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Hans Georg Richter Becerra

Profesor Titular

Universidad Austral de Chile

Valdivia, Chile

Líneas de Investigación


Circadian system • Pregnancy • Developmental Cardiovascular Physiology • Fetal programming of adult disease • Gestational chronodisruption • Melatonin • Functional genomics • Transcriptomics • Epigenetics

Educación

  •  PhD: Cell & Molecular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2001
  •  Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994

Experiencia Académica

  •   Postdoctoral fellow Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2001 - 2003

  •   Senior Postdoctoral Fellow Full Time

    University of Cambridge (UK)

    Biology

    Cambridge, Reino Unido

    2007 - 2010

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2003 - 2005

  •   Profesor Asociado Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2006 - 2012

  •   Director de Instituto Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2012 - 2014

  •   Profesor Titular Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2013 - A la fecha

  •   Director de Investigación y Desarrollo Part Time

    Universidad Austral de Chile

    Valdivia, Chile

    2014 - 2017

  •   Vicerrector de Investigación, Desarrollo y Creación Artística Full Time

    Universidad Austral de Chile

    Valdivia, Chile

    2018 - A la fecha

Formación de Capital Humano


Tesis de Pregrado: 11; Tesis de Magister: 1; Doctorado (copatrocinante): 1; Doctorado (patrocinante): 1; Postdoctorante: 1.


Difusión y Transferencia


Conferencista (keynote speaker): 9.
Apariciones en prensa regional, nacional o internacional: 16.


Premios y Distinciones

  •   • Premio de Doctorado Academia Chilena de Ciencias 2001, Mención Honrosa

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2001

    Mejor Tesis de Doctorado en Biología


 

Article (34)

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates
Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
Fetal Programming of Renal Dysfunction and High Blood Pressure by Chronodisruption
Long-Term Effects of Altered Photoperiod During Pregnancy on Liver Gene Expression of the Progeny
Developmental programming of capuchin monkey adrenal dysfunction by gestational chronodisruption
Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function
Puberty arises with testicular alterations and defective AMH expression in rams prenatally exposed to testosterone
Gestational Chronodisruption Impairs Circadian Physiology in Rat Male Offspring, Increasing the Risk of Chronic Disease.
Gestation under chronic constant light leads to extensive gene expression changes in the fetal rat liver
Environmental control of biological rhythms: effects on development, fertility and metabolism.
Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring.
Heart Disease Link to Fetal Hypoxia and Oxidative Stress
Impact of gestational chronodisruption on fetal cardiac genomics
Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat
Statins Prevent Adverse Effects of Postnatal Glucocorticoid Therapy on the Developing Brain in Rats
Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress
Timed Maternal Melatonin Treatment Reverses Circadian Disruption of the Fetal Adrenal Clock Imposed by Exposure to Constant Light
Oxidative Stress in the Developing Brain: Effects of Postnatal Glucocorticoid Therapy and Antioxidants in the Rat
Investigation of the Use of Antioxidants to Diminish the Adverse Effects of Postnatal Glucocorticoid Treatment on Mortality and Cardiac Development
Redox Modulation of the Fetal Cardiovascular Defence to Hypoxaemia
Cryptochrome 2 expression level is critical for adrenocorticotropin stimulation of cortisol production in the capuchin monkey adrenal.
Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy
Circadian cortisol secretion and circadian adrenal responses to ACTH are maintained in dexamethasone suppressed capuchin monkeys (Cebus apella)
Clock gene expression in adult primate suprachiasmatic nuclei and adrenal=> Is the adrenal a peripheral clock responsive to melatonin?
Rhythmic expression of functional MT1 melatonin receptors in the rat adrenal gland
Maternal melatonin stimulates growth and prevents maturation of the capuchin monkey fetal adrenal gland
Synthesis of transthyretin by the ependymal cells of the subcommissural organ
Maternal melatonin selectively inhibits cortisol production in the primate fetal adrenal gland
The subcommissural organ expresses D-2, D-3, D-4, and D-5 dopamine receptors
Transcription of SCO-spondin in the subcommissural organ=> evidence for down-regulation mediated by serotonin
mt1 melatonin receptor in the primate adrenal gland=> Inhibition of adrenocorticotropin-stimulated cortisol production by melatonin
Bovine floor plate explants secrete SCO-spondin
The floor plate cells from bovine express the mRNA encoding for SCO-spondin and its translation products

Abstract (1)

The capuchin monkey adrenal has an intrinsic capacity to oscillate in vivo

Proyecto (16)

III Versión Congreso del Futuro Región de Los Ríos=> difusión de la ciencia, la tecnología y la innovación.
II Versión Congreso del Futuro Región de Los Ríos=> difusión de la ciencia, la tecnología y la innovación.
HIGH-THROUGHPUT AND TOP-DOWN SYSTEMS BIOLOGY ANALYSIS OF MULTI-TISSUE MOLECULAR CHANGES IN RESPONSE TO DEVELOPMENTAL CHRONODISRUPTION
DECODING THE RAT FETAL CIRCADIAN SYSTEM AND THE LINK OF FETAL CHRONODISRUPTION TO DISEASE IN ADULTHOOD
Mecanismos fisiopatológicos de enfermedades crónicas del adulto impuestas por la alteración circadiana prenatal=> valor terapéutico del tratamiento con melatonina a la madre expuesta a turnos nocturnos durante la gestación
DEVELOPMENTAL PROGRAMMING OF CHRONIC DISEASES IN ADULT AND AGING INDIVIDUALS=> THE ROLE OF MATERNAL MELATONIN IN THE REGULATION OF FETAL TRANSCRIPTIONAL AND GENE PROMOTER ACTIVITY.
Developmental Programming of Cardiovascular Disease by Hypoxia and Oxidative Stress
ACCION DE LA MELATONINA MATERNA DURANTE LA GESTACION Y SU EFECTO SOBRE LA HIPERFUNCION POSTNATAL DE LA GLANDULA SUPRARRENAL EN PRIMATES.
ACCIONES DE MLATONINA Y ACTH SOBRE LA FUNCION CIRCADIANA DE LA GLANDULA SUPRARRENAL DE RATA.
Melatonina como transductor neuroendocrino para los ritmos circadianos de expresión génica en la glándula suprarrenal
INVESTIGACION DE LAS ALTERACIONES EN EL LINAJE DE CELULAS EPENDIMARIAS QUE GATILLAN(I)EL INICIO DE LA HIDROCEFALIA EN EL EMBRION Y (II)EL DESARROLLO POSNATAL DE HIDROCEFALIA SEVERA
INVESTIGACION DE ASPECTOS FUNCIONALES DEL ORGANO SUBCOMISURAL MEDIANTE ESTUDIOS DE EXPRESION DEL GEN RF-GLY I
INVESTIGACION DE LA HIDROCEFALIA CONGENITA Y DE LAS ALTERACIONES EN LA COMPOSICION DEL LIQUIDO CEFALORRAQUIDEO CAUSADAS POR UNA DISFUNCION DEL ORGANO SUBCOMISURAL DURANTE SU DESARROLLO
INVESTIGACION DE ASPECTOS FUNCIONALES DEL ORGANO SUBCOMISURAL MEDIANTE ESTUDIOS DE EXPRESION DEL GEN RF-GLY I
The subcommissural organ=> an enigmatic brain gland
BIOSINTESIS DE PRODUCTOS SECRETORIOS DEL ORGANO SUBCOMISURAL

Review (1)

The circadian timing system: Making sense of day/night gene expression
19
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

5
Claudia Torres

Full Professor

Instituto de Anatomía, Histología y Patología

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

3
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

2
Lorena Abarzúa

Investigador

Medicina

Universidad de los Andes

Santiago, Chile

2
Carlos Spichiger

Profesor Adjunto

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Natalia Mendez

Profesor Auxiliar

UNIVERSIDAD AUSTRAL DE CHILE

valdivia, Chile

1
Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

1
José Rocha

Research Assistant

Evolutionary Biology

Centro de investigación i-mar

Puerto Montt, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

1
Diego Halabi

Profesor Auxiliar

Escuela de Odontología

Universidad Austral de Chile

Valdivia, Chile

1
Emilio HERRERA

Associate Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Pedro Chana

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

1
Paulina Troncoso

Inserción PhD

Investigación y Desarrollo

Neurognos SpA

Santiago, Chile