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JUAN PABLO HENRIQUEZ HOHMANN

Associate Professor

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Líneas de Investigación


- Signaling pathways in the maintenance and regeneration of the vertebrate neuromuscular junction (NMJ). - Vitamin C transport in skeletal muscle plasticity.

Educación

  •  Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001
  •  Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994

Experiencia Académica

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepcion, Chile

    2004 - A la fecha

  •   Research Associate (as Postdoctoral) Other

    UNIVERSITY COLLEGE LONDON

    Biological Sciences

    Londres, Reino Unido

    2002 - 2004

Experiencia Profesional

  •   Associate Professor Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2004 - A la fecha

Formación de Capital Humano


DOCTORATE THESES

1- Marcela Low Mansilla
"Expression profile and regulation of the vitamin C transporter SVCT2 during skeletal muscle development"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
Finished, 2011

2- Daniel Sandoval Silva
"Study of the expression and subcellular localization of the vitamin C transporter SVCT2 during skeletal muscle plasticity"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
Finished, 2011

3- Ariana Bertín
"Cross-talk between the canonical Wnt and BMP signaling pathways during intramembraneous bone development of the amphibian Xenopus tropicalis"
(Co-mentored with Dr. Sylvain Marcellini)
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
Finished, 2014

4- Jorge Ojeda
"Expression and function of Frizzled receptors during vertebrate neuromuscular junction maturation"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2013-

5- Cristina Pinto
"Activation and neuroprotective function of the Wnt and BMP signaling pathways in a motor neuron model of Amyotrophic Lateral Sclerosis"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2013-

6- Viviana Pérez
"Cross-talk between the Wnt and neurotrophin-dependent pathways on postsynaptic maturation of the vertebrate neuromuscular junction"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2013-

7- Andrea Beyer
“Role of the guanine nucleotide exchange factor for heterotrimeric G proteins Ric-8 on motor neuron development”
Co-mentored with Dr. Marcela Torrejón
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2014-

8- Francisca Bermedo-García
"Wnt signaling in the regeneration of the neuromuscular synapse: a role for terminal Schwann cells"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2017-

9- Diego Zelada Varas
"Expression and function of the Wnt receptor Fzd9 during the renegeration of the neuromuscular junction"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2017-

10- Jessica Mella Castro
"Study of the function of the Wnt/b-catenin signaling pathway in the fragmentation of the postsynaptic apparatus at the neuromuscular junction"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2018-

11- Angelymar Medina Moreno
"Control of small Rho GTPases by Wnt signaling in the maintenance of the postsynaptic apparatus of the neuromuscular junction in vertebrates"
Doctorate Thesis. Cell and Molecular Biology Program.
Universidad de Concepcion
In progress 2020-

MASTER THESES

1- Evelyn Avilés Fuentes
"Expression and function of the Wnt receptor Frizzled-9 at the vertebrate neuromuscular junction"
Master Thesis. Biochemistry and Bioinformatics.
Universidad de Concepcion
Finished, 2009

2- Cristina Pinto Figueroa
"Study of Wnt signaling in an in vitro model of Amyotrophic Lateral Sclerosis"
Master Thesis. Physiology.
Universidad de Concepcion
Finished, 2012

3- Esperanza Martínez Campos
"Organization of the neuromuscular connectivity in Branchiostoma lanceolatum"
Master Thesis. Neuroscience.
Universidad de Concepcion
In progress, 2020-

UNDERGRADUATE THESES

1- Miguel Albistur Urrutia
"Expression and subcellular localization of Wnt3 in a mouse in vitro model of motor neurons"
Bioengineer Thesis
Universidad de Concepcion
Finished, 2011

2- Jaime Teneb Lobos
"The in vivo role of the muscle Wnt receptor Frizzled 9 on postsynaptic differentiation"
Bioengineer Thesis
Universidad de Concepcion
Finished, 2012

3- Jorge Ojeda Orellana
"Signaling pathways involved in the positive effect of vitamin C on early myogenesis"
Biochemistry Thesis
Universidad de Concepcion
Finished, 2012

4- Francisca Bermedo-García
"Xenopus tropicalis as a model to study the formation, maturation and maintenance of the neuromuscular junction"
Bioengineer Thesis
Universidad de Concepcion
Finished, 2016

5- Nicolás Moreno Pérez
"Activation of the WNT-beta-catenin pathway during vitamin C-induced myogenesis"
Bioengineer Thesis
Universidad de Concepcion
Finished, 2016

6- Esperanza Martínez Campos
"Characterization of the neuromuscular junction in Branchiostoma lanceolatum through histological techniques"
Master Thesis. Neuroscience.
Universidad de Concepcion
Finished, 2020


Premios y Distinciones

  •   Outstanding Professor

    UNIVERSIDAD DE CONCEPCION

    Chile, 2013

    Given by the Evaluation Committee, Faculty of Biological Sciences, Universidad de Concepcion.

