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Mariana Victoria Casas Atala

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Muscle Plasticity, Frequency decoding in skeletal muscle, Excitation Transcription Coupling, Muscle diseases, Sarcopenia

Cellular and Molecular Biology, UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI. Francia, 2006

Instructor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2006 - 2010
Assistant Professor Full Time

Medicine

Santiago, Chile

2010 - A la fecha

Instructor Full Time

Universidad de Chile, Facultad de Medicina

Santiago, Chile

2006 - 2010
Assistant Professor Full Time

Universidad de Chile

Santiago, Chile

2010 - A la fecha

Profesional title of Medical technology thesis direction:
1. Reinaldo Figueroa. (July 2008).
2. Carlos Tapia. (July 2009).

Profesional title of Biochemistry, thesis direction:
Villalobos, Verónica: "REGENERACIÓN MUSCULAR POR INYECCIÓN LOCAL DE CÉLULAS MESENQUIMALES HUMANAS ESFEROIDES 3D (AT-hMSCs-3D) EN UN MODELO MURINO DE LESIÓN MUSCULAR SEVERA", 2019

UNIVERSIDAD DE CHILE, Magíster/Master/DEA:
1. Francisco Ignacio Jaque Fernández: "Participación de Panexina-1 en la regulación del funcionamiento de Cav1.1", 2016
2. Esteban Quezada, "“PAPEL DEL IP3R EN LOS CAMBIOS DE LA EXPRESIÓN DEL COMPLEJO MCU INDUCIDA POR ESTÍMULO ELÉCTRICO EN MÚSCULO ESQUELÉTICO ADULTO”", 2018

PhD thesis direction
1.Gonzalo Jorquera , PhD in Biomedical Sciences (September 2014)
2.Cristián Campos, PhD in Biomedical Sciences (January 2019)

International Travel Award

Biophysical Society

Estados Unidos, 2009

Support young scientists in attending the Annual Meeting of the Biophysical Society


Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice Contreras-Hernandez, Ignacio; Castro-Sepulveda, Mauricio; Tevy, María Florencia Article ISI SCOPUS AGING-US (2018)
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle Almarza G.; Valladares, D; Casas, M; Toledo, H; Jaimovich, E; Buvinic, S Article ISI SCOPUS Skeletal Muscle (2016)
ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells Diaz-Vegas, A; Campos, CA; Contreras-Ferrat, A; Casas, M; Buvinic, S; Jaimovich, E; Espinosa, A Article ISI SCOPUS PLOS ONE (2015)
Exercise Sensitizes Skeletal Muscle to Extracellular ATP for IL-6 Expression in Mice Fernández-Verdejo, R; Casas, M; Galgani, J; Jaimovich, E; Buvinic, S Article ISI SCOPUS INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2014)
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion Casas, M; Contreras-Ferrat, A; Llanos, P; Galgani, J. E. Article ISI SCOPUS OBESITY REVIEWS (2014)
Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity Jorquera, G; Altamirano F.; Contreras-Ferrat, A; Almarza G.; Buvinic, S; Jacquemond, V; Jaimovich, E; Casas, M Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2013)
Electrical Stimuli Are Anti-Apoptotic in Skeletal Muscle via Extracellular ATP. Alteration of This Signal in Mdx Mice Is a Likely Cause of Dystrophy Valladares, D; Almarza G.; Contreras, A; Pavez, M; Buvinic, S; Jaimovich, E; Casas, M Article ISI SCOPUS PLOS ONE (2013)
Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice Altamirano F.; Valladares, D; Henríquez-Olguin, C; Casas, M; Lopez, JR; Allen, PD; Jaimovich, E Article ISI SCOPUS PLOS ONE (2013)
PI3-kinase is involved in plasticity of adult myofibers acting as a nodal step that originates divergent pathways for gene expression Jorquera, G; Altamirano F.; Buvinic, S; Contreras-Ferrat, A; Jaimovich, E; Casas, M Article FASEB JOURNAL (2013)
Measurement of calcium release due to inositol trisphosphate receptors in skeletal muscle Casas, M; Altamirano F.; Jaimovich, E Article SCOPUS Methods in Molecular Biology (2012)
IP 3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers Casas, M; Figueroa, R; Jorquera, G; Escobar, M; Jaimovich, E; Molgó J. Article JOURNAL OF GENERAL PHYSIOLOGY (2010)
IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers Casas, M; Figueroa, R; Jorquera, G; Escobar, M; Molgó J.; Jaimovich, E Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2010)
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle Buvinic, S; Almarza G.; Bustamante, M; Casas, M; López, J; Riquelme, M; Huidobro-Toro, JP; Jaimovich, E Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)


Cav1.1 controls ATP release to elicit gene expression in adult muscle fibers Jorquera, G; Valladares, D; Pietri-Rouxel, F; Allard, B; Jacquemond, V; Jaimovich, E; Casas, M Abstract ISI FASEB JOURNAL (2014)
Extracellular ATP as a relevant mediator between skeletal muscle depolarizaition and interleukin-6 expression: from cell culture to whole animal adaptations Buvinic, S; Bustamante, M; Fernández-Verdejo, R; Casas, M; Vasquez, J; Jaimovich, E Abstract ISI FASEB JOURNAL (2014)
Muscle slow to fast fiber plasticity is triggered by low frequency stimulation, membrane depolarization and ATP Casas, M; Llanos, P; Jorquera, G; Jaimovich, E Abstract ISI FASEB JOURNAL (2014)
Nifedipine Treatment Improves Muscle Function in Mdx Mice Altamirano F.; Valladares, D; Henríquez-Olguin, C; Casas, M; Lopez, JR; Allen, PD; Jaimovich, E Abstract ISI BIOPHYSICAL JOURNAL (2014)
Atp-Induced Membrane Depolarization Relates to Skeletal Muscle Fibers Plasticity Casas, M; Llanos, P; Jorquera, G; Hidalgo, J; Buvinic, S; Jaimovich, E Abstract BIOPHYSICAL JOURNAL (2013)
Cav1.1 Controls ATP Release in Adult Muscle Fibers Jorquera, G; Pietri-Rouxel, F; Allard, B; Jacquemond, V; Gentil, C; Jaimovich, E; Casas, M Abstract BIOPHYSICAL JOURNAL (2013)
A molecular mechanism for frequency dependent skeletal muscle fiber plasticity Jaimovich, E; Jorquera, G; Buvinic, S; Casas, M Abstract ISI FASEB JOURNAL (2012)
Cav1.1 Acts as a Voltage Sensor for Two Separate Processes in Skeletal Muscle with Different Voltage Dependence Casas, M; Jaimovich, E Abstract ISI BIOPHYSICAL JOURNAL (2011)
Muscle Plasticity Is Regulated by a Process Involving ATP Release and Inositol Trisphosphate Production in Skeletal Myofibers Jorquera, G; Almarza G.; Buvinic, S; Jaimovich, E; Casas, M Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2011)
TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE Jaimovich, E; Buvinic, S; Casas, M; Figueroa, R; García, I Abstract JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Slow calcium signals induced by electrostimulation in adult skeletal muscle fibers. Casas, M; Jaimovich, E Abstract BIOPHYSICAL JOURNAL (2007)


Intracellular calcium modulation of gene expression Casas, M; Jaimovich, E BookWhole SCOPUS Food and Nutritional Components in Focus (2016)


ATP Signaling in Skeletal Muscle: From Fiber Plasticity to Regulation of Metabolism Casas, M; Buvinic, S; Jaimovich, E Review ISI SCOPUS EXERCISE AND SPORT SCIENCES REVIEWS (2014)