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María Luisa Mizgier Rojas

Postdoctorate

Universidad de Los Andes

Santiago, Chile

Diabetes Regulación de la secreción de insulina Resistencia insulinica Comunicación cruzada interórgano

Ciencias Medicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
Biologia celular, fisiología y patología. Nutrición, metabolismo y señalización, UNIVERSITE DENIS DIDEROT - PARIS VII. Francia, 2010
Biologia celular y fisiología, UNIVERSITE DENIS DIDEROT - PARIS VII. Francia, 2008

Postdoctorate fellow Full Time

Centre Européen d'étude de diabete

Strasbourg, Francia

2018 - 2020
Profesor investigador Full Time

UNIVERSIDAD DE LOS ANDES

Chile

2022 - A la fecha

Estudiante de Magister Full Time

Institut Cochin-INSERM U567

Paris, Francia

2009 - 2009
Tesista de Magíster Full Time

Instituto de Nutrición y Tecnología de los Alimentos (INTA) – Universidad de Chile

Santiago, Chile

2009 - 2010
Asistente de laboratorio Full Time

Instituto de Nutrición y Tecnología de los Alimentos (INTA) – Universidad de Chile

Santiago, Chile

2010 - 2012
Tesista Doctorado Full Time

Departamento de Nutrición, Diabetes y Metabolismo. Pontificia Universidad Católica de Chile

Santiago, Chile

2013 - 2016

Formación alumnos pre- y postgrado

2018-2020: Tutor de Tesis Magíster Sciences Analytiques pour les Bioindustries,
Faculté de Chimie, Université de Strasbourg- Mélissa Yepmo.

2018-2020: Tutoría de dos a cuatro estudiantes de Medicina anuales, pasantía de una semana en laboratorio.

2020: Tutor de práctica profesional Licence professionnelle Génétique Moléculaire et Culture Cellulaire, IUT
Nancy Brabois, Université de Lorraine – Léa Kinderstuth.

2018: Tutor de práctica profesional DUT Génie Biologique,
IUT Louis Pasteur, Université de Strasbourg – Margaux Simon.

I believe that communicating science to abroad public is a very important challenge we, as scientific researchers, must consider as crucial. Dissemination of our findings will promote and inform about Science and Research extensively.
During the last years, I actively participated in different event that offered me the possibility to exchange with the community and challenged me to translate our research in a general public language.
- Journées Portes Ouvertes (Open days) 2018-2019 at the European Centre of Study of Diabetes
- Fête de la Science (Science day) 2019 at Strasbourg, France organized by the Ministry of Higher Education, Research and Innovation.
- Running races organized to raise fund for the European Centre if the Study of Diabetes
- Diabetes screening in different events: European Parliament and running races
- Practical workshops for students and high school students
- Supervisor of medicine students doing their one-week lab internship. Two to four students per year.
- E-Newsletters on Diabetes and Health (quarterly)
- Publications on CEED Website (http://ceed-diabete.org/en/), podcasts, social media (Facebook, LinkedIn)

Beca Doctorado Facultad de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2012

Beca de manutención Doctorado en Ciencias Médicas. Duración 2012-1016
Albert Renold Travel Fellowships

European Foundation for the Study of Diabetes (EFSD)

Suiza, 2015

Beca para pasantía en el extrajero. La pasantía fue realizada en el laboratorio del Dr. Bouzakri en Ginebra, Suiza (abril-mayo 2015)
Beca asistencia a congresos

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2015

Beca de apoyo para asistir al 75th Scientific Sessions – American Diabetes Association (ADA). Boston, USA 5-10 Junio 2015.
Beca asistencia a congresos

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2016

Beca de apoyo para asistir al 76th Scientific Sessions – American Diabetes Association (ADA). New Orleans, USA 10-14 Junio 2016.
Beca congresos y cursos cortos

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2016

Beca de apoyo para asistir al 76th Scientific Sessions – American Diabetes Association (ADA). New Orleans, USA 10-14 Junio 2016.
Marie Sklodowska Curie Fellowship