  •   Merit assignment

    UNIVERSIDAD DE CONCEPCION

    Chile, 2011

    A salary assignment for merit behaviour in lecturing, research and outreaching, given by University of Concepcion

  •   Outstanding Professor

    UNIVERSIDAD DE CONCEPCION

    Chile, 2016

    Given by the Evaluation Committee, Faculty of Biological Sciences, Universidad de Concepcion.

  •   Merit assignment

    UNIVERSIDAD DE CONCEPCION

    Chile, 2016

    A salary assignment for merit behaviour in lecturing, research and outreaching, given by University of Concepcion.


 

Article (31)

The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse.
beta-catenin aggregation in models of ALS motor neurons: GSK3 beta inhibition effect and neuronal differentiation
Efficient gene transfer into primary muscle cells to analyze nerve-independent postsynaptic organization in vitro
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
Bone regeneration after traumatic skull injury in Xenopus tropicalis
Physical nanocomposite hydrogels filled with low concentrations of TiO2 nanoparticles: Swelling, networks parameters and cell retention studies
The neuromuscular junction of Xenopus tadpoles: Revisiting a classical model of early synaptogenesis and regeneration
ALS-linked protein disulfide isomerase variants cause motor dysfunction
Wnt-5a/Frizzled9 Receptor Signaling through the G? o -G?? Complex Regulates Dendritic Spine Formation
Cellular and molecular characterization of a novel primary osteoblast culture from the vertebrate model organism Xenopus tropicalis
Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells
Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis
Characterization of Wnt/beta-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development
Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration
The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles
Bone morphogenetic protein 2 inhibits neurite outgrowth of motor neuron-like NSC-34 cells and up-regulates its type II receptor
Cloning and spatiotemporal expression of RIC-8 in Xenopus embryogenesis
Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes
Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblasto]genesis
Polarized Expression of Integrin beta 1 in Diencephalic Roof Plate During Chick Development, a Possible Receptor for SCO-spondin
The ascorbic acid transporter SVCT2 is expressed in slow-twitch skeletal muscle fibres
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Heparin activates Wnt signaling for neuronal morphogenesis
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin
Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease
Extracellular matrix histone H1 binds to perlecan, is present in regenerating skeletal muscle and stimulates myoblast proliferation
WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons.
Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation
Tubulin domains for the interaction of microtubule associated protein DMAP-85 from Drosophila melanogaster
Subpopulations of tau interact with microtubules and actin filaments in various cell types.

Abstract (1)

Oxidative slow-twitch skeletal muscle fibres express the ascorbic acid transporter SVCT2 during chick myogenesis

EditorialMaterial (1)

Editorial: Morphogens in the Wiring of the Nervous System

Proyecto (9)

Núcleo Milenio en Biología Regenerativa (MINREB)
ROLE OF WNT SIGNALING DURING THE MATURATION OF THE NEUROMUSCULAR SYNAPSE.
FUNCTIONAL PROCESSING OF BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR (BMPRII)
THE IN VIVO ROLE OF WNT-FRIZZLED SIGNALING DURING NEUROMUSCULAR JUNCTION DEVELOPMENT.
Anillo de Investigación en Ciencia y Tecnología para el Estudio del Sistema Nervioso=> Biología Celular y Aplicaciones Biomédicas.
Apoyo al Desarrollo de la Cooperación Internacional para la Investigación de Excelencia.
Estudio de la función de la señalización Wnt en la diferenciación postsináptica en la unión neuromuscular de vertebrados.
GLIPICAN-1=> POSIBLE MODULADOR DE LA ACTIVIDAD DE FGF-2 DURANTE LA MIOGENESIS , ESTUDIO DE LOS REQUERIMIENTOS ESTRUCTURALES
GLIPICAN=> DETERMINACION DE SUS POSIBLES FUNCIONES DURANTE LA MIOGENESIS

Review (4)

Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication
Control of osteogenesis by the canonical Wnt and BMP pathways in vivo
Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction
The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction
38
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

6
Nelson Osses

Profesor Titular

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

6
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

5
Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

5
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

5
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

4
Daniel Sandoval

Co-investigador

Ciencia Animal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

4
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

3
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Cristina Pinto

Doctor en ciencias biologicas

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

2
Alejandro Yanez

Full professor

Faculty of Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

2
María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Marcela Torrejon

Associate Professor

Biochemistry and Molecular Biology

Biological Sciences Faculty

Concepcion, Chile

2
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

2
Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

1
German Osorio

Especialista en Microscopia

Biologia Celular

Universidad de Concepción

Concepción, Chile

1
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Maldonado

Asistente de Investigacion

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Romina Bertinat

Investigador asociado

Centro de Microscopía Avanzada, CMA BIO BIO

Universidad de Concepcion

Concepción, Chile

1
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Veronica Cambiazo

Associate Professor

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
Francisca Benavente

Directora de Laboratorio

Bioscell SA

Santiago, Chile

1
Pilar Cárdenas

Encargada de FONDECYT 1191006

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

1
Carola Bruna

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS

Concepción, Chile

1
Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
David Muñoz

Investigador

Biologia Celular

Universidad de Concepción

Concepción, Chile

1
Katia Saez

Profesor Asociado

Departamento de Estadística

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

1
Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile