018. Entrevista acerca de la búsqueda de tratamiento a la hipertensión pulmonar del recién nacido. www.duna.cl

14. Entrevista en Diario La cuarta, 16 de agosto 2018. Buscan en la llamas solución a falla pulmonar. http://edition.pagesuite.com/html5/reader/production/default.aspx?pubname=&pubid=a94a1c16-2ebc-4ecc-b2bc-d60709ea4c26

15. Entrevista – Noticias sitio web Facultad de Medicina, Universidad de Chile, 5 abril 2018. Comité de Bioética sobre Investigación en Animales: Mil historias de un cambio. http://www.uchile.cl/noticias/142309/comite-bioetica-para-investigacion-en-animales-cumple-mil-protocolos

16. Entrevista Chilevisión (CHV) noticiario central, 29 de enero 2018. Regulación de experimentación en animales en Chile. Entrevista como Presidente de Comité de Bioética y Bienestar Animal.

17. Entrevista Diario Las ultimas noticias, 14 de octubre 2017. Triste final de los ratones liberados por animalistas en la U. de Chile. Entrevista como experto en Bienestar Animal. http://www.lun.com/Pages/NewsDetail.aspx?dt=2017-10-14&NewsID=384259&BodyID=0&PaginaId=2

18. Noticias ICBM, 06 de octubre 2017. II Feria de grados académicos, en el marco del XX aniversario del ICBM. Entrevista como Subdirector de Postgrado del ICBM. http://www.icbm.cl/2017/10/06/ii-feria-de-grados-academicos-en-el-marco-del-xx-aniversario-del-icbm/

19. Noticias Universidad de Chile, 10 de Agosto 2017. CICUA impulsa normativa inédita para el bienestar de animales abandonados en la U. de Chile. Entrevista como Presidente del Comité Institucional de Cuidado y Uso de animales de la Universidad de Chile. http://www.uchile.cl/noticias/135898/cicua-crea-normativa-inedita-para-el-bienestar-animal-en-la-u-chile

20. Noticias Universidad de Chile, 25 de Abril 2017. U. de Chile promueve normativas institucionales para el buen uso y cuidado de animales en investigaciones. Entrevista como Presidente del Comité Institucional de Cuidado y Uso de animales de la Universidad de Chile. http://www.uchile.cl/noticias/132570/u-de-chile-promueve-el-buen-cuidado-de-animales-en-investigaciones

21. Entrevista Revista Paula, November 2016. Ventajas de vivir a nivel del mar.

22. Entrevista Diario El Mercurio, October 20, 2013. Vida Saludable (Cuerpo D, Reportajes). “Investigaciones de punta para una mejor salud de madres e hijos.”

23. Entrevista en el Pulso, revista electrónica de la Facultad de Medicina, Universidad de Chile (September 2013): “Las enfermedades, desde su primer origen.” http://elpulso.med.uchile.cl/20130903/noticia1.html

24. Diario El Mercurio, November 11, 2012. Vida Saludable. Programa “Ayudantes Alumnos”, Entrevista a Roberto Macchiavello, ayudante alumno del Laboratorio de Función y Reactividad Vascular, tutor Emilio Herrera.

25. Diario electrónico El Nortero, September 2012: “Hormona del sueño ayudaría a combatir efectos nocivos de la hipoxia en recién nacidos.” http://www.elnortero.cl/noticia/sociedad/hormona-del-sueno-ayudaria-combatir-efectos-nocivos-de-la-hipoxia-en-recien-nacidos

26. Revista Facultad de Medicina U. de Chile (Nº4 – Invierno 2012): “Exitosos resultados con la hormona del sueño.” Emilio Herrera.

