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Victor Antonio Cortes Mora

Associate professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


1.Cellular and molecular determinants of adipose tissue differentiation and maintenance. 2. Endocrine, metabolic and genetic characterization of individuals with severe insulin resistance syndromes. 3. Molecular basis of fatty liver disease

Educación

  •  Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005
  •  Physician surgeon, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001
  •  Medicine, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   Postdoctoral scholar Full Time

    UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS

    Dallas, Estados Unidos

    2006 - 2011

  •   Instructor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2011 - 2012

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2012 - A la fecha

  •   Associate professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Attending physician - diabetology, general medicine Full Time

    Pontificia Universidad Católica de Chile

    Chile

    2005 - A la fecha

  •   Attending physician Part Time

    Hospital Sótero del Río, Ministry of Health

    Chile

    2005 - 2006

  •   Postodoctoral fellow Full Time

    University of Texas Southwestern Medical Center

    Estados Unidos

    2006 - 2011

  •   Integrante grupo de estudio Fondecyt Medicina G1 Other

    Conicyt

    Chile

    2016 - 2019

Formación de Capital Humano


A. Postdoctoral fellows:
1) Pablo Mardones, PhD (University of Amesterdam, Netherlands), Pontificia Universidad Católica de Chile 2012-2013
2) Marta Fernandez, PhD (University of Navarra, Spain), Pontificia Universidad Católica de Chile 2015-2018
3) Marcela Fuentes, PhD (Unversity of Chile, Chile), Pontificia Universidad Católica de Chile 2015-2018

B. PhD thesis:
1) Kelly Cautivo. Biological Sciences Doctoral Program, Molecular Genetics and Microbilogy mention, Pontificia Universidad Católica de Chile, graduated in 2014.
2) Pablo Tapia. Biological Sciences Doctoral Program, Molecular Genetics and Microbilogy mention, Pontificia Universidad Católica de Chile. In progress, to be graduated in 2019.
3) Lila González, Medical Sciences, Pontificia Universidad Católica de Chile. In progress, to be graduated in 2020.
4) Fermín Robledo, Biotechnology. Universidad Nacional Andrés Bello. In progress, to be graduated in 2019.
5) Ana María Figueroa, Medical Sciences, Pontificia Universidad Católica de Chile. Co-director: Verónica Eisner In progress, to be graduated in 2021.
6) Luis R. Cataldo. Biomedical Sciences Doctoral Program, Universidad de los Andes - Chile. Graduated in 2015.

C. Magister thesis:
1) Denisse Goldenberg, Master in Nutrition, Pontificia Universidad Católica de Chile. Graduated in 2013
2) María J. Riveros, Master in Nutrition, Pontificia Universidad Católica de Chile. Graduated in 2014
3) Ana María Figueroa, Master in Nutrition, Pontificia Universidad Católica de Chile. Graduated in 2017
4) Pía Zamora, Master in Nutrition, Pontificia Universidad Católica de Chile. Graduated in 2017
5) Beatriz Villanueva, Master in Nutrition, Pontificia Universidad Católica de Chile. Graduated in 2018
6) Caterina Tiscornia, Master in Nutrition, Pontificia Universidad Católica de Chile. To be graduated in 2020

D. Undergraduate students:
1) Alejandro Jeldres, Medical Student, Pontificia Universidad Católica de Chile, 2012-2013
2) Karen García, Medical Student, Pontificia Universidad Católica de Chile, 2012-2013
3) Roberto Coloma, Medical Student, Pontificia Universidad Católica de Chile, 2012-2013
4) Elizabeth Muñoz, Medical Student, Pontificia Universidad Católica de Chile, 2012-2013


Difusión y Transferencia


- Explora - Conicyt, High school talks, students and teachers´ supervision: 2012 - to date
- Study group - member, Fondecyt Medicine G1: 2015-2019
- Study group - director, Fondecyt Medicine G1: 2017 - 2019
- Memberships: Chilean society of endocrinology and diabetes, Chilean society of cellular biology, Chilean society of nutrition and toxicology


Premios y Distinciones

  •   Honor Scholarship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1993

    Awareded for the highest academic performance at the Medical School

  •   Honor Scholarship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1994

    Awareded for the highest academic performance at the Medical School

  •   Honor Scholarship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1995

    Awareded for the highest academic performance at the Medical School

  •   Doctoral felloswhip

    MINISTRY OF EDUCATION, CULTURE, SPORTS, SCIENCE AND TECHNOLOGY

    Chile, 2001

    Awarded for funding doctoral studies

  •   Doctoral felloswhip

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2004

    Awarded for funding doctoral studies

  •   President of the Republic Fellowship

    Ministry of planification and coorperation

    Chile, 2006

    Awarderd for international postdoctoral studies

  •   Postdoctoral fellowship

    American Heart Association

    Estados Unidos, 2009

    For postdoctoral research


 

