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Dolores Busso PERKINS

Associate Professor

Universidad de Los Andes

Santiago, Chile

Our work is aimed at understanding how nutritional imbalances influence metabolism and reproduction.

PhD in Biology (Physiology), Universidad de Buenos Aires. Argentina, 2005

Assistant Investigator Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2010 - 2012
PostDoc Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Biological Sciences

Santiago, Chile

2005 - 2009
PhD Student Full Time

Instituto de Biología y Medicina Experimental - Universidad de Buenos Aires

Buenos Aires, Argentina

1998 - 2005
Fellow Full Time

Institut de la Sante et Researche Medicale

Paris, Francia

1997 - 1997
Undergraduate Fellow Part Time

Centro de Educación Médica e Investigaciones Clínicas

Buenos Aires, Argentina

1996 - 1996
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2013 - 2016
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Faculty of Medicine

Santiago, Chile

2016 - 2019
Associate Professor Full Time

Universidad de los Andes

Faculty of Medicine

Santiago, Chile

2019 - A la fecha

Undergraduate Research Units

At Pontificia Universidad Católica de Chile
2006-2008. Mentor Biological Sciences student María José Oñate-Alvarado.
2009. Co-Mentor Biological Sciences student María José Marin.
2009. Co-Mentor Biological Sciences student Sebastian Pereda.
2010. Mentor Biochemistry student Nicolás Santander.
2011-2012. Mentor Medicine student Lilian Mascareño.
2012. Mentor Medicine student Isabella Passalaqua.
2012. Mentor Biological Sciences student Linda Quilaqueo.
2014 -2015. Mentor Biochemistry student Paz Molina.
2014 - 2016. Mentor Medicine student Andrés Schneider.
2016. Mentor Medicine student Daniel Gallardo.
2018. Mentor Biochemistry student Maximiliano Villarreal.
2019. Mentor Nutrition students Perina Kutulas and Magdalena Gutiérrez.

At Universidad de los Andes
2021. Mentor Medicine students Javier Gonzalez (4th year) and Ignacio Zaninovic (3rd year).
2022. Mentor Medicine students Helene Francois (4th year) and Antonia Vela (3rd year).
2022. Mentor Medicine student Luis Velazquez (6th year).
2022 – Present. Supervisor Medicine teaching assistants Josefina González and Fernanda Jiménez.
2023. Mentor Medicine students Joaquín Bolívar and Ma. Trinidad Orellana (4th year).

Undergraduate thesis

2011-2012. Thesis in Biochemistry. Nicolás Santander.
2013 - 2014. Thesis in Medical Technology. Constanza Andrea Baeza y Nathaly De La Jara
2013 - 2015. Thesis in Biochemistry. Alonso Quiroz.
2016 - 2017. Thesis in Biochemistry. Paz Molina.
2019. Thesis in Medical Technology. José Chavez.
2019. Thesis in Medical Technology. Nicolás Gonzalez.

Mentoring of international students

2011. MISTI-PUC Grant Fellowship. Allison Hamilos, from MIT (US)
2012. PLISSER Fellowship (Programa de Investigaciones en Salud Sexual y Reproductiva, Asociación Latinoamericana de Investigadores en Reproducción Humana). Natalia Pascuali, Universidad de Buenos Aires (Argentina)
2014. PLISSER Fellowship (Programa de Investigaciones en Salud Sexual y Reproductiva, Asociación Latinoamericana de Investigadores en Reproducción Humana). Paula Accialini Universidad de Buenos Aires (Argentina)
2015. MISTI-PUC Grant Fellowship. Dalia Walzer, from MIT (US)