Centre Européen d'étude du diabete

Francia, 2018

Postdoctoral Individual Fellowship


Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction Banerjee, Subhashis; Ghoshal, Sarbani; Stevens, Joseph R.; McCommis, Kyle S.; Gao, Su; Castro-Sepulveda, Mauricio; Mizgier, Maria L.; Girardet, Clemence; Kumar, K. Ganesh; Galgani, Jose E.; Niehoff, Michael L.; Farr, Susan A.; Zhang, Jinsong; Butler, Andrew A. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Integrin and autocrine IGF2 pathways control fasting insulin secretion in beta-cells Arous, Caroline; Mizgier, Maria Luisa; Rickenbach, Katharina; Pinget, Michel; Bouzakri, Karim; Wehrle-Haller, Bernhard Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Skeletal Muscle-Released Extracellular Vesicles: State of the Art Rome, Sophie; Forterre, Alexis; Mizgier, Maria Luisa; Bouzakri, Karim Article ISI FRONTIERS IN PHYSIOLOGY (2019)
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells Cataldo, Luis Rodrigo; Mizgier, María L.; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos, Paola; Busso, Dolores; Olmos, Pablo; Galgani, José E.; Santos, José L.; Cortés, Víctor A.; Wagner, Bridget Article ISI SCOPUS PLOS ONE (2017)
Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion Galgani, JE; Gomez, C; Mizgier, ML; Gutierrez, J; Santos, JL; Olmos, P; Mari, A Article ISI SCOPUS (2016)
Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion Mizgier, Maria L.; Cataldo, Luis R.; Gutierrez, Juan; Santos, José L.; Casas, Mariana; Llanos, Paola; Contreras-Ferrat, Ariel E.; Moro, Cedric; Bouzakri, Karim; Galgani, Jose E. Article ISI SCOPUS JOURNAL OF DIABETES RESEARCH (2016)
Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 ? -Cells Treated with Palmitate and Oleate Cataldo, L. R.; Mizgier, M. L.; Busso, D.; Olmos, P.; Galgani, J. E.; Valenzuela, R.; Mezzano, D.; Aranda, E.; Cort?s, V. A.; Santos, J. L. Article ISI SCOPUS JOURNAL OF DIABETES RESEARCH (2016)
Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 beta-cells Cataldo, LR; Cortes, VA; Mizgier, ML; Aranda, E; Mezzano D.; Olmos, P; Galgani, JE; Suazo, J; Santos, JL Article ISI SCOPUS Experimental and Clinical Endocrinology and Diabetes (2015)
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion Mizgier M.L.; Casas M.; Contreras-Ferrat, A; Llanos P.; Galgani, J. E. Article ISI SCOPUS OBESITY REVIEWS (2014)
Probiotic Screening and Safety Evaluation of Lactobacillus Strains from Plants, Artisanal Goat Cheese, Human Stools, and Breast Milk Gotteland M.; Cires, MJ; Carvallo C.; Vega, N; Ramirez, MA; Morales P.; Rivas, P; Astudillo F.; Navarrete P.; Dubos C.; Figueroa, A; Troncoso M.; Ulloa C.; Mizgier, ML; Carrasco-Pozo, C; Speisky H.; Brunser O.; Figueroa G. Article ISI SCOPUS JOURNAL OF MEDICINAL FOOD (2014)
Relationship between whole-body macronutrient oxidative partitioning and pancreatic insulin secretion/beta-cell function in non-diabetic humans Galgani, JE; Mizgier, ML; Mari, A; Ravussin E. Article ISI SCOPUS METABOLISM-CLINICAL AND EXPERIMENTAL (2014)
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells Carrasco-Pozo, C; Mizgier M.L.; Speisky H.; Gotteland M. Article ISI SCOPUS Chemico-Biological Interactions (2012)


Relationship of whole-body fuel oxidative partitioning with insulin secretion and beta cell function in non-diabetic humans Galgani, JE; Mizgier, ML; Mari, A; Ravussin E. Abstract ISI DIABETOLOGIA (2014)
EFFECT OF THE ADMINISTRATION OF A MILK PRODUCT CONTAINING A HEAT-TREATED PROBIOTIC AND A PREBIOTIC IN PRESCHOOL CHILDREN Mizgier, ML; Brignardello J.; Morales P.; Carvallo C.; Cires, MJ; Cruchet S.; Prioult, G; Benyacoub, J; Mukherjee R.; Henriquez, D; Gotteland M.; Brunser O. Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2013)


Absorción intestinal y Metabolismo de Polifenoles de la dieta y de Vitamina C Carrasco-Pozo C.; Mizgier, ML; Cruchet, S; Gotteland M.; Brunse, O BookSection (2013)