27. Radio Universidad de Chile, April 3, 2012: “Hormona del sueño ayudaría a combatir efectos nocivos de la hipoxia en recién nacidos.” http://radio.uchile.cl/noticias/146593/

28. Entrevista en el Pulso, revista electrónica de la Facultad de Medicina, Universidad de Chile (March 2012): “Hormona del sueño muestra exitosos resultados frente a efectos nocivos de hipoxia crónica en el recién nacido.” http://www.med.uchile.cl/2012/marzo/7182-hormona-del-sueno-muestra-exitosos-resultados-frente-a-efectos-nocivos-de-hipoxia-cronica-en-el-recien-nacido.html

29. Article in Science Website about Fetal Programming & Oxygenation (February 2012): “Embryos starved of oxygen may be 'programmed' for heart disease.” http://news.sciencemag.org/sciencenow/2012/02/embryos-starved-of-oxygen-may-be.html?ref=hp

30. Entrevista en el Pulso, revista electrónica de la Facultad de Medicina, Universidad de Chile (May 2011): “Usarán hormona del sueño para revertir efectos nocivos de la hipoxia crónica en el recién nacido.” http://www.med.uchile.cl/2011/mayo/6241-usaran-hormona-del-sueno-para-revertir-efectos-nocivos-de-la-hipoxia-cronica-en-el-recien-nacido.html


Premios y Distinciones

  •   Beca Mideplan

    MINISTERIO DE PLANIFICACION Y COOPERACION

    Chile, 1999

    Beca MIDEPLAN para programa de intercambio entre Universidad Austral de Chile (Chile) y Virginia Tech University (USA). Internado de cirugía en animales pequeños (3 meses).

  •   ALFA Project NºII-0379-FCD

    ALFA Grants to support co-operation between Higher Education Institutions of the European Union and Latin America.

    Francia, 2005

    Primer seleccionado Programa ALFA Project NºII-0379-FCD. Estadía de 2 meses en Centre de Genetique moleculaire et cellulaire (CGMC), CNRS - Université Claude Bernard, Lyon1, France.

  •   Beca del Departamento de Post-grado de la Universidad de Chile

    UNIVERSIDAD DE CHILE

    Chile, 2005

    Beca del Departamento de Post-grado de la Universidad de Chile (Beca U.Chile PG/54/2005). Financiamiento parcial de tesis doctoral.

  •   Beca MECESUP

    MINISTERIO DE EDUCACION

    Chile, 2005

    Programa de Mejoramiento de la Calidad y la Equidad de la Educación Superior (MECESUP), para tesistas de Doctorado.

  •   Beca Presidente de la Republica

    MINISTERIO DE PLANIFICACION Y COOPERACION

    Chile, 2007

    Beca Presidente de la República, MIDEPLAN, Gobierno de Chile. Financiamiento parcial para realizar estudios de postgrado en el extranjero (Universidad de Cambridge, Inglaterra).

  •   SGI President’s Presenter Awards 2009

    Society For Gynecological Investigation (SGI)

    Reino Unido, 2009

    SGI President’s Presenter Awards 2009: “Xanthine Oxidase Inhibition Alters the Fetal Hypothalamo-Pituitary-Adrenal (HPA) Axis Response to Stress” (Co-autor). Este premio reconoce a las mejores 25 presentaciones del congreso (U$1,000.00).

  •   SGI President’s Presenter Awards 2009

    Society for Gynecological Investigation (SGI)

    Chile, 2009

    SGI President’s Presenter Awards 2009: “Chronic Hypoxia during Pregnancy Alters the Anatomy and Function of the Fetal Aorta at the End of Gestation”. Este premio reconoce a las mejores 25 presentaciones del congreso (U$1,000.00).

  •   Lang-Pardi Foundation Award 2009

    Lang Pardi Foundation

    Italia, 2009

    Lang-Pardi Foundation Award at the SGI 2009: “Antioxidants increase umbilical blood flow via nitric oxide dependent and independent pathways”. Este premio reconoce esfuerzo y premia al mejor trabajo realizado por un joven investigador. Entrega €2,500.00 para futuras investigaciones en el tema.

  •   SGI Best Poster (Young researcher) Awards 2011

    Society for Gynecological Investigation (SGI)

    Estados Unidos, 2011

    SGI Best Poster (Young researcher) Awards 2011: “Statins Prevent Adverse Effects of Postnatal Glucocorticoid Therapy on Cardiovascular Function in Rats.” 58th SGI Annual Scientific Meeting, Miami, USA. Este premio reconoce a las mejores 20 presentaciones del congreso.

  •   VET 2011

    SOCIEDAD DE MEDICINA VETERINARIA DE CHILE

    Chile, 2011

    VET2011(Chile), Reconocimiento por la contribución a la investigación e innovación de la Medicina Veterinaria. Premio Nacional a los 10 investigadores más destacados en la celebración de los 250 años de la profesión Médico Veterinaria.

  •   Premio al mejor trabajo científico

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Premio al mejor trabajo científico (Tercer Lugar). “Melatonina mejora la capacidad antioxidante y la función vascular pulmonar neonatal”. II Congreso Ciencia Joven 2012, ICBM, Facultad de Medicina, Universidad de Chile.

  •   Premio al mejor trabajo científico.

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Premio al mejor trabajo científico. “Melatonina mejora la función vascular cerebral en neonatos hipóxicos crónicos”. VII JORNADA PROGRAMA AYUDANTES ALUMNOS, Facultad de Medicina, Universidad de Chile.

  •   Premio a los 16 mejores resúmenes del Congreso

    Sociedad Latinoamericana de Investigación Pediátrica (SLAIP)

    Argentina, 2012

    Premio a los 16 mejores resúmenes del Congreso: 1. “La exposición postnatal a tierras bajas modifica la presión arterial, reactividad y remodelamiento pulmonar en corderos recién nacidos en el Alto Andino”. 50a Reunión Sociedad Latinoamericana de Investigación Pediátrica, Buenos Aires, Argentina.

  •   Premio a los 16 mejores resúmenes del Congreso.

    Sociedad Latinoamericana de Investigación Pediátrica (SLAIP)

    Argentina, 2012

    Premio a los 16 mejores resúmenes del Congreso: 2. “Melatonin modifies cardiac function in pulmonary hypertensive neonates”. 50a Reunión Sociedad Latinoamericana de Investigación Pediátrica, Buenos Aires, Argentina.

  •   The Bo Gennser Memorial Prize.

    Fetal and Neonatal Physiological Society

    Chile, 2013

    “Prenatal melatonin improves systemic and cerebrovascular function in neonatal lambs gestated under chronic hypoxia”. Premio al mejor trabajo científico (Poster). 40th Annual Meeting of the Fetal and Neonatal Physiological Society.

  •   Premio a los 5 mejores resúmenes del Congreso.

    Sociedad Colombiana de Cardiología

    Colombia, 2014

    Premio a los 5 mejores resúmenes del Congreso: “Pre- and post-natal melatonin affects pulmonary vascular function and structure in chronic hypoxic neonates”. 1ª Jornadas Latinoamericanas de Hipertensión Pulmonar en Niños, Cartagena de Indias, Colombia.

  •   FNPS 2014 Samsung Award (Best Poster).

    Fetal and Neonatal Physiological Society

    Italia, 2014

    FNPS 2014 Samsung Award (Best Poster). “PDGF expression and pulmonary artery remodeling in newborn lambs differentially exposed to perinatal hypoxia”. 41st Annual Meeting of the Fetal and Neonatal Physiological Society. St. Vincent, Italy, September 2014.

  •   Beca ALFA programme Project NºII-0379-FCD

    UNIVERSIDAD PERUANA CAYETANO HEREDIA

    Peru, 2006

    Beca para estadía en el Laboratorio de Transporte de Oxígeno, Universidad Cayetano Heredia, Lima, Perú. Noviembre 2006.

  •   Avrith Travel Fund.

    UNIVERSITY OF CAMBRIDGE

    Reino Unido, 2008

    Beca de financiamiento para asistir a la 35th Annual Meeting of the Fetal and Neonatal Physiological Society, Maastricht, Holanda, 2008.

  •   Beca Ramón Areces

    FUNDACION RAMON ARECES

    España, 2009

    XVII International Symposium on PerinataI Biology and Development, Universidad CEU San Pablo, Madrid. Beca de estadía e inscripción al Simposio. Julio 2009.

  •   Royal Society Travel Funding.

    ROYAL SOCIETY

    Reino Unido, 2009

    Beca ayuda de viaje para asistir a 36th Fetal and Neonatal Physiological Society Meeting, Lake Arrowhead, EEUU. 26 Septiembre - 1 Octubre, 2009.

  •   Best poster award

    UNIVERSIDAD DEL BIO-BIO

    Chile, 2015

    Best poster award (Sr. Sebastian Castillo). “Evaluación de 2APB, bloqueador putativo de SOC como fármaco para la hipertensión pulmonar neonatal en corderos gestados parcialmente en altura”. I Reunión de Investigación e Innovación en Salud Vascular – III Jornada de Estudio en Hipertensión del Embarazo. Chillán, Chile. Abril 2015.