Graduate Students

2012. Mentor Research Unit No. 1, PhD Program in Medical Sciences, School of Medicine UC. Lic. María José Parga.
2013. Mentor Research Unit No. 1, PhD Program in Medical Sciences, School of Medicine UC. Biochemist Nicolás Santander.
2015. Mentor Research Unit No. 2, PhD Program in Medical Sciences, School of Medicine UC. Biochemist Loni Berlowitz.
2018. Mentor Research Unit No. 2, PhD Program in Medical Sciences, School of Medicine UC. Biochemist Alonso Quiroz.
2021-2022. Mentor Research Units I and II, PhD Program in Biomedicine, Universidad de los Andes. Biochemist Fujiko Saavedra.
2023-2024. Mentor Research Units I and II, PhD Program in Biomedicine, Universidad de los Andes. Biologist Yessica Ortega.
2024-present. Mentor Research Unit I. PhD Program in Biomedicine, Universidad de los Andes. Biochemist Geraldine Lazcano.

Masters Thesis

2012-2013. Co-Mentor Master's Thesis in Nutrition, School of Medicine, Pontificia Universidad Católica de Chile. M.D. Grettel Martelo.
2016. Mentor Master's Thesis in Nutrition, School of Medicine, Pontificia Universidad Católica de Chile. Lic. Marcela Riquelme.
2017-2018. Mentor Master's Thesis in Nutrition, School of Medicine, Pontificia Universidad Católica de Chile. M.D. Andrea David.
2020-2021. Mentor Master's Thesis in Nutrition, School of Medicine, Pontificia Universidad Católica de Chile. M.D. Fernanda Cárdenas.
2020-2022. Mentor Master's Thesis in Health Sciences Research, School of Medicine, Pontificia Universidad Católica de Chile. Lic. Gabriela Belledonne.
2023-2024. Mentor Master's Thesis in Biotechnology and Life Sciences, Faculty of Life Sciences, Universidad Andrés Bello. Lic. Camilia Romero.

Ph.D. Thesis

2013-2016. Mentor PhD Thesis in Physiological Sciences, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. Francisca Salas.
2013-2016. Co-Mentor PhD Thesis in Medical Sciences, School of Medicine, Pontificia Universidad Católica de Chile. Susana Contreras.
2014-2018. Mentor PhD Thesis in Medical Sciences, School of Medicine, Pontificia Universidad Católica de Chile. Nicolás Santander.
2019-2022. Mentor PhD Thesis in Medical Sciences, School of Medicine, Pontificia Universidad Católica de Chile. Alonso Quiroz.
2019-2022. Co-Mentor PhD Thesis in Biomedicine, Universidad de los Andes. Carolina Echeverría.
2019-2024. Mentor PhD Thesis in Biological Sciences, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. Andreina Arias.
2022-Present. Mentor PhD Thesis in Biomedicine, Universidad de los Andes. Fujiko Saavedra.
2022-Present. Co-Mentor PhD Thesis in Biomedicine, Universidad de los Andes. Barbara Maturana.
2022-Present. Mentor PhD Thesis in Medical Sciences, School,of Medicine, Pontificia Universidad Católica de Chile. Gabriela Belledonne.

Administration (Internal Management & Governance)

In Scientific Societies:

2007-2012. Board Member of the Chilean Society of Reproduction and Development (Treasurer, Director, Secretary).
2016-2018. Board Member, Chilean Society of Reproduction and Development (Santiago Representative).
2020-2022. Vice President, Chilean Society of Reproduction and Development.
2021-2024. Director, Latin American Society of Maternal-Fetal Interaction.
2023-2024. President, Chilean Society of Reproduction and Development.

In Research Agencies and Public Institutions:

2014 - Present. Member, National Accreditation Commission (CNA) Peer Review Register.
2016-2018. Member, FONDECYT Study Group Medicine G1.
2022-2023. Member, Interdisciplinary Evaluation Panel, ANID Exploration 2022 Competition.
2022-Present. Member, FONDEF Health Area Panel, ANID.

In Bioethics Committees and Laboratory Animal Activities:

2013-2023. Various leadership roles in ethical committees (Member, President, Vice President).
2017-2019. Director, UC Cryopreservation Program.
2020-2023. Academic Coordinator, Animal Facility, Universidad de los Andes.
2022-2023. Coordinator, Bioethics Committee, Universidad de los Andes.
2023-Present. Member, Bioethics Committee, Universidad de los Andes.