Les vésicules extracellulaires musculaires humaines ont une signature génétique propre qui dépend du type de fibre et exercent un effet autocrine. Mizgier, ML; Forterre, A; Reininger, L; Akbar, N; Hamdard, H; Rome, s; Pinget, M; Bouzakri K. ConferencePoster (2021)
Insulin-resistance induced by TNF-alpha in C2C12 increased the release of exosome-like vesicles, which affect insulin secretion of pancreatic beta-cells Reininger, L; Jalabert, A; Pais de Barros, JP; Colosetti, P; Akbar, N; Choudhury, R; Pinget, M; Mizgier, ML; Bouzakri K.; Rome, S ConferencePoster (2019)
Regulation of exosomes secretion by muscle fiber and insulin sensitivity Mizgier, ML; Hamdard,H; Pinget, M; Bouzakri, K ConferencePoster (2019)
Beta-Cells Function and Survival are Modulated Differentially by Type I or Type II Muscle trough specific myokines Mizgier, ML; Rutti, S; Pinget, M; Bouzakri, K ConferencePoster (2018)
. Effect of conditioned media from insulin-treated human myotubes on glucose-stimulated insulin secretion in isolated murine islets and β cells Mizgier, ML; Cataldo, LR; Gutierrez J.; Santos, JL; Casas M.; Llanos P.; Contreras-Ferrat, A; Moro C.; Bouzakri K.; Galgani, JE ConferencePoster (2016)
Assessment of the Role of Glucose Oxidation and Circulating Factors on Insulin Secretion in Non-Diabetic Humans Galgani, JE; Gómez C; Mizgier, ML; Santos, JL; Olmos, P; Mari, A ConferencePoster (2016)
Comparación de dos métodos de medición simultánea de quemoquinas y citoquinas circulantes Mizgier, ML; Gutierrez J.; Galgani, JE ConferencePoster (2016)
Efecto del medio condicionado de miotubos humanos tratados con insulina sobre la secreción de insulina en islotes y células beta Pancreáticas Mizgier, ML; Cataldo, LR; Gutierrez J.; Santos, JL; Casas M.; Llanos P.; Contreras-Ferrat, A; Moro M; Bouzakri K.; Galgani, JE ConferencePoster (2016)
Effect of Human Myotube Conditioned Media on Glucose-Stimulated Insulin Secretion from Mice Islets Mizgier, ML; Louche K; Garrido G.; Cataldo, LR; Santos, JL; Casas M.; Llanos P.; Contreras-Ferrat, A; Moro C.; Galgani, JE ConferencePoster (2015)
Serotonin acting through Htr2b negatively regulates glucose stimulated insulin secretion impairing mitochondrial function with increased gene expression of PGC-1α and UCP2 in β-cells Cataldo, LR; Mizgier, ML; Busso, D.; Olmos, P; Galgani, JE; Santos, JL; Cortes, VA ConferencePoster (2015)
Efecto de la serotonina intracelular y extracelular sobre la secreción de insulina estimulada por glucosa en células β-pancréaticas Cataldo, LR; Mizgier, ML; Cortes, VA; Galgani, JE; Santos, JL ConferencePoster (2013)
Modulation of plasmatic sCD14 by symbiotics in obese subjects Peña F; Mizgier, ML; Morales P.; Rios I.; Carrasco-Pozo C.; Diaz, E.; Brunser O.; Gotteland M. ConferencePoster (2011)


Assessment of peripheral glucose utilization as a determinant factor of glucose-stimulated insulin secretion in humans (ISSI) FONDECYT (1130217) Proyecto 2012-2016 Tesista
Evaluación de un producto lácteo con un probiótico y prebióticos para el apoyo nutricional y protección de lactantes y preescolares Nesstec Proyecto 2009-2011 Personal técnico y/o de apoyo
¿Tiene la microbiota intestinal un papel en la modulación de la inflamación de bajo grado en el sujeto obeso? FONDECYT (1080519) Proyecto 2008-2011 Tesista
¿Tiene la microbiota intestinal un papel en la modulación de la inflamación de bajo grado en el sujeto obeso? FONDECYT (1080519) Proyecto 2008-2011 Personal técnico y/o de apoyo


Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function Mizgier M.L.; FernÃ¡ndez-Verdejo R.; Cherfan J.; Pinget M.; Bouzakri K.; Galgani, J. E. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)