  •   Universia 2015

    Banco Santander

    Chile, 2015

    Coinvestigador de III versión Premio a la Investigación Científica Universitaria “Hipertensión arterial, dislipidemias y enfermedades coronarias”, 2015 – Banco Santander (Universia). “Cardioprotección con ácidos grasos omega 3 en patologías cardiovasculares en modelos animales y humanos: Del Infarto Agudo al Miocardio a la Hipoxia Hipobárica Intermitente”.

  •   Mejor Tesis Feria de Grados Academicos

    UNIVERSIDAD DE CHILE

    Chile, 2016

    Mejor Tesis del Programa de Magister en Fisiopatología, 1ª Feria de Grados Académicos, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile “Efecto de la administración postnatal de melatonina sobre la función y estructura cardíaca en neonatos de oveja gestados y nacidos en hipoxia crónica”.

  •   Mejor trabajo

    SOCIEDAD CHILENA DE HIPERTENSION

    Chile, 2016

    Estudio seleccionado dentro de los mejores trabajos del II Congreso Chileno de Hipertension Arterial con su trabajo “Efecto de la administración postnatal de melatonina sobre la estructura cardíaca en hipertensión arterial pulmonar del recién nacido”.

  •   ISI-WOS 6%

    UNIVERSIDAD DE CHILE

    Chile, 2016

    Reconocimiento por el aporte hecho durante el año 2015 con publicaciones en las mejores revistas cientificas (ISI-WOS 6%) por el paper “Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep. J Pineal Res. 58(3):362-73, 2015.”

  •   Concurso de Productividad (CAP), ICBM, Facultad de Medicina

    UNIVERSIDAD DE CHILE

    Chile, 2017

    Primer Lugar de 102 postulantes en el Concurso Asignación de Productividad (CAP) del ICBM, Facultad de Medicina, Universidad de Chile.

  •   Best Poster Award

    GrivasHealth

    Chile, 2017

    Best poster award of the II Meeting on Research and Innovation in Vascular Health & IV Research Meeting on Hypertension in Pregnancy. “Chronic intermittent hypobaric hypoxia have differential effects on carotid and femoral vascular function”. Chillan, Chile, 6-8 July 2017.

  •   Mejor Unidad de Investigación del área de Fisiopatología

    Facultad de Medicina

    Chile, 2018

    Mejor Unidad de Investigación del área de Fisiopatología, Facultad de Medicina. Curso Unidades de Investigación Medicina II año.

  •   Atacama-Leh Meeting; Coping with hypoxia at high altitude: How lung, blood and brain respond and crosstalk.

    Pulmonary Vascular Research Institute (PVRI)

    Chile, 2018

    Best poster award of the Atacama-Leh Meeting; Coping with hypoxia at high altitude: How lung, blood and brain respond and crosstalk. ”Soluble and particulate guanylyl cyclases in the regulation of pulmonary circulation in chronically hypoxic and pulmonary hypertensive neonatal lambs”. San Pedro de Atacama, Chile. Marzo 4-9, 2018.

  •   Premio Anual “Aporte a la Investigación en la Universidad de Chile por ISI-WOS 6%”

    UNIVERSIDAD DE CHILE

    Chile, 2017

    Premio Anual (2017) “Aporte a la Investigación en la Universidad de Chile por ISI-WOS 6%” por aporte a la investigación de la Universidad de Chile.

  •   Concurso Asignación de Productividad (CAP) del ICBM

    ICBM, Facultad de Medicina

    Chile, 2019

    Primer Lugar de 92 postulantes en el Concurso Asignación de Productividad (CAP) del ICBM, Facultad de Medicina, Universidad de Chile.


 

Article (163)

Analysis of the passive biomechanical behavior of a sheep-specific aortic artery in pulsatile flow conditions
Comment on Melatonin as a potential adjuvant treatment for COVID-19
Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates
Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner
Adult vascular dysfunction in fetal growth restricted guinea pigs is associated with a neonate-adult switching in Nos3 DNA methylation.
Adult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep
Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.
Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs
El tratamiento postnatal con melatonina modula la expresión de agentes prostanoides en pulmón de neonatos de oveja con hipertensión pulmonar.
Intervention against hypertension in the next generation programmed by developmental hypoxia
Intervention against hypertension in the next generation programmed by developmental hypoxia.
Premature Vascular Aging in Guinea Pigs Affected by Fetal Growth Restriction
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions.
Circulation in neonatal llamas and sheep: A tale of two species
Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic.
Improving pregnancy outcomes in humans through studies in sheep
Mechanical characterization of arteries affected by fetal growth restriction in guinea pigs (Cavia porcellus)
Mechanical characterization of arteries affected by fetal growth restriction in guinea pigs (Cavia porcellus).
Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress
Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model=> Role of Oxidative Stress.
Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs
Melatonin decreases pulmonary vascular remodelling and oxygen sensitivity in pulmonary hypertensive newborn lambs.
Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth
Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth.
Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet=> Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats.
Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia.
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
Efecto de la administración prenatal de melatonina en pulmones de neonatos de oveja crónicamente hipóxicos.
Fetal Growth Restriction Induces Heterogeneous Effects on Vascular Biomechanical and Functional Properties in Guinea Pigs (Cavia porcellus)
Fetal Growth Restriction Induces Heterogeneous Effects on Vascular Biomechanical and Functional Properties in Guinea Pigs (Cavia porcellus).
Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation
Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation.
Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation.
Modelling and numerical simulation of the in vivo mechanical response of the ascending aortic aneurysm in Marfan syndrome
Modelling and numerical simulation of the in vivo mechanical response of the ascending aortic aneurysm in Marfan syndrome.
Modelling and numerical simulation of the in vivo mechanical response of the ascending aortic aneurysm in Marfan syndrome.
N-acetyl cysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs.
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs.
Pulmonary Hypertension due to Lung Diseases and/or Hypoxia: What Do We Actually Know?
Pulmonary Hypertension due to Lung Diseases and/or Hypoxia=> What Do We Actually Know?
2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude
Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs
Assessment of in vivo fetal growth and placental vascular function in a novel IUGR model of progressive uterine artery occlusion in guinea pigs.
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano
Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean Altiplano.
Fetal in vivo continuous cardiovascular function during chronic hypoxia
Fetal in vivo continuous cardiovascular function during chronic hypoxia.
Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease.
Modelling and numerical simulation of the in vivo mechanical response of the ascending aortic aneurysm in Marfan syndrome.
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress.
Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction=> findings in pregnant sheep.
Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs
Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs.
Pharmacological approaches in either intermittent or permanent hypoxia=> A tale of two exposures.
Induction of controlled hypoxic pregnancy in large mammalian species.
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep.
omega 3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats
omega 3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures.
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses.
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses.
Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses.
The study of high altitude pulmonary hypertension at the Chilean Andean Altiplano.
The study of high altitude pulmonary hypertension at the Chilean Andean Altiplano. Perspective Learners` Corner.
Ω3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats.
Effects of Chronic Intermittent Hypoxia and Polyunsaturated Fatty Acids on Infarct Size and Oxidative Stress Markers in Cardiac Ischemia Reperfusion.
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity.
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs.
Effects of Chronic Intermittent Hypoxia and Polyunsaturated Fatty Acids on Infarct Size and Oxidative Stress Markers in Cardiac Ischemia Reperfusion
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity.
Heart Disease Link to Fetal Hypoxia and Oxidative Stress
Heart disease link to fetal hypoxia and oxidative stress.
Impact of maternal melatonin suppression on amount and functionality of brown adipose tissue (BAT) in the newborn sheep
Impact of Maternal Melatonin Suppression on Amount and Functionality of Brown Adipose Tissue (BAT) in the Newborn Sheep.
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs.