In Postgraduate Programs:

2010-2019. Faculty member of various postgraduate programs at Pontificia Universidad Católica de Chile.
2019-Present. Faculty member, PhD Program in Biomedicine, Universidad de los Andes.
Co-Director, PhD Program in Biomedicine.
2023-Present. Director, PhD Program in Biomedicine.

Outreach (External Engagement & Knowledge Dissemination)

In Scientific Societies:

2014-2015. Member, Scientific Committee, VI Congress SLIMP, Mar del Plata. Argentina.
2016-2017. Member, Organizing Committee, VII Congress SLIMP, Puerto Varas, Chile.
2023. Chair Annual Joint Meeting Chilean Society of Reproduction and Development and Latinamerican DoHAD Society, Valdivia, Chile.
2024. Chair Annual Meeting Chilean Society of Reproduction and Development, Concepción, Chile.

In Research Agencies and Public Institutions:

2015. Reviewer, UK-Chile Joint Evaluation Panel for Research Projects (CONICYT – RCUK).
2015. Reviewer, FONDECYT Regular 2016 (Medicine G1 Study Group).
2019. Expert Advisory Team on National Micronutrient Policies (Folic Acid), Ministry of Health, Chile.
2020. Reviewer, FONDECYT 2021 (Medicine G1 Study Group).


Editorial: In celebration of women in molecular and cellular reproduction Da Ros, Vanina Gabriela; Cuasnicu, Patricia S. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
The protective effect of 1400W against ischaemia and reperfusion injury is countered by transient medullary kidney endothelial dysregulation Jara, Valeria Article ISI JOURNAL OF PHYSIOLOGY-LONDON (2024)
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos Belledonne, Gabriela; González, Javier Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2024)
A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational Diabetes Mellitus GONZÁLEZ, ADRIÁN; González, Javier; Olmos, Pablo; Marette, Andre; Enrione, Javier Article ISI MOLECULAR NUTRITION & FOOD RESEARCH (2023)
Obesity is related to maternal periodontitis severity in pregnancy: a cross-sectional study Hoare, Anilei; Chaparro, Alejandra Article ISI CLINICAL ORAL INVESTIGATIONS (2023)
Folate status in women of childbearing age in the Urban Metropolitan Region of Chile: results from the National Health Survey 2016-2017 Article ISI PUBLIC HEALTH NUTRITION (2021)
Intake of Vitamin E and C in Women of Reproductive Age: Results from the Latin American Study of Nutrition and Health (ELANS) David, Andrea; Rigotti, Attilio; ELANS Study Grp Article ISI NUTRIENTS (2021)
Lipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in mice Amigo, Ludwig; Carrasco, Gonzalo; Andia, Marcelo E.; Rigotti, Attilio Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)
Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle Hoare, Anilei; Chaparro, Alejandra Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Ovarian cholesterol efflux: ATP-binding cassette transporters and follicular fluid HDL regulate cholesterol content in mouse oocytes Article SCOPUS Biology of Reproduction (2020)
Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice Chen, P.; Uribe, S.; Kopp, S.; Kern, S.; Marsche, G.; Busso, D.; Wadsack, C.; Rigotti A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2018)
High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation Birner-Gruenberger, Ruth; Wadsack, Christian; Rigotti, Attilio Article ISI SCOPUS JOURNAL OF TRANSLATIONAL MEDICINE (2018)
INTAKE OF RED WINE GRAPE POMACE DECREASED ATHEROSCLEROSIS, ATTENUATED MYOCARDIAL DAMAGE AND INCREASED SURVIVAL IN A MURINE MODEL OF LETHAL CORONARY HEART DISEASE Rivera, Katherine; Dicenta, Sara; Uribe, Sergio; Busso, Dolores; Attilio Rigotti Article ISI ATHEROSCLEROSIS SUPPLEMENTS (2018)
Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure Lizama, Carlos; Godoy, Alejandro; Rigotti, Attilio Article ISI SCOPUS BMC GENOMICS (2018)
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI Article ISI SCOPUS Scientific Reports (2017)
Gugulipid causes hypercholesterolemia leading to endothelial dysfunction, increased atherosclerosis, and premature death by ischemic heart disease in male mice Contreras-Duarte, Susana; Amigo, Ludwig; Sepúlveda, Esteban; Quiñones, Verónica; Vinci, Maria Cristina Article ISI SCOPUS PloS one (2017)
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells Wagner, Bridget Article ISI SCOPUS PloS one (2017)
Efecto del ciprofibrato sobre el metabolismo del colesterol HDL y la capacidad antioxidante plasmática en el ratón Camila Mendoza; Verónica Quiñones; Ludwig Amigo; Dolores Busso; Alberto Maiz; Attilio Rigotti Article SCIELO REVISTA CHILENA DE CARDIOLOGIA (2016)
Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 beta-Cells Treated with Palmitate and Oleate Cataldo, L. R.; Mizgier, M. L.; Cort?s, V. A.; Santos, J. L. Article ISI SCOPUS JOURNAL OF DIABETES RESEARCH (2016)
ANTIOXIDANT DYSFUNCTIONALITY OF HIGH-DENSITY LIPOPROTEINS (HDL) IN DECOMPENSATED DIABETIC PATIENTS Awad, F; Contreras-Duarte, S; Molina, P; Quiñones V.; Serrano, V; Abbott E.; Maiz A.; Busso, D.; Rigotti A. Article ISI SCOPUS Nutricion Hospitalaria (2015)
Preventive Letter: Doubling the Return Rate After Gestational Diabetes Mellitus Borzone, GR; Berkowitz L.; Mertens N.; Busso, D.; Vera C.; Belmar C.; Goldenberg D.; Samith, B; Acosta, AM; Escalona, M. Article ISI SCOPUS Maternal and Child Health Journal (2015)
Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis Busso, D.; Mascareno, L; Salas, F; Berkowitz L.; Santander N.; Quiroz, A.; Amigo, L; Valdes G.; Rigotti A. Article ISI SCOPUS BIOMED RESEARCH INTERNATIONAL (2014)
Excess cholesterol induces mouse egg activation and may cause female infertility Yesilaltay A.; Dokshin, GA; Busso, D.; Wang L.; Galiani, D; Chavarria, T; Vasile, E; Quilaqueo, L; Walzer, D; Shalgi, R; et al. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Human fertilization: Epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3 Muñoz M.W.; Chirinos M.; Busso, D.; Raffo F.G.E.; Battistone M.A.; Larrea, F Article SCOPUS Molecular Human Reproduction (2014)
Maternal Hypertriglyceridemia: A Link Between Maternal Overweight-Obesity and Macrosomia in Gestational Diabetes Olmos, Pablo R.; Rigotti, Attilio; Busso, Dolores; Berkowitz, Loni; Santos, Jose L.; Borzone, Gisella R.; Poblete, José A; Vera, Claudio; Belmar, Cristián; Goldenberg, Denisse; et al. Article ISI SCOPUS OBESITY (2014)
Papel protector de las lipoproteínas de alta densidad en sepsis: aspectos básicos e implicancias clínicas Susana Contreras Duarte; Pablo Varas; Fernanda Awad; Dolores Busso; Attilio Rigotti Article SCIELO SCOPUS Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología (2014)
Perfil lipídico en mujeres embarazadas sanas de tres regiones de Chile Pablo Olmos C; Manuel Escalona O; Sebasti Illanes L; Javier Caradeux B; Gabriel Mardones; Daniela Olivari U; Leoncio Fuentes V; Ana Acosta B; Attilio Rigotti R; Dolores Busso P; et al. Article SCIELO SCOPUS REVISTA CHILENA DE OBSTETRICIA Y GINECOLOGIA (2014)
Physiological and pathological implications of cholesterol Busso, D.; Maiz A.; Arteaga A.; Nervi, F; Rigotti A. Article ISI SCOPUS FRONTIERS IN BIOSCIENCE-LANDMARK (2014)
Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet Busso, D.; Ramirez, G; Campos, M.; Rigotti A.; Eugenín J.; von Bernhardi R. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2014)
Protective role of high density lipoproteins in sepsis: basic issues and clinical implications Contreras-Duarte, S; Varas, P; Awad, F; Busso, D.; Rigotti A. Article ISI Revista chilena de infectología : órgano oficial de la Sociedad Chilena de Infectología (2014)
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability Busso D, Oñate-Alvarado MJ, Balboa E, Castro J, Lizama C, Morales G, Vargas S, Härtel S, Moreno RD and S Zanlungo Article ISI SCOPUS REPRODUCTION FERTILITY AND DEVELOPMENT (2014)
Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI Santander NG; Contreras-Duarte, S; Awad, MF; Lizama, C.; Passalacqua, I; Rigotti A.; Busso, D. Article ISI SCOPUS Human Molecular Genetics (2013)
Fertilization Induces a Transient Exposure of Phosphatidylserine in Mouse Eggs Curia, CA; Ernesto, JI; Stein P.; Busso, D.; Schultz, RM; Cuasnicu, PS; Cohen, DJ Article ISI SCOPUS PloS one (2013)
Evaluation of Testicular Sperm CRISP2 as a Potential Target for Contraception. Busso, D. Article ISI JOURNAL OF ANDROLOGY (2012)
Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice Amigo, L; Quiñones V.; Leiva A.; Busso, D.; Zanlungo S.; Nervi, F; Rigotti A. Article ISI SCOPUS Liver International (2011)
Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice Busso, D.; Onate-Alvarado, MJ; Balboa E.; Zanlungo S. Article ISI SCOPUS Molecular and Cellular Endocrinology (2010)
Life-giving caspases: revealing new roles during mouse embryo preimplantation development Busso, D.; Domínguez C.; Perez-Acle, T Article ISI SCOPUS International Journal of Developmental Biology (2010)
Immunocontraceptive properties of recombinant protein DE: implications for the development of novel contraceptives Busso, D. Article ISI FERTILITY AND STERILITY (2008)
Participation of cysteine-rich secretory proteins (CRISP) in mammalian sperm-egg interaction Cohen, Debora J.; Busso, Dolores; Da Ros, Vanina; Ellerman, Diego A.; Maldera, Julieta A.; Goldweic, Nadia; Cuasnicu, Patricia S. Article INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2008)
A novel function for CRISP1 in rodent fertilization: Involvement in sperm-zona pellucida interaction Busso, D.; Cohen, DJ; Maidera, JA; Dernatteis, A; Cuasnicu, PS Article ISI SCOPUS BIOLOGY OF REPRODUCTION (2007)
Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion Busso, D.; Goldweic N.M.; Hayashi M.; Kasahara, M. Article SCOPUS BIOLOGY OF REPRODUCTION (2007)
Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation. Da Ros, V.G.; Busso, D.; Ellerman, D.; Maldera, J.; Goldweic, N. Article ISI ASIAN JOURNAL OF ANDROLOGY (2007)
Sperm protein DE mediates gamete fusion through an evolutionarily conserved site of the CRISP family Ellerman, D.A.; Da Ros, V.G.; Morgenfeld, M; Busso, D. Article ISI DEVELOPMENTAL BIOLOGY (2006)
Expression and structure-function analysis of de, a sperm cysteine-rich secretory protein that mediates gamete fusion. Ellerman DA1, Da Ros VG, Cohen DJ, Busso D, Morgenfeld MM, Cuasnicú PS. Article BIOLOGY OF REPRODUCTION (2002)
Molecular mechanisms involved in mammalian fusion Ellerman, D.A.; Busso, D.; Morgenfeld, M.A.; Da Ros, V.G. Article ARCHIVES OF MEDICAL RESEARCH (2001)
Relationship between the association of rat epididymal protein “DE” with spermatozoa and the behavior and function of the protein Cohen D.; Rochwerger, D.; Ellerman, D.A.; Morgenfeld, M.A.; Busso, D. Article ISI MOLECULAR REPRODUCTION AND DEVELOPMENT (2000)
Bicarbonate is required for migration of sperm epididymal protein DE/CRISP-1 to the equatorial segment and expression of rat sperm fusion ability. Da Ros, V.G.; Marín-Briggiler C.I.; Busso, D.; Viconti, P.; Cuansicú. P.S. Article Biolegy of Reproduction
Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg Ellerman, D.A.; Busso, D.; Morgenfeld, M.A.; Piazza A.; Hayashi M.; Young E.; Kasahara, M. Article BIOLOGY OF REPRODUCTION
Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction Busso, D.; Hayashi M.; Kasahara, M.; Cuasncú, P.S. Article MOLECULAR HUMAN REPRODUCTION
Molecular mechanisms involved in gamete interaction. Da Ros, V.G.; Busso, D.; Maldera, J.; Goldweic, N. Article ANIMAL REPRODUCTION SCIENCE
Morphologic and functional determinants of primordial and primary follicles in the monkey ovary. Gougeon, A.; Busso, D. Article MOLECULAR AND CELLULAR ENDOCRINOLOGY
Studies on the participation of epididymal sperm protein DE/CRISP-1 in egg activation. Busso, D.; Da Ros, V.G.; Fissore, R Article CELLULAR AND MOLECULAR BIOLOGY


