Man

Teresa - Caprile Elola-olaso

Associate profesor

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

Líneas de Investigación


Cerebrospinal fluid signaling. Developmental Biology. Subcommissural Organ. Axon guidance, Neurogenesis

Educación

  •  Cell biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2001
  •  Biologist, Universidad Autonoma de Madrid. España, 1995

Experiencia Académica

  •   Associate professor Full Time

    Universidad de Concepcion

    Facultad de Ciencias Biológicas

    Concepción., Chile

    2003 - A la fecha

  •   Postdoctorate Full Time

    UNIVERSIDAD DE CONCEPCION

    Facultad de Ciencias Biológicas

    Concepcion, Chile

    2001 - 2003

Formación de Capital Humano


TUTOR OF POSTGRADUATE STUDENTS

-Karen Stanic. PhD in cell biology, University of Concepción (2011-2017)
Title: "Study of the posterior commissure formation during Embryonic Development in Gallus Gallus".

-Melissa Gonzalez. Mgs in Biochemistry and Informatics. University iof Concepcion (2012-2015)
Title: "Variation of cerebrospinal fluid during early stages of embryonic development".

-America Vera. Mgs in Biochemistry and Bioinformatics. University of Concepción (2012-2015)
Title: "SCO-spondin contained in cerebrospinal fluid participates in early neurogenesis".

-Antonia Recabal. PhD in cell biology. University of Concepción (2015- in ejecution)
Title: "Effect of diet on hypothalamic neurogenesis"

-Sergio Lopez. Mgs in Biochemistry and Informatics. University of Concepción (2017-in ejecution)
Title:"Effect of diet in neurogenesis at the area postrema"

TUTOR OF UNDERGRADUATE STUDENTS

-Karen Stanich. Thesis of biochemistry. University of Concepción (2009-2011)
Title: "Expression of axonal guidance molecules in the diencephalic roof plate and its role in the formation of the posterior commissure".

-Melissa Gonzalez. Thesis of Bioingeniery.University of Concepción (2012-2014)
Title: "Standardization of two-dimensional electrophoresis of embryonic cerebrospinal fluid"

-Antonia Recabal.Thesis of Bioingeniery. University of Concepción (2013- 2014)
Title"Development of a methodology to establish the dynamics of embryonic cerebrospinal fluid"

- Carolina Cifuentes, Luisa Ríos and Manuel .Thesis of pedagogy in biology University of Concepción (2014-2015).
Title "Proposal for the preparation of pedagogical material for the unit "cell-organism integration"".

-Natalia Saldivia. Thesis of Bioingeniery. University of Concepción (2013- 2014).
"Expression of EphA4 and EphA2 during posterior commissure development".

-Israel Diaz and Natalia Sanchez. Thesis of pedagogy in biology.University of Concepción (2013-2014).
Title: "Methodological proposal for the unit organization and function of the nervous system ".

-Tatiana Alvarez Quintanillas. Thesis of pedagogy in biology, University of Concepción (2018).
Title: "How prepared are our students in preventing HIV virus infection?".

-Andrea Monsalvez Rojas and Javiera Reyes. Thesis of pedagogy in biology, University of Concepción (2018-2019).
Title: "Are the students of high school informed about ITS and contraception methods?.


Difusión y Transferencia


A-CONGRESS OF THE SPECIALITY

-Stanic K., Gonzalez M., Montecinos H., Caprile T. (2014) Formation of the posterior commissure: a multi-step journey of commissural axons. Mechanism of Neuronal development. EMBO workshop. Kibbutz ein-Gedi, Israel. Marzo, 2014.

- Stanic K., Gonzalez M., Montecinos H., Caprile T. (2014) Axon guidance along caudal diencephalon: expression pattern of guidance cues towards the formation of the posterior commissure. 9th FENS forum of Neuroscience. Milán, Italia. Julio 2014

- González M.,Stanic K., Montecinos H., Caprile T. (2014) Chick embryonic cerebrospinal fluid analysis by 2D-PAGE.XXVIII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas. Octubre 2014.

- Stanic K., González M., Saldivia N., Montecinos H., Caprile T (2014). Expression pattern of guidance cues and extracellular matrix molecules along axonal navigation pathways in posterior commissure formation. XXVIII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas. Octubre 2014.