Article (55)

Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: a whole cell and plasma membrane lipidomic analysis of adipogenesis
Eating behaviour in contrasting adiposity phenotypes: Monogenic obesity and congenital generalized lipodystrophy
Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels
Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology
Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo-2 cells by upregulating SR-BI via a PI3K, AKT, and mTOR-dependent pathway
Abdominal obesity is a common finding in normal and overweight subjects of Chile and is associated with increased frequency of cardiometabolic risk factors
Nonalcoholic fatty liver disease, cholesterol gallstones, and cholecystectomy: new insights on a complex relationship
Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients: a pilot study
Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients=> a pilot study
Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice
Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice
Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cell
AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue
AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue
Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 Beta-Cells Treated with Palmitate and Oleate
AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism
AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism
Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 beta cells
Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 beta-cells
Lipodystrophies=> adipose tissue disorders with severe metabolic implications
Metabolic Effects of Cholecystectomy: Gallbladder Ablation Increases Basal Metabolic Rate through G-Protein Coupled Bile Acid Receptor Gpbar1-Dependent Mechanisms in Mice
Metabolic effects of cholecystectomy=> gallbladder ablation increases basal metabolic rate through G-protein coupled bile acid receptor Gpbar1-dependent mechanisms in mice
Asociación entre diabetes mellitus y patología cardiovascular en la población adulta de Chile: estudio de la Encuesta Nacional de Salud 2009-2010
Asociación entre diabetes mellitus y patología cardiovascular en la población adulta de Chile=> estudio de la Encuesta Nacional de Salud 2009-2010
Association between diabetes mellitus and cardiovascular disease in Chilean adults. Analysis of the national health survey 2009-2010
Divergent Metabolic Phenotype between Two Sisters with Congenital Generalized Lipodystrophy Due to Double AGPAT2 Homozygous Mutations. A Clinical, Genetic and In Silico Study
Divergent metabolic phenotype between two sisters with congenital generalized lipodystrophy due to double AGPAT2 homozygous mutations. a clinical, genetic and in silico study.
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2(-/-) lipodystrophic mice independent of hepatocyte leptin receptors
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Novel physiological and therapeutic implications of leptin [Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina]
Nuevas proyecciones fisiológicas y terapéuticas de la leptina
Papel de la serotonina periférica en la secreción de insulina y la homeostasis de la glucosa
Physiological and pathological implications of cholesterol
Physiological and pathological implications of cholesterol.
Advances in the physiological and pathological implications of cholesterol.
The contribution of Goldstein and Brown to the study of cholesterol metabolism [Rememorando la contribución de Goldstein y Brown al estudio del metabolismo del colesterol=> A un cuarto de siglo del Premio Nobel de Medicina
Human 1-Acylglycerol-3-phosphate O-Acyltransferase isoforms 1 and 2: Biochemical characterization and inability to rescue hepatic steatosis in Agpat2 -/- gene lipodystrophic mice
Human 1-Acylglycerol-3-phosphate O-Acyltransferase isoforms 1 and 2=> Biochemical characterization and inability to rescue hepatic steatosis in Agpat2 -/- gene lipodystrophic mice
Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology
Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor alpha (LXR alpha) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1
Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy
NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors
NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors.
Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice
Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice.
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction.
Liver heparan sulfate proteoglycans: Old molecules provide new insights on lipoprotein metabolism - Commentary
Liver heparan sulfate proteoglycans=> old molecules provide new insights on lipoprotein metabolism.
[New heterodimeric nuclear receptors=> key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus].
Nuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus
Synergism between neuropeptide Y and norepinephrine highlights sympathetic cotransmission: Studies in rat arterial mesenteric bed with neuropeptide Y, analogs, and BIBP 3226
Stimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: Involvement of neuropeptide Y-Y 1 receptors

Abstract (3)

Insulin regulates SRBI and ABCG8 in a mTOR dependent pathway in CaCo-2 cells
STRATEGIES FOR SEARCHING GENETIC CAUSES OF NUTRITION-RELATED EXTREME METABOLIC PHENOTYPES
Adenovirus-mediated hepatic overexpression of syndecan-1 increases plasma lipoprotein cholesterol without changes in liver and biliary cholesterol content in mice

BookSection (1)

Carbohydrate, Fat, and Protein Metabolism in Obesity

BookWhole (2)

Genetics of body composition: From severe obesity to extreme leanness
Manual de dislipidemias. Metabolismo y clínica

Proyecto (23)

