Man

Mariana Victoria Casas Atala

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Muscle Plasticity, Frequency decoding in skeletal muscle, Excitation Transcription Coupling, Muscle diseases, Sarcopenia

Educación

  •  Cellular and Molecular Biology, UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI. Francia, 2006

Experiencia Académica

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    2006 - 2010

  •   Assistant Professor Full Time

    Medicine

    Santiago, Chile

    2010 - A la fecha

Experiencia Profesional

  •   Instructor Full Time

    Universidad de Chile, Facultad de Medicina

    Santiago, Chile

    2006 - 2010

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha

Formación de Capital Humano


Profesional title of Medical technology thesis direction:
1. Reinaldo Figueroa. (July 2008).
2. Carlos Tapia. (July 2009).

Profesional title of Biochemistry, thesis direction:
Villalobos, Verónica: "REGENERACIÓN MUSCULAR POR INYECCIÓN LOCAL DE CÉLULAS MESENQUIMALES HUMANAS ESFEROIDES 3D (AT-hMSCs-3D) EN UN MODELO MURINO DE LESIÓN MUSCULAR SEVERA", 2019

UNIVERSIDAD DE CHILE, Magíster/Master/DEA:
1. Francisco Ignacio Jaque Fernández: "Participación de Panexina-1 en la regulación del funcionamiento de Cav1.1", 2016
2. Esteban Quezada, "“PAPEL DEL IP3R EN LOS CAMBIOS DE LA EXPRESIÓN DEL COMPLEJO MCU INDUCIDA POR ESTÍMULO ELÉCTRICO EN MÚSCULO ESQUELÉTICO ADULTO”", 2018

PhD thesis direction
1.Gonzalo Jorquera , PhD in Biomedical Sciences (September 2014)
2.Cristián Campos, PhD in Biomedical Sciences (January 2019)


Premios y Distinciones

  •   International Travel Award

    Biophysical Society

    Estados Unidos, 2009

    Support young scientists in attending the Annual Meeting of the Biophysical Society


 

Article (15)

Evaluating the essential role of RONS in vivo in exercised human muscle.
Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse
Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells
Exercise Sensitizes Skeletal Muscle to Extracellular ATP for IL-6 Expression in Mice
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion
Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity
Electrical Stimuli Are Anti-Apoptotic in Skeletal Muscle via Extracellular ATP. Alteration of This Signal in Mdx Mice Is a Likely Cause of Dystrophy
Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice
PI3-kinase is involved in plasticity of adult myofibers acting as a nodal step that originates divergent pathways for gene expression
Measurement of calcium release due to inositol trisphosphate receptors in skeletal muscle
IP 3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers
IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle

Abstract (11)

Cav1.1 controls ATP release to elicit gene expression in adult muscle fibers
Extracellular ATP as a relevant mediator between skeletal muscle depolarizaition and interleukin-6 expression: from cell culture to whole animal adaptations
Muscle slow to fast fiber plasticity is triggered by low frequency stimulation, membrane depolarization and ATP
Nifedipine Treatment Improves Muscle Function in Mdx Mice
Atp-Induced Membrane Depolarization Relates to Skeletal Muscle Fibers Plasticity
Cav1.1 Controls ATP Release in Adult Muscle Fibers
A molecular mechanism for frequency dependent skeletal muscle fiber plasticity
Cav1.1 Acts as a Voltage Sensor for Two Separate Processes in Skeletal Muscle with Different Voltage Dependence
Muscle Plasticity Is Regulated by a Process Involving ATP Release and Inositol Trisphosphate Production in Skeletal Myofibers
TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE
Slow calcium signals induced by electrostimulation in adult skeletal muscle fibers.

BookWhole (1)

Intracellular calcium modulation of gene expression

Proyecto (10)

Nueva Terapia Farmacológica para el tratamiento de sarcopenia y distrofias musculares=> Prueba de concepto
EXCITATION-METABOLISM COUPLING IN SKELETAL MUSCLE; BASIC MECHANISMS AND THEIR ALTERATION IN OBESITY AND AGING
UNVEILING MOLECULAR BASIS FOR MUSCLE REMODELING AND MUSCLE-BONE CROSSTALK AT THE MASTICATORY APPARATUS=> EXTRACELLULAR ATP AS A SIGNALING MOLECULE.
Purinergic signaling in the adult muscle fiber=> functional crosstalk with the inositol phosphate pathway
Assessment of peripheral glucose utilization as a determinant factor of glucose-stimulated insulin secretion in humans
A new role for Cav1.1 as a frequency decoder for signals related to skeletal muscle plasticity
Señalización por estrés metabólico en cáncer, enfermedades cardiovasculares y diabetes
SIGNAUX CALCIQUES VOLTAGEDEPENDANTS GENERES PAR LE RECEPTEUR A L'INOSITOL TRISPHOSPHATE DANS LA FIBRE MUSCULAIRE ADULTE DE MAMMIFERE
Membrane potential dependence of IP3-elicited calcium signals triggered by DHPR in adult muscle fibers
A NEW ROLE FOR DYSTROPHIN IN EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE

Review (1)

ATP Signaling in Skeletal Muscle: From Fiber Plasticity to Regulation of Metabolism
27
Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

18
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

10
Sonja Buvinic

Associate Professor

Institute for Research in Dental Sciences

Universidad de Chile

Santiago, Chile

6
Gonzalo Jorquera

Profesor Auxiliar

Instituto de Fisiología

Universidad de Valparaíso

Valparaíso, Chile

5
Denisse Valladares

Assistant Professor

Universidad de O'Higgins

Rancagua, Chile

3
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

2
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Alexis Diaz

PhD stundent

Fisiología

universidad de Chile

Santiago, Chile

1
María Mizgier

NA

NA

NA

Santiago, Chile

1
Maria Tevy

Assistant Professor/Researcher

UNIVERSIDAD MAYOR

Santiago de Chile, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cristian Campos

Entrenamiento Post Doctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Mauricio Castro

Investigador

Universidad Finis Terrae

Santiago , Chile

1
Matias Escobar

Postdoctoral Researcher

Cancer Biology

University of Pennsylvania

Philadelphia, Chile