-Vera A., Recabal A., Riffo E., Montecinos H.,Caprile T. (2014) SCO-spondin from embryonic cerebrospinal fluid binds lipoproteins to regulate the early neurogénesis.XXVIII Annual Meeting of the Chilean Society for Cell Biology, Puerto Varas. Octubre 2014.

-Stanic K., Saldivia N., González M., Forstera B., Benitez JR.,Montecinos H., Caprile T.(2015) Expression pattern of extracellular matrix proteins in the prosomere I during posterior commissure development. Society for neuroscience, Chicago EEUU. Octubre 2015

-Recabal A., Saldivia N.,Montecinos H., Caprile T.(2015) Development of methodology for establishing the embryonic cerebrospinal fluid dynamics. XXIX Annual Meeting of the Chilean Society for Cell Biology, Chile, Puerto Varas. Octubre 2015

-Zelada D., Pinto C., Caprile T., Henríquez JP., Osses N. (2015) C-terminal tallo f BMP receptor type II translocates to the nuceus and inhibits morphological differentiation of motor neuron cells. XXIX Annual Meeting of the Chilean Society for Cell Biology, Chile, Puerto Varas. Octubre 2015

-Saldivia N., Stanic K., Recabal A., Montecinos H., Caprile T. (2015) Expression pattern of ephrin-a2 at early stages of posterior commissure formation. XXIX Annual Meeting of the Chilean Society for Cell Biology, Chile, Puerto Varas. Octubre 2015

-Stanic K., Forstera B., Benitez JR.,Montecinos H., Caprile T.(2016) Molecular expression n of guidance cues and extracellular matrix in the pretectal área during posterior commissure development. 10th FENS forum of Neuroscience. Copenhague, Dinamarca. Julio 2016

-Astuya A., Rodriguez F., Aballay-Gonzalez A., Ulloa V, Caprile T. (2016) In vitro approach for the study of toxic effects of harmful marine microalgae. The 17 International Conference of harmful Algae. Florianopolis, Brasil. Octubre 2016

- Recabal A, Fernández P, Caprile T, Sáez JC, García MA.(2017) Connexin 43 participates in the proliferation of Tanycytes in vitro. XXXI Annual Meeting of the Chilean Society for Cell Biology, Chile, Puerto Varas. Octubre 2017

-Recabal A; Elizondo-Vega R.,Palma A., Caprile T., Philippot C., Steinhauser C., Garcia-Robles MA. (2018) Role of connexin 43 in the formation of radial glia-like features in hypothalamic tanycytes: coupling and proliferation. 11th FENS forum of Neuroscience. Julio 2018, Berlin, Alemania.

B-OUTREACH ACTIVITIES

-Talk at Tomas Jefferson school for students of the last years of secundary education. Title "How to train your brain". Concepción, July 2014.

-Talk at Aurora de Chile school for students of the last years of secundary education. Title: "In search of the perfect synapse ". Chiguayante,october 2014

-Talk at Saint Johns school for college student. Títle “Navigating between synapses”. San Pedro de la Paz, October 2016.

-Talk in the course “Bioingenieria bajo la lupa”. Course organized by the faculty of biological sciences for students of the last years of secondary education. Title: Brain Hemispheres: Two Connected Worlds. December 2017

- Talk at Saint Johns school for college student. Títle "The brain, an organ in constant development"”. San Pedro de la Paz, mayo 2018.

-Talk in the course “Bioingenieria bajo la lupa”. Course organized by the faculty of biological sciences for students of the last years of secondary education. Title: Brain Hemispheres: Two Connected Worlds. December 2018

Talk at the Instituto de niñas school. Title "The brain in the sleeping world: why we need sleep?". March 2019

-Talk at the Santisima Trinidad school for student of the last years of secundary education. Title "The brain, an organ in constant development". April 2019.

-Reviewer in Explora congress, evaluating the scientific work of the differents schools of the Bio-Bio region. 2015-2018

C-OUTREACH AND EDUCATION GRANTS

-Education proyect Nº15-009 (2015-2017). Coautor. Title “Video platform as a complementary tool to face-to-face teaching to strengthen the teaching-learning process in subjects of Cell Biology and Histology".