ROLE OF MITOCHONDRIA AND CAVEOLAE LIPID COMPOSITION ON AGPAT2-DEPENDENT LIPODYSTROPHY
Association between gene variants of the mitochondrial genome and proteome with insulin secretion/sensitivity indexes and glycemic-related traits
ASSOCIATION BETWEEN GENE VARIANTS OF THE MITOCHONDRIAL GENOME AND PROTEOME WITH INSULIN SECRETION/SENSITIVITY INDEXES AND GLYCEMIC-RELATED TRAITS
HAVE LIPID DROPLET ABNORMALITIES AND OXIDATIVE STRESS A ROLE IN THE ADIPOSE CELL DEATH OF LIPODYSTROPHIC AGPAT2 DEFICIENT MICE?
ROL DEL EPITELIO INTESTINAL EN LA DISLIPIDEMIA DIABÉTICA
"STUDYING BROWN ADIPOGENESIS IN VIVO=> MECHANISMS FOR BROWN ADIPOSE TISSUE LACK IN AGPAT2-DEFICIENT LIPODYSTROPHIC ORGANISMS"
Have lipid droplet abnormalities and oxidative stress a role in the adipose cell death of lipodystrophic Agpat2 deficient mice?
Rol del epitelio intestinal en la dislipidemia diabetica
STUDYING BROWN ADIPOGENESIS IN VIVO: MECHANISMS FOR BROWN ADIPOSE TISSUE LACK IN AGPAT2-DEFICIENT LIPODYSTROPHIC ORGANISMS
Diseño de matrices alimentarias saludables
Efectos de la obesidad y la cirugía bariátrica sobre el sistema inflamasoma, resistencia insulínica e inflamación sistémica
EFFECT OF CHOLECYSTECTOMY ON SERUM TRIGLYCERIDE AND HEPATIC FAT LEVELS IN WOMEN AND THE DEVELOPMENT OF NONALCOHOLIC FATTY LIVER DISEASE IN MICE.
Effect of cholecystectomy on serum triglyceride and hepatic fat levels on women and the development of nonalcoholic fatty liver disease in mice
Effect of gastric bypass, selective gastrectomy and duodenal-jejunal bypass on bile acid homeostasis. Role=> Associate investigator
EFFECT OF GASTRIC BYPASS, SLEEVE GASTRECTOMY AND DUODENALJEJUNAL BYPASS ON BILE ACID HOMEOSTASIS.
Evaluación de la salud oral en pacientes diabéticos tipo 2 y su relación con el control metabólico de la diabetes
PPAR-GAMMA COACTIVATOR-1 ALPHA (PGC1ALPHA) AND SEROTONIN METABOLISM: INDEPENDENT AND COMBINED EFFECTS ON MITOCHONDRIAL FUNCTION AND INSULIN SECRETION OF PANCREATIC BETA CELLS
Ppar-gamma coactivator-1 alpha and serotonin metabolism=> independent and combined effects on mitochondrial function and insulin secretion of pancreatic beta cells.
Establecimiento y Consolidación de un Laboratorio de Investigación de la Fisiología Molecular del Tejido Adiposo, Nutrición y Metabolismo
MECHANISMS OF LIPODYSTROPHY IN THE AGPAT2 DEFICIENT MOUSE
Mechanisms of lipodystrophy in the AGPAT2 deficient mice
Phenotypic characterization of AGPAT2 deficient mice, a novel model of human lipodystrophy
ASSOCIATION BETWEEN GENE VARIANTS OF THE MITOCHONDRIAL GENOME AND PROTEOME WITH INSULIN SECRETION/SENSITIVITY INDEXES AND GLYCEMIC-RELATED TRAITS

Review (10)

Pathophysiological connections between gallstone disease, insulin resistance, and obesity
Clinical presentation and treatment of primary lipodystrophies
Biology and pathological implications of brown adipose tissue: promises and caveats for the control of obesity and its associated complications
Lipodystrophies: adipose tissue disorders with severe metabolic implications
Novel physiological and therapeutic implications of leptin
ROLE OF PERIPHERAL SEROTONIN IN THE INSULIN SECRETION AND GLUCOSE HOMEOSTASIS
Advances in the physiological and pathological implications of cholesterol
Rememorando la contribución de Goldstein y Brown al estudio del metabolismo del colesterol: a un cuarto de siglo del Premio Nobel de Medicina
The contribution of Goldstein and Brown to the study of cholesterol metabolism
New heterodimeric nuclear receptors: key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus
53
Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

17
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

7
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

4
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
PABLO TAPIA

Investigador postdoctoral

Centro de Biología Celular y Biomedicina (CEBICEM)

Universidad San Sebastián

Santiafgo, Chile

2
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Dolores Busso

Associate Professor

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

2
Nicolás Santander

Postdoctoral scholar

Pediatrics

University of California, San Francisco

San Francisco, Estados Unidos

2
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

1
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

1
Juan Pedemonte

Profesor Clinico Asistente

Anestesiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nicolas Quezada

Adjunct Researcher

Digestive Surgery

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Pablo Mardones

Research Associate

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
María Mizgier

PhD

Nutrición, Diabetes y Metabolismo

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Uribe

Associated professor

Radiology

PONTIFICIA UNIVERSIDAD CATÓLICA

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

1
Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile