
ANDRES DAVID KLEIN POSTERNACK
Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile
Design of novel strategies for uncovering modifier genes/pathways of biological processes in health and disease based on natural genetic variations of yeast, fly, mouse and humans combined with other omics approaches. Systems Genetics.
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Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
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Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
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Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
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Life Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
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Postdoc Full Time
WEIZMANN INSTITUTE OF SCIENCE
Rehovot, Israel
2011 - 2015
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Postdoc Full Time
STANFORD UNIVERSITY
Stanford, Estados Unidos
2009 - 2011
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Group Leader Full Time
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile
2017 - A la fecha
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Staff Scientist Full Time
Telethon Institute of Genetics and Medicine
POZZUOLI, Italia
2015 - 2017
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Staff Scientist Full Time
Telethon Institute of Genetics and Medicine
POZZUOLI, Italia
2015 - 2017
He dirigido a 3 tesistas de pregrado y actualmente dirigo a 2 tesistas de doctorado
Selection of congress presentations:
-- Klein A, Cancino GI, Amigo J, Lazo O, Bronfman F, Alvarez AR and Zanlungo S; Papel de la vía c-Abl/p73 en neurodegeneración en la enfermedad de Niemann-Pick tipo C (NPC); poster; 2006; CHILE; Annual Meeting of the Chilean Cell Biology Society (Best doctorate panel)
- Klein AD, Lopez ME, Scott MP; poster; 2011 USA; Temporal and spatial rescue of the lysosomal storage disorder Niemann-Pick C; Gordon Research Conference on LSDs. Selected to give a short oral talk.
- Klein AD, Vitner EB, Farfel-Becker T, Zigdon H, Futerman AH; oral 2012; GERMANY; Pathology of Neuronal Forms of Gaucher Disease; B4B Meeting.
- Klein AD, Futerman AH; poster; 2013 ITALY; Identifying novel genes that modify the severity of Gaucher disease; Gordon Research Conference in LSDs. Selected to give a short oral talk.
Invited talks
- Klein AD; 2013; CHILE. Gaucher disease: from cell dysfunction to phenotypic variability. First Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2014; TURKEY. Pathological mechanisms in neuronal forms of Gaucher disease: FEBS Advanced Lecture Course: 360° Degree Lysosome.
- Klein AD; 2014; BRAZIL. Gaucher disease: from early neuronal alterations to phenotypic variability. Second Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2015: USA. "Genome wide association studies in mouse models of Gaucher disease unraveled novel potential modifier genes of disease progression". Gordon Research Seminar.
- Klein AD 2016; Germany. Identification of modifier genes in lysosomal storage disorders. MPS2016 meeting.
- Klein AD 2016; UK. Moving forwards towards precision medicine in lysosomal disorders. UCL, invited by Prof. John Hardy.
Scientific Advisory Boaard:
2017-2020: Scientific Advisory Board member at Cures Within Reach.
http://www.cureswithinreach.org/about-us/boards/science-advisory-board
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Innovadores menores de 35 años
MIT technology reviews
Chile, 2013
For design and implement a mouse genetics strategy for uncovering modifier genes of gaucher disease progression
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100 líderes jóvenes chienos del 2013
Revista del sábado, diario "El Mercurio"
Chile, 2013
For design and implement a mouse genetics strategy for uncovering modifier genes of Gaucher disease progression
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Scientific Advisory Board
Cures Within Reach
Estados Unidos, 2017
Science Advisory and Grant Review Board
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Pew Latin American Fellow in the Biomedical Sciences
Pew Charitable Trust
Chile, 2009
Postdoctoral Fellowship
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Postdoctoral Fellowship
UK Gaucher Association
Reino Unido, 2013
Postdoctoral Fellowship
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Postdoctoral Fellowship
Ara Parseghian Medical Research Foundation
Estados Unidos, 2009
Postdoctoral research fellowship for Niemann-Pick type C studies
Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease |
Uncovering the genetic basis of phenotypic heterogeneity in Parkinson disease |
UNCOVERING MODIFIER GENES OF LYSOSOMAL BIOLOGY BY EXPLOITING THE NATURAL GENETIC VARIATION OF INBRED MOUSE STRAINS |
LysoMod |
Unraveling the role of cellular clearance in GM2 gangiosidosis |
Unraveling the role of cellular clearance in GM2 gangiosidosis |
Identification of novel genes that modify the severity of Gaucher disease |
Identification of novel genes that modify the severity of Gaucher disease |
LysoMod |

ANDRES KLEIN
Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine
Centro de Genética y Genómica
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile

Silvana Zanlungo
Full Professor
Gastroenterology
Pontificia Universidad Católica de Chile
Santiago, Chile

Alejandra Alvarez
Full professor
Cell and Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS
Santiago, Chile

Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA
Santiago, Chile

Juan Miquel
Full Professor
Gastroenterology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile

Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile

Gonzalo Cancino
Assistant Professor
Faculty of Biological Sciences
Pontificia Universidad Católica de Chile
Santiago, Chile

Francisca Bronfman
Full Professor
Instituto de Ciencias Biomédicas
Universidad Andrés Bello
Santiago, Chile

Claudio Hetz
Deputy Director
INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Carla Castillo
Associate Professor
Centro de Epidemiología y Políticas de Salud / Center of Epidemiology and Health Policy
Universidad del Desarrollo
Santiago, Chile

Maria Repetto
Profesora Titular
Center for Genetics and Genomics
FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO
Santiago, Chile

Patricio Olguín
Assistant Professor
Facultad de Medicina, ICBM, Departamento de Neurociencia
Universidad de Chile
Santiago, Chile

LUIS SOBREVIA
Professor
Division of Obstetrics and Gynaecology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile

Enrique Guzman
Profesor Asistente
Bioquímica Clínica e Inmunología
Universidad de Concepción
Concepción, Chile

Tamara Marín
PhD en Ciencias médicas
Gastroenterología
Pontificia Universidad Católica de Chile
Santiago, Chile

Ximena Aguilera
Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy
Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)
Universidad del Desarrollo
Santiago, Chile

Gonzalo Encina
Investigador
Instituto de Ciencias e Innovación en Medicina
Universidad del Desarrollo
Santiago, Chile

KAREN DUBOIS
Postdoctoral fellow Fondef IDeA ID17I10064 IDI17
Instituto de Ciencias Biomédicas
Universidad de Chile
Santiago, Chile

Juan Orellana
Associate Professor
Departamento de Neurología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile

Juan Lecaros
Associate professor
Institute of Science and Innovation in Medicine
Universidad del Desarrollo
Santiago, Chile

Jaime Gutierrez
Associate Professor and Researcher
Tecnología Médica
Universidad San Sebastián
Santiago, Chile

Victor Cortes
Associate professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile

PABLO TAPIA
Investigador postdoctoral
Centro de Biología Celular y Biomedicina (CEBICEM)
Universidad San Sebastián
Santiafgo, Chile

Gabriela Martinez
Profesor Asociado
Filosofía y educación
Universidad Metropolitana de Ciencias de la Educación
santiago, Chile

Carolina Cabeza
Académica y Jefa de Centro de Investigación
Universidad Bernardo O'Higgins
Santiago , Chile

Macarena Las Heras
Investigadora postdoctoral
Facultad de Química y Biología
Universidad de Santiago de Chile
Santiago, Chile

Alexis Martinez
Investigador postdoctoral senior
Facultad de medicina
Instituto de Neurcoeincia Biomedica
Santiago, Chile