-University of Concepcion outreach grant " Hundred years, hundred children, hundred microscopes". This project is financed by the University of Concepcion, and delivers folding microscopes (foldscopes) to 100 children of vulnerable rural schools, accompanied by lectures and delivery of biological matherial. The project ends with the visit of the children to the Concepcion Unversity and a prize to the best images taken with the microscope delivered. 2018-2019 (in phase final of ejecution)


Premios y Distinciones

  •   premio Asignacion Academica

    Universidad de Concepcion

    Chile, 2007

    This award is a distintcion for academic excellence, that increments in 20% the salary for 3 years.

  •   premio Asignacion Academica

    Universidad de Concepcion

    Chile, 2011

    This award is a distintcion for academic excellence, that increments in 20% the salary for 3 years.


 

Article (20)

Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network
Study of the ichthyotoxic microalga Heterosigma akashiwo by transcriptional activation of sublethal marker Hsp70b in Transwell co-culture assays
Hypothalamic Neurogenesis as an Adaptive Metabolic Mechanism
Matrix effects on a cell-based assay used for the detection of paralytic shellfish toxins in bivalve shellfish samples
Interaction between SCO-spondin and low density lipoproteins from embryonic cerebrospinal fluid modulates their roles in early neurogenesis
Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis
Complementary expression of EphA7 and SCO-spondin during posterior commissure development
Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration
SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development
Subdivisions of Chick Diencephalic Roof Plate: Implication in the Formation of the Posterior Commissure
Physiological response of bovine subcommissural organ to endothelin 1 and bradykinin
Polarized Expression of Integrin beta 1 in Diencephalic Roof Plate During Chick Development, a Possible Receptor for SCO-spondin
The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells
Synthesis of transthyretin by the ependymal cells of the subcommissural organ
Vitamin C uptake and recycling among normal and tumor cells from the central nervous system
Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid
Functional aspects of the subcommissural organ-Reissner's fiber complex with emphasis in the clearance of brain monoamines
High-affinity sodium-vitamin C co-transporters (SVCT) expression in embryonic mouse neurons
Spatial distribution of Reissner's fiber glycoproteins in the filum terminale of the rat and rabbit

Abstract (4)

Vitamin C transporters in ependymal cells
Comparative kinetic characterization of vitamin C transporters in neurons, melanocytes and glial cells
Comparative analysis of the vitamin C transport in embryonic neurons and astrocytes.
Endothelin receptors in the subcommissural organ

Note (1)

Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies

Proyecto (5)

SCO-SPONDIN: A CEREBROSPINAL FLUID MATRICELLULAR PROTEIN FULFILLING CRUCIAL NEUROGENIC FUNCTIONS
Hypothalamic control of feeding behavior
Deteccion de VMP mediante metodos in vitro alternativos a bioensayo de raton: generacion de soluciones/herramientas biorecnologicas para monitoreos rutinarios de marea roja
Diencephalic roof plate, a source of axonal guidance cues
Disruption of the neuroepithelium/ependyma (ventricular zone) during development leads to hydrocephalus, abnormal brain development and impaired postnatal neurogenesis. Strategies aimed to diminish/ repair the outcomes of ventricular zone
43
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

13
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

6
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

6
Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

6
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

6
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

5
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

4
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

4
Antonia Recabal

Docente

Universidad Católica de la Santisima Concepción

Concepción, Chile

3
Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile

2
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

2
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

1
César González

Profesor Asistente

Facultad de Medicina y Ciencias

Universidad San Sebastián

Puerto Montt, Chile

1
Victor Hernandez

Associate Professor (and Vicedean Faculty)

Botany Department

UNIVERSIDAD DE CONCEPCION, LABORATORIO DE QUÍMICA DE PRODUCTOS NATURALES

Concepcion, Chile

1
Lorena Delgado

Encargada laboratorio Biotoxinas marinas

Salud Ambiental

Instituto de Salud Pública de Chile

Santiago, Chile

1
Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

1
Hans Richter

Profesor Titular

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

1
Carla Aburto

Investigador Postdoctoral

Escuela de Ingeniería Bioquímica

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

1
Magdiel Salgado

INVESTIGADOR

BIOLOGIA CELULAR

Universidad de Concepción

CONCEPCION, Chile

1
German Osorio

Especialista en Microscopia

Biologia Celular

Universidad de Concepción

Concepción, Chile