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ANDRES DAVID KLEIN POSTERNACK
Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile
Design of novel strategies for uncovering modifier genes/pathways of biological processes in health and disease based on natural genetic variations of yeast, fly, mouse and humans combined with other omics approaches. Systems Genetics.
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Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
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Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
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Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
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Life Science, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
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Postdoc Full Time
WEIZMANN INSTITUTE OF SCIENCE
Rehovot, Israel
2011 - 2015
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Postdoc Full Time
STANFORD UNIVERSITY
Stanford, Estados Unidos
2009 - 2011
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Group Leader Full Time
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile
2017 - A la fecha
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Staff Scientist Full Time
Telethon Institute of Genetics and Medicine
POZZUOLI, Italia
2015 - 2017
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Staff Scientist Full Time
Telethon Institute of Genetics and Medicine
POZZUOLI, Italia
2015 - 2017
He dirigido a 3 tesistas de pregrado y actualmente dirigo a 2 tesistas de doctorado
Selection of congress presentations:
-- Klein A, Cancino GI, Amigo J, Lazo O, Bronfman F, Alvarez AR and Zanlungo S; Papel de la vía c-Abl/p73 en neurodegeneración en la enfermedad de Niemann-Pick tipo C (NPC); poster; 2006; CHILE; Annual Meeting of the Chilean Cell Biology Society (Best doctorate panel)
- Klein AD, Lopez ME, Scott MP; poster; 2011 USA; Temporal and spatial rescue of the lysosomal storage disorder Niemann-Pick C; Gordon Research Conference on LSDs. Selected to give a short oral talk.
- Klein AD, Vitner EB, Farfel-Becker T, Zigdon H, Futerman AH; oral 2012; GERMANY; Pathology of Neuronal Forms of Gaucher Disease; B4B Meeting.
- Klein AD, Futerman AH; poster; 2013 ITALY; Identifying novel genes that modify the severity of Gaucher disease; Gordon Research Conference in LSDs. Selected to give a short oral talk.
Invited talks
- Klein AD; 2013; CHILE. Gaucher disease: from cell dysfunction to phenotypic variability. First Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2014; TURKEY. Pathological mechanisms in neuronal forms of Gaucher disease: FEBS Advanced Lecture Course: 360° Degree Lysosome.
- Klein AD; 2014; BRAZIL. Gaucher disease: from early neuronal alterations to phenotypic variability. Second Latin American Symposium: Gaucher Disease Today.
- Klein AD; 2015: USA. "Genome wide association studies in mouse models of Gaucher disease unraveled novel potential modifier genes of disease progression". Gordon Research Seminar.
- Klein AD 2016; Germany. Identification of modifier genes in lysosomal storage disorders. MPS2016 meeting.
- Klein AD 2016; UK. Moving forwards towards precision medicine in lysosomal disorders. UCL, invited by Prof. John Hardy.
Scientific Advisory Boaard:
2017-2020: Scientific Advisory Board member at Cures Within Reach.
http://www.cureswithinreach.org/about-us/boards/science-advisory-board
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Innovadores menores de 35 años
MIT technology reviews
Chile, 2013
For design and implement a mouse genetics strategy for uncovering modifier genes of gaucher disease progression
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100 líderes jóvenes chienos del 2013
Revista del sábado, diario "El Mercurio"
Chile, 2013
For design and implement a mouse genetics strategy for uncovering modifier genes of Gaucher disease progression
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Scientific Advisory Board
Cures Within Reach
Estados Unidos, 2017
Science Advisory and Grant Review Board
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Pew Latin American Fellow in the Biomedical Sciences
Pew Charitable Trust
Chile, 2009
Postdoctoral Fellowship
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Postdoctoral Fellowship
UK Gaucher Association
Reino Unido, 2013
Postdoctoral Fellowship
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Postdoctoral Fellowship
Ara Parseghian Medical Research Foundation
Estados Unidos, 2009
Postdoctoral research fellowship for Niemann-Pick type C studies
Controversies on the potential therapeutic use of rapamycin for treating a lysosomal cholesterol storage disease |
Uncovering the genetic basis of phenotypic heterogeneity in Parkinson disease |
UNCOVERING MODIFIER GENES OF LYSOSOMAL BIOLOGY BY EXPLOITING THE NATURAL GENETIC VARIATION OF INBRED MOUSE STRAINS |
LysoMod |
Unraveling the role of cellular clearance in GM2 gangiosidosis |
Unraveling the role of cellular clearance in GM2 gangiosidosis |
Identification of novel genes that modify the severity of Gaucher disease |
Identification of novel genes that modify the severity of Gaucher disease |
LysoMod |
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ANDRES KLEIN
Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine
Centro de Genética y Genómica
Universidad del Desarrollo-Clínica Alemana
SANTIAGO, Chile
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Silvana Zanlungo
Full Professor
Gastroenterology
Pontificia Universidad Católica de Chile
Santiago, Chile
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Alejandra Alvarez
Full professor
Cell and Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS
Santiago, Chile
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Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA
Santiago, Chile
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Juan Miquel
Full Professor
Gastroenterology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile
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Attilio Rigotti
Full Professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile
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Francisca Bronfman
Full Professor
Instituto de Ciencias Biomédicas
Universidad Andrés Bello
Santiago, Chile
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Gonzalo Cancino
Assistant Professor
Faculty of Biological Sciences
Pontificia Universidad Católica de Chile
Santiago, Chile
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Carla Castillo
Assistant Professor
Centro de Epidemiología y Políticas de Salud / Center of Epidemiology and Health Policy
Universidad del Desarrollo
Santiago, Chile
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Maria Repetto
Profesor Titular
Center for Genetics and Genomics
FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO
Santiago, Chile
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Patricio Olguín
Assistant Professor
Facultad de Medicina, ICBM, Departamento de Neurociencia
Universidad de Chile
Santiago, Chile
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LUIS SOBREVIA
Professor
Division of Obstetrics and Gynaecology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
SANTIAGO, Chile
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Enrique Guzman
Profesor Asistente
Bioquímica Clínica e Inmunología
Universidad de Concepción
Concepción, Chile
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Tamara Marín
PhD en Ciencias médicas
Gastroenterología
Pontificia Universidad Católica de Chile
Santiago, Chile
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Ximena Aguilera
Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy
Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)
Universidad del Desarrollo
Santiago, Chile
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Gonzalo Encina
Investigador
Instituto de Ciencias e Innovación en Medicina
Universidad del Desarrollo
Santiago, Chile
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KAREN DUBOIS
Postdoctoral fellow Fondef IDeA ID17I10064 IDI17
Instituto de Ciencias Biomédicas
Universidad de Chile
Santiago, Chile
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Juan Orellana
Associate Professor
Departamento de Neurología
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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Juan Lecaros
Associate professor
Observatory of Bioethics and Law
Universidad del Desarrollo
Santiago, Chile
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Jaime Gutierrez
Associate Professor and Researcher
Tecnología Médica
Universidad San Sebastián
Santiago, Chile
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Victor Cortes
Associate professor
Nutrition, Diabetes and Metabolism
Pontificia Universidad Católica de Chile
Santiago, Chile
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PABLO TAPIA
Investigador postdoctoral
Centro de Biología Celular y Biomedicina (CEBICEM)
Universidad San Sebastián
Santiafgo, Chile
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Carolina Cabeza
Académica y Jefa de Centro de Investigación
Universidad Bernardo O'Higgins
Santiago , Chile
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Oscar Lazo
Research Fellow
UK Dementia Research Institute and Department of Neuromuscular diseases
UCL Queen Square Institute of Neurology
London, Reino Unido
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Macarena Las Heras
Investigadora postdoctoral
Facultad de Química y Biología
Universidad de Santiago de Chile
Santiago, Chile
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Alexis Martinez
Investigador postdoctoral senior
Facultad de medicina
Instituto de Neurcoeincia Biomedica
Santiago, Chile