Blood lipids during pregnancy: A progressively appreciated subject in basic and clinical research EditorialMaterial ISI SCOPUS ATHEROSCLEROSIS (2018)


Magnetic resonance imaging technology for aging related diseases: brain, heart and vessels Pablo Irarrázaval,; Cristian Tejos; Dolores Busso; Steren Chabert; Sergio Ruiz; Rene Botnar, etc (14 in total) Proyecto (2016)
Tecnologías de Imágenes por Resonancia Magnética para enfermedades asociadas a la vejez=> cerebro, corazón y vasos. Anillo de Investigación en Ciencia y Tecnología (n°ACT1416) Proyecto 2015-2018 Investigador(a)
Cholesterol is bad for eggs as much as eggs are bad for cholesterol. Monty Krieger, Dolores Busso and Attilio Rigotti Proyecto (2014)
Cholesterol is bad for eggs as much as eggs are bad for cholesterol. MISTI-PUC Seed Grant (711506708) Proyecto 2014-2015 Inv. Principal
Impact of high density lipoprotein metabolism in mouse oocyte and embryo physiology: underlying mechanisms, pathological implications and potential interventions Dolores Busso Proyecto (2014)
IMPACT OF HIGH DENSITY LIPOPROTEIN METABOLISM IN MOUSE OOCYTE AND EMBRYO PHYSIOLOGY=> UNDERLYING MECHANISMS, PATHOLOGICAL IMPLICATIONS AND POTENTIAL INTERVENTIONS. FONDECYT (1141236) Proyecto 2014-2018 Inv. Responsable
Role of Good Cholesterol HDL in Female Fertility Monty Krieger, Attilio Rigotti, Dolores Busso and Ayce Yesilaltay Proyecto (2012)
Role of Good Cholesterol HDL in Female Fertility. MISTI [Massachussetts Institute of Technology (MIT) - Pontificia Universidad Católica de Chile] Seed Fund Proyecto 2012-2013 Inv. Principal
Unrelenting Macrosomia Despite Optimal Glycemic Control in Gestational Diabetes Mellitus: is an Excessive Rise of Maternal Serum Lipids the Link Between Prepregnancy Overweight and Excessive Fetal Growth? Pablo Olmos; Dolores Busso; Attilio Rigotii Proyecto (2012)
Unrelenting Macrosomia Despite Optimal Glycemic Control in Gestational Diabetes Mellitus=> is an Excessive Rise of Maternal Serum Lipids the Link Between Prepregnancy Overweight and Excessive Fetal Growth? FONDECYT (1120682) Proyecto 2012-2015 Coinvestigador(a)
Centro para fortalecer las capacidades de Investigación, Desarrollo e Innovación en Chile, mediante la creación de un bioterio de clase mundial que asegure la calidad de la I+D+I en Biotecnología FONDEQUIP (ECM-07) Proyecto 2011-2016 Personal técnico y/o de apoyo
Fortalecimiento del Programa de Doctorado en Ciencias Médicas y de la investigación avanzada en metabolismo, inflamación y enfermedades crónicas en la Escuela de Medicina de la Pontificia Universidad Católica de Chile. PAI (79090028 M) Proyecto 2010-2013 Inv. Principal
Involvement of receptor-dependent high density lipoprotein metabolism on mouse female fertility and embryonic development Dolores Busso Proyecto (2009)
Involvement of receptor-dependent high density lipoprotein metabolism on mouse female fertility and embryonic development. FONDECYT (11090064) Proyecto 2009-2013 Inv. Principal
Contribución de la proteína transportadora de colesterol NPC2 a la síntesis de esteroides y el desarrollo folicular en el ovario. FONDECYT (308022) Proyecto 2007-2009 Inv. Principal
Contribution of the NPC2 cholesterol transport protein to steroid synthesis and follicular development in the ovary Dolores Busso Proyecto (2007)
Relevance of Niemann Pick C proteins in physiology and pathophysiology Dolores Busso Proyecto (2006)
Relevancia de las proteínas Niemann Pick C en fisiología y fisiopatología. FONDECYT (1070622) Proyecto 2006-2007 Coinvestigador(a)
Role of testicular protein TPX-1 in fertilization and its potential use to regulate fertility Dolores Busso Proyecto (2003)
Role of testicular protein TPX-1 in fertilization and its potential use to regulate fertility. Subsidio de Inserción en el país de origen (Re-entry Grant). Organización Mundial de la Salud (OMS), Programa de Reproducción Humana (HRP). Proyecto 2003-2005 Inv. Principal
Participación de una proteína de la familia de la proteína epididimaria “DE” en el proceso de fertilización. Programa Latinoamericano de Capacitación e Investigación en Reproducción Humana (PLACIRH) Proyecto 2000-2001 Inv. Principal
Participation of a protein family of epididymal protein DE in the process of fertilization. Dolores Busso Proyecto (2000)


Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility Arias, Andreina Review ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Advances in the physiological and pathological implications of cholesterol Busso, D.; Mardones P.; Maiz A.; Arteaga A.; Nervi, F; Rigotti A. Review ISI SCOPUS Biological Reviews (2013)
La hipótesis de Pedersen no es suficiente: Otros nutrientes además de la glucosa explicarían la macrosomía fetal en pacientes diabéticas gestacionales con sobrepeso y buen control glicémico Olmos, Pablo; Martelo, Grettel; Reimer, Verena; Rigotti, Attilio; Busso, Dolores; Belmar, Cristián; González, Rogelio; Goldenberg, Denisse; Samith, Bárbara; Santos, José-Luis; et al. Review SCIELO SCOPUS REVISTA MEDICA DE CHILE (2013)
Nutrients other than glucose might explain fetal overgrowth in gestational diabetic pregnancies Olmos, P; Martelo G.; Reimer, V; Rigotti A.; Busso, D.; Belmar C.; Gonzalez R.; Goldenberg D.; Samith, B; Escalona, M.; et al. Review ISI REVISTA MEDICA DE CHILE (2013)
Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism Leiva A.; Verdejo H.; Benitez ML; Martinez A.; Busso, D.; Rigotti A. Review ISI SCOPUS Atherosclerosis (2011)

Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

Emma Hernandez

Directora

Servicio de Anatomía Patológica

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Claudio Vera

Assitant Professor

Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Alberto Martin

Associate professor

Centro Ciencia & Vida

Universidad San Sebastián

Santiago, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Francisca Salas

Asistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

paula margozzini

Associate Professor

Public Health

Pontificia Universidad Católica de Chile

Santiago, Chile

Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Álvaro Passi

PhD student

Research Department of Epidemiology & Public Health

University College London

London, Reino Unido

Guadalupe Echeverría

Manager

Center for Molecular Nutrition and Chronic Diseases

Pontificia Universidad Católica de Chile

Santiago, Chile

María Mizgier

Postdoctorate

Universidad de Los Andes

Santiago, Chile

Alvaro Martínez

Director Asociado de Propiedad Intelectual y Transferencia Tecnológica

FUNDACIÓN CIENCIA PARA LA VIDA (FCV)

Santiago, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

valentina serrano

PROFESOR ASISTENTE

NUTRICION, DIABETES Y METABOLISMO

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Barbara Samith

Profesor Instructor Adjunto

Ciencias de la Salud

Pontificia Universidad Católica de Chile

Santiago, Chile

Eduardo Abbott

Profesor Asistente

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

Adrián González

Investigador

Fonoaudiología

Universidad San Sebastián

Santiago de Chile, Chile

Loni Berkowitz

Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Reyna Peñailillo

Postdoctorado

Centro de Investigación Biomédica

Universidad de Los Andes

Santiago, Chile

Gisela Canedo

Investigadora y Profesora

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

Nicolás Santander

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

Aline Carvalho da Silva

Assistant Professor

Universidad de Santiago de Chile

Región metropolitana, Chile

Katherine Rivera

PhD (c) student in Medical Science

Pontificia Universidad Católica de Chile

Santiago, Chile

Leandro Murgas

Bioinformático

Meristem Spa.

Huechuraba, Chile

Dolores Busso PERKINS

Líneas de Investigación

Educación

PhD in Biology (Physiology), Universidad de Buenos Aires. Argentina, 2005

Experiencia Académica

Assistant Investigator Full Time

PostDoc Full Time

PhD Student Full Time

Fellow Full Time

Undergraduate Fellow Part Time

Assistant Professor Full Time

Associate Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (52)

EditorialMaterial (1)

Proyecto (22)

Tecnologías de Imágenes por Resonancia Magnética para enfermedades asociadas a la vejez=> cerebro, corazón y vasos.

Cholesterol is bad for eggs as much as eggs are bad for cholesterol.

IMPACT OF HIGH DENSITY LIPOPROTEIN METABOLISM IN MOUSE OOCYTE AND EMBRYO PHYSIOLOGY=> UNDERLYING MECHANISMS, PATHOLOGICAL IMPLICATIONS AND POTENTIAL INTERVENTIONS.

Role of Good Cholesterol HDL in Female Fertility.

Unrelenting Macrosomia Despite Optimal Glycemic Control in Gestational Diabetes Mellitus=> is an Excessive Rise of Maternal Serum Lipids the Link Between Prepregnancy Overweight and Excessive Fetal Growth?

Centro para fortalecer las capacidades de Investigación, Desarrollo e Innovación en Chile, mediante la creación de un bioterio de clase mundial que asegure la calidad de la I+D+I en Biotecnología

Fortalecimiento del Programa de Doctorado en Ciencias Médicas y de la investigación avanzada en metabolismo, inflamación y enfermedades crónicas en la Escuela de Medicina de la Pontificia Universidad Católica de Chile.

Involvement of receptor-dependent high density lipoprotein metabolism on mouse female fertility and embryonic development.

Contribución de la proteína transportadora de colesterol NPC2 a la síntesis de esteroides y el desarrollo folicular en el ovario.

Relevancia de las proteínas Niemann Pick C en fisiología y fisiopatología.

Role of testicular protein TPX-1 in fertilization and its potential use to regulate fertility.

Participación de una proteína de la familia de la proteína epididimaria “DE” en el proceso de fertilización.

Review (5)