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs.
The placental pursuit for an adequate oxidant balance between the mother and the fetus
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy.
Antioxidant treatment improves neonatal survival and prevents impaired cardiac function at adulthood following neonatal glucocorticoid therapy.
Store operated channels in the pulmonary circulation of high and low altitude neonatal lambs.
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy.
Antioxidant treatment improves neonatal survival and prevents impaired cardiac function at adulthood following neonatal glucocorticoid therapy.
Antioxidants Prevent Intrauterine Growth Restriction (IUGR) and Cardiac Dysfunction in Chronically-Hypoxic Fetal Sheep
Downregulation of Cystathionine gamma-Lyase (CSE) in Pre-Eclampsia in Placentas with Abnormal Umbilical Artery Doppler Waveforms and Its Potential Regulation by microRNA-21
High altitude hypoxia and blood pressure dysregulation in adult chickens
High altitude hypoxia and blood pressure dysregulation in adult chickens.
Reduced cystathionine γ-lyase and increased miR-21 are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator.
Reduced Cystathionine gamma-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies Hydrogen Sulfide as a Placental Vasodilator
Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies=> hydrogen sulfide as a placental vasodilator.
Statins prevent adverse effects of postnatal glucocorticoid therapy on the developing brain in rats.
Statins prevent adverse effects of postnatal glucocorticoid therapy on the developing brain in rats.
Store operated channels in the pulmonary circulation of high and low altitude neonatal lambs
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs.
Vitamin C prevents intrauterine programming of in vivo cardiovascular dysfunction in the rat.
Vitamin C prevents intrauterine programming of in vivo cardiovascular dysfunction in the rat.
A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep.
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress.
High altitude hypoxia and blood pressure dysregulation in adult chickens.
Morphological and Functional Alterations in the Aorta of the Chronically Hypoxic Fetal Rat
Morphological and functional alterations in the aorta of the chronically hypoxic fetal rat.
Morphological and Functional Alterations in the Aorta of the Chronically Hypoxic Fetal Rat.
Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability
Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability.
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude.
Cardiopulmonary response to stepwise oxygenations in newborn sheep from different altitudes.
Cardiopulmonary response to stepwise oxygenations in newborn sheep from different altitudes.
COUNTERPOINT: HIGH ALTITUDE IS NOT FOR THE BIRDS!
Counterpoint=> high altitude is not for the birds!
Fetal and postnatal pulmonary circulation in the Alto Andino
Fetal and postnatal pulmonary circulation in the Alto Andino.
Last word on point=>counterpoint=> high altitude is/is not for the birds!
Role of the alpha-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species
The role of the {alpha}-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species.
VASODILATOR EFFECT OF HYDROGEN SULPHIDE (H2S) IN THE PERFUSED HUMAN PLACENTA
Antioxidant treatment alters peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats
Antioxidant treatment alters peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats.
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level.
Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms
Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms.
Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function
Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function.
Professor Giorgio Pardi and his legacy
Professor Giorgio Pardi and his legacy
Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano
Carbon monoxide=> a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano.
EVIDENCE OF A ROLE FOR MELATONIN IN FETAL SHEEP PHYSIOLOGY: DIRECT ACTIONS OF MELATONIN ON FETAL CEREBRAL ARTERY, BROWN ADIPOSE TISSUE AND ADRENAL GLAND
Evidence of a role for melatonin in fetal sheep physiology=> direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland.
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep
Sildenafil reverses hypoxic pulmonary hypertension in highland and lowland newborn sheep.
Carbon monoxide and pulmonary vasodilatation in neonatal llamas (Lama glama) at the Andean altiplano.
Evolving in thin air - Lessons from the llama fetus in the altiplano
Evolving in thin air--lessons from the llama fetus in the altiplano.
High altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep.
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
Fetal brain hypometabolism during prolonged hypoxaemia in the llama
Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia
Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia.
Vasodilator tone in the llama fetus=> the role of nitric oxide during normoxemia and hypoxemia.
The fetal llama versus the fetal sheep: Different strategies to withstand hypoxia
The fetal llama versus the fetal sheep: different strategies to withstand hypoxia.
Regional brain blood flow and cerebral hemispheric oxygen consumption during acute hypoxaemia in the Ilama fetus
Regional brain blood flow and cerebral hemispheric oxygen consumption during acute hypoxaemia in the llama fetus
Use of fetal biometry to determine fetal age in late pregnancy in llamas
Use of fetal biometry to determine fetal age in late pregnancy in llamas.
Low-dose inhaled carbon monoxide reduces pulmonary vascular hypoxemia resistance during acute in adult sheep
Low-dose inhaled carbon monoxide reduces pulmonary vascular resistance during acute hypoxemia in adult sheep.
Cardiovascular responses to arginine vasopressin blockade during acute hypoxemia in the llama fetus
Cardiovascular responses to arginine vasopressin blockade during acute hypoxemia in the llama fetus.

Abstract (35)

Differential Adverse and Protective Effects of Pre- and Post-Natal Protein Restriction on Cardiovascular Function at Adulthood in Mice.
PROGRESSIVE UTERINE ARTERY OCCLUSION IN GUINEA PIGS INCREASES OXIDATIVE STRESS LEVELS AND DISRUPTS GLYCOGEN METABOLISM IN THE MATERNAL DECIDUA
DNA Methylation of nos3 Promoter in IUGR Guinea Pig Fetuses Does Not Predict Endothelial Function and DNA Methylation Later in Life
Weak Cardiovascular Defence to Hypotensive Stress in the Chronically Hypoxic Fetus.
INTRAUTERINE GROWTH RESTRICTION IN GUINEA PIG IMPAIRS UMBILICAL AND SYSTEMIC VASCULAR FUNCTION
Do Adverse Conditions during Pregnancy Trigger a Fetal Origin of Heart Disease or Do They Programme Cardiac Disease in Later Life by Altering Adaptive Responses to Later Challenges?
FOETAL AND UMBILICAL VASCULAR REACTIVITY IN A MODEL OF IUGR THROUGH GRADUAL UTERINE ARTERY OCCLUSION IN GUINEA PIGS
Intervention Against Programmed Cardiovascular Disease in High Risk Ovine Pregnancy.
Hepatic Insulin Resistance: Effects of Postnatal Glucocorticoid and Antioxidant Therapy
Maternal Melatonin: Effective Intervention Against Developmental Programming of Cardiovascular Dysfunction in Adult Offspring of Complicated Pregnancy
MELATONIN MODIFIES CARDIAC FUNCTION IN PULMONARY HYPERTENSIVE NEONATES
SEA LEVEL POSTNATAL EXPOSURE MODIFIES THE PULMONARY ARTERIAL PRESSURE, REACTIVITY AND REMODELING IN NEONATAL LAMBS BORN IN HIGHLANDS
Statins Prevent Detrimental Effects of Postnatal Glucocorticoid Therapy on Arterial Blood Pressure and the Kidney in Rats
Vasodilator Role of Hydrogen Sulphide (H2S) in Human Placentae from Healthy and Pathological Pregnancies
FETAL AND NEONATAL PULMONARY CIRCULATION IN THE ALTO ANDINO
Hemin Increases Pulmonary HO Protein Expression and Pulmonary CO Production in Newborn Lambs from the Andean Altiplano
Persistent pulmonary hypertension of the newborn even following transient exposure of the pregnancy to high altitude
Adrenocortical response to a superimposed episode of acute hypoxia in high altitude fetal lambs
Blood flow redistribution in the llama fetus during acute hypoxemia: The role of nitric oxide
Brain hypometabolism after 24h of hypoxemia in the llama fetus
Carbon monoxide (CO): A key vasodilator in the pulmonary circulation in the llama neonate
Cardiovascular responses to acute hypoxemia in low altitude(LA)and high altitude (HA) fetal sheep (FS)
Differential femoral and pulmonary adrenergic vascular reactivity in high and low altitude newborn lambs
Differential prostaglandins (PGs) role in the pulmonary circulation in hich and low altitude newborn lambs during hypoxemia
Melatonin blocks noradrenaline-induced vasoconstriction in middle cerebral artery in lowland fetal sheep
Melatonin restrains cortisol production in sheep fetal adrenal in late gestation
Regional changes of NaKATPase activity in the brain of the hypoxemic llama fetus
The ET-1 system in the pulmonary circulation from newborn lambs submitted to chronic hypoxia
Nakatpase, temperature and ion channels in the fetal llama brain submitted to hypoxia.
Role of nitric oxide in the pulmonary circulation in high- and low-altitude newborn lambs.
Chronic hypoxia decreases the soluble guanylate cyclase in the neonatal lung of lowland species.
Chronic hypoxia modifies the cardiovascular function and the arterial contractility in the neonatal sheep
Contractile responses to endothelin-1 in isolated femoral arteries from newborn llama and sheep
Effects of high altitude-chronic hypoxia on the expression levels of COX1 and COX2 in sheep and llamas newborn lung.
Lambs born at high altitude have a blunted pituitary-adrenal axis response to acute hypoxia.

BookReview (1)

Heart Disease Link to Fetal Hypoxia and Oxidative Stress.

BookSection (2)

Epigenetic programming of cardiovascular disease by perinatal hypoxia and fetal growth restriction.
Realidad en Chile acerca de los Comité Institucional de Cuidado y Uso de Animales de Laboratorio (CICUAL)

BookWhole (1)

Programa Institucional de Cuidado y Uso de Animales

Letter (1)

Last Word on Point:Counterpoint: High altitude is/is not for the birds!

Proyecto (14)

Time-course modeling of the vascular epigenetic programming by fetal growth restriction: role of endothelial-derived miRNAs on hypoxia- and oxidative stress-induced responses
Biomechanical Behaviour of Arteries from Chronic Hypoxic Animals: Experiments, Modelling, Numerical Simulation and Validation
To be born high and flat (Andean Altiplano): healing vascular function and pulmonary arterial hypertension by a combined treatment in neonatal lambs
After years of “NO” treatment, we seek for YES treatments: soluble and particulate guanylyl cyclases could say yes to treat pulmonary arterial hypertension of the newborn
Heme oxygenase induction by hemin reduces lung inflammation, oxidative stress, pulmonary vascular proliferation and pulmonary arterial hypertension in chronically hypoxic neonates in the Andean Altiplano
Melatonina revierte la disfunción endotelial y el remodelamiento de la arteria mesentérica de ratones obesos mediante la regulación de la expresión génica de ENOS y NOX/24
Modeling the epigenetic programming of vascular dysfunction by oxidative stress in the lntrauterine Growth Restricted fetus: role of prenatal antioxidants in preventing long-term vascular dysfunction
Blockade of store operated channels and ryanodine receptors as a strategy to treat the neonatal pulmonary hypertension induced by chronic hypoxia
Melatonin therapy for preventing/treating pulmonary hypertension in the high altitude neonate under oxidative stress: a new light for the night hormone
Developmental programming of cardiovascular disease by hypoxia and oxidative stress
Hypoxia and reactive oxygen species in fetal cardiovascular function
Hypoxia inducible factor (HIF) and some of its target genes expression in pulmonary vascular bed of the chronic hypoxic newborn sheep
Cardioprotección con ácidos grasos omega 3 en patologías cardiovasculares en modelos animales y humanos: Del Infarto Agudo al Miocardio a la Hipoxia Hipobárica Intermitente
Hemoxigenasa, monóxido de carbono y canales iónicos en la regulación de la circulación y remodelamiento pulmonar de recién nacidos de tierras bajas y altas

Review (7)

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress
Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures
Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity
The placental pursuit for an adequate oxidant balance between the mother and the fetus
The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude
136
Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

24
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

22
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

20
Jorge Llanos

PROFESOR TITULAR

FISIOPATOLOGÍA

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

13
Víctor Reyes

Profesor Asociado

Instituto de Ciencias Biomédicas

UNIVERSIDAD DE CHILE - FACULTA DE MEDICINA

Santiago, Chile

10
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Marcela Diaz

Directora de Departamento

Promocion de la Salud de la Mujer y el recién Nacido

Universidad de Chile/Facultad de Medicina

Santiago, Chile

5
Fernando Moraga

Profesor Asociado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

5
Alejandro Gonzalez

investigador Postdoctoral

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

4
Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Claudio Garcia

Associate Professor

Departamento de Ingenieria Mecanica

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

4
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

3
Diego Celentano

Full Professor

Mechanical and Metallurgical Engineering

Pontificia Universidad Católica de Chile

santiago de chile, Chile

3
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

2
Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

2
ISMAEL HERNANDEZ

TECNOLOGO MEDICO

FISIOPATOLOGIA

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

SANTIAGO, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

1
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Daniela Parrau

Profesor asistente

Morfofunción

Universidad Diego Portales

Santiago, Chile

1
Gloria Calaf

Directora Laboratorio Biología del cáncer

Universidad de Tarapacá

Arica, Chile

1
Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

1
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Stefania Short

Profesional

Ingeniería Química

Universidad de La Frontera

Temuco, Chile

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile