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Hans Georg Richter Becerra

Profesor Titular

Universidad Austral de Chile

Valdivia, Chile

Circadian system • Pregnancy • Developmental Cardiovascular Physiology • Fetal programming of adult disease • Gestational chronodisruption • Melatonin • Functional genomics • Transcriptomics • Epigenetics

PhD: Cell & Molecular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2001
Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994

Postdoctoral fellow Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Santiago, Chile

2001 - 2003
Senior Postdoctoral Fellow Full Time

University of Cambridge (UK)

Biology

Cambridge, Reino Unido

2007 - 2010

Profesor Asistente Full Time

Universidad Austral de Chile

Valdivia, Chile

2003 - 2005
Profesor Asociado Full Time

Universidad Austral de Chile

Valdivia, Chile

2006 - 2012
Director de Instituto Part Time

Universidad Austral de Chile

Valdivia, Chile

2012 - 2014
Profesor Titular Full Time

Universidad Austral de Chile

Valdivia, Chile

2013 - A la fecha
Director de Investigación y Desarrollo Part Time

Universidad Austral de Chile

Valdivia, Chile

2014 - 2017
Vicerrector de Investigación, Desarrollo y Creación Artística Full Time

Universidad Austral de Chile

Valdivia, Chile

2018 - A la fecha

Tesis de Pregrado: 11; Tesis de Magister: 1; Doctorado (copatrocinante): 1; Doctorado (patrocinante): 1; Postdoctorante: 1.

Conferencista (keynote speaker): 9.
Apariciones en prensa regional, nacional o internacional: 16.

• Premio de Doctorado Academia Chilena de Ciencias 2001, Mención Honrosa

ACADEMIA CHILENA DE CIENCIAS

Chile, 2001

Mejor Tesis de Doctorado en Biología


Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates Garcia-Huerta, Paula; Troncoso-Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol; Henriquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L.; Hetz, Claudio Article ISI ACTA NEUROPATHOLOGICA (2020)
Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness Niechi, I; Uribe-Ojeda, A; Erices, JI; Torres, A; Uribe, D; Rocha, JD; Silva, P; Richter, HG; San Martin, R; Quezada, C Article ISI CELLS (2019)
Fetal Programming of Renal Dysfunction and High Blood Pressure by Chronodisruption Mendez, Natalia; Torres-Farfan, Claudia; Salazar, Esteban; Bascur, Pía; Bastidas, Carla; Vergara, Karina; Spichiger, Carlos; Halabi, Diego; Vio, Carlos P; Richter, Hans G. Article ISI SCOPUS FRONTIERS IN ENDOCRINOLOGY (2019)
Long-Term Effects of Altered Photoperiod During Pregnancy on Liver Gene Expression of the Progeny Carmona P.; PÃ©rez B.; Trujillo C.; Espinosa G.; Miranda F.; Mendez N.; Torres-Farfan C.; Richter H.G.; Vergara K.; Brebi P.; Sarmiento J. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
Developmental programming of capuchin monkey adrenal dysfunction by gestational chronodisruption Richter HG, Mendez N; Abarzua-Catalan L, Valenzuela GJ; Seron-Ferre MJ, Torres-Farfan C Article BioMed Research International (2018)
Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function Salazar, E. R.; Richter, H. G.; Spichiger, C.; Mendez, N.; Halabi, D.; Vergara, K.; Alonso, I. P.; Corvalán, F. A.; Azpeleta, C.; Seron-Ferre, M.; Torres-Farfan, C. Article ISI SCOPUS Journal of Physiology (2018)
Puberty arises with testicular alterations and defective AMH expression in rams prenatally exposed to testosterone Recabarren S.E., Recabarren M.; Sandoval D., Carrasco A.; Padmanabhan V., Rey R.; Richter H.G., Perez-Marin C.C.; Sir-Petermann T., Rojas-Garcia P.P. Article Domestic Animal Endocrinology (2017)
Gestational Chronodisruption Impairs Circadian Physiology in Rat Male Offspring, Increasing the Risk of Chronic Disease. Mendez, Natalia; Halabi, Diego; Spichiger, Carlos; Salazar, Esteban R; Vergara, Karina; Alonso-Vasquez, Pamela; Carmona, Pamela; Sarmiento, Jose M; Richter, Hans G; Seron-Ferre, Maria; Torres-Farfan, Claudia Article Endocrinology (2016)
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver Spichiger, C; Torres-Farfan, C; Galdames, HA; Mendez N.; Alonso-Vazquez, P; Richter, HG Article Physiological Genomics (2015)
Environmental control of biological rhythms: effects on development, fertility and metabolism. Amaral, F G; Castrucci, A M; Cipolla-Neto, J; Poletini, M O; Mendez, N; Richter, H G; Sellix, M T Article Journal of neuroendocrinology (2014)
Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring. Vilches, Nelson; Spichiger, Carlos; Mendez, Natalia; Abarzua-Catalan, Lorena; Galdames, Hugo A; Hazlerigg, David G; Richter, Hans G; Torres-Farfan, Claudia Article PloS one (2014)
Heart Disease Link to Fetal Hypoxia and Oxidative Stress Giussani, DA; Niu, YG; Herrera, EA; Richter, HG; Camm, EJ; Thakor, AS; Kane, AD; Hansell, JA; Brain, KL; Skeffington, KL; Itani, N; Wooding, FBP; Cross, CM; Allison, BJ Article Advances in Experimental Medicine and Biology (2014)
Impact of gestational chronodisruption on fetal cardiac genomics Galdames H.A.; Torres-Farfan, C; Spichiger, C.; Mendez, N.; Abarzua-Catalan, L; Alonso-Vazquez, P; Richter, H. G. Article ISI SCOPUS JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)
Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat Kane A.D.; Camm E.J.; Richter, H. G.; Lusby C.; Tijsseling D.; Kaandorp J.J.; Derks J.B.; Ozanne S.E.; Giussani D.A. Article SCOPUS PHYSIOLOGICAL REPORTS (2013)
Statins Prevent Adverse Effects of Postnatal Glucocorticoid Therapy on the Developing Brain in Rats Tijsseling, Deodata; Camm, Emily J.; Richter, Hans G.; Herrera, Emilio A.; Kane, Andrew D.; Niu, Youguo; Cross, Christine M.; de Vries, Willem B.; Derks, Jan B.; Giussani, Dino A. Article WOS Core Collection ISI PEDIATRIC RESEARCH (2013)
Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats Richter, H. G.; Camm E.J.; Modi B.N.; Naeem F.; Cross C.M.; Cindrova-Davies, T; Spasic-Boskovic O.; Dunster, C.; Mudway I.S.; Kelly, F. J.; Burton G.J.; Poston, L; Giussani D.A. Article ISI SCOPUS Journal of Physiology (2012)
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress Giussani D.A.; Camm E.J.; Niu Y.; Richter, H. G.; Blanco C.E.; Gottschalk R.; Blake E.Z.; Horder K.A.; Thakor, A. S.; Hansell, J. A.; Kane A.D.; Wooding F.B.P.; Cross C.M.; Herrera, E. A. Article SCOPUS PLOS ONE (2012)
Timed Maternal Melatonin Treatment Reverses Circadian Disruption of the Fetal Adrenal Clock Imposed by Exposure to Constant Light Mendez, N.; Abarzua-Catalan, L; Vilches, N; Galdames H.A.; Spichiger, C.; Richter, H. G.; Valenzuela G.J.; Seron-Ferre, M; Torres-Farfan, C Article ISI SCOPUS PLOS ONE (2012)
Oxidative Stress in the Developing Brain: Effects of Postnatal Glucocorticoid Therapy and Antioxidants in the Rat Camm, Emily J.; Tijsseling, Deodata; Richter, Hans G.; Adler, Alexandra; Hansell, Jeremy A.; Derks, Jan B.; Cross, Christine M.; Giussani, Dino A. Article WOS Core Collection ISI PLOS ONE (2011)
Investigation of the Use of Antioxidants to Diminish the Adverse Effects of Postnatal Glucocorticoid Treatment on Mortality and Cardiac Development Adler, Alexandra; Camm, Emily J.; Hansell, Jeremy A.; Richter, Hans G.; Giussani, Dino A. Article WOS Core Collection ISI NEONATOLOGY (2010)
Redox Modulation of the Fetal Cardiovascular Defence to Hypoxaemia Thakor, A. S.; Richter, Hans G.; Kane, Andrew D.; Dunster, C.; Kelly, F. J.; Poston, Lucilla; Giussani, Dino A. Article JOURNAL OF PHYSIOLOGY-LONDON (2010)
Cryptochrome 2 expression level is critical for adrenocorticotropin stimulation of cortisol production in the capuchin monkey adrenal. Torres-Farfan, C; Abarzua-Catalan, L; Valenzuela, F J; Mendez, N; Richter, H G; Valenzuela, G J; Serón-Ferré, M Article Endocrinology (2009)
Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy Richter, Hans G.; Hansell, Jeremy A.; Raut, Shruti; Giussani, Dino A. Article WOS core collection ISI JOURNAL OF PINEAL RESEARCH (2009)
Circadian cortisol secretion and circadian adrenal responses to ACTH are maintained in dexamethasone suppressed capuchin monkeys (Cebus apella) Torres-Farfan, C; Valenzuela, FJ; Ebensperger, R; Mendez N., Campino; C, Richter; HG, Valenzuela; GJ, Seron-Ferre Article AMERICAN JOURNAL OF PRIMATOLOGY (2008)
Clock gene expression in adult primate suprachiasmatic nuclei and adrenal=> Is the adrenal a peripheral clock responsive to melatonin? Valenzuela, FJ; Torres-Farfan, C; Richter, HG; Mendez N., Campino; C, Torrealba F; Valenzuela, GJ; Seron-Ferre, M Article Endocrinology (2008)
Rhythmic expression of functional MT1 melatonin receptors in the rat adrenal gland Richter, HG; Torres-Farfan, C; Garcia-Sesnich, J; Abarzua-Catalan, L; Henriquez, MG; Alvarez-Felmer, M; Gaete F, Rehren; GE, Seron-Ferre Article Endocrinology (2008)
Maternal melatonin stimulates growth and prevents maturation of the capuchin monkey fetal adrenal gland Torres-Farfan, C; Valenzuela, FJ; Germain, AM; Viale, ML; Campino, C; Torrealba F, Valenzuela; GJ, Richter; HG, Seron-Ferre Article JOURNAL OF PINEAL RESEARCH (2006)
Synthesis of transthyretin by the ependymal cells of the subcommissural organ Montecinos, HA; Richter, H; Caprile T.; Rodriguez, EM Article ISI SCOPUS CELL AND TISSUE RESEARCH (2005)
Maternal melatonin selectively inhibits cortisol production in the primate fetal adrenal gland Torres-Farfan, C; Richter, HG; Germain, AM; Valenzuela, GJ; Campino, C; Rojas-Garcia, P; Forcelledo, ML; Torrealba F, Seron-Ferre Article JOURNAL OF PHYSIOLOGY-LONDON (2004)
The subcommissural organ expresses D-2, D-3, D-4, and D-5 dopamine receptors Tome M.; Jimenez, AJ; Richter, H; Vio, K; Bermudez-Silva, FJ; Rodriguez, EM; Perez-Figares, JM Article ISI CELL AND TISSUE RESEARCH (2004)
Transcription of SCO-spondin in the subcommissural organ=> evidence for down-regulation mediated by serotonin Richter, HG; Tome, MM; Yulis, CR; Vio, KJ; Jimenez, AJ; Perez-Figares, JM; Rodriguez, EM Article Molecular Brain research (2004)
mt1 melatonin receptor in the primate adrenal gland=> Inhibition of adrenocorticotropin-stimulated cortisol production by melatonin Torres-Farfan, C; Richter, HG; Rojas-Garcia, P; Vergara M, Forcelledo; ML, Valladares; LE, Torrealba F; Valenzuela, GJ; Seron-Ferre, M Article The Journal of Clinical Endocrinology and Metabolism (2003)
Bovine floor plate explants secrete SCO-spondin Guinazu, MF; Richter, HG; Rodriguez, EM Article CELL AND TISSUE RESEARCH (2002)
The floor plate cells from bovine express the mRNA encoding for SCO-spondin and its translation products Richter, HG; Munoz, RI; Millan, CS; Guinazu, MF; Yulis, CR; Rodriguez, EM Article Molecular Brain research (2001)


The capuchin monkey adrenal has an intrinsic capacity to oscillate in vivo Torres-Farfan, C; Ebensperger, R; Mendez, N.; Campino C.; Richter, H; Seron-Ferre, M Abstract ISI PLACENTA (2006)


III Versión Congreso del Futuro Región de Los Ríos=> difusión de la ciencia, la tecnología y la innovación. CORFO (17PAEILR-82168) Proyecto 2017-2018 Director(a)
II Versión Congreso del Futuro Región de Los Ríos=> difusión de la ciencia, la tecnología y la innovación. CORFO (16PAEI-68007) Proyecto 2016-2017 Director(a)
HIGH-THROUGHPUT AND TOP-DOWN SYSTEMS BIOLOGY ANALYSIS OF MULTI-TISSUE MOLECULAR CHANGES IN RESPONSE TO DEVELOPMENTAL CHRONODISRUPTION FONDECYT (1150069) Proyecto 2015-2019 Inv. Responsable
DECODING THE RAT FETAL CIRCADIAN SYSTEM AND THE LINK OF FETAL CHRONODISRUPTION TO DISEASE IN ADULTHOOD FONDECYT (1120938) Proyecto 2012-2016 Coinvestigador(a)
Mecanismos fisiopatológicos de enfermedades crónicas del adulto impuestas por la alteración circadiana prenatal=> valor terapéutico del tratamiento con melatonina a la madre expuesta a turnos nocturnos durante la gestación Programa de Investigación Asociativa CONICYT (ANILLO ACT1116) Proyecto 2012-2016 Subdirector(a)
DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES IN ADULT AND AGING INDIVIDUALS=> THE ROLE OF MATERNAL MELATONIN IN THE REGULATION OF FETAL TRANSCRIPTIONAL AND GENE PROMOTER ACTIVITY. FONDECYT (1110220) Proyecto 2011-2015 Inv. Responsable
Developmental Programming of Cardiovascular Disease by Hypoxia and Oxidative Stress British Heart Foundation (UK) (PG06/060/20918) Proyecto 2007-2011 Postdoctorado
ACCION DE LA MELATONINA MATERNA DURANTE LA GESTACION Y SU EFECTO SOBRE LA HIPERFUNCION POSTNATAL DE LA GLANDULA SUPRARRENAL EN PRIMATES. FONDECYT (1050833) Proyecto 2005-2008 Coinvestigador(a)
ACCIONES DE MLATONINA Y ACTH SOBRE LA FUNCION CIRCADIANA DE LA GLANDULA SUPRARRENAL DE RATA. FONDECYT (1050389) Proyecto 2005-2008 Inv. Responsable
Melatonina como transductor neuroendocrino para los ritmos circadianos de expresión génica en la glándula suprarrenal Dirección de Investigación y Desarrollo, Universidad Austral de Chile (S-200433) Proyecto 2004-2005 Inv. Responsable
INVESTIGACION DE LAS ALTERACIONES EN EL LINAJE DE CELULAS EPENDIMARIAS QUE GATILLAN(I)EL INICIO DE LA HIDROCEFALIA EN EL EMBRION Y (II)EL DESARROLLO POSNATAL DE HIDROCEFALIA SEVERA FONDECYT (1030265) Proyecto 2003-2007 Coinvestigador(a)
INVESTIGACION DE ASPECTOS FUNCIONALES DEL ORGANO SUBCOMISURAL MEDIANTE ESTUDIOS DE EXPRESION DEL GEN RF-GLY I FONDECYT (4000001) Proyecto 2000-2001 Inv. Responsable
INVESTIGACION DE LA HIDROCEFALIA CONGENITA Y DE LAS ALTERACIONES EN LA COMPOSICION DEL LIQUIDO CEFALORRAQUIDEO CAUSADAS POR UNA DISFUNCION DEL ORGANO SUBCOMISURAL DURANTE SU DESARROLLO FONDECYT (1000435) Proyecto 2000-2003 Tesista
INVESTIGACION DE ASPECTOS FUNCIONALES DEL ORGANO SUBCOMISURAL MEDIANTE ESTUDIOS DE EXPRESION DEL GEN RF-GLY I FONDECYT (2990011) Proyecto 1999-2001 Inv. Responsable
The subcommissural organ=> an enigmatic brain gland Volkswagen Stiftung (Alemania) (I/74062) Proyecto 1995-1998 Investigador(a)
BIOSINTESIS DE PRODUCTOS SECRETORIOS DEL ORGANO SUBCOMISURAL FONDECYT (1930398) Proyecto 1993-1995 Coinvestigador(a)


The circadian timing system: Making sense of day/night gene expression Richter, HG; Torres-Farfan, C; Rojas-Garcia, PP; Campino C.; Torrealba, F.; Seron-Ferre, M Review ISI SCIELO BIOLOGICAL RESEARCH (2004)